JP2017525755A5 - - Google Patents
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- Publication number
- JP2017525755A5 JP2017525755A5 JP2017519448A JP2017519448A JP2017525755A5 JP 2017525755 A5 JP2017525755 A5 JP 2017525755A5 JP 2017519448 A JP2017519448 A JP 2017519448A JP 2017519448 A JP2017519448 A JP 2017519448A JP 2017525755 A5 JP2017525755 A5 JP 2017525755A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- amino acid
- linker
- compound according
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014912P | 2014-06-20 | 2014-06-20 | |
| US62/014,912 | 2014-06-20 | ||
| US201462015661P | 2014-06-23 | 2014-06-23 | |
| US62/015,661 | 2014-06-23 | ||
| PCT/US2015/036414 WO2015195904A1 (en) | 2014-06-20 | 2015-06-18 | Her2 antibody-drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525755A JP2017525755A (ja) | 2017-09-07 |
| JP2017525755A5 true JP2017525755A5 (enExample) | 2018-07-26 |
Family
ID=54936097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519448A Pending JP2017525755A (ja) | 2014-06-20 | 2015-06-18 | Ｈｅｒ２抗体−薬物抱合体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20160051695A1 (enExample) |
| EP (1) | EP3157560A4 (enExample) |
| JP (1) | JP2017525755A (enExample) |
| KR (1) | KR20170063507A (enExample) |
| CN (1) | CN106659783A (enExample) |
| AU (1) | AU2015277100A1 (enExample) |
| BR (1) | BR112016029588A2 (enExample) |
| CA (1) | CA2952834A1 (enExample) |
| IL (1) | IL249626A0 (enExample) |
| MX (1) | MX2016017117A (enExample) |
| PH (1) | PH12016502509A1 (enExample) |
| RU (1) | RU2017101331A (enExample) |
| SG (2) | SG11201610468XA (enExample) |
| TW (1) | TW201625315A (enExample) |
| WO (1) | WO2015195904A1 (enExample) |
| ZA (1) | ZA201700306B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10953106B2 (en) | 2015-02-16 | 2021-03-23 | Lonza Ltd | Antibodies |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2718325A4 (en) | 2011-06-13 | 2015-03-11 | ABGENOMICS COöPERATIEF U A | ANTI-PSGL-1 ANTIBODIES AND USES THEREOF |
| US9089614B2 (en) | 2012-12-21 | 2015-07-28 | Bioalliance C.V. | Hydrophilic self-immolative linkers and conjugates thereof |
| US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| SMT202000614T1 (it) * | 2015-06-29 | 2021-01-05 | Immunogen Inc | Coniugati di anticorpi ingegnerizzati con cisteina |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| US11661438B2 (en) * | 2015-12-21 | 2023-05-30 | Pfizer, Inc. | Purification of antibody drug conjugates using a sodium phosphate gradient |
| IL260289B (en) | 2016-01-08 | 2022-08-01 | Bioalliance Cv | Tetravalent anti-psgl-1 antibodies and uses thereof |
| CN107029244B (zh) * | 2016-02-04 | 2021-04-27 | 浙江昭华生物医药有限公司 | 抗her2抗体-药物偶联物及其应用 |
| IL268959B2 (en) * | 2017-02-28 | 2025-01-01 | Seagen Inc | Cystine-mutated antibodies, compositions containing them and uses thereof |
| KR20190125310A (ko) | 2017-03-10 | 2019-11-06 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 접합체 |
| US20200155702A1 (en) * | 2017-06-16 | 2020-05-21 | Eli Lilly And Company | Engineered Antibody Compounds and Conjuates Thereof |
| SG10201801219VA (en) | 2018-02-13 | 2019-09-27 | Agency Science Tech & Res | Anti-HER2 Antibodies |
| KR20220127380A (ko) * | 2018-03-09 | 2022-09-19 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 항체 접합체 |
| JP7193058B2 (ja) * | 2018-08-08 | 2022-12-20 | イミューンオンコ バイオファーマシューティカルズ （シャンハイ） インコーポレイテッド | Ｃｄ４７およびｈｅｒ２を標的とする組換え二機能性タンパク質 |
