LUC00125I2 - - Google Patents

Download PDF

Info

Publication number
LUC00125I2
LUC00125I2 LU00125C LUC00125C LUC00125I2 LU C00125 I2 LUC00125 I2 LU C00125I2 LU 00125 C LU00125 C LU 00125C LU C00125 C LUC00125 C LU C00125C LU C00125 I2 LUC00125 I2 LU C00125I2
Authority
LU
Luxembourg
Prior art keywords
compound
acetylaminoisoindoline
methylsulfonylethyl
dione
solvate
Prior art date
Application number
LU00125C
Other languages
English (en)
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28457137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00125(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of LUC00125I1 publication Critical patent/LUC00125I1/fr
Publication of LUC00125I2 publication Critical patent/LUC00125I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
LU00125C 2002-03-20 2019-06-14 LUC00125I2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36651502P 2002-03-20 2002-03-20
US43845003P 2003-01-07 2003-01-07
PCT/US2003/008738 WO2003080049A1 (fr) 2002-03-20 2003-03-20 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: leurs procedes d'utilisation et leurs compositions
EP03721414A EP1485087B1 (fr) 2002-03-20 2003-03-20 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione pour le traitement du psoriasis par administration orale
EP09003138.6A EP2074995B1 (fr) 2002-03-20 2003-03-20 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: leurs procedes d'utilisation et leurs compositions

Publications (2)

Publication Number Publication Date
LUC00125I1 LUC00125I1 (fr) 2019-06-18
LUC00125I2 true LUC00125I2 (fr) 2019-12-24

Family

ID=28457137

Family Applications (1)

Application Number Title Priority Date Filing Date
LU00125C LUC00125I2 (fr) 2002-03-20 2019-06-14

Country Status (24)

