RU2015129800A - Гидрофильные саморазрушающиеся линкеры и их конъюгаты - Google Patents

Гидрофильные саморазрушающиеся линкеры и их конъюгаты Download PDF

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RU2015129800A
RU2015129800A RU2015129800A RU2015129800A RU2015129800A RU 2015129800 A RU2015129800 A RU 2015129800A RU 2015129800 A RU2015129800 A RU 2015129800A RU 2015129800 A RU2015129800 A RU 2015129800A RU 2015129800 A RU2015129800 A RU 2015129800A
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linker
compound
self
bond
salt
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RU2015129800A
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Russian (ru)
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Ронг-Хва ЛИН
Ших-Яо ЛИН
Юй-чи ХСИЕХ
Чиу-чень ХУАН
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Биоэллаенс К. В.
Эбдженомикс Интернэшнл Инк.
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Publication of RU2015129800A publication Critical patent/RU2015129800A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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RU2015129800A 2012-12-21 2013-12-20 Гидрофильные саморазрушающиеся линкеры и их конъюгаты RU2015129800A (ru)

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US201261745448P 2012-12-21 2012-12-21
US61/745,448 2012-12-21
US201361785027P 2013-03-14 2013-03-14
US61/785,027 2013-03-14
PCT/US2013/077306 WO2014100762A1 (en) 2012-12-21 2013-12-20 Hydrophilic self-immolative linkers and conjugates thereof

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