JP2016508136A5 - - Google Patents
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- JP2016508136A5 JP2016508136A5 JP2015549842A JP2015549842A JP2016508136A5 JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5 JP 2015549842 A JP2015549842 A JP 2015549842A JP 2015549842 A JP2015549842 A JP 2015549842A JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5
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- JP
- Japan
- Prior art keywords
- linker
- self
- bond
- compound
- destructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745448P | 2012-12-21 | 2012-12-21 | |
| US61/745,448 | 2012-12-21 | ||
| US201361785027P | 2013-03-14 | 2013-03-14 | |
| US61/785,027 | 2013-03-14 | ||
| PCT/US2013/077306 WO2014100762A1 (en) | 2012-12-21 | 2013-12-20 | Hydrophilic self-immolative linkers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508136A JP2016508136A (ja) | 2016-03-17 |
| JP2016508136A5 true JP2016508136A5 (enExample) | 2018-06-14 |
| JP6482471B2 JP6482471B2 (ja) | 2019-03-13 |
Family
ID=50979293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549842A Expired - Fee Related JP6482471B2 (ja) | 2012-12-21 | 2013-12-20 | 親水性の自壊性リンカー及びそのコンジュゲート |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9089614B2 (enExample) |
| EP (1) | EP2935259B1 (enExample) |
| JP (1) | JP6482471B2 (enExample) |
| KR (2) | KR20210132742A (enExample) |
| CN (2) | CN105102455B (enExample) |
| AR (1) | AR094280A1 (enExample) |
| AU (1) | AU2013364065B2 (enExample) |
| BR (1) | BR112015014712A2 (enExample) |
| CA (1) | CA2896690A1 (enExample) |
| CL (1) | CL2015001735A1 (enExample) |
| DK (1) | DK2935259T3 (enExample) |
| ES (1) | ES2714951T3 (enExample) |
| IL (1) | IL239506B (enExample) |
| MX (1) | MX379355B (enExample) |
| MY (1) | MY169117A (enExample) |
| NZ (1) | NZ630601A (enExample) |
| PH (1) | PH12015501422B1 (enExample) |
| PT (1) | PT2935259T (enExample) |
| RU (2) | RU2019105549A (enExample) |
| SG (2) | SG11201504887TA (enExample) |
| TW (1) | TWI716339B (enExample) |
| WO (1) | WO2014100762A1 (enExample) |
| ZA (1) | ZA201504941B (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| CA2837840C (en) | 2011-06-10 | 2020-08-04 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| MX2015004757A (es) | 2012-10-16 | 2015-07-17 | Endocyte Inc | Conjugados de suministro de farmacos que contienen aminoacidos no naturales y metodo para usarlos. |
| AU2013364065B2 (en) | 2012-12-21 | 2018-10-04 | Altrubio Inc. | Hydrophilic self-immolative linkers and conjugates thereof |
| MX368258B (es) | 2013-03-15 | 2019-09-25 | Zymeworks Inc | Compuestos citotoxicos y antimitoticos y metodos de uso de los mismos. |
| ES2726850T3 (es) | 2013-10-11 | 2019-10-09 | Mersana Therapeutics Inc | Conjugados de proteína-polímero-fármaco |
| KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| KR102384740B1 (ko) | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| BR112016015105A8 (pt) | 2013-12-27 | 2018-04-24 | Var2 Pharmaceuticals Aps | conjugados var2csa-droga |
| JP2017525755A (ja) * | 2014-06-20 | 2017-09-07 | アブジェノミクス インターナショナル インコーポレイテッド．Ａｂｇｅｎｏｍｉｃｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃ． | Ｈｅｒ２抗体−薬物抱合体 |
| EP3157960A4 (en) * | 2014-06-20 | 2018-01-24 | BioAlliance C.V. | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
| WO2015196089A1 (en) * | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| US10967068B2 (en) * | 2014-08-28 | 2021-04-06 | Pfizer Inc. | Stability-modulating linkers for use with antibody drug conjugates |
| AU2015318556C1 (en) | 2014-09-17 | 2021-01-07 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| EP3134128B1 (en) | 2014-10-03 | 2019-06-05 | Synaffix B.V. | Sulfamide linker, conjugates thereof, and methods of preparation |
| AU2015358532C1 (en) | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| EP3973980A1 (en) * | 2015-03-31 | 2022-03-30 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a trimeric tnf family ligand |