Country Link
US (14) US6962940B2 (fr)
EP (9) EP2962690B1 (fr)
JP (4) JP2005525386A (fr)
KR (6) KR101263786B1 (fr)
CN (2) CN100427085C (fr)
AT (1) ATE440599T1 (fr)
AU (1) AU2003224729C9 (fr)
BE (1) BE2019C008I2 (fr)
CA (2) CA2479666C (fr)
CY (6) CY1109380T1 (fr)
DE (1) DE60328974D1 (fr)
DK (6) DK2295055T3 (fr)
ES (8) ES2742729T3 (fr)
FR (1) FR19C1046I2 (fr)
HK (3) HK1073426A1 (fr)
HU (5) HUE029682T2 (fr)
IL (3) IL164147A0 (fr)
LU (1) LUC00125I2 (fr)
MX (2) MX366328B (fr)
NL (1) NL300994I2 (fr)
NZ (1) NZ535798A (fr)
PT (6) PT2223687T (fr)
SI (5) SI1485087T1 (fr)
WO (1) WO2003080049A1 (fr)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1361210B1 (fr) * 1996-08-12 2008-12-24 Celgene Corporation Nouvel agent immunothérapeutique et son emploi dans la réduction de la concentration en cytokine
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7276529B2 (en) * 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CA2379887C (fr) * 2002-04-09 2004-01-20 Bernard Charles Sherman Comprimes stables contenant de la simvastatine
KR101059041B1 (ko) * 2002-05-17 2011-08-24 셀진 코포레이션 암과 다른 질병의 치료 및 처리를 위한 선택적 사이토카인억제 약물을 사용하는 방법 및 조성물
US20100129363A1 (en) * 2002-05-17 2010-05-27 Zeldis Jerome B Methods and compositions using pde4 inhibitors for the treatment and management of cancers
MXPA05003889A (es) * 2002-10-15 2005-06-22 Celgene Corp Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico.
US20040087558A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US20050203142A1 (en) * 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US7776907B2 (en) 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
MXPA05004777A (es) * 2002-11-06 2005-07-22 Celgene Corp Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos.
EP1581205A1 (fr) * 2002-11-18 2005-10-05 Celgene Corporation Compositions comprenant un (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide et methodes d'utilisation de ces compositions
BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
BRPI0408113A (pt) * 2003-03-06 2006-03-01 Celgene Corp métodos para tratar ou prevenir um distúrbio do sistema nervoso central, para controlar um distúrbio do sistema nervoso central e para reduzir ou evitar um efeito adverso associado com a administração de um ingrediente ativo secundário em um paciente que sofre de um distúrbio do sistema nervoso central, e, composição farmacêutica
WO2004087148A1 (fr) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co. Ltd. Agent therapeutique et/ou agent prophylactique destine aux maladies pulmonaires
CA2543132A1 (fr) * 2003-10-23 2005-05-19 Celgene Corporation Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
US20070270448A1 (en) * 2003-11-06 2007-11-22 Celgene Corporation Methods of Using and Compositions Comprising a Jnk Inhibitor for the Treatment and Management of Asbestos-Related Diseases and Disorders
JPWO2005056009A1 (ja) * 2003-12-12 2007-07-05 協和醗酵工業株式会社 肺疾患治療剤
LT2574341T (lt) 2004-03-29 2017-09-11 University Of South Florida Navikų ir vėžio efektyvus gydymas triciribino fosfatu
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20110008327A1 (en) * 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
CN1972686A (zh) * 2004-04-14 2007-05-30 细胞基因公司 选择性细胞因子抑制药在髓发育不良综合征中的用途
AU2005234783A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension
AU2004319814A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
GB0410103D0 (en) * 2004-05-06 2004-06-09 Biolipox Ab New method
WO2005108353A2 (fr) * 2004-05-06 2005-11-17 Ceptor Corporation Composes destines a traiter des maladies neurologiques, des maladies otologiques ou des maladies ophtalmologiques et leurs methodes d'utilisation
US20070190070A1 (en) * 2004-09-03 2007-08-16 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
JP2008523102A (ja) * 2004-12-13 2008-07-03 セルジーン・コーポレーション Ｐｄｅ４モジュレーターを含有する組成物及び気道炎症の治療又は予防のためのそれらの使用
ME01513B (me) * 2005-06-30 2014-04-20 Celgene Corp Postupak dobijanja spojeva 4-amin0-2-(2,6-dioksopiperidin-3-il)izoindolin-1,3-diona
US20080138295A1 (en) * 2005-09-12 2008-06-12 Celgene Coporation Bechet's disease using cyclopropyl-N-carboxamide
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
US20080103086A1 (en) * 2006-10-25 2008-05-01 Jeon-Soo Shin Methods for the treatment of diseases associated with the secretion of hmgb1
