SG11201810655QA - Method for producing substituted polycyclic pyridone derivative and crystal of same - Google Patents
Method for producing substituted polycyclic pyridone derivative and crystal of sameInfo
- Publication number
- SG11201810655QA SG11201810655QA SG11201810655QA SG11201810655QA SG11201810655QA SG 11201810655Q A SG11201810655Q A SG 11201810655QA SG 11201810655Q A SG11201810655Q A SG 11201810655QA SG 11201810655Q A SG11201810655Q A SG 11201810655QA SG 11201810655Q A SG11201810655Q A SG 11201810655QA
- Authority
- SG
- Singapore
- Prior art keywords
- crystal
- same
- substituted polycyclic
- pyridone derivative
- producing substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013078 crystal Chemical class 0.000 title 1
- -1 polycyclic pyridone derivative Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016121453 | 2016-06-20 | ||
| PCT/JP2017/022478 WO2017221869A1 (ja) | 2016-06-20 | 2017-06-19 | 置換された多環性ピリドン誘導体の製造方法およびその結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810655QA true SG11201810655QA (en) | 2019-01-30 |
Family
ID=60783429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810655QA SG11201810655QA (en) | 2016-06-20 | 2017-06-19 | Method for producing substituted polycyclic pyridone derivative and crystal of same |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11261198B2 (hr) |
| EP (2) | EP3473629B1 (hr) |
| JP (2) | JP6212678B1 (hr) |
| KR (2) | KR102586854B1 (hr) |
| CN (2) | CN109311911B (hr) |
| AR (1) | AR108812A1 (hr) |
| AU (1) | AU2017282305B2 (hr) |
| BR (1) | BR112018076600A2 (hr) |
| CA (1) | CA3027840A1 (hr) |
| HR (1) | HRP20221540T1 (hr) |
| IL (1) | IL263812B2 (hr) |
| MX (1) | MX2018016267A (hr) |
| SG (1) | SG11201810655QA (hr) |
| TW (1) | TWI750188B (hr) |
| WO (1) | WO2017221869A1 (hr) |
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| CA3008607A1 (en) | 2015-12-15 | 2017-06-22 | Shionogi & Co., Ltd. | A medicament for treating influenza characterized by combining a cap-dependent endonuclease inhibitor and an anti-influenza drug |
| HRP20221540T1 (hr) * | 2016-06-20 | 2023-03-03 | Shionogi & Co., Ltd. | Postupak za proizvodnju supstituiranog derivata policikličkog piridona i njegovog kristala |
| WO2018030463A1 (ja) * | 2016-08-10 | 2018-02-15 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
| CN109721615B (zh) | 2017-09-18 | 2020-12-29 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| SG11202002789XA (en) | 2017-10-06 | 2020-04-29 | Shionogi & Co | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| CN110357850A (zh) * | 2018-03-26 | 2019-10-22 | 广东东阳光药业有限公司 | 一种含硫杂环化合物的制备方法 |
| KR102501180B1 (ko) | 2018-04-24 | 2023-02-21 | 시오노기세야쿠 가부시키가이샤 | 안정성이 우수한 고형 제제 |
| CN108558907B (zh) * | 2018-06-01 | 2019-08-09 | 海化生命(厦门)科技有限公司 | 一种关键中间体2的制备方法 |
| CN110872247A (zh) * | 2018-08-29 | 2020-03-10 | 上海复星星泰医药科技有限公司 | Xofluza含硫杂环化合物、其中间体及制备方法 |
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| CN109721585B (zh) * | 2018-12-19 | 2020-09-29 | 浙江工业大学 | 一种巴洛沙韦关键中间体的制备方法 |
| CN109516998B (zh) * | 2018-12-25 | 2021-06-25 | 深圳市华先医药科技有限公司 | 一种巴洛沙韦中间体的合成方法 |
| CN109504721B (zh) * | 2018-12-26 | 2021-07-09 | 杭州科巢生物科技有限公司 | 一种抗流感药物的合成方法 |
| CN111484508B (zh) * | 2019-01-29 | 2022-11-25 | 北京四环制药有限公司 | 一种用于制备巴罗萨韦或其衍生物的化合物及其制备方法和其应用 |
| CN111574386B (zh) * | 2019-02-19 | 2024-02-23 | 广东东阳光药业股份有限公司 | 一种氧代乙胺化合物的纯化方法 |
| EP3934758A1 (en) | 2019-03-05 | 2022-01-12 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
| WO2020183227A1 (en) | 2019-03-12 | 2020-09-17 | Shionogi & Co., Ltd. | Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a complication risk factor |
| CN111825699B (zh) * | 2019-04-15 | 2023-02-21 | 上海复星星泰医药科技有限公司 | 含硫杂环化合物及其制备方法 |
| CN110143941B (zh) * | 2019-06-04 | 2021-05-25 | 北京四环制药有限公司 | 一种巴罗萨韦玛波酯中间体的合成方法 |
| CN110105327A (zh) * | 2019-06-05 | 2019-08-09 | 南京焕然生物科技有限公司 | 一种7,8-二氟-6,11-二氢-二苯并噻吩并-11-醇的制备方法 |
| CN110305091B (zh) * | 2019-06-19 | 2021-05-18 | 江苏理工学院 | 一种巴洛沙韦中间体化合物的制备方法 |
| CN112521386B (zh) * | 2019-09-19 | 2023-05-26 | 周雨恬 | 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途 |
