RU2019119565A - Пробиотическая композиция, содержащая штаммы lactobacillus rhamnosus и lactobacillus paracasei - Google Patents
Пробиотическая композиция, содержащая штаммы lactobacillus rhamnosus и lactobacillus paracasei Download PDFInfo
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- RU2019119565A RU2019119565A RU2019119565A RU2019119565A RU2019119565A RU 2019119565 A RU2019119565 A RU 2019119565A RU 2019119565 A RU2019119565 A RU 2019119565A RU 2019119565 A RU2019119565 A RU 2019119565A RU 2019119565 A RU2019119565 A RU 2019119565A
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- lactobacillus
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- 241000186605 Lactobacillus paracasei Species 0.000 title claims 9
- 241000218588 Lactobacillus rhamnosus Species 0.000 title claims 8
- 239000006041 probiotic Substances 0.000 title 1
- 230000000529 probiotic effect Effects 0.000 title 1
- 235000018291 probiotics Nutrition 0.000 title 1
- 238000000034 method Methods 0.000 claims 3
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 241000917009 Lactobacillus rhamnosus GG Species 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000001332 colony forming effect Effects 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 210000005026 intestinal epithelial barrier Anatomy 0.000 claims 1
- 229940059406 lactobacillus rhamnosus gg Drugs 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/165—Paracasei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Claims (19)
1. Композиция, содержащая:
данный штамм Lactobacillus rhamnosus и
данный штамм Lactobacillus paracasei, где отношение указанного данного штамма Lactobacillus rhamnosus к указанному данному штамму Lactobacillus paracasei (LRα:LPα) выше или равно 8:1.
2. Композиция по п. 1, где отношение LRa:LPa составляет между 9:1 10 и 15:1.
3. Композиция по п. 1 или 2, где композиция содержит по меньшей мере 106 колониеобразующих единиц на мл (КОЕ/мл) указанного данного штамма Lactobacillus rhamnosus.
4. Композиция по любому из пп. 1-3, где указанный данный штамм Lactobacillus rhamnosus выбран из группы, состоящей из штамма Lactobacillus rhamnosus CNCM I-3690 и штамма Lactobacillus rhamnosus GG (ATCC 53103).
5. Композиция по любому из пп. 1-4, где указанный данный штамм Lactobacillus paracasei выбран из группы, состоящей из Lactobacillus paracasei CNCM I-3689 и Lactobacillus paracasei CNCM I-1518.
6. Композиция по любому из пп. 1-5, где композиция содержит по меньшей мере один дополнительный штамм Lactobacillus paracasei.
7. Композиция по любому из пп. 1-6, где композиция представляет собой пищевую композицию.
8. Композиция по любому из пп. 1-7, где композиция представляет собой молочный продукт.
9. Композиция по любому из пп. 1-8 для применения в улучшении целостности эпителиального барьера кишечника.
10. Композиция по любому из пп. 1-8 для применения в способе профилактики или лечения организма человека или животного.
11. Композиция по любому из пп. 1-8 для применения в профилактике или лечении нарушения, выбранного из группы, состоящей из нарушения желудочно-кишечного тракта, диабета 1 типа и ожирения.
12. Композиция для применения по п. 11, где нарушение желудочно-кишечного тракта представляет собой воспалительное заболевание кишечника (IBD) и/или синдром раздраженной кишки (IBS).
13. Способ получения композиции, включающий стадии:
добавления в среду данного штамма Lactobacillus rhamnosus и данного штамма Lactobacillus paracasei таким образом, чтобы получить отношение LRα:LPα в композиции, выше или равное 8:1, или
инокуляции среды для ферментации указанным данным штаммом Lactobacillus rhamnosus и указанным данным штаммом Lactobacillus paracasei, и
ферментации инокулированной среды посредством инкубации при температуре, подходящей для роста указанных штаммов, пока отношение LRα:LPα не станет выше или равным 8:1.