TW200920381A (en) * 2007-07-17 2009-05-16 Combinatorx Inc Treatments of B-cell proliferative disorders
EP2178370A4 (fr) * 2007-07-17 2011-01-12 Zalicus Inc Combinaisons pour le traitement des troubles prolifératifs des lymphocytes b
US20090081173A1 (en) * 2007-08-10 2009-03-26 The Board Of Regents Of The University Of Texas System Methods and compositions involving bacteriophage isolates
CN102036663A (zh) * 2008-03-24 2011-04-27 细胞基因公司 用环丙基-n-{2-[(1s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基]-3-氧代异吲哚啉-4基}甲酰胺治疗银屑病或者银屑病关节炎
CN102702070A (zh) * 2008-03-27 2012-10-03 细胞基因公司 包含(+)-2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮的固体形式、其组合物及其用途
EP2687213B1 (fr) 2008-03-27 2019-01-23 Celgene Corporation Formes solides comprenant de la (+)-2-[1-(3-éthoxy-4-méthoxyphényl)-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione, leurs compositions, et utilisations associées
CN102898349A (zh) * 2008-03-27 2013-01-30 细胞基因公司 包含一种化合物的固体形式、其组合物及其用途
CA2718601A1 (fr) 2008-03-27 2009-10-01 Celgene Corporation Formes solides comprenant de la (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, leurs compositions, et utilisations associees
US8053364B2 (en) * 2008-05-01 2011-11-08 Intermolecular, Inc. Closed-loop sputtering controlled to enhance electrical characteristics in deposited layer
US20100009934A1 (en) * 2008-06-09 2010-01-14 Combinatorx, Incorporated Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
WO2010025199A1 (fr) * 2008-09-01 2010-03-04 Mitsubishi Digital Electronics America, Inc. Systèmes et procédés pour l'amélioration du visionnage sur un téléviseur
US20100186234A1 (en) * 2009-01-28 2010-07-29 Yehuda Binder Electric shaver with imaging capability
PE20151143A1 (es) * 2009-02-10 2015-08-07 Celgene Corp Metodos para utilizar y composiciones que comprenden moduladores pde4 para tratamiento, prevencion y control de tuberculosis
WO2010130224A1 (fr) 2009-05-14 2010-11-18 天津和美生物技术有限公司 Dérivés de thiophène
DK2456853T3 (da) * 2009-07-21 2021-02-01 Abt Holding Co Anvendelse af stamceller til reduktion af leukocyt-ekstravasation
CN102053449A (zh) * 2009-10-28 2011-05-11 中国科学院福建物质结构研究所 一种谷氨酸衍生的手性金属-有机非线性光学材料
CN102053448A (zh) * 2009-10-28 2011-05-11 中国科学院福建物质结构研究所 一种硝基苯胺类手性非线性光学材料
ES2727733T3 (es) * 2009-11-10 2019-10-18 Celgene Corp Nanosuspensión de un fármaco poco soluble preparada por el proceso de microfluidización
JP5937060B2 (ja) 2010-04-07 2016-06-22 セルジーン コーポレイション 呼吸器ウイルス感染症の治療方法
MX341896B (es) 2010-06-15 2016-09-07 Celgene Corp * Biomarcadores para el tratamiento de psoriasis.
WO2012083153A1 (fr) * 2010-12-16 2012-06-21 Nektar Therapeutics Composés comprenant une fraction apremilast et contenant un oligomère
US9532977B2 (en) 2010-12-16 2017-01-03 Celgene Corporation Controlled release oral dosage forms of poorly soluble drugs and uses thereof
ES2753198T5 (es) 2010-12-16 2023-05-31 Amgen Europe Gmbh Formas farmacéuticas orales de liberación controlada de fármacos poco solubles y sus usos
JP2014505054A (ja) 2011-01-10 2014-02-27 セルジーン コーポレイション シクロプロパンカルボン酸｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシ−フェニル）−２−メタンスルホニル−エチル］−３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−４−イル｝−アミドの経口剤形
US8853175B2 (en) 2011-01-10 2014-10-07 Celgene Corporation Phenethylsulfone isoindoline derivatives and their use
WO2012097116A2 (fr) 2011-01-14 2012-07-19 Celgene Corporation Isotopologues de dérivés d'isoindole
JP2014511393A (ja) * 2011-03-07 2014-05-15 セルジーン コーポレイション イソインドリン化合物を用いた疾患の治療方法
CA2834355A1 (fr) * 2011-04-28 2012-11-01 Celgene Corporation Methodes et compositions utilisant des inhibiteurs de la phosphodiesterase 4 (pde4) pour le traitement et la prise en charge de maladies auto-immunes et inflammatoires
SI2797581T1 (sl) * 2011-12-27 2020-08-31 Amgen (Europe) GmbH Formulacije (+)-2-(1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil)- 4-acetil aminoizoindolin-1,3-diona
WO2013119607A2 (fr) 2012-02-08 2013-08-15 Celgene Corporation Formulations à libération modifiée à base de (+)-2-[1-(3-éthoxy-4-méthoxy-phényl)-2-méthanesulfonyl-éthyl]-4-acétyl aminoisoindoline-1,3-dione
