SG10201800972PA - Synthesis of boronic ester and acid compounds - Google Patents
Synthesis of boronic ester and acid compoundsInfo
- Publication number
- SG10201800972PA SG10201800972PA SG10201800972PA SG10201800972PA SG10201800972PA SG 10201800972P A SG10201800972P A SG 10201800972PA SG 10201800972P A SG10201800972P A SG 10201800972PA SG 10201800972P A SG10201800972P A SG 10201800972PA SG 10201800972P A SG10201800972P A SG 10201800972PA
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- acid compounds
- boronic ester
- boronic
- ester
- Prior art date
Links
- 239000002253 acid Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55753504P | 2004-03-30 | 2004-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201800972PA true SG10201800972PA (en) | 2018-03-28 |
Family
ID=34968044
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201800972PA SG10201800972PA (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG2012049763A SG182999A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG10201600029PA SG10201600029PA (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG2012049755A SG182998A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG200902156-9A SG151322A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012049763A SG182999A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG10201600029PA SG10201600029PA (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG2012049755A SG182998A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
| SG200902156-9A SG151322A1 (en) | 2004-03-30 | 2005-03-24 | Synthesis of boronic ester and acid compounds |
Country Status (41)
Families Citing this family (72)
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| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| ME01975B (me) | 2004-03-30 | 2015-05-20 | Millennium Pharm Inc | Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline |
| WO2008075376A1 (en) * | 2006-12-18 | 2008-06-26 | Natco Pharma Limited | Polymorphic forms of bortezomib and process for their preparation |
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| PL2178888T3 (pl) | 2007-08-06 | 2012-11-30 | Millennium Pharm Inc | Inhibitory proteasomów |
| EA034601B1 (ru) * | 2007-08-06 | 2020-02-25 | Милленниум Фармасьютикалз, Инк. | Способ получения бороновых кислот |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| AU2016253697A1 (en) * | 2007-08-06 | 2016-11-24 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
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| US7838673B2 (en) | 2007-10-16 | 2010-11-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| EP2730579A1 (en) * | 2008-06-17 | 2014-05-14 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
| AU2013204874B2 (en) * | 2008-09-29 | 2016-11-10 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclobutylethylboronic acid |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
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| EP2280016A1 (en) | 2009-07-27 | 2011-02-02 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters via substituted alk-1-ynes |
| EP2443128B1 (en) | 2009-06-19 | 2017-12-20 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters |
| EP2270019A1 (en) | 2009-06-19 | 2011-01-05 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters |
| AU2010341530B2 (en) | 2009-12-22 | 2016-03-10 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
| US20110178287A1 (en) | 2010-01-19 | 2011-07-21 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| EP2534159A1 (en) | 2010-02-09 | 2012-12-19 | Ranbaxy Laboratories Limited | Process for the preparation of bortezomib |
