SI1485087T1 - (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4- acetilaminoizoindolin-1,3-dion za uporabo za zdravljenje psoriaze s peroralnim dajanjem - Google Patents
(+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4- acetilaminoizoindolin-1,3-dion za uporabo za zdravljenje psoriaze s peroralnim dajanjemInfo
- Publication number
- SI1485087T1 SI1485087T1 SI200331659T SI200331659T SI1485087T1 SI 1485087 T1 SI1485087 T1 SI 1485087T1 SI 200331659 T SI200331659 T SI 200331659T SI 200331659 T SI200331659 T SI 200331659T SI 1485087 T1 SI1485087 T1 SI 1485087T1
- Authority
- SI
- Slovenia
- Prior art keywords
- acetylaminoisoindoline
- methylsulfonylethyl
- dione
- methoxyphenyl
- ethoxy
- Prior art date
Links
- 201000004681 Psoriasis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- IMOZEMNVLZVGJZ-UHFFFAOYSA-N n-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 IMOZEMNVLZVGJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36651502P | 2002-03-20 | 2002-03-20 | |
US43845003P | 2003-01-07 | 2003-01-07 | |
EP03721414A EP1485087B1 (en) | 2002-03-20 | 2003-03-20 | (+)-2- [1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione for use in treating psoriasis by oral administration |
PCT/US2003/008738 WO2003080049A1 (en) | 2002-03-20 | 2003-03-20 | (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
Publications (1)
Publication Number | Publication Date |
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SI1485087T1 true SI1485087T1 (sl) | 2009-12-31 |
Family
ID=28457137
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332599T SI2223688T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-Etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- isoindolin-1,3-dion: Metode uporabe in njegova sestava |
SI200331659T SI1485087T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4- acetilaminoizoindolin-1,3-dion za uporabo za zdravljenje psoriaze s peroralnim dajanjem |
SI200332535T SI2223687T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4- acetilaminoizoindolin-1,3-dion: metode uporabe in sestavki le-tega |
SI200332539T SI2295055T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- izoindolin-1, 3-dion: Metode uporabe in njegovi sestavki |
SI200332591T SI2962690T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- izoindolin-1,3-dion: postopki uporabe in njegovi sestavki |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332599T SI2223688T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-Etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- isoindolin-1,3-dion: Metode uporabe in njegova sestava |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332535T SI2223687T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4- acetilaminoizoindolin-1,3-dion: metode uporabe in sestavki le-tega |
SI200332539T SI2295055T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- izoindolin-1, 3-dion: Metode uporabe in njegovi sestavki |
SI200332591T SI2962690T1 (sl) | 2002-03-20 | 2003-03-20 | (+)-2-(1-(3-etoksi-4-metoksifenil)-2-metilsulfoniletil)-4-acetilamino- izoindolin-1,3-dion: postopki uporabe in njegovi sestavki |
Country Status (24)
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US (14) | US6962940B2 (sl) |
EP (9) | EP2311453B1 (sl) |
JP (4) | JP2005525386A (sl) |
KR (6) | KR101263786B1 (sl) |
CN (2) | CN100427085C (sl) |
AT (1) | ATE440599T1 (sl) |
AU (1) | AU2003224729C9 (sl) |
BE (1) | BE2019C008I2 (sl) |
CA (2) | CA2479666C (sl) |
CY (6) | CY1109380T1 (sl) |
DE (1) | DE60328974D1 (sl) |
DK (6) | DK2295055T3 (sl) |
ES (8) | ES2742729T3 (sl) |
FR (1) | FR19C1046I2 (sl) |
HK (3) | HK1073426A1 (sl) |
HU (5) | HUE029682T2 (sl) |
IL (3) | IL164147A0 (sl) |
LU (1) | LUC00125I2 (sl) |
MX (2) | MXPA04009075A (sl) |
NL (1) | NL300994I2 (sl) |
NZ (1) | NZ535798A (sl) |
PT (6) | PT2420490T (sl) |
SI (5) | SI2223688T1 (sl) |
WO (1) | WO2003080049A1 (sl) |
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CA2262906C (en) * | 1996-08-12 | 2006-10-31 | Celgene Corporation | Novel immunotherapeutic agents and their use in the reduction of cytokine levels |
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US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
CA2379887C (en) * | 2002-04-09 | 2004-01-20 | Bernard Charles Sherman | Stable tablets comprising simvastatin |
US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
NZ570777A (en) * | 2002-05-17 | 2009-04-30 | Celgene Corp | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
BR0315316A (pt) * | 2002-10-15 | 2005-08-16 | Celgene Corp | Métodos de tratar, prevenir ou controlar uma sìndrome mielodisplásica, e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo em um paciente sofrendo de uma sìndrome mielodisplásica, composição farmacêutica, forma de dosagem unitária, e, kit |
US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
US7776907B2 (en) * | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
ZA200503653B (en) * | 2002-11-06 | 2006-08-30 | Celgene Corp | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
AU2003294311B8 (en) * | 2002-11-18 | 2008-06-05 | Celgene Corporation | Method of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
BR0316256A (pt) * | 2002-11-18 | 2005-10-04 | Celgene Corp | Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto |
US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
AU2004220607B2 (en) * | 2003-03-06 | 2009-06-11 | Celgene Corporation | Selective cytokine inhibitory drugs for treating disorders of the central nervous system |
JPWO2004087148A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 肺疾患の治療および/または予防剤 |
JP2007524656A (ja) * | 2003-10-23 | 2007-08-30 | セルジーン・コーポレーション | 疼痛を治療、改変および管理するための選択的サイトカイン阻害薬を含む組成物ならびにその使用方法 |
BRPI0416266A (pt) * | 2003-11-06 | 2007-01-09 | Celgene Corp | método para tratar, prevenir e/ou controlar uma doença ou distúrbio relacionada com amianto em um paciente |
US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
WO2005056009A1 (ja) * | 2003-12-12 | 2005-06-23 | Kyowa Hakko Kogyo Co., Ltd. | 肺疾患治療剤 |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
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