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US8981117B2 (en) 2012-09-14 2015-03-17 Celgene Corporation Processes for the preparation of isoindole compounds and isotopologues thereof
WO2014074846A1 (fr) * 2012-11-09 2014-05-15 Celgene Corporation Méthodes de traitement de la perte osseuse
CN105050624A (zh) 2013-03-14 2015-11-11 细胞基因公司 利用阿普斯特来治疗银屑病关节炎的方法
WO2014204825A1 (fr) * 2013-06-17 2014-12-24 Celgene Corporation Formulations de comprime de (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
KR101561828B1 (ko) 2013-08-23 2015-10-20 주식회사 아미노로직스 α-아미노산의 라세미화 방법
EP3096749B1 (fr) 2014-01-24 2019-05-15 Celgene Corporation Méthodes de traitement de l'obésité à l'aide d'aprémilast
JP2014114308A (ja) * 2014-01-31 2014-06-26 Celgene Corp （＋）−２−［１−（３−エトキシ−４−メトキシフェニル）−２−メチルスルホニルエチル］−４−アセチルアミノイソインドリン−１，３−ジオンを含む固形物形態、その組成物およびその使用
CN103864670B (zh) * 2014-03-17 2015-08-26 苏州明锐医药科技有限公司 阿普司特的制备方法
IN2014MU01283A (fr) 2014-04-04 2015-10-09 Cadila Healthcare Ltd
WO2015173792A1 (fr) 2014-05-11 2015-11-19 Mapi Pharma Ltd. Forme amorphe d'aprémilast
AU2015259608B2 (en) 2014-05-12 2019-10-03 Sumitomo Corporation Of Americas Brine leaching process for recovering valuable metals from oxide materials
EP3142748B1 (fr) 2014-05-15 2019-09-11 Celgene Corporation Utilisation d'inhibiteurs de pde4 et de leurs combinaisons pour le traitement de la fibrose kystique
WO2015175956A1 (fr) 2014-05-16 2015-11-19 Celgene Corporation Compositions et procédés de traitement de maladies cardiovasculaires athérosclérotiques à l'aide de modulateurs de pde4
EP2949645A1 (fr) 2014-05-28 2015-12-02 LEK Pharmaceuticals d.d. Procédés de préparation de composés ß-aminosulfone
ES2749433T3 (es) 2014-06-23 2020-03-20 Celgene Corp Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática
CN105294534B (zh) * 2014-07-15 2020-04-10 上海优拓医药科技有限公司 制备阿普司特及其中间体的产业化方法
WO2016016824A1 (fr) 2014-07-29 2016-02-04 Fundacio Hospital Universitari Vall D' Hebron-Institut De Recerca Diagnostic différentiel et choix de thérapie pour la polyarthrite rhumatoïde et l'arthrite psoriasique
EP3188745A1 (fr) 2014-08-15 2017-07-12 Celgene Corporation Dosage d'aprémilast pour le traitement de maladies améliorées par l'inhibition de pde4
CN105622380B (zh) * 2014-10-29 2020-06-30 南京安源生物医药科技有限公司 一种阿普斯特的制备方法及其中间体
CN105588886B (zh) * 2014-11-18 2020-01-31 重庆医药工业研究院有限责任公司 一种采用液相色谱法测定阿普斯特及其制剂中杂质的方法
EP3034496A1 (fr) 2014-12-18 2016-06-22 LEK Pharmaceuticals d.d. Nouveaux solvates de n-[2-[(1s)-1-(3-ethoxy-4-méthoxyphényl)-2-(méthylsulfonyl)éthyl]-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl] acétamide
CN104529869B (zh) * 2014-12-19 2017-06-13 苏州亚宝药物研发有限公司 一种 (s)‑2‑[1‑(3‑乙氧基‑4‑甲氧基苯基)‑2‑甲磺酰基乙基]‑4‑乙酰基氨基异吲哚啉‑1,3‑二酮异构体的制备方法
WO2016135755A1 (fr) 2015-02-27 2016-09-01 Mylan Laboratories Limited Aprémilast amorphe, pré-mélanges correspondant et nouvelles formes cristallines d'aprémilast
CN104803906A (zh) * 2015-03-17 2015-07-29 南京新伟方医药科技有限公司 化合物及其制备方法和用途
CN107635962A (zh) 2015-03-19 2018-01-26 印度商西伯拉有限公司 用于制备阿普斯特的改进工艺
EP3280701B1 (fr) 2015-04-09 2019-10-16 Zentiva K.S. Procédé de résolution chirale de l'intermédiaire clé de la synthèse d'aprémilast et son utilisation pour la préparation d'aprémilast pur
CN106146384B (zh) * 2015-04-23 2020-09-22 石药集团中奇制药技术（石家庄）有限公司 一种高光学纯度的阿普司特的制备方法、所得产品及其应用
WO2016169533A1 (fr) 2015-04-24 2016-10-27 Zentiva, K.S. Forme solide d'aprémilast et un procédé pour sa préparation
US10370329B2 (en) * 2015-04-27 2019-08-06 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
CN104945306B (zh) * 2015-05-25 2017-07-21 山东铭康医药技术有限公司 制备光学纯阿普斯特的方法
WO2016189486A1 (fr) 2015-05-26 2016-12-01 Lupin Limited Procédé amélioré pour la préparation d'aprémilast et de nouveaux polymorphes de celui-ci
CZ2015383A3 (cs) 2015-06-05 2016-12-14 Zentiva, K.S. Způsob přípravy klíčového intermediátu apremilastu, využívající enzymatické štěpení racemických aminů
EP3106457A1 (fr) 2015-06-15 2016-12-21 LEK Pharmaceuticals d.d. Nouvelle voie synthetique vers l'apremilast
CN105111127B (zh) * 2015-08-20 2019-02-19 济南纽华医药科技有限公司 阿普斯特无定形及其制备方法
ES2909827T3 (es) 2015-08-26 2022-05-10 Glenmark Life Sciences Ltd Proceso de preparación de apremilast
WO2017033206A2 (fr) 2015-08-27 2017-03-02 Msn Laboratories Private Limited Formes à l'état solide de n-[2-[(1 s)-1 -(3-éthoxy-4-méthoxyphényl)-2-(méthyl sulfonyl)éthyl]-2,3-dihydro-1,3-dioxo-l h-isoindol-4-yl]acétamide et procédé de préparation associé
