AR043271A1 - Compuestos de dihidropironas con heterociclos unidos y su uso en composicines farmaceuticas que poseen actividad inhibidora de hiv proteasa - Google Patents
Compuestos de dihidropironas con heterociclos unidos y su uso en composicines farmaceuticas que poseen actividad inhibidora de hiv proteasaInfo
- Publication number
- AR043271A1 AR043271A1 ARP990104528A ARP990104528A AR043271A1 AR 043271 A1 AR043271 A1 AR 043271A1 AR P990104528 A ARP990104528 A AR P990104528A AR P990104528 A ARP990104528 A AR P990104528A AR 043271 A1 AR043271 A1 AR 043271A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr
- branched
- alkyl
- straight
- pnr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El uso de estos compuestos para la preparación de composiciones farmacéuticas, con actividad inhibitoria de HIV proteasa utilizable en combinación con AZT y otro agente retroviral en el tratamiento del SIDA. Reivindicación 1: Un compuesto de dihidropironas con heterociclos unidos, caracterizado por tener la fórmula (1), o una sal farmacológicamente aceptable de él, donde R1 es H, un alquilo recto o ramificado C1-6 o un carbociclo C3-6; R2 es H, un alquilo recto o ramificado C1-5; R3 es H, (CR'2)nOR, (CR'2)nN(R)2, (CR'2)nNR'COR, (CR'2)nCO2R, (CR'2)nOCOR, (CR'2)nCON(R)2, (CR'2)nOCON(R)2, (CR'2)nR, (CR'2)nNR'CON(R)2, (CR'2)nNR'CO2R, (CR'2)nOSO2N(R)2, (CR'2)nNR'SO2OR, (CR'2)nNR'SO2N(R)2, (CR'2)nOSO2R, (CR'2)nNR'SO2R, (CR'2)nSOpR, (CR'2)nNR'CSN(R)2, (CR'2)nNR'C(NR')N(R)2, (CR'2)nSO2N(R)2, (CR'2)nC(NR')N(R)2, (CR'2)nCOR, O(CR'2)mOR, NR(CR'2)mOR, F, Cl, Br, CF3, CF3, CN, u =O; R4, R5 y R6 son independientemente H, un alquilo recto o ramificado C1-6, un cicloalquilo C3-6, (CR'2)nOR, (CR'2)nN(R)2, F, Cl, Br. CN, CF3, (CR'2)pNR'COR, (CR'2)pSOpR, (CR'2)pR, (CR'2)pOCOR, O(CR'2)mOR, NR(CR'2)mOR, (CR'2)pNR'CON(R)2, (CR'2)pOCON(R)2, (CR'2)pNR'CO2R, (CR'2)pCOR, (CR'2)pCO2R, (CR'2)pCON(R)2, (CR'2)pNR'SO2R, (CR'2)pSO2N(R)2, (CR'2)2NR' SO2OR, (CR'2)pOSO2N(R)2, (CR'2)pNR'SO2N(R)2, (CR'2)pC(NR')N(R)2, (CR'2)pNR'C(NR')N(R)2, (CR'2)pHet; dos cualquiera de R1-R3 o R4-R6 pueden formar juntos un anillo de 5 a 6 átomos totales que pueden contener de 0 a 3 heteroátomos; n es un número entero de 0 a 3; m es un número entro de 2 a 4; p es un número entero de 0 a 2; R7 es un alquilo recto o ramificado C1-6 o un carbociclo C3-6; R es independientemente H, un alquilo recto o ramificado C1-4, (CH)2nPh, o un heterociclo (CH2)n de 5 a 6 átomos que contienen de 1 a 2 heteroátomos y donde el (R)2 en N(R)2 puede formar un heterociclo que contiene el nitrógeno, todos optativamente sustituidos por F, Cl, Br, OR', CN, CO2R', N(R')2, NR'COR', CF3, u =O; R' es independientemente H, un alquilo recto o ramificado C1-4, o fenilo; R'' es independientemente H, un alquilo recto o ramificado C1-4, F, Cl, Br, OR', o N(R')2; Ar1 y Ar2 son independientemente fenilo o Het con la salvedad de que al menos un Ar es Het; Het es un heterociclo de 5 a 6 átomos que tienen de 1 a 4 heteroátomos o un heterociclo fusionado de 9 a 10 átomos que tienen de 1 a 3 heteroátomos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9994698P | 1998-09-11 | 1998-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043271A1 true AR043271A1 (es) | 2005-07-27 |
Family
ID=22277357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990104528A AR043271A1 (es) | 1998-09-11 | 1999-09-09 | Compuestos de dihidropironas con heterociclos unidos y su uso en composicines farmaceuticas que poseen actividad inhibidora de hiv proteasa |
Country Status (13)
Country | Link |
---|---|
US (3) | US6528510B1 (es) |
EP (1) | EP1112269A2 (es) |
JP (1) | JP2002524560A (es) |
KR (1) | KR20010085780A (es) |
AR (1) | AR043271A1 (es) |
AU (2) | AU773567B2 (es) |
BR (1) | BR9913598A (es) |
