MX368396B - Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. - Google Patents

Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada.

Info

Publication number
MX368396B
MX368396B MX2016009070A MX2016009070A MX368396B MX 368396 B MX368396 B MX 368396B MX 2016009070 A MX2016009070 A MX 2016009070A MX 2016009070 A MX2016009070 A MX 2016009070A MX 368396 B MX368396 B MX 368396B
Authority
MX
Mexico
Prior art keywords
cancer
duocarmycin
treatment
adcs
relates
Prior art date
Application number
MX2016009070A
Other languages
English (en)
Other versions
MX2016009070A (es
Inventor
Henry Beusker Patrick
Johannes Goedings Peter
DOKTER Willem
Franciscus Maria Verheijden Gijsbertus
Original Assignee
Synthon Biopharmaceuticals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals Bv filed Critical Synthon Biopharmaceuticals Bv
Publication of MX2016009070A publication Critical patent/MX2016009070A/es
Publication of MX368396B publication Critical patent/MX368396B/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a conjugados de anticuerpo-fármaco (ADC) que contienen duocarmicina para su uso en el tratamiento de tumores sólidos humanos y malignidades hematológicas que expresan a HER2, en particular cáncer de mama, cáncer gástrico, cáncer de vejiga, cáncer de ovario, cáncer de pulmón, cáncer de próstata, cáncer pancreático, cáncer colorrectal, cáncer escamocelular de cabeza y cuello u osteosarcoma y leucemia lirifoblástica aguda; en particular, la presente invención se refiere a ADC que contienen duocarmicina para su uso en el tratamiento de tumores sólidos humanos con estado de tejido HER2 IHC 2+ o 1+ y negativo para FISH de HER2; en forma ventajosa, la presente invención se refiere a ADC que contienen duocarmicina para su uso en el tratamiento de cáncer de mama triplemente negativo (TNBC).
MX2016009070A 2014-01-10 2015-01-09 Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. MX368396B (es)

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US11382982B2 (en) 2022-07-12
US20170014525A1 (en) 2017-01-19
US20180140711A1 (en) 2018-05-24
US9421278B2 (en) 2016-08-23
ZA201604535B (en) 2018-11-28
MX2016009070A (es) 2016-09-09
CL2016001760A1 (es) 2017-06-09
NO3069735T3 (es) 2018-08-11
CY1120288T1 (el) 2019-07-10
SG10201911860VA (en) 2020-02-27
RU2016132759A (ru) 2018-02-16
PT2948184T (pt) 2016-07-08
ES2575508T3 (es) 2016-06-29
ES2668984T3 (es) 2018-05-23
MX374126B (es) 2025-03-05
KR102323302B1 (ko) 2021-11-09
RU2016132759A3 (es) 2018-08-14
HRP20180876T1 (hr) 2018-07-13
JP2018039809A (ja) 2018-03-15
PT3069735T (pt) 2018-05-18
RU2019114963A3 (es) 2021-09-28
DK3069735T3 (en) 2018-05-22
JP6342517B2 (ja) 2018-06-13
JP2017503858A (ja) 2017-02-02
HRP20160697T1 (hr) 2016-07-15
CN105899236A (zh) 2016-08-24
US20160008486A1 (en) 2016-01-14
PL3069735T3 (pl) 2018-08-31
LT3069735T (lt) 2018-06-11
KR20160106693A (ko) 2016-09-12
AU2019264575A1 (en) 2019-12-05
RU2019114963A (ru) 2019-07-17
WO2015104385A2 (en) 2015-07-16
EP3069735B1 (en) 2018-03-14
HUE029255T2 (en) 2017-02-28
WO2015104385A3 (en) 2015-08-27
EP3069735A1 (en) 2016-09-21
ZA201800350B (en) 2019-07-31
BR112016015848A2 (pt) 2017-08-08
AU2015205509A1 (en) 2016-07-07
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CN105899236B (zh) 2019-07-26
HUE037250T2 (hu) 2018-08-28
PL2948184T3 (pl) 2016-11-30
RU2769700C2 (ru) 2022-04-05
US10603387B2 (en) 2020-03-31
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EP2948184A2 (en) 2015-12-02
KR20210130826A (ko) 2021-11-01
US20190314513A1 (en) 2019-10-17
JP6430603B2 (ja) 2018-11-28
CA2935433A1 (en) 2015-07-16
KR102344354B1 (ko) 2021-12-28
CA2935433C (en) 2019-04-02
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