DK0975347T3 - Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonister - Google Patents
Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonisterInfo
- Publication number
- DK0975347T3 DK0975347T3 DK98913584T DK98913584T DK0975347T3 DK 0975347 T3 DK0975347 T3 DK 0975347T3 DK 98913584 T DK98913584 T DK 98913584T DK 98913584 T DK98913584 T DK 98913584T DK 0975347 T3 DK0975347 T3 DK 0975347T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonists
- adenylate cyclase
- guanyl
- cyclist
- synergistic combination
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 4
- 102000030621 adenylate cyclase Human genes 0.000 title abstract 2
- 108060000200 adenylate cyclase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- 108010078321 Guanylate Cyclase Proteins 0.000 abstract 1
- 102000014469 Guanylate cyclase Human genes 0.000 abstract 1
- 206010061876 Obstruction Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000038016 acute inflammation Diseases 0.000 abstract 1
- 230000006022 acute inflammation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000621 bronchi Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19708049 | 1997-02-28 | ||
| PCT/EP1998/001047 WO1998037894A1 (de) | 1997-02-28 | 1998-02-24 | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0975347T3 true DK0975347T3 (da) | 2008-06-16 |
Family
ID=7821764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98913584T DK0975347T3 (da) | 1997-02-28 | 1998-02-24 | Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonister |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6333354B1 (da) |
| EP (1) | EP0975347B1 (da) |
| JP (2) | JP2001513097A (da) |
| AT (1) | ATE386531T1 (da) |
| AU (1) | AU6823098A (da) |
| CY (1) | CY2607B2 (da) |
| DE (1) | DE59814173D1 (da) |
| DK (1) | DK0975347T3 (da) |
| ES (1) | ES2302350T3 (da) |
| PT (1) | PT975347E (da) |
| SI (1) | SI0975347T1 (da) |
| WO (1) | WO1998037894A1 (da) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2222613T3 (es) * | 1997-09-12 | 2005-02-01 | Pharis Biotec Gmbh | Composicion para la terapia de diabetes mellitus y de la obesidad. |
| TR200100500T2 (tr) * | 1998-08-26 | 2001-06-21 | Smithkline Beecham Corporation | Pulmoner hastalıkların tedavisi için terapiler |
| IL137429A0 (en) * | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
| CA2378257A1 (en) * | 1999-08-10 | 2001-02-15 | William E. Sponsel | Method for increasing optic nerve, choroidal and retinal blood flow to facilitate the preservation of sight |
| CZ302882B6 (cs) * | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| TWI224966B (en) * | 1999-11-02 | 2004-12-11 | Pfizer | Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient |
| SK17052002A3 (sk) | 2000-06-05 | 2003-12-02 | Altana Pharma Ag | Pyridazinónové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
| WO2002022127A1 (en) * | 2000-09-13 | 2002-03-21 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
| DE10061137B4 (de) * | 2000-12-07 | 2016-10-06 | Takeda Gmbh | Neue pharmazeutische Zubereitung |
| WO2003032964A2 (en) * | 2001-10-17 | 2003-04-24 | University Of Wales College Of Medecine | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
| AU2002361417A1 (en) * | 2001-12-17 | 2003-06-30 | Altana Pharma Ag | Use of selective PDE5 inhibitors for treating partial and global respiratory failure |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| WO2003086373A1 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US20050118715A1 (en) * | 2002-04-12 | 2005-06-02 | Hariri Robert J. | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20040087653A1 (en) * | 2002-05-16 | 2004-05-06 | Manning Pamela T. | Methods for the treatment of respiratory diseases and conditions with a selective iNOS inhibitor and a PDE inhibitor and compositions therefor |