| EA202190749A1 (ru) | 2018-09-10 | 2021-07-09 | Мирати Терапьютикс, Инк. | Способы комбинированной терапии |
| CA3112473A1 (en) | 2018-09-12 | 2020-03-19 | Quiapeg Pharmaceuticals Ab | Releasable glp-1 conjugates |
| WO2020197934A1 (en) * | 2019-03-22 | 2020-10-01 | The Regents Of The University Of California | Compositions and methods for modification of target molecules |
| AU2021232625A1 (en) * | 2020-03-05 | 2022-09-29 | Umc Utrecht Holding B.V. | Membrane ubiquitin ligases to target protein degradation |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| CN112618726B (zh) * | 2020-12-21 | 2022-11-11 | 江南大学 | 一种抗体缀合物、增强抗体分子免疫效应功能的方法 |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| KR20250169306A (ko) | 2023-04-18 | 2025-12-02 | 아스트라제네카 아베 | 절단가능한 링커를 포함하는 접합체 |
| TW202519268A (zh) * | 2023-09-11 | 2025-05-16 | 美商卡蒂那生物科學股份有限公司 | 多肽結合組合物及使用方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2478912B1 (en) * | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| WO2005101017A1 (en) * | 2004-04-07 | 2005-10-27 | Genentech, Inc. | Mass spectrometry of antibody conjugates |
| US8309093B2 (en) * | 2009-03-06 | 2012-11-13 | Agensys, Inc. | Antibody drug conjugates (ADC) that bind to 24P4C12 proteins |
| EP2711018A1 (en) * | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| GB0920127D0 (en) * | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| SI2528625T1 (sl) * | 2010-04-15 | 2013-11-29 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
| PT3056203T (pt) * | 2010-04-21 | 2018-02-15 | Syntarga Bv | Conjugados de análogos de cc-1065 e ligantes bifuncionais |
| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| US9089614B2 (en) * | 2012-12-21 | 2015-07-28 | Bioalliance C.V. | Hydrophilic self-immolative linkers and conjugates thereof |
| EP2953976B1 (en) * | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| CA2935433C (en) * | 2014-01-10 | 2019-04-02 | Synthon Biopharmaceuticals B.V. | Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies |
-
2015
- 2015-06-18 AU AU2015277100A patent/AU2015277100A1/en not_active Abandoned
- 2015-06-18 WO PCT/US2015/036414 patent/WO2015195904A1/en not_active Ceased
- 2015-06-18 TW TW104119839A patent/TW201625315A/zh unknown
- 2015-06-18 EP EP15809482.1A patent/EP3157560A4/en not_active Withdrawn
- 2015-06-18 CA CA2952834A patent/CA2952834A1/en not_active Abandoned
- 2015-06-18 JP JP2017519448A patent/JP2017525755A/ja active Pending
- 2015-06-18 MX MX2016017117A patent/MX2016017117A/es unknown
- 2015-06-18 BR BR112016029588A patent/BR112016029588A2/pt not_active IP Right Cessation
- 2015-06-18 SG SG11201610468XA patent/SG11201610468XA/en unknown
- 2015-06-18 RU RU2017101331A patent/RU2017101331A/ru not_active Application Discontinuation
- 2015-06-18 US US14/743,351 patent/US20160051695A1/en not_active Abandoned
- 2015-06-18 KR KR1020177001643A patent/KR20170063507A/ko not_active Withdrawn
- 2015-06-18 SG SG10201811124YA patent/SG10201811124YA/en unknown
- 2015-06-18 CN CN201580043407.5A patent/CN106659783A/zh active Pending
-
2016
- 2016-12-15 PH PH12016502509A patent/PH12016502509A1/en unknown
- 2016-12-18 IL IL249626A patent/IL249626A0/en unknown
-
2017
- 2017-01-13 ZA ZA2017/00306A patent/ZA201700306B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10953106B2 (en) | 2015-02-16 | 2021-03-23 | Lonza Ltd | Antibodies |
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