JP2017525755A5 - - Google Patents
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- Publication number
- JP2017525755A5 JP2017525755A5 JP2017519448A JP2017519448A JP2017525755A5 JP 2017525755 A5 JP2017525755 A5 JP 2017525755A5 JP 2017519448 A JP2017519448 A JP 2017519448A JP 2017519448 A JP2017519448 A JP 2017519448A JP 2017525755 A5 JP2017525755 A5 JP 2017525755A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- amino acid
- linker
- compound according
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014912P | 2014-06-20 | 2014-06-20 | |
| US62/014,912 | 2014-06-20 | ||
| US201462015661P | 2014-06-23 | 2014-06-23 | |
| US62/015,661 | 2014-06-23 | ||
| PCT/US2015/036414 WO2015195904A1 (en) | 2014-06-20 | 2015-06-18 | Her2 antibody-drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525755A JP2017525755A (ja) | 2017-09-07 |
| JP2017525755A5 true JP2017525755A5 (enExample) | 2018-07-26 |
Family
ID=54936097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519448A Pending JP2017525755A (ja) | 2014-06-20 | 2015-06-18 | Ｈｅｒ２抗体−薬物抱合体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20160051695A1 (enExample) |
| EP (1) | EP3157560A4 (enExample) |
| JP (1) | JP2017525755A (enExample) |
| KR (1) | KR20170063507A (enExample) |
| CN (1) | CN106659783A (enExample) |
| AU (1) | AU2015277100A1 (enExample) |
| BR (1) | BR112016029588A2 (enExample) |
| CA (1) | CA2952834A1 (enExample) |
| IL (1) | IL249626A0 (enExample) |
| MX (1) | MX2016017117A (enExample) |
| PH (1) | PH12016502509A1 (enExample) |
| RU (1) | RU2017101331A (enExample) |
| SG (2) | SG11201610468XA (enExample) |
| TW (1) | TW201625315A (enExample) |
| WO (1) | WO2015195904A1 (enExample) |
| ZA (1) | ZA201700306B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10953106B2 (en) | 2015-02-16 | 2021-03-23 | Lonza Ltd | Antibodies |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130209449A9 (en) | 2011-06-13 | 2013-08-15 | Abgenomics Cooperatief U.A. | Anti-psgl-1 antibodies and uses thereof |
| KR20150119848A (ko) | 2012-12-21 | 2015-10-26 | 바이오얼라이언스 씨.브이. | 친수성 자기-희생 링커 및 그것의 포합체 |
| CN106661124A (zh) | 2014-06-20 | 2017-05-10 | 荷商台医(有限合伙)公司 | 抗叶酸受体α(FRA)抗体‑药物缀合物及其使用方法 |
| MD3313845T2 (ro) * | 2015-06-29 | 2021-02-28 | Immunogen Inc | Conjugați cu anticorpi având cisteină modificată prin inginerie genetică |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| EP3394082B1 (en) * | 2015-12-21 | 2020-08-12 | Pfizer Inc | Purification of antibody drug conjugates using a sodium phosphate gradient |
| JP7078536B2 (ja) | 2016-01-08 | 2022-05-31 | アルトゥルバイオ， インコーポレイテッド | 四価抗ｐｓｇｌ－１抗体とその使用 |
| CN107029244B (zh) * | 2016-02-04 | 2021-04-27 | 浙江昭华生物医药有限公司 | 抗her2抗体-药物偶联物及其应用 |
| SG11201907288RA (en) * | 2017-02-28 | 2019-09-27 | Seattle Genetics Inc | Cysteine mutated antibodies for conjugation |
| AU2018231832A1 (en) | 2017-03-10 | 2019-08-08 | Quiapeg Pharmaceuticals Ab | Releasable conjugates |
| EP3638699A1 (en) * | 2017-06-16 | 2020-04-22 | Eli Lilly and Company | Engineered antibody compounds and conjugates thereof |
| SG10201801219VA (en) | 2018-02-13 | 2019-09-27 | Agency Science Tech & Res | Anti-HER2 Antibodies |
| KR20220127380A (ko) * | 2018-03-09 | 2022-09-19 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 항체 접합체 |
| WO2020029982A1 (en) * | 2018-08-08 | 2020-02-13 | Immuneonco Biopharmaceuticals (Shanghai) Co., Ltd | Recombinant bifunctional protein targeting cd47 and her2 |
