HUE053799T2 - Antitest-duokarmicin gyógyszer-konjugátumokat tartalmazó készítmények - Google Patents
Antitest-duokarmicin gyógyszer-konjugátumokat tartalmazó készítményekInfo
- Publication number
- HUE053799T2 HUE053799T2 HUE16736481A HUE16736481A HUE053799T2 HU E053799 T2 HUE053799 T2 HU E053799T2 HU E16736481 A HUE16736481 A HU E16736481A HU E16736481 A HUE16736481 A HU E16736481A HU E053799 T2 HUE053799 T2 HU E053799T2
- Authority
- HU
- Hungary
- Prior art keywords
- antibody
- compositions
- drug conjugates
- duocarmycin drug
- duocarmycin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15176307 | 2015-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE053799T2 true HUE053799T2 (hu) | 2021-07-28 |
Family
ID=53673006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE16736481A HUE053799T2 (hu) | 2015-07-10 | 2016-07-08 | Antitest-duokarmicin gyógyszer-konjugátumokat tartalmazó készítmények |
Country Status (17)
Country | Link |
---|---|
US (1) | US11077204B2 (hu) |
EP (1) | EP3319597B1 (hu) |
JP (1) | JP6522806B2 (hu) |
CN (1) | CN107847449B (hu) |
AU (2) | AU2016292759B2 (hu) |
CA (1) | CA2986508C (hu) |
CY (1) | CY1124425T1 (hu) |
DK (1) | DK3319597T3 (hu) |
ES (1) | ES2866050T3 (hu) |
HR (1) | HRP20210547T1 (hu) |
HU (1) | HUE053799T2 (hu) |
LT (1) | LT3319597T (hu) |
PL (1) | PL3319597T3 (hu) |
PT (1) | PT3319597T (hu) |
RU (1) | RU2687237C1 (hu) |
WO (1) | WO2017009255A1 (hu) |
ZA (1) | ZA201707475B (hu) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105899237B (zh) | 2014-01-10 | 2019-09-03 | 斯索恩生物制药有限公司 | 用于治疗子宫内膜癌的倍癌霉素adc |
CA2935433C (en) | 2014-01-10 | 2019-04-02 | Synthon Biopharmaceuticals B.V. | Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies |
WO2017009255A1 (en) | 2015-07-10 | 2017-01-19 | Synthon Biopharmaceuticals B.V. | Compositions comprising antibody-duocarmycin drug conjugates |
CA3073383C (en) * | 2017-08-23 | 2023-10-31 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate preparation and lyophilization for same |
CN110960490A (zh) * | 2018-09-28 | 2020-04-07 | 江苏恒瑞医药股份有限公司 | 一种抗egfr抗体偶联药物组合物及其用途 |
CN112969478B (zh) * | 2018-11-09 | 2023-10-27 | 拜奥迪斯私人有限公司 | 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法 |
FI3811979T3 (fi) * | 2019-03-26 | 2024-01-11 | Remegen Co Ltd | Farmaseuttinen valmiste anti-HER2-vasta-aine-lääkekonjugaatti |
WO2020233534A1 (zh) * | 2019-05-17 | 2020-11-26 | 百奥泰生物制药股份有限公司 | 抗体-药物偶联物制剂、制备方法及应用 |
CN113116812A (zh) * | 2019-12-30 | 2021-07-16 | 百奥泰生物制药股份有限公司 | 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用 |
BR112022015062A2 (pt) * | 2020-02-06 | 2022-09-20 | Byondis Bv | Conjugado anticorpo-fármaco para uso no tratamento de um tumor, composição, uso de um conjugado anticorpo-fármaco, produto compreendendo um conjugado anticorpo-fármaco, e, método para prevenção ou redução da toxicidade associada à administração de um conjugado anticorpo-fármaco |
WO2023143154A1 (zh) * | 2022-01-28 | 2023-08-03 | 四川科伦博泰生物医药股份有限公司 | 一种药物组合物及其制备方法和应用 |
WO2023185907A1 (en) * | 2022-03-29 | 2023-10-05 | Genequantum Healthcare (Suzhou) Co., Ltd. | A freeze-drying process for an ADC |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX369959B (es) * | 2003-05-14 | 2019-11-27 | Immunogen Inc | Composicion de farmaco conjugado. |
AU2007357156B2 (en) | 2007-08-01 | 2013-01-10 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
AU2009246516B2 (en) | 2008-05-13 | 2015-03-05 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
ES2647317T3 (es) | 2008-11-03 | 2017-12-20 | Syntarga B.V. | Análogos de CC-1065 y sus conjugados |
PT3108886T (pt) | 2010-04-21 | 2020-08-27 | Syntarga Bv | Conjugados de analógicos cc-1065 e ligantes bifuncionais |
KR102537084B1 (ko) * | 2010-06-25 | 2023-05-26 | 샤이어 휴먼 지네틱 테라피즈 인크. | 아릴설파타제 a의 cns 전달을 위한 방법들 및 조성물들 |
US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
BR112014006798A2 (pt) * | 2011-09-26 | 2017-06-13 | Swedish Orphan Biovitrum Ab (Publ) | formulações melhoradas de lípase estimulada por sal billiar humana recombinantes |