| CN101781326B (zh) * | 2010-02-11 | 2013-08-21 | 福建南方制药股份有限公司 | 一种制备手性氨基硼酸的中间体及其制备方法 |
| WO2011107912A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Polymorphic forms of bortezomib |
| US8263578B2 (en) | 2010-03-18 | 2012-09-11 | Innopharma, Inc. | Stable bortezomib formulations |
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| CN101812026B (zh) * | 2010-04-12 | 2013-08-28 | 亚邦医药股份有限公司 | 一种硼替佐米的合成方法 |
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| US8884009B2 (en) | 2010-10-14 | 2014-11-11 | Synthon Bv | Process for making bortezomib and intermediates for the process |
| TW201309303A (zh) | 2011-03-03 | 2013-03-01 | Cephalon Inc | 用於治療狼瘡的蛋白酶體抑制劑 |
| CN102206188B (zh) * | 2011-04-08 | 2013-02-27 | 苏州二叶制药有限公司 | N-(吡嗪-2-基羰基)-l-苯丙氨酸的制备方法 |
| US8497374B2 (en) | 2011-05-12 | 2013-07-30 | Scinopharm Taiwan, Ltd. | Process for preparing and purifying bortezomib |
| CN102268029B (zh) * | 2011-05-19 | 2013-10-09 | 苏州二叶制药有限公司 | 化合物（1s,2s,3r,5s）-蒎烷二醇-l-苯丙氨酸-l-亮氨酸硼酸酯的制备 |
| WO2012177835A1 (en) | 2011-06-22 | 2012-12-27 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
| CN102351890B (zh) * | 2011-09-30 | 2014-07-02 | 重庆泰濠制药有限公司 | 一种硼替佐米的合成方法 |
| CN102492021B (zh) * | 2011-12-13 | 2013-10-23 | 重庆泰濠制药有限公司 | 硼替佐米的制备工艺 |
| SG11201403254QA (en) * | 2011-12-22 | 2014-07-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| CN103374026A (zh) * | 2012-04-27 | 2013-10-30 | 重庆医药工业研究院有限责任公司 | 一种硼替佐米中间体的制备方法 |
| CN103450331B (zh) * | 2012-06-05 | 2016-05-25 | 山东新时代药业有限公司 | 一种硼替佐米的精制方法 |
| CN104822688A (zh) * | 2012-09-11 | 2015-08-05 | 西普拉有限公司 | 制备硼替佐米的方法 |
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| CA2891822A1 (en) | 2012-11-16 | 2014-05-22 | Shilpa Medicare Limited | Crystalline bortezomib process |
| CN105026407B (zh) | 2012-12-07 | 2017-09-08 | 维纳拓尔斯制药公司 | β‑内酰胺酶抑制剂 |
| CN103897027A (zh) * | 2012-12-29 | 2014-07-02 | 曹亚英 | 关键中间体晶型，制备方法及其在硼替佐米合成中的运用 |
| CN103897026A (zh) * | 2012-12-29 | 2014-07-02 | 朱继东 | 硼替佐米关键中间体的晶型，制备方法及其运用 |
| EP2943204B1 (en) | 2013-01-10 | 2019-03-13 | Venatorx Pharmaceuticals Inc | Beta-lactamase inhibitors |
| CA2909519A1 (en) | 2013-04-16 | 2014-10-23 | Cipla Limited | Process for the preparation of bortezomib mannitol ester |
| CN104211758B (zh) * | 2013-05-29 | 2020-06-12 | 深圳翰宇药业股份有限公司 | 一种硼替佐米的制备方法 |
| CN103497233B (zh) * | 2013-09-30 | 2015-04-08 | 哈药集团技术中心 | 一种硼替佐米的制备方法 |
| CN103554219A (zh) * | 2013-10-01 | 2014-02-05 | 昆明贵研药业有限公司 | 一种制备硼替佐米的方法 |
| KR101691353B1 (ko) * | 2013-12-09 | 2016-12-30 | 주식회사 경보제약 | 보르테조밉의 제조방법 및 그의 신규 중간체 |
| CN111116622A (zh) | 2014-02-03 | 2020-05-08 | 俄亥俄州创新基金会 | 硼酸酯和其药物制剂 |
| MA39964A (fr) | 2014-05-20 | 2015-11-26 | Millennium Pharm Inc | Inhibiteurs du protéasome contenant du bore destinés à être utilisés après une thérapie contre le cancer primaire |
| PT3154989T (pt) | 2014-06-11 | 2021-05-18 | Venatorx Pharmaceuticals Inc | Inibidores de beta-lactamase |
| JP6420629B2 (ja) * | 2014-10-30 | 2018-11-07 | ボーグワーナー インコーポレーテッド | チェーンガイドおよびチェーンテンショナアーム |
| DE102015204151B4 (de) * | 2015-03-09 | 2025-12-24 | Adidas Ag | Ball, insbesondere Fußball, und Verfahren zur Herstellung eines Balls |
| JP6223508B2 (ja) * | 2016-06-27 | 2017-11-01 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤 |
| EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
| CN110312727A (zh) * | 2017-02-17 | 2019-10-08 | 费森尤斯卡比肿瘤学有限公司 | 一种改进的制备硼酸酯的方法 |