| AU2016262107B2 (en) | 2015-05-12 | 2021-01-21 | Blinkbio, Inc. | Silicon based drug conjugates and methods of using same |
| US11173213B2 (en) * | 2015-06-29 | 2021-11-16 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| ES2880731T3 (es) | 2016-01-08 | 2021-11-25 | Altrubio Inc | Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos |
| WO2017137423A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| WO2017137456A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| EP3413915A1 (en) | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137458A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
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| US20140363454A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Antibody-Drug Conjugates, Compositions and Methods of Use |
| CN105899236B (zh) | 2014-01-10 | 2019-07-26 | 斯索恩生物制药有限公司 | 表现出改进的体内抗肿瘤活性的倍癌霉素adc |
| JP2017525755A (ja) | 2014-06-20 | 2017-09-07 | アブジェノミクス インターナショナル インコーポレイテッド．Ａｂｇｅｎｏｍｉｃｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃ． | Ｈｅｒ２抗体−薬物抱合体 |
| EP3157960A4 (en) | 2014-06-20 | 2018-01-24 | BioAlliance C.V. | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
| WO2015196089A1 (en) | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| ES2880731T3 (es) | 2016-01-08 | 2021-11-25 | Altrubio Inc | Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos |
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2013
- 2013-12-20 AU AU2013364065A patent/AU2013364065B2/en not_active Ceased
- 2013-12-20 RU RU2019105549A patent/RU2019105549A/ru unknown
- 2013-12-20 KR KR1020217034685A patent/KR20210132742A/ko not_active Abandoned
- 2013-12-20 MY MYPI2015001576A patent/MY169117A/en unknown
- 2013-12-20 NZ NZ630601A patent/NZ630601A/en not_active IP Right Cessation
- 2013-12-20 PT PT13865282T patent/PT2935259T/pt unknown
- 2013-12-20 US US14/137,799 patent/US9089614B2/en not_active Expired - Fee Related
- 2013-12-20 CA CA2896690A patent/CA2896690A1/en not_active Abandoned
- 2013-12-20 KR KR1020157019681A patent/KR20150119848A/ko not_active Abandoned
- 2013-12-20 ES ES13865282T patent/ES2714951T3/es active Active
- 2013-12-20 CN CN201380073519.6A patent/CN105102455B/zh not_active Expired - Fee Related
- 2013-12-20 JP JP2015549842A patent/JP6482471B2/ja not_active Expired - Fee Related
- 2013-12-20 AR ARP130105028A patent/AR094280A1/es unknown
- 2013-12-20 EP EP13865282.1A patent/EP2935259B1/en active Active
- 2013-12-20 SG SG11201504887TA patent/SG11201504887TA/en unknown
- 2013-12-20 DK DK13865282.1T patent/DK2935259T3/en active
- 2013-12-20 US US14/654,486 patent/US9943610B2/en active Active
- 2013-12-20 TW TW102147572A patent/TWI716339B/zh not_active IP Right Cessation
- 2013-12-20 RU RU2015129800A patent/RU2015129800A/ru unknown
- 2013-12-20 BR BR112015014712A patent/BR112015014712A2/pt not_active Application Discontinuation
- 2013-12-20 MX MX2015007918A patent/MX379355B/es unknown
- 2013-12-20 SG SG10201705150RA patent/SG10201705150RA/en unknown
- 2013-12-20 CN CN201810460861.6A patent/CN108546283A/zh active Pending
- 2013-12-20 WO PCT/US2013/077306 patent/WO2014100762A1/en not_active Ceased
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2015
- 2015-06-17 US US14/742,621 patent/US9408923B2/en not_active Expired - Fee Related
- 2015-06-18 CL CL2015001735A patent/CL2015001735A1/es unknown
- 2015-06-18 IL IL239506A patent/IL239506B/en active IP Right Grant
- 2015-06-19 PH PH12015501422A patent/PH12015501422B1/en unknown
- 2015-07-09 ZA ZA2015/04941A patent/ZA201504941B/en unknown
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2018
- 2018-03-13 US US15/920,229 patent/US20180264131A1/en not_active Abandoned
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2020
- 2020-12-10 US US17/118,228 patent/US20210113710A1/en not_active Abandoned
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