ES2714951T3 - Enlazadores autoinmoladores hidrófilos y conjugados de los mismos - Google Patents

Enlazadores autoinmoladores hidrófilos y conjugados de los mismos Download PDF

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Publication number
ES2714951T3
ES2714951T3 ES13865282T ES13865282T ES2714951T3 ES 2714951 T3 ES2714951 T3 ES 2714951T3 ES 13865282 T ES13865282 T ES 13865282T ES 13865282 T ES13865282 T ES 13865282T ES 2714951 T3 ES2714951 T3 ES 2714951T3
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linker
compound
antibody
self
link
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Spanish (es)
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Rong-Hwa Lin
Shih-Yao Lin
Yu-Chi Hsieh
Chiu-Chen Huang
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Bioalliance CV
Abgenomics International Inc
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Bioalliance CV
Abgenomics International Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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  • Reproductive Health (AREA)
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  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES13865282T 2012-12-21 2013-12-20 Enlazadores autoinmoladores hidrófilos y conjugados de los mismos Active ES2714951T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745448P 2012-12-21 2012-12-21
US201361785027P 2013-03-14 2013-03-14
PCT/US2013/077306 WO2014100762A1 (en) 2012-12-21 2013-12-20 Hydrophilic self-immolative linkers and conjugates thereof

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ES2714951T3 true ES2714951T3 (es) 2019-05-30

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ES13865282T Active ES2714951T3 (es) 2012-12-21 2013-12-20 Enlazadores autoinmoladores hidrófilos y conjugados de los mismos

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EP (1) EP2935259B1 (enExample)
JP (1) JP6482471B2 (enExample)
KR (2) KR20210132742A (enExample)
CN (2) CN105102455B (enExample)
AR (1) AR094280A1 (enExample)
AU (1) AU2013364065B2 (enExample)
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CA (1) CA2896690A1 (enExample)
CL (1) CL2015001735A1 (enExample)
DK (1) DK2935259T3 (enExample)
ES (1) ES2714951T3 (enExample)
IL (1) IL239506B (enExample)
MX (1) MX379355B (enExample)
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