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| CN111057070A (zh) * | 2019-10-30 | 2020-04-24 | 浙江工业大学 | 一种巴洛沙韦关键中间体的合成方法 |
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| CN115135646B (zh) * | 2019-12-23 | 2024-05-17 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
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| CN111875619B (zh) * | 2020-07-30 | 2021-06-25 | 深圳市新阳唯康科技有限公司 | 巴洛沙韦酯的晶型及其制备方法 |
| WO2022128934A1 (en) * | 2020-12-15 | 2022-06-23 | Synthon B.V. | Solid forms of baloxavir, salts of baloxavir and cocrystals of baloxavir |
| CN114671889A (zh) * | 2020-12-24 | 2022-06-28 | 江苏威凯尔医药科技有限公司 | 一种取代三环吡啶酮衍生物的晶型及其制备方法 |
| CN115594692A (zh) * | 2021-07-08 | 2023-01-13 | 重庆博腾制药科技股份有限公司（Cn） | 一种制备抗流感病毒药物中间体的方法 |
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| CN113717199B (zh) * | 2021-08-13 | 2022-04-01 | 北京北朋科技有限公司 | 巴洛沙韦的氘代衍生物及其在抗流感病毒中的应用 |
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| HRP20221540T1 (hr) * | 2016-06-20 | 2023-03-03 | Shionogi & Co., Ltd. | Postupak za proizvodnju supstituiranog derivata policikličkog piridona i njegovog kristala |
| WO2018030463A1 (ja) | 2016-08-10 | 2018-02-15 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
| US9862675B1 (en) | 2017-07-05 | 2018-01-09 | King Fahd University Of Petroleum And Minerals | Method of N-formylating amines with a phosphonic anhydride |
| SG11202002789XA (en) | 2017-10-06 | 2020-04-29 | Shionogi & Co | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
-
2017
- 2017-06-19 HR HRP20221540TT patent/HRP20221540T1/hr unknown
- 2017-06-19 TW TW106120359A patent/TWI750188B/zh active
- 2017-06-19 CA CA3027840A patent/CA3027840A1/en active Pending
- 2017-06-19 CN CN201780038096.2A patent/CN109311911B/zh active Active
- 2017-06-19 SG SG11201810655QA patent/SG11201810655QA/en unknown
- 2017-06-19 CN CN202110909230.XA patent/CN113717198A/zh active Pending
- 2017-06-19 BR BR112018076600-3A patent/BR112018076600A2/pt unknown
- 2017-06-19 MX MX2018016267A patent/MX2018016267A/es unknown
- 2017-06-19 AU AU2017282305A patent/AU2017282305B2/en active Active
- 2017-06-19 IL IL263812A patent/IL263812B2/en unknown
- 2017-06-19 US US16/310,897 patent/US11261198B2/en active Active
- 2017-06-19 WO PCT/JP2017/022478 patent/WO2017221869A1/ja unknown
- 2017-06-19 EP EP17815337.5A patent/EP3473629B1/en active Active
- 2017-06-19 AR ARP170101679A patent/AR108812A1/es unknown
- 2017-06-19 EP EP22206730.8A patent/EP4194459A1/en not_active Withdrawn
- 2017-06-19 JP JP2017538748A patent/JP6212678B1/ja active Active
- 2017-06-19 KR KR1020227019438A patent/KR102586854B1/ko active IP Right Grant
- 2017-06-19 KR KR1020197001315A patent/KR102447711B1/ko active IP Right Grant
- 2017-09-05 JP JP2017170491A patent/JP6959077B2/ja active Active
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2022
- 2022-01-19 US US17/578,743 patent/US11807648B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2017221869A1 (ja) | 2018-07-05 |
| JP2018024682A (ja) | 2018-02-15 |
| US11807648B2 (en) | 2023-11-07 |
| WO2017221869A1 (ja) | 2017-12-28 |
| TWI750188B (zh) | 2021-12-21 |
| KR102447711B1 (ko) | 2022-09-28 |
| EP4194459A1 (en) | 2023-06-14 |
| JP6212678B1 (ja) | 2017-10-11 |
| KR102586854B1 (ko) | 2023-10-11 |
| IL263812B1 (en) | 2023-05-01 |
| HRP20221540T1 (hr) | 2023-03-03 |
| EP3473629A4 (en) | 2020-01-22 |
| CN113717198A (zh) | 2021-11-30 |
| IL263812B2 (en) | 2023-09-01 |
| US20220251107A1 (en) | 2022-08-11 |
| US11261198B2 (en) | 2022-03-01 |
| CA3027840A1 (en) | 2017-12-28 |
| EP3473629B1 (en) | 2022-11-16 |
| CN109311911B (zh) | 2021-11-16 |
| JP6959077B2 (ja) | 2021-11-02 |
| KR20220084425A (ko) | 2022-06-21 |
| US20210230187A1 (en) | 2021-07-29 |
| AR108812A1 (es) | 2018-09-26 |
| EP3473629A1 (en) | 2019-04-24 |
| KR20190017991A (ko) | 2019-02-20 |
| TW201802097A (zh) | 2018-01-16 |
| BR112018076600A2 (pt) | 2019-04-16 |
| CN109311911A (zh) | 2019-02-05 |
| IL263812A (en) | 2019-01-31 |
| MX2018016267A (es) | 2019-05-20 |
| AU2017282305B2 (en) | 2021-06-10 |
| AU2017282305A1 (en) | 2018-12-06 |
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