CN114258395A - 一种酯化合物的晶型及其制备方法 - Google Patents
一种酯化合物的晶型及其制备方法 Download PDFInfo
- Publication number
- CN114258395A CN114258395A CN202080057717.3A CN202080057717A CN114258395A CN 114258395 A CN114258395 A CN 114258395A CN 202080057717 A CN202080057717 A CN 202080057717A CN 114258395 A CN114258395 A CN 114258395A
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- CN
- China
- Prior art keywords
- solvent
- baloxavir marboxil
- crystal form
- ray powder
- powder diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种酯化合物的晶型及其制备方法，属于医药化工技术领域。所述晶型具有较好的稳定性和溶解性，粉末流动性较好，可以应用于药物制剂的制备。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019109231254 | 2019-09-27 | ||
| CN201910923125 | 2019-09-27 | ||
| PCT/CN2020/117325 WO2021057834A1 (zh) | 2019-09-27 | 2020-09-24 | 一种酯化合物的晶型及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114258395A true CN114258395A (zh) | 2022-03-29 |
Family
ID=75166743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080057717.3A Pending CN114258395A (zh) | 2019-09-27 | 2020-09-24 | 一种酯化合物的晶型及其制备方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114258395A (zh) |
| WO (1) | WO2021057834A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114478575A (zh) * | 2020-11-12 | 2022-05-13 | 上海迪赛诺生物医药有限公司 | 一种巴洛沙韦酯晶型d及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201808963A (zh) * | 2016-08-10 | 2018-03-16 | 日商塩野義製藥股份有限公司 | 經取代之多環性吡啶酮衍生物及含有其前體之醫藥組合物 |
| CN111377944A (zh) * | 2018-12-25 | 2020-07-07 | 广东东阳光药业有限公司 | Baloxavir marboxil晶型及其制备方法 |
| WO2020181025A1 (en) * | 2019-03-05 | 2020-09-10 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
| CN111647005A (zh) * | 2020-06-15 | 2020-09-11 | 安徽皓元药业有限公司 | 巴洛沙韦新晶型及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3428170T (lt) * | 2015-04-28 | 2021-02-10 | Shionogi & Co., Ltd | Policiklinis piridono darinys nuo gripo ir jo provaistas |
| HRP20221540T1 (hr) * | 2016-06-20 | 2023-03-03 | Shionogi & Co., Ltd. | Postupak za proizvodnju supstituiranog derivata policikličkog piridona i njegovog kristala |
-
2020
- 2020-09-24 CN CN202080057717.3A patent/CN114258395A/zh active Pending
- 2020-09-24 WO PCT/CN2020/117325 patent/WO2021057834A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201808963A (zh) * | 2016-08-10 | 2018-03-16 | 日商塩野義製藥股份有限公司 | 經取代之多環性吡啶酮衍生物及含有其前體之醫藥組合物 |
| CN111377944A (zh) * | 2018-12-25 | 2020-07-07 | 广东东阳光药业有限公司 | Baloxavir marboxil晶型及其制备方法 |
| WO2020181025A1 (en) * | 2019-03-05 | 2020-09-10 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
| CN111647005A (zh) * | 2020-06-15 | 2020-09-11 | 安徽皓元药业有限公司 | 巴洛沙韦新晶型及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021057834A1 (zh) | 2021-04-01 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Applicant after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd. Address before: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Applicant before: SUNSHINE LAKE PHARMA Co.,Ltd. |