IL124461A - Angiogenesis inhibiting 3-(1,2,4-thiadiazol-5-yl)piperazine pyridazine derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Angiogenesis inhibiting 3-(1,2,4-thiadiazol-5-yl)piperazine pyridazine derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL124461A
IL124461A IL12446197A IL12446197A IL124461A IL 124461 A IL124461 A IL 124461A IL 12446197 A IL12446197 A IL 12446197A IL 12446197 A IL12446197 A IL 12446197A IL 124461 A IL124461 A IL 124461A
Authority
IL
Israel
Prior art keywords
6alkyl
alk
amino
6alkyloxy
hydrogen
Prior art date
Application number
IL12446197A
Other languages
English (en)
Other versions
IL124461A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL124461A0 publication Critical patent/IL124461A0/xx
Publication of IL124461A publication Critical patent/IL124461A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
IL12446197A 1996-01-15 1997-01-14 Angiogenesis inhibiting 3-(1,2,4-thiadiazol-5-yl)piperazine pyridazine derivatives their preparation and pharmaceutical compositions containing them IL124461A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200085 1996-01-15
PCT/EP1997/000201 WO1997026258A1 (en) 1996-01-15 1997-01-14 Angiogenesis inhibiting pyridazinamines

Publications (2)

Publication Number Publication Date
IL124461A0 IL124461A0 (en) 1998-12-06
IL124461A true IL124461A (en) 2000-07-26

Family

ID=8223585

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12446197A IL124461A (en) 1996-01-15 1997-01-14 Angiogenesis inhibiting 3-(1,2,4-thiadiazol-5-yl)piperazine pyridazine derivatives their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US5985878A (xx)
EP (1) EP0876366B1 (xx)
JP (1) JP4169368B2 (xx)
KR (1) KR100443893B1 (xx)
CN (1) CN1104430C (xx)
AT (1) ATE203534T1 (xx)
AU (1) AU717744B2 (xx)
CA (1) CA2237273C (xx)
DE (1) DE69705819T2 (xx)
DK (1) DK0876366T3 (xx)
ES (1) ES2162235T3 (xx)
GR (1) GR3036900T3 (xx)
IL (1) IL124461A (xx)
MY (1) MY117098A (xx)
NO (1) NO309653B1 (xx)
NZ (1) NZ326354A (xx)
PT (1) PT876366E (xx)
SI (1) SI0876366T1 (xx)
TW (1) TW480256B (xx)
WO (1) WO1997026258A1 (xx)
ZA (1) ZA97288B (xx)

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US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
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US6833369B2 (en) 1997-06-24 2004-12-21 Janssen Pharmaceutica, Nv Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives
US6265407B1 (en) 1997-06-24 2001-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting thiadiazolyl pyridazine derivatives
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
AR013693A1 (es) * 1997-10-23 2001-01-10 Uriach & Cia Sa J Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria
ATE491689T1 (de) * 1997-10-27 2011-01-15 Neurosearch As Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
AU1600599A (en) * 1998-02-27 1999-09-15 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
US6833370B1 (en) 1999-05-21 2004-12-21 Abbott Laboratories Heterocycle substituted aminoazacycles useful as central nervous system agents
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
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US7208503B2 (en) 2000-04-21 2007-04-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives
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GB0111078D0 (en) 2001-05-04 2001-06-27 Novartis Ag Organic compounds
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
WO2005011655A2 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
DE102004003812A1 (de) * 2004-01-25 2005-08-11 Aventis Pharma Deutschland Gmbh Arylsubstituierte Heterozyklen, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
TW200533356A (en) * 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
US20080167321A1 (en) * 2004-09-20 2008-07-10 Xenon Pharmaceuticals Inc. Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
US8071603B2 (en) 2004-09-20 2011-12-06 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
JP4958786B2 (ja) * 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
EP1799668A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7592343B2 (en) * 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
WO2006034341A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
WO2006071875A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
US7635698B2 (en) 2004-12-29 2009-12-22 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
RU2007134259A (ru) * 2005-02-16 2009-03-27 Шеринг Корпорейшн (US) Гетероциклические замещенные пиперазины, обладающие антагонистическим действием к cxcr3
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BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
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WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
SI2074120T1 (sl) 2007-10-25 2010-06-30 Exelixis Inc Tropan spojine
AU2009241561B2 (en) 2008-04-29 2013-05-16 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
WO2010062507A1 (en) 2008-11-03 2010-06-03 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
AU2009314288B2 (en) 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
ES2392759T3 (es) 2008-11-17 2012-12-13 Eli Lilly And Company Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2011002067A1 (ja) * 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
WO2013085954A1 (en) 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors
WO2013085957A1 (en) * 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
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HRP20220331T1 (hr) 2018-03-08 2022-05-13 Incyte Corporation Spojevi aminopirazin diola kao inhibitori pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CN108912116A (zh) * 2018-08-15 2018-11-30 翟学旭 一种含氮杂环类衍生物及其在视网膜疾病中的应用
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US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
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Also Published As

Publication number Publication date
IL124461A0 (en) 1998-12-06
DE69705819T2 (de) 2002-04-11
JP4169368B2 (ja) 2008-10-22
NZ326354A (en) 1999-05-28
CN1104430C (zh) 2003-04-02
ZA97288B (en) 1998-07-14
JP2000503014A (ja) 2000-03-14
NO309653B1 (no) 2001-03-05
AU717744B2 (en) 2000-03-30
SI0876366T1 (en) 2001-12-31
NO982037L (no) 1998-09-15
EP0876366B1 (en) 2001-07-25
DK0876366T3 (da) 2001-11-05
WO1997026258A1 (en) 1997-07-24
NO982037D0 (no) 1998-05-05
EP0876366A2 (en) 1998-11-11
CA2237273A1 (en) 1997-07-24
GR3036900T3 (en) 2002-01-31
KR100443893B1 (ko) 2004-10-15
DE69705819D1 (de) 2001-08-30
MY117098A (en) 2004-05-31
AU1443997A (en) 1997-08-11
CN1208415A (zh) 1999-02-17
US5985878A (en) 1999-11-16
KR19990067654A (ko) 1999-08-25
TW480256B (en) 2002-03-21
ATE203534T1 (de) 2001-08-15
ES2162235T3 (es) 2001-12-16
CA2237273C (en) 2009-01-13
PT876366E (pt) 2002-01-30

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