CO4940430A1 - POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS - Google Patents

POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS

Info

Publication number
CO4940430A1
CO4940430A1 CO98037374A CO98037374A CO4940430A1 CO 4940430 A1 CO4940430 A1 CO 4940430A1 CO 98037374 A CO98037374 A CO 98037374A CO 98037374 A CO98037374 A CO 98037374A CO 4940430 A1 CO4940430 A1 CO 4940430A1
Authority
CO
Colombia
Prior art keywords
polyclic
staurosporin
growth
tumor cells
compounds containing
Prior art date
Application number
CO98037374A
Other languages
Spanish (es)
Inventor
Jorg Zimmermann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO4940430A1 publication Critical patent/CO4940430A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Abstract

La presente invención se relaciona con derivados de tetra- uoctahidroestauosporina N-mono- o N,N-di-sustituidos, es decir, derivados de 1, 2, 3, 4-tetrahidro, 8, 9, 10, 11-tetrahidro- ó 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11-octahidro-estaurosporina insustituidos o N-mono- o N,N-di-sustituidos, con procesos para su preparación preparaciones farmacéuticas que contienen a estos compuestos, y con métodos de tratamiento con estos compuestos, y con su uso como agentes farmacológicos o para preparación de un agente farmacológico.The present invention relates to N-mono- or N, N-di-substituted tetra-uoctahydrostantosporine derivatives, i.e. derivatives of 1, 2, 3, 4-tetrahydro, 8, 9, 10, 11-tetrahydro- or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11-octahydro-staurosporine unsubstituted or N-mono- or N, N-di-substituted, with processes for their preparation pharmaceutical preparations containing a these compounds, and with methods of treatment with these compounds, and with their use as pharmacological agents or for the preparation of a pharmacological agent.

CO98037374A 1997-07-07 1998-07-02 POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS CO4940430A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH164697 1997-07-07
CH214597 1997-09-11

Publications (1)

Publication Number Publication Date
CO4940430A1 true CO4940430A1 (en) 2000-07-24

Family

ID=25688257

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98037374A CO4940430A1 (en) 1997-07-07 1998-07-02 POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS

Country Status (4)

Country Link
AU (1) AU8856298A (en)
CO (1) CO4940430A1 (en)
PE (1) PE84299A1 (en)
WO (1) WO1999002532A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917990A1 (en) * 1999-04-20 2000-11-02 Florian Lang Medicament containing inhibitors of cell volume regulated human kinase h-sgk
EP1201668A4 (en) * 1999-07-13 2003-05-21 Kyowa Hakko Kogyo Kk Staurosporin derivatives
FR2801054B1 (en) * 1999-11-17 2003-06-13 Adir NOVEL DERIVATIVES OF 12,13- (PYRANOSYL) -INDOLO [2,3-A] PYRROLO [3,4-C] CARBAZOLE AND 12,13- (PYRANOSYL) -FURO [3,4-C] INDOLO [2,3 -A] CARBAZOLE, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE10042137A1 (en) * 2000-08-28 2002-03-14 Florian Lang sgk2 and sgk3 as diagnostic and therapeutic targets
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en) * 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
WO2002041882A2 (en) * 2000-11-22 2002-05-30 Novartis Ag Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
PL368942A1 (en) 2001-03-22 2005-04-04 Bristol-Myers Squibb Company Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
DK1439863T3 (en) 2001-10-29 2011-03-14 Boehringer Ingelheim Int MNK kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
JP4959918B2 (en) 2001-10-30 2012-06-27 ノバルティス アーゲー Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
CA2478473A1 (en) * 2002-01-25 2004-09-02 Pharmacia Corporation Aldosterone blocker therapy to prevent or treat inflammation-related disorders
CA2533861A1 (en) 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines
ES2326459B1 (en) 2008-04-08 2010-05-28 Universidad De Oviedo GLYCOLSILATED INDOLOCARBAZOLS, ITS PROCESSING PROCEDURE AND ITS USES.
CN102101866A (en) * 2010-11-04 2011-06-22 中国海洋大学 Halogenated derivatives of staurosporine, and preparation method thereof and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
WO1995000520A1 (en) * 1993-06-17 1995-01-05 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor
WO1995032976A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
WO1997007081A2 (en) * 1995-08-11 1997-02-27 Yale University Glycosylated indolocarbazole synthesis

Also Published As

Publication number Publication date
AU8856298A (en) 1999-02-08
WO1999002532A2 (en) 1999-01-21
WO1999002532A3 (en) 1999-04-01
PE84299A1 (en) 1999-09-09

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