WO1999002532A3 - Partially hydrogenated polycyclic compounds - Google Patents

Partially hydrogenated polycyclic compounds Download PDF

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Publication number
WO1999002532A3
WO1999002532A3 PCT/EP1998/004141 EP9804141W WO9902532A3 WO 1999002532 A3 WO1999002532 A3 WO 1999002532A3 EP 9804141 W EP9804141 W EP 9804141W WO 9902532 A3 WO9902532 A3 WO 9902532A3
Authority
WO
WIPO (PCT)
Prior art keywords
ring
partially hydrogenated
wavy lines
absent
replaced
Prior art date
Application number
PCT/EP1998/004141
Other languages
French (fr)
Other versions
WO1999002532A2 (en
Inventor
Juerg Zimmermann
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Juerg Zimmermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh, Juerg Zimmermann filed Critical Novartis Ag
Priority to AU88562/98A priority Critical patent/AU8856298A/en
Publication of WO1999002532A2 publication Critical patent/WO1999002532A2/en
Publication of WO1999002532A3 publication Critical patent/WO1999002532A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Abstract

The invention relates to a compound of formula (I), wherein R1, R2, R3, R4, R5, n, m, p, X and Z are as defined in the description; and either the two bonds characterised by wavy lines are absent in ring A and replaced by a total of 4 hydrogen atoms, and the two wavy lines in ring B each, together with the respective parallel bond, signify a double bond; or the two bonds characterised by wavy lines are absent in ring B and replaced by a total of 4 hydrogen atoms, and the two wavy lines in ring A each, together with the respective parallel bond, signify a double bond; or both in ring A and in ring B all of the 4 wavy bonds are absent and are replaced by a total of 8 hydrogen atoms; or a salt thereof, if at least one salt-forming group is present. These have, for example, an antitumour effect.
PCT/EP1998/004141 1997-07-07 1998-07-03 Partially hydrogenated polycyclic compounds WO1999002532A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU88562/98A AU8856298A (en) 1997-07-07 1998-07-03 Partially hydrogenated polycyclic compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH164697 1997-07-07
CH1646/97 1997-07-07
CH2145/97 1997-09-11
CH214597 1997-09-11

Publications (2)

Publication Number Publication Date
WO1999002532A2 WO1999002532A2 (en) 1999-01-21
WO1999002532A3 true WO1999002532A3 (en) 1999-04-01

Family

ID=25688257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004141 WO1999002532A2 (en) 1997-07-07 1998-07-03 Partially hydrogenated polycyclic compounds

Country Status (4)

Country Link
AU (1) AU8856298A (en)
CO (1) CO4940430A1 (en)
PE (1) PE84299A1 (en)
WO (1) WO1999002532A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917990A1 (en) * 1999-04-20 2000-11-02 Florian Lang Medicament containing inhibitors of cell volume regulated human kinase h-sgk
CA2379035A1 (en) 1999-07-13 2001-01-18 Shiro Akinaga Staurosporin derivatives
FR2801054B1 (en) * 1999-11-17 2003-06-13 Adir NOVEL DERIVATIVES OF 12,13- (PYRANOSYL) -INDOLO [2,3-A] PYRROLO [3,4-C] CARBAZOLE AND 12,13- (PYRANOSYL) -FURO [3,4-C] INDOLO [2,3 -A] CARBAZOLE, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE10042137A1 (en) * 2000-08-28 2002-03-14 Florian Lang sgk2 and sgk3 as diagnostic and therapeutic targets
US6677450B2 (en) * 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
ATE369894T1 (en) * 2000-11-22 2007-09-15 Novartis Pharma Gmbh COMBINATION CONTAINING AN AGENT FOR REDUCING VEGF ACTIVITY AND AN AGENT FOR REDUCING AGENT EGF ACTIVITY
RU2003131269A (en) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Derivatives of indolopyrrolocarbazoles and sugars, cytotoxic and selective in relation to topoisomerase I
DE10294485T5 (en) 2001-10-29 2004-04-29 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteins homologous with Mnk kinase, which are involved in the regulation of energy homeostasis and organelle metabolism
DE60213842T2 (en) 2001-10-30 2007-09-06 Novartis Ag STAUROSPORINE DERIVATIVES AS INHIBITORS OF THE FLT3 RECEPTOR TYROSINE KINASE EFFECT
AU2002368473A1 (en) * 2002-01-25 2004-09-09 Pharmacia Corporation Aldosterone blocker therapy to prevent or treat inflammation-related disorders
AU2004262927B2 (en) 2003-08-08 2008-05-22 Novartis Ag Combinations comprising staurosporines
ES2326459B1 (en) 2008-04-08 2010-05-28 Universidad De Oviedo GLYCOLSILATED INDOLOCARBAZOLS, ITS PROCESSING PROCEDURE AND ITS USES.
CN102101866A (en) * 2010-11-04 2011-06-22 中国海洋大学 Halogenated derivatives of staurosporine, and preparation method thereof and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388962A2 (en) * 1989-03-23 1990-09-26 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
WO1995000520A1 (en) * 1993-06-17 1995-01-05 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor
WO1995032976A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
WO1997007081A2 (en) * 1995-08-11 1997-02-27 Yale University Glycosylated indolocarbazole synthesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388962A2 (en) * 1989-03-23 1990-09-26 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
WO1995000520A1 (en) * 1993-06-17 1995-01-05 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor
WO1995032976A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
WO1997007081A2 (en) * 1995-08-11 1997-02-27 Yale University Glycosylated indolocarbazole synthesis

Also Published As

Publication number Publication date
WO1999002532A2 (en) 1999-01-21
AU8856298A (en) 1999-02-08
PE84299A1 (en) 1999-09-09
CO4940430A1 (en) 2000-07-24

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