RU2365372C2 - Циклические ингибиторы протеинтирозинкиназ - Google Patents

Циклические ингибиторы протеинтирозинкиназ Download PDF

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RU2365372C2
RU2365372C2 RU2005132408/04A RU2005132408A RU2365372C2 RU 2365372 C2 RU2365372 C2 RU 2365372C2 RU 2005132408/04 A RU2005132408/04 A RU 2005132408/04A RU 2005132408 A RU2005132408 A RU 2005132408A RU 2365372 C2 RU2365372 C2 RU 2365372C2
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day
formula
patient
weight
pharmaceutically acceptable
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RU2005132408/04A
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RU2005132408A (ru
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Джагабандху ДЭС (US)
Джагабандху ДЭС
Рамеш ПАДМАНАБХА (US)
Рамеш Падманабха
Пинг ЧЕН (US)
Пинг Чен
Дерек Дж. НОРРИС (US)
Дерек Дж. Норрис
Артур М. П. ДОВЕЙКО (US)
Артур М. П. ДОВЕЙКО
Джоел БАРРИШ (US)
Джоел Барриш
Джон ВИТЯК (US)
Джон ВИТЯК
Луис Дж. ЛОМБАРДО (US)
Луис Дж. Ломбардо
Фрэнсис И. Ф. ЛИ (US)
Фрэнсис И. Ф. ЛИ
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Бристол-Маерс Сквибб Компани
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  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Настоящее изобретение относится к способу лечения хронической миелогенной лейкемии, стромальной опухоли желудочно-кишечного тракта, герминогенной опухоли, мелкоклеточного рака легких, меланомы, рака поджелудочной железы, рака простаты, хронической миелогенной лейкемии, резистентной к STI-571, заключающемуся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли ! ! 8 н. и 2 з.п. ф-лы, 2 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (10)

1. Способ лечения хронической миелогенной лейкемии, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000190
2. Способ по п.1, отличающийся тем, что хроническая миелогенная лейкемия является резистентной к STI-571.
3. Способ по п.1, отличающийся тем, что соединение формулы (IV) вводят один раз в день в течение 5 последовательных дней с последующим перерывом без лечения в течение 2 дней.
4. Способ лечения стромальной опухоли желудочно-кишечного тракта, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000191
5. Способ лечения герминогенной опухоли, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000192
6. Способ лечения мелкоклеточного рака легких, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000193
7. Способ лечения меланомы, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000194
8. Способ лечения рака поджелудочной железы, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000195
9. Способ лечения рака простаты, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000196
10. Способ лечения хронической миелогенной лейкемии, резистентной к STI-571, заключающийся в пероральном введении пациенту от 1 до 4 раз в день от 0,1 до 100 мг/кг веса соединения формулы (IV) или его фармацевтически приемлемой соли
Figure 00000197
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