14. Способ получения композиции по любому из пп. 1-8.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2016/002022 WO2018109520A1 (en) | 2016-12-16 | 2016-12-16 | Probiotic composition comprising lactobacillus rhamnosus and lactobacillus paracasei strains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019119565A3 RU2019119565A3 (ru) | 2021-01-18 |
| RU2019119565A true RU2019119565A (ru) | 2021-01-18 |
| RU2744271C2 RU2744271C2 (ru) | 2021-03-04 |
Family
ID=58745272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019119565A RU2744271C2 (ru) | 2016-12-16 | 2016-12-16 | Пробиотическая композиция, содержащая штаммы Lactobacillus rhamnosus и Lactobacillus paracasei |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11207358B2 (ru) |
| EP (1) | EP3554517B1 (ru) |
| DK (1) | DK3554517T3 (ru) |
| ES (1) | ES2965306T3 (ru) |
| RU (1) | RU2744271C2 (ru) |
| WO (1) | WO2018109520A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20131467A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
| MA39710A (fr) | 2014-04-23 | 2015-10-29 | Sofar Spa | Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin |
| MA45288A (fr) | 2016-06-08 | 2019-04-17 | Sofar Spa | Nouvelle utilisation médicale de probiotiques |
| IT201600122724A1 (it) | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
| ES2965306T3 (es) * | 2016-12-16 | 2024-04-12 | Gervais Danone Sa | Composición probiótica que comprende cepas de Lactobacillus rhamnosus y Lactobacillus paracasei |
| IT201600127498A1 (it) | 2016-12-16 | 2018-06-16 | Sofar Spa | Probiotici per uso nella diverticolosi e malattia diverticolare |
| WO2020018482A1 (en) * | 2018-07-16 | 2020-01-23 | Stc.Unm | Treatment methods and compositions |
| IT201900016865A1 (it) * | 2019-09-20 | 2021-03-20 | Sofar Spa | Composizioni a base di ceppi batterici e loro uso come antinfiammatori |
| US11751597B2 (en) | 2019-11-05 | 2023-09-12 | Alfasigma S.P.A. | Compositions comprising bacterial strains for use in increasing the bioavailability of amino acids derived from proteins, and related food product methods and systems |
| CN113396976B (zh) * | 2021-07-01 | 2023-01-24 | 光明乳业股份有限公司 | 一种副干酪乳杆菌发酵乳(粉)及其制备方法与在改善肠屏障受损中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| ATE173135T1 (de) | 1995-01-02 | 1998-11-15 | Gervais Danone Co | Milchsäureferment, und ihre verwendung zur herstellung von antidiarrhöeprodrukten |
| EP1974735A1 (en) * | 2007-03-28 | 2008-10-01 | Nestec S.A. | Reduction of risk of diarrhoea |
| FR2928935B1 (fr) * | 2008-03-19 | 2011-05-20 | Gervais Danone Sa | Souche de lactobacillus rhamnosus. |
| FR2930264B1 (fr) * | 2008-04-18 | 2013-02-22 | Gervais Danone Sa | Nouvelle souche de lactobacillus paracasei subsp. paracasei dotee de proprietes antimicrobiennes et immunomodulatrices. |
| WO2011141762A1 (en) * | 2010-05-12 | 2011-11-17 | Compagnie Gervais Danone | Synergistic fermentation of lactobacillus rhamnosus and lactobacillus paracasei subsp paracasei |
| PT2693885T (pt) | 2011-04-08 | 2018-06-04 | Chr Hansen As | Efeito antimicrobiano sinérgico |
| KR101228035B1 (ko) | 2011-06-29 | 2013-01-30 | 주식회사 쎌바이오텍 | 신규한 유산균 및 이를 포함하는 당뇨병 예방 및 치료용 조성물 |
| WO2015159125A1 (en) * | 2014-04-15 | 2015-10-22 | Compagnie Gervais Danone | Use of lactobacillus rhamnosus for promoting recovery of the intestinal microbiota diversity after antibiotic dysbiosis |
| ES2965306T3 (es) * | 2016-12-16 | 2024-04-12 | Gervais Danone Sa | Composición probiótica que comprende cepas de Lactobacillus rhamnosus y Lactobacillus paracasei |
-
2016
- 2016-12-16 ES ES16867404T patent/ES2965306T3/es active Active
- 2016-12-16 WO PCT/IB2016/002022 patent/WO2018109520A1/en active Application Filing
- 2016-12-16 RU RU2019119565A patent/RU2744271C2/ru active
- 2016-12-16 DK DK16867404.2T patent/DK3554517T3/da active
- 2016-12-16 US US16/468,520 patent/US11207358B2/en active Active
- 2016-12-16 EP EP16867404.2A patent/EP3554517B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019119565A3 (ru) | 2021-01-18 |
| EP3554517A1 (en) | 2019-10-23 |
| US20200078420A1 (en) | 2020-03-12 |
| US11207358B2 (en) | 2021-12-28 |
| DK3554517T3 (da) | 2023-12-18 |
| RU2744271C2 (ru) | 2021-03-04 |
| EP3554517B1 (en) | 2023-09-13 |
| ES2965306T3 (es) | 2024-04-12 |
| WO2018109520A1 (en) | 2018-06-21 |
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