| CN1652843A (zh) * | 2002-05-16 | 2005-08-10 | 法玛西雅公司 | 使用选择性iNOS抑制剂治疗呼吸系统疾病和病症 |
| KR20050043923A (ko) * | 2002-09-16 | 2005-05-11 | 알콘 매뉴팩츄어링, 리미티드 | 혈관신생 치료를 위한 pde-ⅳ 저해제의 용도 |
| PL216752B1 (pl) * | 2002-11-27 | 2014-05-30 | Nycomed Gmbh | Środek leczniczy do zapobiegania objawom lub do leczenia chorób dróg oddechowych u ludzi i zastosowanie |
| ME00488B (me) * | 2002-11-27 | 2011-10-10 | Astrazeneca Ab | Sinergička kombinacija koja uključuje roflumilast i (r,r)-formoterol |
| US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| KR101227626B1 (ko) | 2003-01-28 | 2013-02-01 | 아이언우드 파마슈티컬스, 인코포레이티드 | 위장병 치료 방법 및 위장병 치료용 조성물 |
| MXPA05011225A (es) * | 2003-04-18 | 2005-12-14 | Pharmacia & Upjohn Co Llc | Politerapias. |
| DK2366393T3 (da) | 2005-04-19 | 2013-10-21 | Takeda Gmbh | Roflumilast til behandlingen af pulmonal hypertension |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2008030651A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2268279A1 (en) * | 2008-03-24 | 2011-01-05 | Celgene Corporation | Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl¨-3-oxoisoindoline-4-yl}carboxamide |
| WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
| CA2748607A1 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| ES2735992T3 (es) | 2013-04-12 | 2019-12-23 | Ardelyx Inc | Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos |
| JP6687550B2 (ja) | 2014-06-23 | 2020-04-22 | セルジーン コーポレイション | 肝疾患又は肝機能異常を治療するためのアプレミラスト |
| CN106333953A (zh) * | 2015-07-08 | 2017-01-18 | 珠海津之敦医药科技有限公司 | 尤克那非新用途 |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| JP7292207B2 (ja) | 2017-01-09 | 2023-06-16 | アルデリックス, インコーポレイテッド | 消化管障害を処置するために有用な化合物 |
| WO2020186235A1 (en) | 2019-03-14 | 2020-09-17 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPH01153634A (ja) * | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 吸入剤 |
| IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
| EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
| US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
| US5602110A (en) | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
-
1998
- 1998-02-24 DK DK98913584T patent/DK0975347T3/da active
- 1998-02-24 SI SI9830909T patent/SI0975347T1/sl unknown
- 1998-02-24 PT PT98913584T patent/PT975347E/pt unknown
- 1998-02-24 US US09/367,850 patent/US6333354B1/en not_active Expired - Lifetime
- 1998-02-24 AU AU68230/98A patent/AU6823098A/en not_active Abandoned
- 1998-02-24 ES ES98913584T patent/ES2302350T3/es not_active Expired - Lifetime
- 1998-02-24 EP EP98913584A patent/EP0975347B1/de not_active Expired - Lifetime
- 1998-02-24 DE DE59814173T patent/DE59814173D1/de not_active Expired - Lifetime
- 1998-02-24 JP JP53729498A patent/JP2001513097A/ja not_active Withdrawn
- 1998-02-24 AT AT98913584T patent/ATE386531T1/de active
- 1998-02-24 WO PCT/EP1998/001047 patent/WO1998037894A1/de not_active Ceased
-
2008
- 2008-11-13 JP JP2008290751A patent/JP2009073853A/ja active Pending
-
2009
- 2009-06-11 CY CY0900008A patent/CY2607B2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT975347E (pt) | 2008-05-23 |
| AU6823098A (en) | 1998-09-18 |
| JP2001513097A (ja) | 2001-08-28 |
| US6333354B1 (en) | 2001-12-25 |
| DE59814173D1 (de) | 2008-04-03 |
| WO1998037894A1 (de) | 1998-09-03 |
| ATE386531T1 (de) | 2008-03-15 |
| EP0975347B1 (de) | 2008-02-20 |
| ES2302350T3 (es) | 2008-07-01 |
| SI0975347T1 (sl) | 2008-08-31 |
| CY2607B2 (en) | 2010-04-28 |
| EP0975347A1 (de) | 2000-02-02 |
| JP2009073853A (ja) | 2009-04-09 |
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