PL2723323T3 (pl) * | 2012-03-28 | 2016-05-31 | Discovery Lab Inc | Liofilizacja syntetycznego liposomalnego surfaktantu płucnego |
JP6590803B2 (ja) * | 2013-11-21 | 2019-10-16 | ゲンマブ エー/エス | 抗体−薬物コンジュゲート凍結乾燥製剤 |
CA2935433C (en) | 2014-01-10 | 2019-04-02 | Synthon Biopharmaceuticals B.V. | Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies |
CN105899237B (zh) | 2014-01-10 | 2019-09-03 | 斯索恩生物制药有限公司 | 用于治疗子宫内膜癌的倍癌霉素adc |
WO2017009255A1 (en) | 2015-07-10 | 2017-01-19 | Synthon Biopharmaceuticals B.V. | Compositions comprising antibody-duocarmycin drug conjugates |
-
2016
- 2016-07-08 WO PCT/EP2016/066347 patent/WO2017009255A1/en active Application Filing
- 2016-07-08 AU AU2016292759A patent/AU2016292759B2/en active Active
- 2016-07-08 PL PL16736481T patent/PL3319597T3/pl unknown
- 2016-07-08 ES ES16736481T patent/ES2866050T3/es active Active
- 2016-07-08 DK DK16736481.9T patent/DK3319597T3/da active
- 2016-07-08 RU RU2018100656A patent/RU2687237C1/ru active
- 2016-07-08 CN CN201680040280.6A patent/CN107847449B/zh active Active
- 2016-07-08 CA CA2986508A patent/CA2986508C/en active Active
- 2016-07-08 PT PT167364819T patent/PT3319597T/pt unknown
- 2016-07-08 HU HUE16736481A patent/HUE053799T2/hu unknown
- 2016-07-08 LT LTEP16736481.9T patent/LT3319597T/lt unknown
- 2016-07-08 JP JP2017567296A patent/JP6522806B2/ja active Active
- 2016-07-08 EP EP16736481.9A patent/EP3319597B1/en active Active
- 2016-07-08 US US15/743,413 patent/US11077204B2/en active Active
-
2017
- 2017-11-03 ZA ZA2017/07475A patent/ZA201707475B/en unknown
-
2021
- 2021-04-06 HR HRP20210547TT patent/HRP20210547T1/hr unknown
- 2021-04-23 CY CY20211100350T patent/CY1124425T1/el unknown
- 2021-05-24 AU AU2021203331A patent/AU2021203331A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2016292759A1 (en) | 2017-11-23 |
JP2018519303A (ja) | 2018-07-19 |
US20190216942A9 (en) | 2019-07-18 |
RU2687237C1 (ru) | 2019-05-08 |
EP3319597A1 (en) | 2018-05-16 |
WO2017009255A1 (en) | 2017-01-19 |
CY1124425T1 (el) | 2022-07-22 |
JP6522806B2 (ja) | 2019-05-29 |
ZA201707475B (en) | 2021-04-28 |
CN107847449A (zh) | 2018-03-27 |
LT3319597T (lt) | 2021-07-26 |
US11077204B2 (en) | 2021-08-03 |
ES2866050T3 (es) | 2021-10-19 |
AU2016292759B2 (en) | 2021-05-20 |
PT3319597T (pt) | 2021-04-27 |
EP3319597B1 (en) | 2021-02-17 |
HRP20210547T1 (hr) | 2021-05-14 |
AU2021203331A1 (en) | 2021-06-24 |
PL3319597T3 (pl) | 2021-10-11 |
CA2986508C (en) | 2021-06-15 |
US20180200382A1 (en) | 2018-07-19 |
DK3319597T3 (da) | 2021-04-06 |
CN107847449B (zh) | 2021-04-30 |
CA2986508A1 (en) | 2017-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL271657A (en) | medical preparation | |
ZA201707475B (en) | Compositions comprising antibody-duocarmycin drug conjugates | |
IL271759A (en) | Pharmaceutical preparations that include anthraxtinib | |
GB201608323D0 (en) | Pharmaceutical compositions | |
HK1254573A1 (zh) | 包含苯基氨基嘧啶衍生物的藥物組合物 | |
GB201705303D0 (en) | Pharmaceutical compositions | |
SG11202001179YA (en) | Pharmaceutical compositions | |
GB201521462D0 (en) | Pharmaceutical composition | |
GB201705305D0 (en) | Pharmaceutical compositions | |
HK1245073A1 (zh) | 藥物組合物 | |
GB201515310D0 (en) | Pharmaceutical composition | |
GB201705304D0 (en) | Pharmaceutical compositions | |
GB201705306D0 (en) | Pharmaceutical compositions | |
GB201520862D0 (en) | Pharmaceutical composition | |
IL263999A (en) | Pharmaceutical compositions | |
IL272044A (en) | Pharmacy preparations | |
ZA201705782B (en) | Pharmaceutical compositions | |
IL272428A (en) | pharmaceutical preparations | |
ZA202000014B (en) | Pharmaceutical compositions | |
ZA201705783B (en) | Pharmaceutical compositions | |
GB201715404D0 (en) | Pharmaceutical compositions | |
GB201710114D0 (en) | Pharmaceutical compositions | |
GB201706816D0 (en) | Pharmaceutical compositions | |
GB201700831D0 (en) | Pharmaceutical compositions | |
GB201705302D0 (en) | Pharmaceutical compositions |