JP2017528418A5 - - Google Patents
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- JP2017528418A5 JP2017528418A5 JP2016574072A JP2016574072A JP2017528418A5 JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5 JP 2016574072 A JP2016574072 A JP 2016574072A JP 2016574072 A JP2016574072 A JP 2016574072A JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5
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- Prior art keywords
- linker
- amino acid
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- antibody
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462015321P | 2014-06-20 | 2014-06-20 | |
| US62/015,321 | 2014-06-20 | ||
| PCT/US2015/036824 WO2015196167A1 (en) | 2014-06-20 | 2015-06-19 | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528418A JP2017528418A (ja) | 2017-09-28 |
| JP2017528418A5 true JP2017528418A5 (enExample) | 2018-08-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574072A Pending JP2017528418A (ja) | 2014-06-20 | 2015-06-19 | 抗葉酸受容体アルファ（ｆｒａ）抗体−薬物コンジュゲート及びその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9950077B2 (enExample) |
| EP (1) | EP3157960A4 (enExample) |
| JP (1) | JP2017528418A (enExample) |
| KR (1) | KR20170020868A (enExample) |
| CN (1) | CN106661124A (enExample) |
| AR (1) | AR100935A1 (enExample) |
| AU (1) | AU2015276821A1 (enExample) |
| BR (1) | BR112016029860A2 (enExample) |
| CA (1) | CA2952876A1 (enExample) |
| IL (1) | IL249442A0 (enExample) |
| MX (1) | MX2016016490A (enExample) |
| PH (1) | PH12016502524A1 (enExample) |
| RU (1) | RU2017101662A (enExample) |
| SG (1) | SG11201610620UA (enExample) |
| TW (1) | TWI654995B (enExample) |
| WO (1) | WO2015196167A1 (enExample) |
| ZA (1) | ZA201608779B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2935259T (pt) | 2012-12-21 | 2019-04-04 | Abgenomics Int Inc | Ligantes de autoimolação hidrofílicos e conjugados dos mesmos |
| AU2015276821A1 (en) | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| LT3313845T (lt) | 2015-06-29 | 2020-12-10 | Immunogen, Inc. | Cisteino inžinerijos antikūnų konjugatai |
| EP3400239B1 (en) | 2016-01-08 | 2021-06-02 | AltruBio Inc. | Tetravalent anti-psgl-1 antibodies and uses thereof |
| WO2018098258A2 (en) | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| CN107446020B (zh) * | 2017-07-28 | 2019-10-01 | 中国药科大学 | 叶酸受体α特异性结合肽2及其应用 |
| KR20200051802A (ko) * | 2017-09-18 | 2020-05-13 | 서트로 바이오파마, 인크. | 항-엽산 수용체 알파 항체 접합체 및 이의 용도 |
| BR112020016469A2 (pt) | 2018-03-13 | 2020-12-15 | Phanes Therapeutics, Inc. | Anticorpos do receptor anti-folato 1 e seus usos |
| CN112955548B (zh) * | 2018-07-09 | 2023-11-24 | 普众发现医药科技(上海)有限公司 | 叶酸受体α特异性抗体 |
| CN109053882B (zh) * | 2018-08-28 | 2019-08-23 | 东莞市朋志生物科技有限公司 | 一种ns1蛋白的结合蛋白以及应用 |
| WO2020060944A1 (en) * | 2018-09-17 | 2020-03-26 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
| CN119613486A (zh) * | 2019-05-20 | 2025-03-14 | 诺华股份有限公司 | 具有包含亲水性基团的接头的抗体药物缀合物 |
| CN111393528B (zh) * | 2020-01-19 | 2023-01-31 | 中国药科大学 | 一种靶向叶酸受体α的单链抗体及其应用 |
| US10981996B1 (en) * | 2020-06-01 | 2021-04-20 | Abexxa Biologics, Inc. | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US11976120B2 (en) * | 2020-06-01 | 2024-05-07 | Boehringer Ingelheim International Gmbh | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| AU2022394559A1 (en) | 2021-11-17 | 2024-05-09 | Altrubio Inc. | Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers |
| AU2024256916A1 (en) | 2023-04-18 | 2025-12-04 | Astrazeneca Ab | Conjugates comprising cleavable linkers |
| WO2025036307A1 (zh) * | 2023-08-11 | 2025-02-20 | 百奥泰生物制药股份有限公司 | 抗frα抗体药物偶联物在治疗疾病中的应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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-
2015
- 2015-06-19 AU AU2015276821A patent/AU2015276821A1/en not_active Abandoned
- 2015-06-19 RU RU2017101662A patent/RU2017101662A/ru not_active Application Discontinuation
- 2015-06-19 JP JP2016574072A patent/JP2017528418A/ja active Pending
- 2015-06-19 CA CA2952876A patent/CA2952876A1/en not_active Abandoned
- 2015-06-19 WO PCT/US2015/036824 patent/WO2015196167A1/en not_active Ceased
- 2015-06-19 SG SG11201610620UA patent/SG11201610620UA/en unknown
- 2015-06-19 EP EP15810153.5A patent/EP3157960A4/en not_active Withdrawn
- 2015-06-19 BR BR112016029860A patent/BR112016029860A2/pt not_active Application Discontinuation
- 2015-06-19 KR KR1020177001294A patent/KR20170020868A/ko not_active Withdrawn
- 2015-06-19 US US14/745,336 patent/US9950077B2/en active Active
- 2015-06-19 MX MX2016016490A patent/MX2016016490A/es unknown
- 2015-06-19 CN CN201580044557.8A patent/CN106661124A/zh active Pending
- 2015-06-22 TW TW104120020A patent/TWI654995B/zh not_active IP Right Cessation
- 2015-06-22 AR ARP150101993A patent/AR100935A1/es unknown
-
2016
- 2016-12-07 IL IL249442A patent/IL249442A0/en unknown
- 2016-12-16 PH PH12016502524A patent/PH12016502524A1/en unknown
- 2016-12-20 ZA ZA2016/08779A patent/ZA201608779B/en unknown
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