| KR102871791B1 (ko) | 2018-09-10 | 2025-10-15 | 미라티 테라퓨틱스, 인크. | 병용 요법 |
| EP3849660A1 (en) | 2018-09-12 | 2021-07-21 | QuiaPEG Pharmaceuticals AB | Releasable glp-1 conjugates |
| CA3134423A1 (en) * | 2019-03-22 | 2020-10-01 | The Regents Of The University Of California | Compositions and methods for modification of target molecules |
| EP4114854A1 (en) * | 2020-03-05 | 2023-01-11 | UMC Utrecht Holding B.V. | Membrane ubiquitin ligases to target protein degradation |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| CN112618726B (zh) * | 2020-12-21 | 2022-11-11 | 江南大学 | 一种抗体缀合物、增强抗体分子免疫效应功能的方法 |
| CA3213636A1 (en) | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| DK4601703T3 (da) | 2023-04-18 | 2026-05-11 | Astrazeneca Ab | Konjugater omfattende spaltelige linkere |
| IL326995A (en) * | 2023-09-11 | 2026-05-01 | Catena Biosciences Inc | Polypeptide conjugate compositions and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3434275A1 (en) * | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| WO2005101017A1 (en) * | 2004-04-07 | 2005-10-27 | Genentech, Inc. | Mass spectrometry of antibody conjugates |
| CA2754531A1 (en) * | 2009-03-06 | 2010-09-30 | Seattle Genetics, Inc. | Antibody drug conjugates (adc) that bind to 24p4c12 proteins |
| CA2766405A1 (en) * | 2009-06-22 | 2011-01-13 | Medimmune, Llc | Engineered fc regions for site-specific conjugation |
| GB0920127D0 (en) * | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| WO2011130598A1 (en) * | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CA2956934C (en) * | 2010-04-21 | 2019-07-09 | Syntarga B.V. | Novel conjugates of cc-1065 analogs and bifunctional linkers |
| CN103566377A (zh) * | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| KR20150119848A (ko) * | 2012-12-21 | 2015-10-26 | 바이오얼라이언스 씨.브이. | 친수성 자기-희생 링커 및 그것의 포합체 |
| CA2900755C (en) * | 2013-02-08 | 2021-07-20 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| MX368396B (es) * | 2014-01-10 | 2019-10-01 | Synthon Biopharmaceuticals Bv | Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. |
-
2015
- 2015-06-18 CN CN201580043407.5A patent/CN106659783A/zh active Pending
- 2015-06-18 SG SG11201610468XA patent/SG11201610468XA/en unknown
- 2015-06-18 AU AU2015277100A patent/AU2015277100A1/en not_active Abandoned
- 2015-06-18 CA CA2952834A patent/CA2952834A1/en not_active Abandoned
- 2015-06-18 MX MX2016017117A patent/MX2016017117A/es unknown
- 2015-06-18 US US14/743,351 patent/US20160051695A1/en not_active Abandoned
- 2015-06-18 BR BR112016029588A patent/BR112016029588A2/pt not_active IP Right Cessation
- 2015-06-18 JP JP2017519448A patent/JP2017525755A/ja active Pending
- 2015-06-18 EP EP15809482.1A patent/EP3157560A4/en not_active Withdrawn
- 2015-06-18 TW TW104119839A patent/TW201625315A/zh unknown
- 2015-06-18 KR KR1020177001643A patent/KR20170063507A/ko not_active Withdrawn
- 2015-06-18 RU RU2017101331A patent/RU2017101331A/ru not_active Application Discontinuation
- 2015-06-18 SG SG10201811124YA patent/SG10201811124YA/en unknown
- 2015-06-18 WO PCT/US2015/036414 patent/WO2015195904A1/en not_active Ceased
-
2016
- 2016-12-15 PH PH12016502509A patent/PH12016502509A1/en unknown
- 2016-12-18 IL IL249626A patent/IL249626A0/en unknown
-
2017
- 2017-01-13 ZA ZA2017/00306A patent/ZA201700306B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10953106B2 (en) | 2015-02-16 | 2021-03-23 | Lonza Ltd | Antibodies |
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