RU2018113245A - Новая лактобактерия, характеризующаяся различными функциями, и ее применение - Google Patents
Новая лактобактерия, характеризующаяся различными функциями, и ее применение Download PDFInfo
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- RU2018113245A RU2018113245A RU2018113245A RU2018113245A RU2018113245A RU 2018113245 A RU2018113245 A RU 2018113245A RU 2018113245 A RU2018113245 A RU 2018113245A RU 2018113245 A RU2018113245 A RU 2018113245A RU 2018113245 A RU2018113245 A RU 2018113245A
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- lactobacillus plantarum
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- 239000000203 mixture Substances 0.000 claims 11
- 240000006024 Lactobacillus plantarum Species 0.000 claims 10
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 10
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 10
- 101000946040 Homo sapiens Lysosomal-associated transmembrane protein 4B Proteins 0.000 claims 9
- 102100034726 Lysosomal-associated transmembrane protein 4B Human genes 0.000 claims 9
- 235000013305 food Nutrition 0.000 claims 9
- 239000006166 lysate Substances 0.000 claims 6
- 206010067125 Liver injury Diseases 0.000 claims 5
- 208000026935 allergic disease Diseases 0.000 claims 5
- 230000006378 damage Effects 0.000 claims 5
- 231100000234 hepatic damage Toxicity 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 230000008818 liver damage Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000000968 intestinal effect Effects 0.000 claims 4
- 241001608472 Bifidobacterium longum Species 0.000 claims 3
- 229940009291 bifidobacterium longum Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 229920006008 lipopolysaccharide Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 102000053187 Glucuronidase Human genes 0.000 claims 1
- 108010060309 Glucuronidase Proteins 0.000 claims 1
- 240000001929 Lactobacillus brevis Species 0.000 claims 1
- 235000013957 Lactobacillus brevis Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003870 intestinal permeability Effects 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
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- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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Claims (13)
1. Lactobacillus plantarum LC27 (номер доступа: KCCM 11801P), его культура, его лизат или его экстракт.
2. Lactobacillus plantarum LC27 по п. 1, где Lactobacillus plantarum LC27 обладает одной или более характеристиками, выбранными из антиоксидантной активности, активности, подавляющей бета-глюкуронидазу, активности, подавляющей продуцирование липополисахаридов (LPS), и активности, индуцирующей экспрессию белка плотного контакта.
3. Lactobacillus plantarum LC27 по п. 1, где Lactobacillus plantarum LC27 содержит нуклеотидную последовательность 16S rDNA, представленную под SEQ ID NO: 5.
4. Фармацевтическая композиция для предупреждения или лечения одного или более заболеваний, выбранных из группы, состоящей из повреждения кишечника, повреждения печени, аллергического заболевания и воспалительного заболевания, содержащая Lactobacillus plantarum LC27, его культуру, его лизат или его экстракт по п. 1.
5. Пищевая композиция для предупреждения или уменьшения тяжести одного или более заболеваний, выбранных из группы, состоящей из повреждения кишечника, повреждения печени, аллергического заболевания и воспалительного заболевания, содержащая Lactobacillus plantarum LC27, его культуру, его лизат или его экстракт по п. 1.
6. Пищевая композиция по п. 5, где пищевая композиция дополнительно содержит одну или более молочнокислых бактерий, выбранных из группы, состоящей из Lactobacillus brevis CH23 (номер доступа: KCCM 11762P), Bifidobacterium longum CH57 (номер доступа: KCCM 11764P), Lactobacillus plantarum LC5 (номер доступа: KCCM 11800P) и Bifidobacterium longum LC67 (номер доступа: KCCM 11802P).
7. Пищевая композиция по п. 5, где пищевая композиция дополнительно содержит Bifidobacterium longum LC67 (номер доступа: KCCM 11802P), его культуру, его лизат или его экстракт.
8. Пищевая композиция по п. 5, где повреждение кишечника представляет собой синдром кишечной проницаемости.
9. Пищевая композиция по п. 5, где повреждение печени выбрано из группы, состоящей из гепатита, ожирения печени и цирроза печени.
10. Пищевая композиция по п. 5, где аллергическое заболевание выбрано из группы, состоящей из атопического дерматита, астмы, фарингита и хронического дерматита.
11. Пищевая композиция по п. 5, где воспалительное заболевание выбрано из группы, состоящей из гастрита, язвы желудка, колита и артрита.
12. Способ предупреждения или лечения одного или более заболеваний, выбранных из группы, состоящей из повреждения кишечника, повреждения печени, аллергического заболевания и воспалительного заболевания, предусматривающий введение субъекту композиции, содержащей Lactobacillus plantarum LC27 (номер доступа: KCCM 11801P), его культуру, его лизат или его экстракт.
13. Применение композиции, содержащей Lactobacillus plantarum LC27 (номер доступа: KCCM 11801P), его культуру, его лизат или его экстракт, для изготовления лекарственного препарата для предупреждения или лечения одного или более заболеваний, выбранных из группы, состоящей из повреждения кишечника, повреждения печени, аллергического заболевания и воспалительного заболевания.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2015-0130124 | 2015-09-15 | ||
| KR20150130124 | 2015-09-15 | ||
| KR10-2016-0005018 | 2016-01-15 | ||
| KR1020160005018A KR20170032816A (ko) | 2015-09-15 | 2016-01-15 | 다양한 기능성을 가진 신규 유산균 및 이의 용도 |
| PCT/KR2016/009994 WO2017047968A1 (ko) | 2015-09-15 | 2016-09-07 | 다양한 기능성을 가진 신규 유산균 및 이의 용도 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2020132171A Division RU2766715C2 (ru) | 2015-09-15 | 2020-09-30 | Новый штамм бифидобактерии, характеризующийся различными функциями, и его применение |
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| Publication Number | Publication Date |
|---|---|
| RU2018113245A true RU2018113245A (ru) | 2019-10-22 |
| RU2018113245A3 RU2018113245A3 (ru) | 2019-10-22 |
| RU2734031C2 RU2734031C2 (ru) | 2020-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2018113245A RU2734031C2 (ru) | 2015-09-15 | 2016-09-07 | Новая лактобактерия, характеризующаяся различными функциями, и ее применение |
| RU2020132171A RU2766715C2 (ru) | 2015-09-15 | 2020-09-30 | Новый штамм бифидобактерии, характеризующийся различными функциями, и его применение |
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| RU2020132171A RU2766715C2 (ru) | 2015-09-15 | 2020-09-30 | Новый штамм бифидобактерии, характеризующийся различными функциями, и его применение |
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| Country | Link |
|---|---|
| US (3) | US10471111B2 (ru) |
| EP (2) | EP3351616A4 (ru) |
| JP (2) | JP6626569B2 (ru) |
| KR (5) | KR20170032815A (ru) |
| CN (3) | CN108603162B (ru) |
| AU (3) | AU2016324846B2 (ru) |
| BR (1) | BR112018005195A2 (ru) |
| CA (3) | CA2998877C (ru) |
| HK (1) | HK1254665A1 (ru) |
| MX (2) | MX2018003230A (ru) |
| NZ (1) | NZ741028A (ru) |
| PH (1) | PH12018500566A1 (ru) |
| RU (2) | RU2734031C2 (ru) |
| SG (4) | SG11201802145SA (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170032815A (ko) | 2015-09-15 | 2017-03-23 | 경희대학교 산학협력단 | 신규 유산균 및 퇴행성 뇌질환 또는 인지기능의 예방, 개선 또는 치료용 조성물 |
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