SK287783B6 - Imunoterapeutická kombinácia na imunoterapiu nádorov, ktoré nadmerne exprimujú gangliozidy, a jej použitie - Google Patents
Imunoterapeutická kombinácia na imunoterapiu nádorov, ktoré nadmerne exprimujú gangliozidy, a jej použitie Download PDFInfo
- Publication number
- SK287783B6 SK287783B6 SK1216-2003A SK12162003A SK287783B6 SK 287783 B6 SK287783 B6 SK 287783B6 SK 12162003 A SK12162003 A SK 12162003A SK 287783 B6 SK287783 B6 SK 287783B6
- Authority
- SK
- Slovakia
- Prior art keywords
- ganglioside
- vaccine
- antibody
- mab
- tumors
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
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- Food Science & Technology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2001008420010084A CU23007A1 (es) | 2001-04-06 | 2001-04-06 | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| PCT/CU2002/000002 WO2002081661A2 (fr) | 2001-04-06 | 2002-04-08 | Combinaisons immunotherapeutiques utilisees dans le traitement de tumeurs surexprimant les gangliosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK12162003A3 SK12162003A3 (sk) | 2004-05-04 |
| SK287783B6 true SK287783B6 (sk) | 2011-09-05 |
Family
ID=40291118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1216-2003A SK287783B6 (sk) | 2001-04-06 | 2002-04-08 | Imunoterapeutická kombinácia na imunoterapiu nádorov, ktoré nadmerne exprimujú gangliozidy, a jej použitie |
| SK1226-2003A SK287914B6 (sk) | 2001-04-06 | 2002-04-08 | Chimeric monoclonal antibody and its use in the preparation of medicament for the treatment of malignant tumors, cell line and pharmaceutical composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1226-2003A SK287914B6 (sk) | 2001-04-06 | 2002-04-08 | Chimeric monoclonal antibody and its use in the preparation of medicament for the treatment of malignant tumors, cell line and pharmaceutical composition |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US20050069535A1 (fr) |
| EP (3) | EP1798243B1 (fr) |
| JP (2) | JP4366080B2 (fr) |
| KR (3) | KR100863509B1 (fr) |
| CN (3) | CN1319991C (fr) |
| AR (2) | AR033123A1 (fr) |
| AT (3) | ATE378356T1 (fr) |
| AU (3) | AU2002308347B2 (fr) |
| BG (2) | BG66304B1 (fr) |
| BR (3) | BR0208676B1 (fr) |
| CA (2) | CA2441845C (fr) |
| CU (1) | CU23007A1 (fr) |
| CZ (2) | CZ304424B6 (fr) |
| DE (2) | DE60228561D1 (fr) |
| DK (2) | DK1384726T3 (fr) |
| EA (2) | EA006936B1 (fr) |
| EC (2) | ECSP034788A (fr) |
| ES (2) | ES2296986T3 (fr) |
| HK (3) | HK1066818A1 (fr) |
| HR (2) | HRP20030805B1 (fr) |
| HU (2) | HU228105B1 (fr) |
| IL (2) | IL158246A0 (fr) |
| IS (2) | IS2701B (fr) |
| MX (2) | MXPA03008738A (fr) |
| MY (3) | MY137078A (fr) |
| NO (2) | NO331533B1 (fr) |
| NZ (2) | NZ528599A (fr) |
| PE (1) | PE20020972A1 (fr) |
| PL (2) | PL371770A1 (fr) |
| PT (2) | PT1411064E (fr) |
| SG (1) | SG161737A1 (fr) |
| SI (2) | SI1411064T1 (fr) |
| SK (2) | SK287783B6 (fr) |
| UA (3) | UA75393C2 (fr) |
| UY (2) | UY27243A1 (fr) |
| WO (2) | WO2002081661A2 (fr) |
| ZA (2) | ZA200307585B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7297336B2 (en) * | 2003-09-12 | 2007-11-20 | Baxter International Inc. | Factor IXa specific antibodies displaying factor VIIIa like activity |
| ES2523172T3 (es) * | 2005-02-04 | 2014-11-21 | Survac Aps | Vacuna de péptido de survivina |
| FI20055398A0 (fi) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Menetelmä solupopulaatioiden evaluoimiseksi |
| GB2429013C (en) * | 2005-08-11 | 2012-11-28 | Arpi Matossian-Rogers | Peptides for treatment and diagnosis of autoimmunedisease |
| CN101379086B (zh) | 2005-08-19 | 2013-07-17 | 惠氏公司 | 抗gdf-8的拮抗剂抗体以及在als和其他gdf-8-相关病症治疗中的用途 |
| ITFI20060163A1 (it) * | 2006-06-29 | 2006-09-28 | Menarini Internat Operations Luxembourg Sa | Composizione farmaceutica contenente un anticorpo monoclonale anti idiotipico anti-ca-125 ed alluminio |
| TWI434855B (zh) * | 2006-11-21 | 2014-04-21 | Hoffmann La Roche | 結合物及其在免疫分析中作為參考標準之用途 |
| JP5465542B2 (ja) * | 2008-02-22 | 2014-04-09 | 片山化学工業株式会社 | 合成糖脂質含有リポソーム |
| EP2166085A1 (fr) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Cellules modifiées bivalentes |
| TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| ES2593583T3 (es) | 2009-03-10 | 2016-12-09 | Biogen Ma Inc. | Anticuerpos anti-BCMA |