US9765026B2 (en) 2015-08-28 2017-09-19 Scinopharm Taiwan, Ltd. Forms of apremilast and the process of making the same
EP3144393A1 (fr) 2015-09-18 2017-03-22 LEK Pharmaceuticals d.d. Voie synthétique vers l'apremilast
WO2017059040A1 (fr) * 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Procédés de préparation d'aprémilast, et ses intermédiaires
CN105218428A (zh) * 2015-10-20 2016-01-06 南京美嘉宁逸医药研究开发有限公司 一种高手性纯度的阿普斯特的制备方法
WO2017070291A1 (fr) 2015-10-21 2017-04-27 Celgene Corporation Modulateurs de pde4 pour le traitement et la prévention du syndrome inflammatoire de reconstitution immunitaire (iris)
EP3373916A1 (fr) 2015-11-11 2018-09-19 Celgene Corporation Formes pharmaceutiques orales à libération contrôlée de médicaments faiblement solubles et leurs utilisations
WO2017085568A1 (fr) 2015-11-19 2017-05-26 Alembic Pharmaceuticals Limited Procédé amélioré et nouvelle forme polymorphe d'aprémilast
CN105348172B (zh) * 2015-12-04 2017-11-14 新发药业有限公司 (s)‑1‑(4‑甲氧基‑3‑乙氧基)苯基‑2‑甲磺酰基乙胺的制备及阿普斯特的制备方法
EP3181549A1 (fr) 2015-12-17 2017-06-21 Zaklady Farmaceutyczne Polpharma SA Procédé de préparation de l'apremilast
CN105486785A (zh) * 2015-12-23 2016-04-13 成都百裕金阁莱药业有限公司 阿普斯特中对映异构体杂质的检测方法
CZ20165A3 (cs) 2016-01-06 2017-07-19 Zentiva, K.S. Způsoby přípravy amorfního apremilastu
US10774041B2 (en) 2016-04-15 2020-09-15 Davuluri Ramamohan Rao Process for the preparation of apremilast
US10774042B2 (en) 2016-05-12 2020-09-15 Zaklady Farmaceutyczne Polpharma Sa Crystalline forms of apremilast
CN109310624A (zh) 2016-06-15 2019-02-05 托伦特药物有限公司 阿普斯特的局部组合物
US10196355B2 (en) 2016-06-20 2019-02-05 Johnson Matthey Public Limited Company Forms of apremilast
CN106187857B (zh) 2016-06-30 2021-04-06 浙江华海药业股份有限公司 一种制备阿普斯特的方法
IT201600083132A1 (it) * 2016-08-05 2018-02-05 Dipharma Francis Srl Procedimento per la preparazione di un inibitore della fosfodiesterasi 4
CN110049968A (zh) * 2016-11-09 2019-07-23 广东东阳光药业有限公司 阿普斯特共晶及其制备方法
EP3339292A1 (fr) 2016-12-23 2018-06-27 Zaklady Farmaceutyczne Polpharma SA Co-cristaux d'apremilast
AU2018213249A1 (en) * 2017-01-27 2019-09-19 Sarudbhava Formulations Private Limited Therapeutic topical compositions of Apremilast
CN107445875A (zh) * 2017-03-22 2017-12-08 陕西科技大学 一种用于制备阿普斯特的高纯度中间体的手性拆分方法
EP3606908B1 (fr) 2017-04-04 2020-06-17 Quimica Sintetica, S.A. Résolution de composés beta-aminosulfone racémiques
US10919855B2 (en) 2017-05-04 2021-02-16 Unichem Laboratories Ltd Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide
US20200254093A1 (en) 2017-09-14 2020-08-13 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
CN107721902A (zh) * 2017-11-08 2018-02-23 中国科学院上海药物研究所 阿普斯特与烟酰胺的共结晶及其制备方法和应用
CN111821299A (zh) * 2019-04-16 2020-10-27 天津合美医药科技有限公司 噻吩衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用
CN111821297A (zh) * 2019-04-16 2020-10-27 天津合美医药科技有限公司 异吲哚啉衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用
US11357775B2 (en) * 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
CA3138473A1 (fr) 2019-04-30 2020-11-05 Celgene Corporation Polytherapies comprenant de l'apremilast et des inhibiteurs de tyk2
US11194866B2 (en) * 2019-08-08 2021-12-07 Google Llc Low entropy browsing history for content quasi-personalization
DE112020000136T5 (de) 2019-08-08 2021-07-29 Google Llc Browserverlauf mit geringer Entropie für die Quasi-Personalisierung von Inhalten
TWI733294B (zh) * 2019-12-30 2021-07-11 國立臺灣師範大學 製備阿普斯特片之方法
EP3929179A1 (fr) 2020-06-22 2021-12-29 Biohorm, S.L. Composés anti-inflammatoires et leurs procédés de fabrication
CN112220785B (zh) * 2020-09-22 2021-12-31 北京鑫开元医药科技有限公司 一种pde4抑制剂药物组合物及其制备方法与用途
KR20220047105A (ko) 2020-10-08 2022-04-15 주식회사 엔비피헬스케어 아프레밀라스트를 함유하는 약학 조성물
CN115068467A (zh) * 2021-03-15 2022-09-20 中国医学科学院药物研究所 穿心莲内酯作为ltb4受体抑制剂的医药用途
CN114790164B (zh) 2021-08-13 2022-12-27 苏州璞正医药有限公司 一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途
EP4183389A1 (fr) 2021-11-18 2023-05-24 KRKA, d.d., Novo mesto Composition pharmaceutique comprenant de l'aprémilast
WO2023105286A1 (fr) 2021-12-06 2023-06-15 My Personal Therapeutics Ltd Polythérapie contre le cancer
WO2023121670A1 (fr) * 2021-12-23 2023-06-29 Amgen Inc. Suspension orale d'aprémilast