CA (1) | CA2339275A1 (es) |
NZ (1) | NZ510013A (es) |
PE (1) | PE20001052A1 (es) |
UY (1) | UY25708A1 (es) |
WO (1) | WO2000015634A2 (es) |
ZA (1) | ZA200100806B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9913598A (pt) * | 1998-09-11 | 2001-05-29 | Warner Lambert Co | Inibidores de protease de hiv |
WO2003091230A1 (en) * | 2002-04-26 | 2003-11-06 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate |
DOP2003000641A (es) * | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
US7148226B2 (en) * | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
GEP20115305B (en) * | 2004-08-18 | 2011-10-10 | Pfizer | Inhibitors of hepatitis c virus rna-dependent rna polymerase, compositions containing them and using the same for treatment |
PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
US20100292232A1 (en) * | 2007-11-09 | 2010-11-18 | Daniel Elleder | Non-nucleoside reverse transcriptase inhibitors |
CN101903367B (zh) | 2007-12-20 | 2015-08-05 | 法马马有限公司 | 抗肿瘤化合物 |
FR2933982A1 (fr) * | 2008-07-18 | 2010-01-22 | Sanofi Aventis | Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3786063A (en) * | 1971-05-24 | 1974-01-15 | Universal Oil Prod Co | Thiazolethiosulfonates |
ES2176263T3 (es) * | 1993-11-19 | 2002-12-01 | Parke Davis & Co | 5,6-dihidropironas derivadas como inhibidores de proteasa y agentes antivirus. |
US5840751A (en) * | 1993-11-19 | 1998-11-24 | Warner-Lambert Company | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
NZ275961A (en) * | 1993-11-19 | 2001-11-30 | Parke Davis & Co | 5,6-dihydropyrone derivatives and pharmaceutical compositions as anti-viral agents in the treatment of HIV infection |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
BR9913598A (pt) * | 1998-09-11 | 2001-05-29 | Warner Lambert Co | Inibidores de protease de hiv |
-
1999
- 1999-08-18 BR BR9913598-1A patent/BR9913598A/pt not_active IP Right Cessation
- 1999-08-18 JP JP2000570172A patent/JP2002524560A/ja not_active Abandoned
- 1999-08-18 AU AU57802/99A patent/AU773567B2/en not_active Ceased
- 1999-08-18 WO PCT/US1999/018986 patent/WO2000015634A2/en not_active Application Discontinuation
- 1999-08-18 EP EP99969092A patent/EP1112269A2/en not_active Withdrawn
- 1999-08-18 KR KR1020017003109A patent/KR20010085780A/ko not_active Application Discontinuation
- 1999-08-18 US US09/674,652 patent/US6528510B1/en not_active Expired - Fee Related
- 1999-08-18 NZ NZ510013A patent/NZ510013A/en unknown
- 1999-08-18 CA CA002339275A patent/CA2339275A1/en not_active Abandoned
- 1999-09-09 AR ARP990104528A patent/AR043271A1/es unknown
- 1999-09-10 UY UY25708A patent/UY25708A1/es not_active Application Discontinuation
- 1999-09-10 PE PE1999000916A patent/PE20001052A1/es not_active Application Discontinuation
-
2001
- 2001-01-29 ZA ZA200100806A patent/ZA200100806B/en unknown
-
2002
- 2002-11-19 US US10/299,510 patent/US6852711B2/en not_active Expired - Fee Related
-
2004
- 2004-08-27 AU AU2004205322A patent/AU2004205322A1/en not_active Abandoned
- 2004-09-09 US US10/938,442 patent/US20050075390A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR9913598A (pt) | 2001-05-29 |
NZ510013A (en) | 2003-11-28 |
KR20010085780A (ko) | 2001-09-07 |
EP1112269A2 (en) | 2001-07-04 |
US20040106606A1 (en) | 2004-06-03 |
UY25708A1 (es) | 1999-11-17 |
ZA200100806B (en) | 2002-01-29 |
US20050075390A1 (en) | 2005-04-07 |
WO2000015634A3 (en) | 2000-11-16 |
AU5780299A (en) | 2000-04-03 |
AU2004205322A1 (en) | 2004-09-23 |
CA2339275A1 (en) | 2000-03-23 |
US6528510B1 (en) | 2003-03-04 |
PE20001052A1 (es) | 2000-10-18 |
US6852711B2 (en) | 2005-02-08 |
JP2002524560A (ja) | 2002-08-06 |
AU773567B2 (en) | 2004-05-27 |
WO2000015634A2 (en) | 2000-03-23 |
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