JP2017528418A5 - - Google Patents
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- JP2017528418A5 JP2017528418A5 JP2016574072A JP2016574072A JP2017528418A5 JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5 JP 2016574072 A JP2016574072 A JP 2016574072A JP 2016574072 A JP2016574072 A JP 2016574072A JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5
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- JP
- Japan
- Prior art keywords
- linker
- amino acid
- self
- antibody
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000005647 linker group Chemical group 0.000 claims 52
- 150000001413 amino acids Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000000539 amino acid group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 102000010451 Folate receptor alpha Human genes 0.000 claims 10
- 108050001931 Folate receptor alpha Proteins 0.000 claims 10
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- 229940079593 drug Drugs 0.000 claims 8
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- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 7
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- ONCCWDRMOZMNSM-FBCQKBJTSA-N compound Z Chemical compound N1=C2C(=O)NC(N)=NC2=NC=C1C(=O)[C@H]1OP(O)(=O)OC[C@H]1O ONCCWDRMOZMNSM-FBCQKBJTSA-N 0.000 claims 2
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- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462015321P | 2014-06-20 | 2014-06-20 | |
| US62/015,321 | 2014-06-20 | ||
| PCT/US2015/036824 WO2015196167A1 (en) | 2014-06-20 | 2015-06-19 | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528418A JP2017528418A (ja) | 2017-09-28 |
| JP2017528418A5 true JP2017528418A5 (enExample) | 2018-08-02 |
Family
ID=54936169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574072A Pending JP2017528418A (ja) | 2014-06-20 | 2015-06-19 | 抗葉酸受容体アルファ（ｆｒａ）抗体−薬物コンジュゲート及びその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9950077B2 (enExample) |
| EP (1) | EP3157960A4 (enExample) |
| JP (1) | JP2017528418A (enExample) |
| KR (1) | KR20170020868A (enExample) |
| CN (1) | CN106661124A (enExample) |
| AR (1) | AR100935A1 (enExample) |
| AU (1) | AU2015276821A1 (enExample) |
| BR (1) | BR112016029860A2 (enExample) |
| CA (1) | CA2952876A1 (enExample) |
| IL (1) | IL249442A0 (enExample) |
| MX (1) | MX2016016490A (enExample) |
| PH (1) | PH12016502524A1 (enExample) |
| RU (1) | RU2017101662A (enExample) |
| SG (1) | SG11201610620UA (enExample) |
| TW (1) | TWI654995B (enExample) |
| WO (1) | WO2015196167A1 (enExample) |
| ZA (1) | ZA201608779B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013364065B2 (en) | 2012-12-21 | 2018-10-04 | Altrubio Inc. | Hydrophilic self-immolative linkers and conjugates thereof |
| EP3157960A4 (en) | 2014-06-20 | 2018-01-24 | BioAlliance C.V. | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
| LT3313845T (lt) * | 2015-06-29 | 2020-12-10 | Immunogen, Inc. | Cisteino inžinerijos antikūnų konjugatai |
| ES2880731T3 (es) | 2016-01-08 | 2021-11-25 | Altrubio Inc | Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos |
| KR102576550B1 (ko) | 2016-11-23 | 2023-09-07 | 이뮤노젠 아이엔씨 | 벤조다이아제핀 유도체의 선택적인 설폰화 |
| CN107446020B (zh) * | 2017-07-28 | 2019-10-01 | 中国药科大学 | 叶酸受体α特异性结合肽2及其应用 |
| WO2019055909A1 (en) | 2017-09-18 | 2019-03-21 | Sutro Biopharma, Inc. | ALPHA ANTI-FOLATE ANTIBODY-RECEPTOR CONJUGATES AND USES THEREOF |
| US11873335B2 (en) | 2018-03-13 | 2024-01-16 | Phanes Therapeutics, Inc. | Anti-folate receptor 1 antibodies and uses thereof |
| WO2020016661A2 (en) * | 2018-07-09 | 2020-01-23 | Multitude Inc. | Antibodies specific to folate receptor alpha |
| CN109053882B (zh) * | 2018-08-28 | 2019-08-23 | 东莞市朋志生物科技有限公司 | 一种ns1蛋白的结合蛋白以及应用 |
| WO2020060944A1 (en) * | 2018-09-17 | 2020-03-26 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
| CA3140063A1 (en) * | 2019-05-20 | 2020-11-26 | Novartis Ag | Antibody drug conjugates having linkers comprising hydrophilic groups |
| CN111393528B (zh) * | 2020-01-19 | 2023-01-31 | 中国药科大学 | 一种靶向叶酸受体α的单链抗体及其应用 |
| US11976120B2 (en) | 2020-06-01 | 2024-05-07 | Boehringer Ingelheim International Gmbh | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US10981996B1 (en) * | 2020-06-01 | 2021-04-20 | Abexxa Biologics, Inc. | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| AU2022394559A1 (en) | 2021-11-17 | 2024-05-09 | Altrubio Inc. | Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers |
| AU2024258642A1 (en) | 2023-04-18 | 2025-12-04 | Astrazeneca Ab | Conjugates comprising cleavable linkers |
| WO2025036307A1 (zh) * | 2023-08-11 | 2025-02-20 | 百奥泰生物制药股份有限公司 | 抗frα抗体药物偶联物在治疗疾病中的应用 |
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|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5198560A (en) | 1990-04-27 | 1993-03-30 | Bristol-Myers Squibb Company | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof |
| DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
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-
2015
- 2015-06-19 EP EP15810153.5A patent/EP3157960A4/en not_active Withdrawn
- 2015-06-19 BR BR112016029860A patent/BR112016029860A2/pt not_active Application Discontinuation
- 2015-06-19 US US14/745,336 patent/US9950077B2/en active Active
- 2015-06-19 MX MX2016016490A patent/MX2016016490A/es unknown
- 2015-06-19 RU RU2017101662A patent/RU2017101662A/ru not_active Application Discontinuation
- 2015-06-19 AU AU2015276821A patent/AU2015276821A1/en not_active Abandoned
- 2015-06-19 KR KR1020177001294A patent/KR20170020868A/ko not_active Withdrawn
- 2015-06-19 CA CA2952876A patent/CA2952876A1/en not_active Abandoned
- 2015-06-19 SG SG11201610620UA patent/SG11201610620UA/en unknown
- 2015-06-19 WO PCT/US2015/036824 patent/WO2015196167A1/en not_active Ceased
- 2015-06-19 JP JP2016574072A patent/JP2017528418A/ja active Pending
- 2015-06-19 CN CN201580044557.8A patent/CN106661124A/zh active Pending
- 2015-06-22 TW TW104120020A patent/TWI654995B/zh not_active IP Right Cessation
- 2015-06-22 AR ARP150101993A patent/AR100935A1/es unknown
-
2016
- 2016-12-07 IL IL249442A patent/IL249442A0/en unknown
- 2016-12-16 PH PH12016502524A patent/PH12016502524A1/en unknown
- 2016-12-20 ZA ZA2016/08779A patent/ZA201608779B/en unknown
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