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US366515A (en) 1887-07-12 Stove-pipe
US3031450A (en) 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
US3322755A (en) 1964-03-10 1967-05-30 Boehringer Sohn Ingelheim Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
JPS536156B2 (fr) 1972-10-30 1978-03-04
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3820636A (en) * 1973-08-16 1974-06-28 Deere & Co Self-adjusting control linkage for an external band brake
US4162316A (en) 1975-03-12 1979-07-24 Dainippon Pharmaceutical Co., Ltd. 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4001238A (en) 1976-02-18 1977-01-04 Bristol-Myers Company 1,3,4-oxadiazole amides
US4001237A (en) 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4060615A (en) 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4047404A (en) 1976-11-17 1977-09-13 Tanno Senshoku Kogyo Co., Ltd. Printed fabric washing apparatus
US4101548A (en) 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
US4209623A (en) 1978-06-07 1980-06-24 Bristol-Myers Company Pyrimidine-5-N-(1H-tetrazol-5-yl)-carboxamides
GB2063249A (en) 1979-10-09 1981-06-03 Mitsubishi Yuka Pharma 4-Phenylphthalazine derivatives
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4912205A (en) 1986-03-20 1990-03-27 Daicel Chemical Industries, Ltd. Alkyl-substituted phenylcarbamate derivative of polysaccharide
DE3770095D1 (de) 1986-08-21 1991-06-20 Pfizer Chinazolindione und pyridopyrimidindione.
CA1303037C (fr) 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Derives de purinone utilises comme bronchodilatateurs,vasodilatateurs et agents anti-allergiques
GB8814352D0 (en) 1988-06-16 1988-07-20 Smith Kline French Lab Chemical compounds
EP0347146B1 (fr) 1988-06-16 1993-09-01 Smith Kline & French Laboratories Limited Dérivés de pyrimidine condensés, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
US5075310A (en) 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
GB8817651D0 (en) 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
GB8827988D0 (en) 1988-11-30 1989-01-05 Smith Kline French Lab Chemical compounds
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
GB8909560D0 (en) 1989-04-26 1989-06-14 Smith Kline French Lab Chemical compounds
GB8923131D0 (en) 1989-10-13 1989-11-29 Smith Kline French Lab Chemical compounds
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
GB9013750D0 (en) 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
US5401774A (en) 1991-03-08 1995-03-28 University Of Arizona Method for treating patients with precancerous lesions by administering substituted sulfonyl idenyl acetic and propionic acids and esters to patients with lesions sensitive to such compounds
GB9114760D0 (en) 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
PT100905A (pt) 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
GB9121028D0 (en) 1991-10-03 1991-11-13 Pfizer Ltd Therapeutic agents
GB9126260D0 (en) 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5354571A (en) 1992-04-27 1994-10-11 Rheon Automatic Machinery Co., Ltd. Method for aligning and bending individual round elongated dough pieces
US5243826A (en) 1992-07-01 1993-09-14 Apd Cryogenics Inc. Method and apparatus for collecting liquid cryogen
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9218322D0 (en) 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
GB9312210D0 (en) 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
WO1995007267A1 (fr) 1993-09-10 1995-03-16 Eisai Co., Ltd. Compose de quinazoline
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9401090D0 (en) 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5608914A (en) 1994-11-21 1997-03-11 Keesler; Daren Headcover
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5703098A (en) 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
DE19501481A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,8-Disubstituierte Chinazolinone
DE19501480A1 (de) 1995-01-19 1996-07-25 Bayer Ag 9-substituierte 2-(2-n-Alkoxyphenyl)-purin-6-one
DE19501482A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
US5488055A (en) 1995-03-10 1996-01-30 Sanofi Winthrop Inc. Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
