ATE301639T1 - Mcbi analoge von cc-1065 und die duocarmycine - Google Patents

Mcbi analoge von cc-1065 und die duocarmycine

Info

Publication number
ATE301639T1
ATE301639T1 AT97908059T AT97908059T ATE301639T1 AT E301639 T1 ATE301639 T1 AT E301639T1 AT 97908059 T AT97908059 T AT 97908059T AT 97908059 T AT97908059 T AT 97908059T AT E301639 T1 ATE301639 T1 AT E301639T1
Authority
AT
Austria
Prior art keywords
pct
duocarmycines
mcbi
analogue
date sep
Prior art date
Application number
AT97908059T
Other languages
English (en)
Inventor
Dale L Boger
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE301639T1 publication Critical patent/ATE301639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
AT97908059T 1996-03-08 1997-03-07 Mcbi analoge von cc-1065 und die duocarmycine ATE301639T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (1)

Publication Number Publication Date
ATE301639T1 true ATE301639T1 (de) 2005-08-15

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97908059T ATE301639T1 (de) 1996-03-08 1997-03-07 Mcbi analoge von cc-1065 und die duocarmycine

Country Status (9)

Country Link
US (1) US5985908A (de)
EP (1) EP0888301B1 (de)
JP (1) JP2000506168A (de)
AT (1) ATE301639T1 (de)
AU (1) AU711974B2 (de)
CA (1) CA2246783C (de)
DE (1) DE69733942T2 (de)
ES (1) ES2244991T3 (de)
WO (1) WO1997032850A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934269A4 (de) * 1996-05-31 2000-01-12 Scripps Research Inst Analoge von cc-1065 und duocarmycine
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
NZ334344A (en) * 1996-09-12 2000-08-25 Cancer Res Campaign Tech benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs
WO1998025900A1 (fr) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Composes presentant une activite antitumorale
JP3649617B2 (ja) 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 ２本鎖ｄｎａを切断できる化合物及びその使用方法
US6660742B2 (en) * 2000-09-19 2003-12-09 Taiho Pharmaceutical Co. Ltd. Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins
DE60211905T2 (de) * 2001-02-22 2007-01-18 School Of Pharmacy, University Of London Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
US7626026B2 (en) 2001-02-22 2009-12-01 University Of Bradford Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
CN1463270A (zh) 2001-05-31 2003-12-24 梅达莱克斯公司 细胞毒素、其有用的前体药物、连接基团和稳定剂
EP1554271A1 (de) * 2002-10-15 2005-07-20 Rigel Pharmaceuticals, Inc. Substituierte indole und deren verwendung als hcv inhibitoren
WO2005087762A1 (ja) * 2004-03-13 2005-09-22 Tmrc Co., Ltd. Ｄｎａの特定塩基配列をアルキル化する新規インドール誘導体ならびにそれを用いたアルキル化剤および薬剤
NZ550934A (en) * 2004-05-19 2010-05-28 Medarex Inc Chemical linkers and conjugates thereof
US7691962B2 (en) 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
KR20080068084A (ko) * 2005-10-26 2008-07-22 메다렉스, 인코포레이티드 씨씨-1065 유사체를 제조하기 위한 방법 및 화합물
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
CN101616911A (zh) 2007-02-21 2009-12-30 梅达莱克斯公司 具有单个氨基酸的化学连接物及其偶联物
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN102317283A (zh) 2008-11-03 2012-01-11 辛塔佳股份有限公司 新型cc-1065类似物及其缀合物
EP2560645B1 (de) 2010-04-21 2016-07-13 Syntarga B.V. Konjugate von cc-1065 analoga und bifunktionellen linkern
EP2762472B1 (de) 2011-09-28 2017-05-24 Industry-Academia Cooperation Group of Sejong University Selenophenkondensierte aromatische verbindung und herstellungsverfahren dafür
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
MX2015007918A (es) 2012-12-21 2016-06-21 Bioalliance Cv Enlazadores autodestructivos hidrofilos y conjugados de los mismos.
CA2935456C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Method for purifying cys-linked antibody-drug conjugates
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
CA2952876A1 (en) 2014-06-20 2015-12-23 Bioalliance C.V. Anti-folate receptor alpha (fra) antibody-drug conjugates and methods of using thereof
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
RU2766000C2 (ru) 2016-01-08 2022-02-07 АльтруБио Инк. Четырехвалентные антитела к psgl-1 и их применения
KR20220147721A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
JP2021120367A (ja) 2020-01-30 2021-08-19 エイムドバイオ株式会社 ベンゾセレノフェン系化合物、これを含む薬学的組成物及び抗体−薬物複合体

Also Published As

Publication number Publication date
WO1997032850A1 (en) 1997-09-12
AU1990297A (en) 1997-09-22
CA2246783C (en) 2006-07-11
AU711974B2 (en) 1999-10-28
US5985908A (en) 1999-11-16
EP0888301B1 (de) 2005-08-10
DE69733942T2 (de) 2006-06-08
EP0888301A4 (de) 2002-05-08
JP2000506168A (ja) 2000-05-23
CA2246783A1 (en) 1997-09-12
ES2244991T3 (es) 2005-12-16
EP0888301A1 (de) 1999-01-07
DE69733942D1 (de) 2005-09-15

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