JP2016508136A5 - - Google Patents
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- JP2016508136A5 JP2016508136A5 JP2015549842A JP2015549842A JP2016508136A5 JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5 JP 2015549842 A JP2015549842 A JP 2015549842A JP 2015549842 A JP2015549842 A JP 2015549842A JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- self
- bond
- compound
- destructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
- DLGAUVSRZXNATA-DHYYHALDSA-N (2s,3s)-2-amino-3-methylpentanoic acid;(2s)-pyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1.CC[C@H](C)[C@H](N)C(O)=O DLGAUVSRZXNATA-DHYYHALDSA-N 0.000 claims 1
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745448P | 2012-12-21 | 2012-12-21 | |
| US61/745,448 | 2012-12-21 | ||
| US201361785027P | 2013-03-14 | 2013-03-14 | |
| US61/785,027 | 2013-03-14 | ||
| PCT/US2013/077306 WO2014100762A1 (en) | 2012-12-21 | 2013-12-20 | Hydrophilic self-immolative linkers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508136A JP2016508136A (ja) | 2016-03-17 |
| JP2016508136A5 true JP2016508136A5 (enExample) | 2018-06-14 |
| JP6482471B2 JP6482471B2 (ja) | 2019-03-13 |
Family
ID=50979293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549842A Expired - Fee Related JP6482471B2 (ja) | 2012-12-21 | 2013-12-20 | 親水性の自壊性リンカー及びそのコンジュゲート |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9943610B2 (enExample) |
| EP (1) | EP2935259B1 (enExample) |
| JP (1) | JP6482471B2 (enExample) |
| KR (2) | KR20210132742A (enExample) |
| CN (2) | CN105102455B (enExample) |
| AR (1) | AR094280A1 (enExample) |
| AU (1) | AU2013364065B2 (enExample) |
| BR (1) | BR112015014712A2 (enExample) |
| CA (1) | CA2896690A1 (enExample) |
| CL (1) | CL2015001735A1 (enExample) |
| DK (1) | DK2935259T3 (enExample) |
| ES (1) | ES2714951T3 (enExample) |
| IL (1) | IL239506B (enExample) |
| MX (1) | MX379355B (enExample) |
| MY (1) | MY169117A (enExample) |
| NZ (1) | NZ630601A (enExample) |
| PH (1) | PH12015501422B1 (enExample) |
| PT (1) | PT2935259T (enExample) |
| RU (2) | RU2015129800A (enExample) |
| SG (2) | SG10201705150RA (enExample) |
| TW (1) | TWI716339B (enExample) |
| WO (1) | WO2014100762A1 (enExample) |
| ZA (1) | ZA201504941B (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| EP2489372A3 (en) | 2007-03-14 | 2013-01-02 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| RU2523909C2 (ru) | 2007-06-25 | 2014-07-27 | Эндосайт, Инк. | Конъюгаты, содержащие гидрофильные спейсеры линкеров |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2717916B1 (en) | 2011-06-10 | 2017-03-08 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| IN2015DN04147A (enExample) | 2012-10-16 | 2015-10-16 | Endocyte Inc | |
| PT2935259T (pt) | 2012-12-21 | 2019-04-04 | Abgenomics Int Inc | Ligantes de autoimolação hidrofílicos e conjugados dos mesmos |
| CN110143999B (zh) | 2013-03-15 | 2023-12-05 | 酵活英属哥伦比亚省公司 | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| IL245009B (en) | 2013-10-11 | 2022-08-01 | Asana Biosciences Llc | Protein-polymer-drug conjugates |
| BR112016007736B1 (pt) | 2013-10-11 | 2022-09-27 | Mersana Therapeutics, Inc | Armação polimérica, e, composição farmacêutica |
| PL3086815T3 (pl) | 2013-12-27 | 2022-06-13 | Zymeworks Inc. | Układy łącznikowe dla koniugatów leków zawierające ugrupowanie sulfonamidowe |
| AU2014373640B2 (en) | 2013-12-27 | 2018-08-30 | Var2 Pharmaceuticals Aps | VAR2CSA-drug conjugates |
| AU2015276821A1 (en) * | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| SG10201811124YA (en) * | 2014-06-20 | 2019-01-30 | Abgenomics Int Inc | Her2 antibody-drug conjugates |
| AR100919A1 (es) * | 2014-06-20 | 2016-11-09 | Bioalliance Cv | Conjugados de fármaco-anticuerpo anti-cd22 y métodos de uso de los mismos |
| RU2680238C2 (ru) * | 2014-08-28 | 2019-02-18 | Пфайзер Инк. | Модулирующие стабильность линкеры для использования с конъюгатами антитело-лекарственное средство |
| SG11201702143PA (en) | 2014-09-17 | 2017-04-27 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| EP3598983A1 (en) | 2014-10-03 | 2020-01-29 | Synaffix B.V. | Sulfamide linker, conjugates thereof, and methods of preparation |
| EP3226909A1 (en) | 2014-12-03 | 2017-10-11 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| CN114751989B (zh) | 2015-03-31 | 2025-03-14 | 豪夫迈·罗氏有限公司 | 包含三聚体tnf家族配体的抗原结合分子 |
| EP3294810A4 (en) * | 2015-05-12 | 2019-01-02 | Blinkbio Inc. | Silicon based drug conjugates and methods of using same |
| CN107922477B (zh) * | 2015-06-29 | 2022-11-01 | 第一三共株式会社 | 用于选择性制造抗体-药物缀合物的方法 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CN107043406B (zh) | 2015-11-03 | 2021-08-17 | 财团法人工业技术研究院 | 化合物、连接子-药物、及配体-药物耦合体 |
| EP3400239B1 (en) | 2016-01-08 | 2021-06-02 | AltruBio Inc. | Tetravalent anti-psgl-1 antibodies and uses thereof |
| CN109152844B (zh) | 2016-02-08 | 2022-11-22 | 西纳福克斯股份有限公司 | 用于治疗的含有磺酰胺接头的生物缀合物 |
| CN108883191B (zh) | 2016-02-08 | 2022-10-14 | 西纳福克斯股份有限公司 | 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法 |
| WO2017137423A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| US11590239B2 (en) | 2016-02-08 | 2023-02-28 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates |
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| US20140363454A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Antibody-Drug Conjugates, Compositions and Methods of Use |
| WO2015104385A2 (en) | 2014-01-10 | 2015-07-16 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs showing improved in vivo antitumor activity |
| SG10201811124YA (en) | 2014-06-20 | 2019-01-30 | Abgenomics Int Inc | Her2 antibody-drug conjugates |
| AU2015276821A1 (en) | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| AR100919A1 (es) | 2014-06-20 | 2016-11-09 | Bioalliance Cv | Conjugados de fármaco-anticuerpo anti-cd22 y métodos de uso de los mismos |
| EP3400239B1 (en) | 2016-01-08 | 2021-06-02 | AltruBio Inc. | Tetravalent anti-psgl-1 antibodies and uses thereof |
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2013
- 2013-12-20 PT PT13865282T patent/PT2935259T/pt unknown
- 2013-12-20 DK DK13865282.1T patent/DK2935259T3/en active
- 2013-12-20 SG SG10201705150RA patent/SG10201705150RA/en unknown
- 2013-12-20 TW TW102147572A patent/TWI716339B/zh not_active IP Right Cessation
- 2013-12-20 AU AU2013364065A patent/AU2013364065B2/en not_active Ceased
- 2013-12-20 KR KR1020217034685A patent/KR20210132742A/ko not_active Abandoned
- 2013-12-20 AR ARP130105028A patent/AR094280A1/es unknown
- 2013-12-20 MX MX2015007918A patent/MX379355B/es unknown
- 2013-12-20 ES ES13865282T patent/ES2714951T3/es active Active
- 2013-12-20 WO PCT/US2013/077306 patent/WO2014100762A1/en not_active Ceased
- 2013-12-20 US US14/654,486 patent/US9943610B2/en active Active
- 2013-12-20 JP JP2015549842A patent/JP6482471B2/ja not_active Expired - Fee Related
- 2013-12-20 KR KR1020157019681A patent/KR20150119848A/ko not_active Abandoned
- 2013-12-20 EP EP13865282.1A patent/EP2935259B1/en active Active
- 2013-12-20 US US14/137,799 patent/US9089614B2/en not_active Expired - Fee Related
- 2013-12-20 MY MYPI2015001576A patent/MY169117A/en unknown
- 2013-12-20 CN CN201380073519.6A patent/CN105102455B/zh not_active Expired - Fee Related
- 2013-12-20 CA CA2896690A patent/CA2896690A1/en not_active Abandoned
- 2013-12-20 RU RU2015129800A patent/RU2015129800A/ru unknown
- 2013-12-20 CN CN201810460861.6A patent/CN108546283A/zh active Pending
- 2013-12-20 NZ NZ630601A patent/NZ630601A/en not_active IP Right Cessation
- 2013-12-20 SG SG11201504887TA patent/SG11201504887TA/en unknown
- 2013-12-20 BR BR112015014712A patent/BR112015014712A2/pt not_active Application Discontinuation
- 2013-12-20 RU RU2019105549A patent/RU2019105549A/ru unknown
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2015
- 2015-06-17 US US14/742,621 patent/US9408923B2/en not_active Expired - Fee Related
- 2015-06-18 CL CL2015001735A patent/CL2015001735A1/es unknown
- 2015-06-18 IL IL239506A patent/IL239506B/en active IP Right Grant
- 2015-06-19 PH PH12015501422A patent/PH12015501422B1/en unknown
- 2015-07-09 ZA ZA2015/04941A patent/ZA201504941B/en unknown
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2018
- 2018-03-13 US US15/920,229 patent/US20180264131A1/en not_active Abandoned
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2020
- 2020-12-10 US US17/118,228 patent/US20210113710A1/en not_active Abandoned
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