US5614530A (en) 1995-03-10 1997-03-25 Sterling Winthrop Inc. Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
ES2175079T3 (es) 1995-04-10 2002-11-16 Fujisawa Pharmaceutical Co Derivados de indol utiles como inhibidores de cgmp-pde.
TW381092B (en) 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
US5728844A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5728845A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5736537A (en) 1995-09-12 1998-04-07 Estee Lauder, Inc. Dehydroep:androsterone sailcylate useful against skin atrophy
US5658940A (en) 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
DE19540475A1 (de) 1995-10-20 1997-04-24 Schering Ag Chirale Methylphenyloxazolidinone
US5710170A (en) 1995-12-15 1998-01-20 Merck Frosst Canada, Inc. Tri-aryl ethane derivatives as PDE IV inhibitors
GB9526246D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526243D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
JP3063162B2 (ja) 1995-12-28 2000-07-12 藤沢薬品工業株式会社 ベンズイミダゾール誘導体
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19617864A1 (de) 1996-04-23 1997-10-30 Schering Ag Neue chirale Phenyldihydrofuranone
DE19632423A1 (de) 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine
AU724809B2 (en) 1996-08-30 2000-09-28 Kyowa Hakko Kogyo Co. Ltd. Imidazoquinazoline derivatives
WO1998014448A1 (fr) 1996-10-04 1998-04-09 Kyorin Pharmaceutical Co., Ltd. Derives de pyrazolopyridylpyridazinone et procede de preparation des ces derniers
DE19642451A1 (de) 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
KR100239800B1 (ko) 1996-11-28 2000-03-02 손경식 4,5-디아미노 피리미딘 유도체 및 이의 제조방법
WO1998038168A1 (fr) 1997-02-27 1998-09-03 Tanabe Seiyaku Co., Ltd. Derives d'isoquinolinone, procede de preparation desdits derives et leur utilisation en tant qu'inhibiteurs de phosphodiesterase
PT975347E (pt) 1997-02-28 2008-05-23 Nycomed Gmbh Combinação sinérgica de inibidores da pde e agonistas da adenilato ciclase ou agonistas da guanil ciclise
US6035089A (en) * 1997-06-11 2000-03-07 Lockheed Martin Energy Research Corporation Integrated narrowband optical filter based on embedded subwavelength resonant grating structures
BR9815895A (pt) 1997-07-31 2001-01-16 Celgene Corp Substituido ácido alcanohidroxamico e método para reduzir nìveis de tnf alfa
US6034089A (en) 1997-10-03 2000-03-07 Merck & Co., Inc. Aryl thiophene derivatives as PDE IV inhibitors
US6020339A (en) 1997-10-03 2000-02-01 Merck & Co., Inc. Aryl furan derivatives as PDE IV inhibitors
AU751453C (en) 1997-11-25 2003-04-10 Warner-Lambert Company Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
JP2002537383A (ja) 1999-02-25 2002-11-05 メルク フロスト カナダ アンド カンパニー Ｐｄｅｉｖ阻害化合物、組成物および治療方法
US6316472B1 (en) 1999-05-13 2001-11-13 Merck Frosst Canada & Co. Heterosubstituted pyridine derivatives as PDE 4 inhibitors
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
SE9904415D0 (sv) 1999-12-03 1999-12-03 Astra Ab New process
AU770918B2 (en) * 1999-12-23 2004-03-11 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
PT1252158E (pt) 2000-01-31 2005-09-30 Pfizer Prod Inc Derivados heterociclilo benzo-condensado de nicotinamida uteis como inibidores selectivos de isozimas pde4
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) * 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7276529B2 (en) * 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7208516B2 (en) * 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7123975B2 (en) * 2004-07-22 2006-10-17 Taiwan Semiconductor Manufacturing Co., Ltd. Manufacturing management system and method
WO2008063213A2 (fr) 2006-04-10 2008-05-29 Abbott Biotechnology Ltd. Compositions destinées au traitement de la polyarthrite psoriasique et leurs applications
WO2009011383A1 (fr) 2007-07-19 2009-01-22 Sekisui Chemical Co., Ltd. Adhésif pour composant électronique
DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
CA2718601A1 (fr) 2008-03-27 2009-10-01 Celgene Corporation Formes solides comprenant de la (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, leurs compositions, et utilisations associees
CA2777719A1 (fr) 2009-11-19 2011-05-26 Celgene Corporation Apremilast pour le traitement de la sarcoidose
US20130267484A1 (en) 2010-06-02 2013-10-10 Ab Science Treatment of rheumatoid arthritis with masitinib