| US8466260B2 (en) | 2009-04-01 | 2013-06-18 | Genentech, Inc. | Anti-FcRH5 antibodies and immunoconjugates and methods of use |
| CU23736A1 (es) * | 2009-05-04 | 2011-11-15 | Centro Inmunologia Molecular | Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso |
| AU2010291835A1 (en) * | 2009-09-03 | 2012-04-19 | Vancouver Biotech Ltd. | Monoclonal antibodies against gonadotropin-releasing hormone receptor |
| WO2012096994A2 (fr) * | 2011-01-10 | 2012-07-19 | Emory University | Anticorps dirigés contre le virus de la grippe |
| CU24070B1 (es) * | 2011-12-27 | 2015-01-29 | Ct De Inmunología Molecular | Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3) |
| EP2641916A1 (fr) * | 2012-03-23 | 2013-09-25 | Centre National de la Recherche Scientifique (C.N.R.S) | Nouveaux anticorps anti sPLA2-IIA et leurs utilisations |
| JP6433889B2 (ja) | 2012-06-15 | 2018-12-05 | ファイザー・インク | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| AR096687A1 (es) | 2013-06-24 | 2016-01-27 | Genentech Inc | Anticuerpos anti-fcrh5 |
| ES2811923T3 (es) | 2013-12-17 | 2021-03-15 | Genentech Inc | Anticuerpos anti-CD3 y métodos de uso |
| TWI609886B (zh) * | 2014-04-10 | 2018-01-01 | 台灣浩鼎生技股份有限公司 | 抗體、產生該抗體之融合瘤、包含該抗體之藥學組成物及其用途 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| RU2748943C2 (ru) | 2015-06-16 | 2021-06-02 | Дженентек, Инк. | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА И АНТИТЕЛА С СОЗРЕВШЕЙ АФФИННОСТЬЮ ПРОТИВ FcRH5 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2018017864A2 (fr) * | 2016-07-20 | 2018-01-25 | Oncomed Pharmaceuticals, Inc. | Agents de liaison à pvrig et leurs utilisations |
| EP3548071A4 (fr) | 2016-11-30 | 2020-07-15 | OncoMed Pharmaceuticals, Inc. | Méthodes de traitement du cancer comprenant des agents de liaison à tigit |
| CU20170173A7 (es) * | 2017-12-27 | 2019-11-04 | Ct Inmunologia Molecular | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2754206B2 (ja) * | 1987-11-17 | 1998-05-20 | メクト株式会社 | α２→３結合を認識するモノクローナル抗体 |
| US6051225A (en) * | 1988-10-19 | 2000-04-18 | The Dow Chemical Company | Family of high affinity, modified antibodies for cancer treatment |
| ATE188874T1 (de) * | 1992-08-18 | 2000-02-15 | Centro Inmunologia Molecular | Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungen |
| JPH07101999A (ja) * | 1993-10-06 | 1995-04-18 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体に対する抗イデイオタイプ抗体のアミノ酸配列およびそれをコードするｄｎａ塩基配列 |
| US6063379A (en) * | 1993-12-09 | 2000-05-16 | Centro De Inmunologia Molecular | Anti-idiotypic monoclonal antibodies and compositions including the anti-idiotypic monoclonal antibodies |
| CU22702A1 (es) * | 1997-10-21 | 2001-07-31 | Centro Inmunologia Molecular | Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen |
| DE69428763T2 (de) * | 1993-12-09 | 2002-08-01 | Ct De Inmunologia Molecular Ci | Monoklonale Antikörper gegen Ganglioside und deren Verwendung in der spezifischen, aktiven Immuntherapie gegen bösartige Tumoren |
| US6149921A (en) * | 1993-12-29 | 2000-11-21 | Centro De Inmunologia Molecular | Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment |
| CU22420A1 (es) * | 1993-12-29 | 1996-01-31 | Centro Inmunologia Molecular | Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer |
| CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| CU22731A1 (es) * | 1998-02-05 | 2002-02-28 | Centro Inmunologia Molecular | Anticuerpo monoclonal que reconoce el oligosacárido ácido siálico n´glicolilado-galactosa-glucosa (ngcneu-gal-glu) en tumores malignos y composiciones farmacéuticas que los contienen |
| US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
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2001
- 2001-04-06 CU CU2001008420010084A patent/CU23007A1/es unknown
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2002
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- 2002-04-05 UY UY27242A patent/UY27242A1/es not_active Application Discontinuation
- 2002-04-05 MY MYPI20081190A patent/MY145703A/en unknown
- 2002-04-05 AR ARP020101263A patent/AR033122A1/es unknown
- 2002-04-05 MY MYPI20021239A patent/MY157372A/en unknown