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| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
| US11414437B2 (en) | 2017-07-28 | 2022-08-16 | Chengdu Origin Biotechnology Limited Company | Borate compound, and synthesis method therefor and uses thereof |
| CN111065641A (zh) * | 2017-09-02 | 2020-04-24 | 太阳制药工业有限公司 | 柠檬酸伊沙佐米的制备方法 |
| EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| CN111187336B (zh) * | 2018-11-14 | 2022-05-20 | 正大天晴药业集团股份有限公司 | 硼替佐米的精制方法 |
| CN113382713A (zh) | 2018-11-29 | 2021-09-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的组合式组合物及其用途 |
| US11964993B2 (en) | 2021-07-03 | 2024-04-23 | Shilpa Pharma Lifesciences Limited | Crystalline bortezomib process |
| WO2025034812A2 (en) | 2023-08-07 | 2025-02-13 | Tae Life Sciences Llc | Trifluoroborate (bf3) compositions for use in boron neutron capture therapy and methods thereof |
| WO2025080942A1 (en) * | 2023-10-13 | 2025-04-17 | The Brigham And Women’S Hospital, Inc. | Proteasome inhibitors and methods of use thereof |
| CN120248757A (zh) * | 2025-05-28 | 2025-07-04 | 滁州瑞达新能源材料有限公司 | 一种自清洁耐候的铝合金光伏组件边框及其制备方法 |
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| IL31992A (en) * | 1968-05-08 | 1973-07-30 | American Cyanamid Co | Synthetic thyrocalcitonins and method of making them |
| ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
| US4525309A (en) * | 1983-03-15 | 1985-06-25 | Washington State University Research Foundation, Inc. | Lewis acid catalysis of the homologation of boronic esters with haloalkylmetal reagents |
| US4499082A (en) * | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| US4537773A (en) | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
| ES8603405A1 (es) * | 1985-04-22 | 1985-12-16 | Inke Sa | "procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina". |
| SE8506094D0 (sv) * | 1985-12-20 | 1985-12-20 | Astra Laekemedel Ab | New antibacterial agents and intermediates therefor |
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| EP2443128B1 (en) * | 2009-06-19 | 2017-12-20 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters |
-
2005
- 2005-03-24 ME MEP-2011-502A patent/ME01975B/me unknown
- 2005-03-24 EA EA200601795A patent/EA012927B1/ru unknown
- 2005-03-24 NZ NZ586824A patent/NZ586824A/en not_active IP Right Cessation
- 2005-03-24 WO PCT/US2005/009774 patent/WO2005097809A2/en not_active Ceased
- 2005-03-24 PT PT111672648T patent/PT2377869E/pt unknown
- 2005-03-24 ES ES18172486T patent/ES2899606T3/es not_active Expired - Lifetime
- 2005-03-24 CN CN200580017645.5A patent/CN1960996B/zh not_active Expired - Lifetime
- 2005-03-24 CN CN201810192292.1A patent/CN108329337B/zh not_active Expired - Lifetime
- 2005-03-24 MY MYPI20051304A patent/MY145427A/en unknown
- 2005-03-24 SG SG10201800972PA patent/SG10201800972PA/en unknown
- 2005-03-24 SI SI200532318T patent/SI4008721T1/sl unknown
- 2005-03-24 HR HRP20240307TT patent/HRP20240307T3/hr unknown
- 2005-03-24 PL PL05742865T patent/PL1756121T3/pl unknown
- 2005-03-24 NZ NZ598172A patent/NZ598172A/xx not_active IP Right Cessation
- 2005-03-24 DK DK21197526.3T patent/DK4008721T3/da active
- 2005-03-24 FI FIEP21197526.3T patent/FI4008721T3/fi active
- 2005-03-24 CA CA2859119A patent/CA2859119A1/en not_active Abandoned
- 2005-03-24 PL PL18172486T patent/PL3385267T3/pl unknown
- 2005-03-24 HU HUE21197526A patent/HUE065769T2/hu unknown
- 2005-03-24 SG SG2012049763A patent/SG182999A1/en unknown
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