Also Published As

Publication number Publication date
US7659303B2 (en) 2010-02-09
PT2420490T (pt) 2016-10-12
PT2223687T (pt) 2017-07-25
NL300994I1 (nl) 2019-06-26
AU2003224729A1 (en) 2003-10-08
CY2019032I2 (el) 2020-05-29
US20140024695A1 (en) 2014-01-23
ES2637509T3 (es) 2017-10-13
DK2420490T3 (en) 2016-10-03
US20100160405A1 (en) 2010-06-24
US20160151331A1 (en) 2016-06-02
CN101683334A (zh) 2010-03-31
EP2420490B1 (fr) 2016-07-20
ES2595375T3 (es) 2016-12-29
NZ535798A (en) 2006-04-28
US20140371287A1 (en) 2014-12-18
KR20130040257A (ko) 2013-04-23
KR20130100219A (ko) 2013-09-09
US20030187052A1 (en) 2003-10-02
SI1485087T1 (sl) 2009-12-31
US20190000804A1 (en) 2019-01-03
US7358272B2 (en) 2008-04-15
FR19C1046I1 (fr) 2019-08-09
ATE440599T1 (de) 2009-09-15
JP2010106033A (ja) 2010-05-13
EP2295055A2 (fr) 2011-03-16
ES2635361T3 (es) 2017-10-03
EP2223687A1 (fr) 2010-09-01
DK1485087T3 (da) 2009-11-02
CN100427085C (zh) 2008-10-22
DE60328974D1 (de) 2009-10-08
US20080242719A1 (en) 2008-10-02
CY1119204T1 (el) 2018-02-14
HK1073426A1 (en) 2005-10-07
US20050267196A1 (en) 2005-12-01
US9283207B2 (en) 2016-03-15
BE2019C008I2 (fr) 2022-08-09
EP2074995B1 (fr) 2016-11-02
MX366328B (es) 2019-07-05
WO2003080049A1 (fr) 2003-10-02
KR20100040938A (ko) 2010-04-21
CY1119340T1 (el) 2018-02-14
AU2003224729C9 (en) 2023-06-15
US20080027123A1 (en) 2008-01-31
CA2756798A1 (fr) 2003-10-02
US9724330B2 (en) 2017-08-08
AU2003224729C1 (en) 2023-04-27
HUE043539T2 (hu) 2019-08-28
SI2223688T1 (sl) 2019-11-29
HK1219049A1 (zh) 2017-03-24
ES2331991T3 (es) 2010-01-22
SI2962690T1 (sl) 2019-05-31
KR20050012722A (ko) 2005-02-02
US7507759B2 (en) 2009-03-24
US7659302B2 (en) 2010-02-09
SI2223687T1 (sl) 2017-10-30
IL164147A (en) 2010-11-30
US20080207730A1 (en) 2008-08-28
JP2015013893A (ja) 2015-01-22
US8802717B2 (en) 2014-08-12
CY1121888T1 (el) 2020-10-14
PT2223688T (pt) 2019-09-05
HUE029682T2 (en) 2017-02-28
JP2013047262A (ja) 2013-03-07
AU2003224729B2 (en) 2008-01-03
US11040024B2 (en) 2021-06-22
CA2479666C (fr) 2012-01-10
US20050192336A1 (en) 2005-09-01
EP2311453B1 (fr) 2017-06-07
DK2962690T3 (en) 2019-04-15
PT1485087E (pt) 2009-10-23
KR101383845B1 (ko) 2014-04-10
CY2019032I1 (el) 2020-05-29
EP2420490A1 (fr) 2012-02-22
EP2962690A1 (fr) 2016-01-06
US20200306226A1 (en) 2020-10-01
SI2295055T1 (sl) 2017-10-30
US10092542B2 (en) 2018-10-09
EP2295055B1 (fr) 2017-06-07
EP2295055A3 (fr) 2011-03-23
ES2637547T3 (es) 2017-10-13
JP5936521B2 (ja) 2016-06-22
CN1652772A (zh) 2005-08-10
FR19C1046I2 (fr) 2022-07-08
HK1103985A1 (en) 2008-01-04
PT2962690T (pt) 2019-04-30
EP1485087A1 (fr) 2004-12-15
ES2742729T3 (es) 2020-02-17
KR20110022736A (ko) 2011-03-07
CY1121720T1 (el) 2020-05-29
EP2223688B1 (fr) 2019-05-29
US6962940B2 (en) 2005-11-08
PT2295055T (pt) 2017-08-29
US7427638B2 (en) 2008-09-23
EP1485087B1 (fr) 2009-08-26
US8455536B2 (en) 2013-06-04
LUC00125I1 (fr) 2019-06-18
JP2005525386A (ja) 2005-08-25
EP2074995A1 (fr) 2009-07-01
KR100997001B1 (ko) 2010-11-25
EP2223687B1 (fr) 2017-05-17
US20210023051A1 (en) 2021-01-28
KR20120024938A (ko) 2012-03-14
DK2223688T3 (da) 2019-08-19
IL164147A0 (en) 2005-12-18
HUS1900032I1 (hu) 2019-07-29
NL300994I2 (nl) 2019-07-11
US11260046B2 (en) 2022-03-01
EP2223688A1 (fr) 2010-09-01
DK2223687T3 (en) 2017-08-14
MXPA04009075A (es) 2005-07-13
EP3524242A1 (fr) 2019-08-14
CA2479666A1 (fr) 2003-10-02
CY1109380T1 (el) 2014-07-02
DK2295055T3 (en) 2017-09-11
US20170281597A1 (en) 2017-10-05
EP2962690B1 (fr) 2019-01-16
HUE045489T2 (hu) 2019-12-30
IL207149A (en) 2013-12-31
KR101263786B1 (ko) 2013-05-13
EP2311453A1 (fr) 2011-04-20
HUE034348T2 (hu) 2018-02-28
US10610516B2 (en) 2020-04-07
KR101104991B1 (ko) 2012-01-16
ES2717517T3 (es) 2019-06-21
ES2608495T3 (es) 2017-04-11

Similar Documents

Publication Publication Date Title
BE2019C008I2 (fr)
SI1487461T1 (sl) Postopki uporabe in sestavki, ki vsebujejo imunomodulatorne spojine, za zdravljenje in upravljanje mielodisplastičnih sindromov
WO2005046318A3 (fr) Procedes d'utilisation et compositions comprenant des composes immunomodulatoires pour le traitement et la gestion de maladies et de troubles associe(e)s a l'amiante
WO2005105088A3 (fr) Procedes d'utilisation et compositions comportant des composes immunomodulateurs pour le traitement et le controle de l'hypertension pulmonaire
MXPA05004778A (es) Metodos de uso y composiciones que contienen compuestos inmunomoduladores para el tratamiento y manejo de enfermedades mieloproliferativas.
HRP20041092A2 (en) New pharmaceutical compositions containing filbanserin polymorph a
TW200503683A (en) Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
TW200503785A (en) Dosage form containing (S)-pantoprazole as active ingredient
MXPA05010070A (es) Combinacion farmaceutica.
MY137288A (en) New process for the synthesis of n-[(s)-1-ethoxycarbonylbutyl]-(s)-alanine and application in the synthesis of perindopril
MY137391A (en) New process for the synthesis of n-[(s)-1-ethoxycarbonylbutyl]-(s)-alanine and application in the synthesis of perindopril
TW200420560A (en) Crystalline form