- 2002-04-08 WO PCT/CU2002/000002 patent/WO2002081661A2/fr active IP Right Grant
- 2002-04-08 HU HU0401695A patent/HU228105B1/hu not_active IP Right Cessation
- 2002-04-08 US US10/473,978 patent/US20050069535A1/en not_active Abandoned
- 2002-04-08 ES ES02759752T patent/ES2296986T3/es not_active Expired - Lifetime
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- 2002-04-08 DK DK02759751T patent/DK1384726T3/da active
- 2002-04-08 MX MXPA03008738A patent/MXPA03008738A/es not_active Application Discontinuation
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- 2002-04-08 CN CNB028084330A patent/CN1319991C/zh not_active Expired - Fee Related
- 2002-04-08 EP EP06076643A patent/EP1798243B1/fr not_active Expired - Lifetime
- 2002-04-08 AU AU2002308347A patent/AU2002308347B2/en not_active Ceased
- 2002-04-08 DK DK02759752T patent/DK1411064T3/da active
- 2002-04-08 PT PT02759752T patent/PT1411064E/pt unknown
- 2002-04-08 KR KR1020037012938A patent/KR100863509B1/ko not_active IP Right Cessation
- 2002-04-08 CA CA2441845A patent/CA2441845C/fr not_active Expired - Fee Related
- 2002-04-08 EA EA200301097A patent/EA006936B1/ru not_active IP Right Cessation
- 2002-04-08 BR BRPI0208675-1A patent/BRPI0208675B1/pt unknown
- 2002-04-08 JP JP2002580025A patent/JP4366080B2/ja not_active Expired - Fee Related
- 2002-04-08 EA EA200301098A patent/EA006310B1/ru not_active IP Right Cessation
- 2002-04-08 DE DE60228561T patent/DE60228561D1/de not_active Expired - Lifetime
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- 2002-04-08 AT AT02759752T patent/ATE378356T1/de active
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- 2002-04-08 EP EP02759752A patent/EP1411064B1/fr not_active Expired - Lifetime
- 2002-04-08 CN CNB028086309A patent/CN100349920C/zh not_active Expired - Fee Related
- 2002-04-08 US US10/473,977 patent/US20040253233A1/en not_active Abandoned
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- 2002-04-08 PL PL371937A patent/PL208109B1/pl unknown
- 2002-04-08 JP JP2002579482A patent/JP2004528033A/ja active Pending
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- 2002-04-08 KR KR1020037012969A patent/KR100946168B1/ko not_active IP Right Cessation
- 2002-04-08 AU AU2002308348A patent/AU2002308348B2/en not_active Ceased
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- 2002-04-08 EP EP02759751A patent/EP1384726B1/fr not_active Expired - Lifetime
- 2002-04-08 CA CA2443372A patent/CA2443372C/fr not_active Expired - Fee Related
- 2002-04-08 SI SI200230660T patent/SI1411064T1/sl unknown
- 2002-04-08 AT AT02759751T patent/ATE406386T1/de active
- 2002-04-08 SI SI200230766T patent/SI1384726T1/sl unknown
- 2002-04-08 DE DE60223547T patent/DE60223547T2/de not_active Expired - Lifetime
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- 2002-04-08 WO PCT/CU2002/000003 patent/WO2002081496A2/fr active Application Filing
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2003
- 2003-09-23 IS IS6964A patent/IS2701B/is unknown
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- 2003-09-29 ZA ZA200307585A patent/ZA200307585B/en unknown
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- 2003-10-03 NO NO20034436A patent/NO331533B1/no not_active IP Right Cessation
- 2003-10-03 NO NO20034437A patent/NO20034437L/no not_active Application Discontinuation
- 2003-10-06 HR HR20030805A patent/HRP20030805B1/xx not_active IP Right Cessation
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2004
- 2004-12-14 HK HK04109894A patent/HK1066818A1/xx not_active IP Right Cessation
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2005
- 2005-04-01 HK HK05102752A patent/HK1070080A1/xx not_active IP Right Cessation
- 2005-12-20 UA UAA200512270A patent/UA86768C2/ru unknown
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2007
- 2007-10-26 AU AU2007231687A patent/AU2007231687B2/en not_active Expired - Fee Related
- 2007-12-31 HK HK07114311.6A patent/HK1109160A1/xx not_active IP Right Cessation
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2008
- 2008-08-07 KR KR1020087019420A patent/KR100919617B1/ko not_active IP Right Cessation
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2009
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