PE84299A1 - Compuestos policiclicos parcialmente hidrogenados - Google Patents

Compuestos policiclicos parcialmente hidrogenados

Info

Publication number
PE84299A1
PE84299A1 PE00059998A PE00059998A PE84299A1 PE 84299 A1 PE84299 A1 PE 84299A1 PE 00059998 A PE00059998 A PE 00059998A PE 00059998 A PE00059998 A PE 00059998A PE 84299 A1 PE84299 A1 PE 84299A1
Authority
PE
Peru
Prior art keywords
ring
polyclic
compounds
partially hydrogenated
wavy lines
Prior art date
Application number
PE00059998A
Other languages
English (en)
Inventor
Jurg Zimmermann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE84299A1 publication Critical patent/PE84299A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO, HALOGENO, HIDROXI ETERIFICADO O ESTERIFICADO; ENTRE OTROS; n Y m SON 0-4; R3 Y R4 SON H, RADICAL ALIFATICO, CARBOCICLO, HETEROCICLO, ENTRE OTROS; o R3 ES ACILO C1-C30 Y R4 ESTA AUSENTE; o SI P ES CERO, R4 ESTA AUSENTE, SI R3 Y R4 ESTAN PRESENTES, p ES 1; R5 ES H, RADICAL ALIFATICO, CARBOCICLO, HETEROCICLO; X ES H, OH, O; Z ES H o ALQUILO; CUANDO EN EL ANILLO A NO EXISTEN INSATURACIONES, EL ANILLO B PRESENTA 2 INSATURACIONES o EN EL ANILLO A PRESENTA 2 INSATURACIONES Y EL ANILLO B NO EXISTEN 2 INSATURACIONES o EL ANILLO A Y EL ANILLO B NO PRESENTAN INSATURACIONES. UN COMPUESTO PREFERIDO ES 1,2,3,4-TETRAHIDROESTAUROSPORINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I INHIBE A LA QUINASA C, POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE UNA ENFERMEDAD TUMORAL
PE00059998A 1997-07-07 1998-07-03 Compuestos policiclicos parcialmente hidrogenados PE84299A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH164697 1997-07-07
CH214597 1997-09-11

Publications (1)

Publication Number Publication Date
PE84299A1 true PE84299A1 (es) 1999-09-09

Family

ID=25688257

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00059998A PE84299A1 (es) 1997-07-07 1998-07-03 Compuestos policiclicos parcialmente hidrogenados

Country Status (4)

Country Link
AU (1) AU8856298A (es)
CO (1) CO4940430A1 (es)
PE (1) PE84299A1 (es)
WO (1) WO1999002532A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917990A1 (de) * 1999-04-20 2000-11-02 Florian Lang Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk
CA2379035A1 (en) * 1999-07-13 2001-01-18 Shiro Akinaga Staurosporin derivatives
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10042137A1 (de) * 2000-08-28 2002-03-14 Florian Lang sgk2 und sgk3 als diagnostische und therapeutische Targets
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) * 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
ATE369894T1 (de) * 2000-11-22 2007-09-15 Novartis Pharma Gmbh Kombination enthaltend ein mittel zur verminderung von vegf-aktivität und ein mittel zur verminderung von egf-aktivität
US6855698B2 (en) 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
DK1439863T3 (da) 2001-10-29 2011-03-14 Boehringer Ingelheim Int MNK-kinase-homologe proteiner, som er involveret i reguleringen af energihomeostase og organelmetabolisme
CN1582150B (zh) * 2001-10-30 2011-09-07 诺瓦提斯公司 作为flt3受体酪氨酸激酶活性抑制剂的星形孢菌素衍生物
JP2006508174A (ja) * 2002-01-25 2006-03-09 ファルマシア・コーポレーション 炎症関連疾患を予防または治療するためのアルドステロンブロッカー療法
BRPI0413439A (pt) 2003-08-08 2006-10-17 Novartis Ag combinações compreendendo estaurosporinas
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN102101866A (zh) * 2010-11-04 2011-06-22 中国海洋大学 十字孢碱卤代衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
AU7000094A (en) * 1993-06-17 1995-01-17 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor
EP0763042A1 (en) * 1994-06-01 1997-03-19 Novartis AG Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
AU6888196A (en) * 1995-08-11 1997-03-12 Yale University Glycosylated indolocarbazole synthesis

Also Published As

Publication number Publication date
WO1999002532A2 (en) 1999-01-21
AU8856298A (en) 1999-02-08
WO1999002532A3 (en) 1999-04-01
CO4940430A1 (es) 2000-07-24

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal