JP2016508136A5 - - Google Patents
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- JP2016508136A5 JP2016508136A5 JP2015549842A JP2015549842A JP2016508136A5 JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5 JP 2015549842 A JP2015549842 A JP 2015549842A JP 2015549842 A JP2015549842 A JP 2015549842A JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- self
- bond
- compound
- destructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745448P | 2012-12-21 | 2012-12-21 | |
| US61/745,448 | 2012-12-21 | ||
| US201361785027P | 2013-03-14 | 2013-03-14 | |
| US61/785,027 | 2013-03-14 | ||
| PCT/US2013/077306 WO2014100762A1 (en) | 2012-12-21 | 2013-12-20 | Hydrophilic self-immolative linkers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508136A JP2016508136A (ja) | 2016-03-17 |
| JP2016508136A5 true JP2016508136A5 (enExample) | 2018-06-14 |
| JP6482471B2 JP6482471B2 (ja) | 2019-03-13 |
Family
ID=50979293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549842A Expired - Fee Related JP6482471B2 (ja) | 2012-12-21 | 2013-12-20 | 親水性の自壊性リンカー及びそのコンジュゲート |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9943610B2 (enExample) |
| EP (1) | EP2935259B1 (enExample) |
| JP (1) | JP6482471B2 (enExample) |
| KR (2) | KR20150119848A (enExample) |
| CN (2) | CN108546283A (enExample) |
| AR (1) | AR094280A1 (enExample) |
| AU (1) | AU2013364065B2 (enExample) |
| BR (1) | BR112015014712A2 (enExample) |
| CA (1) | CA2896690A1 (enExample) |
| CL (1) | CL2015001735A1 (enExample) |
| DK (1) | DK2935259T3 (enExample) |
| ES (1) | ES2714951T3 (enExample) |
| IL (1) | IL239506B (enExample) |
| MX (1) | MX379355B (enExample) |
| MY (1) | MY169117A (enExample) |
| NZ (1) | NZ630601A (enExample) |
| PH (1) | PH12015501422B1 (enExample) |
| PT (1) | PT2935259T (enExample) |
| RU (2) | RU2015129800A (enExample) |
| SG (2) | SG10201705150RA (enExample) |
| TW (1) | TWI716339B (enExample) |
| WO (1) | WO2014100762A1 (enExample) |
| ZA (1) | ZA201504941B (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| RU2523909C2 (ru) | 2007-06-25 | 2014-07-27 | Эндосайт, Инк. | Конъюгаты, содержащие гидрофильные спейсеры линкеров |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| MX2013014583A (es) | 2011-06-10 | 2014-03-31 | Mersana Therapeutics Inc | Conjugados de proteina-polimero-farmaco. |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| WO2014062697A2 (en) | 2012-10-16 | 2014-04-24 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| CN108546283A (zh) | 2012-12-21 | 2018-09-18 | 荷商台医(有限合伙)公司 | 亲水性自消耗连接子及其缀合物 |
| TR201911139T4 (tr) | 2013-03-15 | 2019-08-21 | Zymeworks Inc | Sitotoksik ve anti-mitotik bileşikler ve bunları kullanmanın yöntemleri. |
| CN115068626A (zh) | 2013-10-11 | 2022-09-20 | 阿萨纳生物科技有限责任公司 | 蛋白-聚合物-药物缀合物 |
| US9849191B2 (en) | 2013-10-11 | 2017-12-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
| AU2014373640B2 (en) | 2013-12-27 | 2018-08-30 | Var2 Pharmaceuticals Aps | VAR2CSA-drug conjugates |
| WO2015195904A1 (en) * | 2014-06-20 | 2015-12-23 | Abgenomics International Inc. | Her2 antibody-drug conjugates |
| EP3157961A4 (en) * | 2014-06-20 | 2018-01-24 | BioAlliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| CN106795203B (zh) * | 2014-08-28 | 2021-01-26 | 辉瑞公司 | 用于抗体药物缀合物的稳定性调节接头 |
| HRP20220123T1 (hr) | 2014-09-17 | 2022-04-15 | Zymeworks Inc. | Citotoksični i antimitotički spojevi, te postupci njihove uporabe |
| ES2740907T3 (es) | 2014-10-03 | 2020-02-07 | Synaffix Bv | Enlazador de sulfamida, conjugados de los mismos y métodos de preparación |
| AU2015358532C1 (en) * | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| EP3973980A1 (en) | 2015-03-31 | 2022-03-30 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a trimeric tnf family ligand |
| WO2016183359A1 (en) | 2015-05-12 | 2016-11-17 | Blinkbio, Inc. | Silicon based drug conjugates and methods of using same |
| ES2938186T3 (es) * | 2015-06-29 | 2023-04-05 | Daiichi Sankyo Co Ltd | Procedimiento de fabricación selectiva de un conjugado anticuerpo-fármaco |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| US10618935B2 (en) | 2015-11-03 | 2020-04-14 | Industrial Technology Research Institute | Antibody-drug conjugate (ADC) and method for forming the same |
| US10472422B2 (en) | 2016-01-08 | 2019-11-12 | Abgenomics International Inc. | Tetravalent anti-PSGL-1 antibodies and uses thereof |
| EP3413920A1 (en) | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| WO2017137458A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| US11338043B2 (en) | 2016-02-08 | 2022-05-24 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting HER2 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137423A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| UY37176A (es) | 2016-03-30 | 2017-10-31 | Convatec Technologies Inc | Apósitos modificados para heridas |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
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| JP6262768B2 (ja) | 2013-01-03 | 2018-01-17 | セルトリオン， インク． | 抗体−リンカー−薬物結合体、その製造方法およびそれを含む抗癌剤組成物 |
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| MY183572A (en) | 2013-03-15 | 2021-02-26 | Regeneron Pharma | Biologically active molecules, conjugates thereof, and therapeutic uses |
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| MX368396B (es) | 2014-01-10 | 2019-10-01 | Synthon Biopharmaceuticals Bv | Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. |
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| EP3157961A4 (en) | 2014-06-20 | 2018-01-24 | BioAlliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| US10472422B2 (en) | 2016-01-08 | 2019-11-12 | Abgenomics International Inc. | Tetravalent anti-PSGL-1 antibodies and uses thereof |
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2013
- 2013-12-20 CN CN201810460861.6A patent/CN108546283A/zh active Pending
- 2013-12-20 SG SG10201705150RA patent/SG10201705150RA/en unknown
- 2013-12-20 EP EP13865282.1A patent/EP2935259B1/en active Active
- 2013-12-20 WO PCT/US2013/077306 patent/WO2014100762A1/en not_active Ceased
- 2013-12-20 PT PT13865282T patent/PT2935259T/pt unknown
- 2013-12-20 RU RU2015129800A patent/RU2015129800A/ru unknown
- 2013-12-20 CN CN201380073519.6A patent/CN105102455B/zh not_active Expired - Fee Related
- 2013-12-20 SG SG11201504887TA patent/SG11201504887TA/en unknown
- 2013-12-20 BR BR112015014712A patent/BR112015014712A2/pt not_active Application Discontinuation
- 2013-12-20 AU AU2013364065A patent/AU2013364065B2/en not_active Ceased
- 2013-12-20 KR KR1020157019681A patent/KR20150119848A/ko not_active Abandoned
- 2013-12-20 DK DK13865282.1T patent/DK2935259T3/en active
- 2013-12-20 ES ES13865282T patent/ES2714951T3/es active Active
- 2013-12-20 US US14/654,486 patent/US9943610B2/en active Active
- 2013-12-20 KR KR1020217034685A patent/KR20210132742A/ko not_active Abandoned
- 2013-12-20 CA CA2896690A patent/CA2896690A1/en not_active Abandoned
- 2013-12-20 AR ARP130105028A patent/AR094280A1/es unknown
- 2013-12-20 NZ NZ630601A patent/NZ630601A/en not_active IP Right Cessation
- 2013-12-20 MX MX2015007918A patent/MX379355B/es unknown
- 2013-12-20 US US14/137,799 patent/US9089614B2/en not_active Expired - Fee Related
- 2013-12-20 MY MYPI2015001576A patent/MY169117A/en unknown
- 2013-12-20 JP JP2015549842A patent/JP6482471B2/ja not_active Expired - Fee Related
- 2013-12-20 TW TW102147572A patent/TWI716339B/zh not_active IP Right Cessation
- 2013-12-20 RU RU2019105549A patent/RU2019105549A/ru unknown
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2015
- 2015-06-17 US US14/742,621 patent/US9408923B2/en not_active Expired - Fee Related
- 2015-06-18 IL IL239506A patent/IL239506B/en active IP Right Grant
- 2015-06-18 CL CL2015001735A patent/CL2015001735A1/es unknown
- 2015-06-19 PH PH12015501422A patent/PH12015501422B1/en unknown
- 2015-07-09 ZA ZA2015/04941A patent/ZA201504941B/en unknown
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2018
- 2018-03-13 US US15/920,229 patent/US20180264131A1/en not_active Abandoned
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2020
- 2020-12-10 US US17/118,228 patent/US20210113710A1/en not_active Abandoned
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