RS50194B - Derivati 4-fenil-piridina i njihova primena kao antagonista nk-1 receptora - Google Patents

Derivati 4-fenil-piridina i njihova primena kao antagonista nk-1 receptora

Info

Publication number
RS50194B
RS50194B YUP-95/00A YUP9500A RS50194B RS 50194 B RS50194 B RS 50194B YU P9500 A YUP9500 A YU P9500A RS 50194 B RS50194 B RS 50194B
Authority
RS
Serbia
Prior art keywords
alkyl
group
hydrogen
thiomorpholin
alkoxy
Prior art date
Application number
YUP-95/00A
Other languages
English (en)
Serbian (sr)
Inventor
Guido Galley
Torsten Hoffmann
Walter Hunkeler
Heinz Stadler
Thierry Godel
Patrick Schnider
Michael Bös
Quirico Branca
Original Assignee
F. Hoffmann-La Roche Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag., filed Critical F. Hoffmann-La Roche Ag.,
Publication of YU9500A publication Critical patent/YU9500A/sh
Publication of RS50194B publication Critical patent/RS50194B/sr

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
YUP-95/00A 1999-02-24 2000-02-22 Derivati 4-fenil-piridina i njihova primena kao antagonista nk-1 receptora RS50194B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99103504 1999-02-24
EP99123689 1999-11-29

Publications (2)

Publication Number Publication Date
YU9500A YU9500A (sh) 2002-11-15
RS50194B true RS50194B (sr) 2009-05-06

Family

ID=26152908

Family Applications (3)

Application Number Title Priority Date Filing Date
YUP-95/00A RS50194B (sr) 1999-02-24 2000-02-22 Derivati 4-fenil-piridina i njihova primena kao antagonista nk-1 receptora
RSP-2008/0562A RS20080562A (en) 1999-02-24 2000-02-22 4-phenyl-pyridine derivatives
RS20080562A RS53869B1 (en) 1999-02-24 2000-02-22 4-PHENYL-PYRIDINE DERIVATIVES

Family Applications After (2)

Application Number Title Priority Date Filing Date
RSP-2008/0562A RS20080562A (en) 1999-02-24 2000-02-22 4-phenyl-pyridine derivatives
RS20080562A RS53869B1 (en) 1999-02-24 2000-02-22 4-PHENYL-PYRIDINE DERIVATIVES

Country Status (54)

Country Link
US (2) US6297375B1 (en:Method)
EP (2) EP1035115B1 (en:Method)
JP (1) JP3399900B2 (en:Method)
KR (1) KR100384904B1 (en:Method)
CN (1) CN1142144C (en:Method)
AR (2) AR029614A1 (en:Method)
AT (2) ATE277905T1 (en:Method)
AU (1) AU767048B2 (en:Method)
BE (1) BE2015C057I2 (en:Method)
BG (1) BG64554B1 (en:Method)
BR (1) BRPI0000908B8 (en:Method)
CA (1) CA2299139C (en:Method)
CY (3) CY1111317T1 (en:Method)
CZ (1) CZ300596B6 (en:Method)
DE (3) DE60045564D1 (en:Method)
DK (2) DK1394150T3 (en:Method)
EA (1) EA003673B1 (en:Method)
EG (1) EG23817A (en:Method)
ES (3) ES2226622T3 (en:Method)
FR (2) FR2790473B1 (en:Method)
GB (1) GB2347422A (en:Method)
GE (1) GEP20022676B (en:Method)
GT (1) GT200000017A (en:Method)
HR (2) HRP20000097B1 (en:Method)
HU (1) HU227629B1 (en:Method)
IL (1) IL134654A (en:Method)
IS (1) IS2116B (en:Method)
IT (1) IT1320763B1 (en:Method)
JO (1) JO2294B1 (en:Method)
LT (1) LTC1035115I2 (en:Method)
LU (1) LU92745I2 (en:Method)
MA (1) MA26722A1 (en:Method)
ME (1) ME00593B (en:Method)
MY (2) MY123648A (en:Method)
NL (1) NL300758I1 (en:Method)
NO (1) NO315554B1 (en:Method)
NZ (1) NZ502948A (en:Method)
OA (1) OA11680A (en:Method)
PA (1) PA8491101A1 (en:Method)
PE (1) PE20001467A1 (en:Method)
PL (1) PL217311B1 (en:Method)
PT (2) PT1035115E (en:Method)
RS (3) RS50194B (en:Method)
SE (1) SE1035115T5 (en:Method)
SG (1) SG91856A1 (en:Method)
SI (1) SI1035115T1 (en:Method)
SK (2) SK287911B6 (en:Method)
SV (1) SV2002000024A (en:Method)
TN (1) TNSN00032A1 (en:Method)
TR (1) TR200000520A3 (en:Method)
TW (1) TWI288746B (en:Method)
UA (1) UA71547C2 (en:Method)
UY (1) UY32314A (en:Method)
ZA (1) ZA200000894B (en:Method)

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US6291465B1 (en) * 1999-03-09 2001-09-18 Hoffmann-La Roche Inc. Biphenyl derivatives
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AU7061901A (en) * 2000-07-14 2002-01-30 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
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CA2299139C (en) 2011-03-29
TR200000520A3 (tr) 2001-06-21
ES2171109A1 (es) 2002-08-16
EA003673B1 (ru) 2003-08-28
BRPI0000908B8 (pt) 2021-05-25
TWI288746B (en) 2007-10-21
AU767048B2 (en) 2003-10-30
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BG64554B1 (bg) 2005-07-29
JP3399900B2 (ja) 2003-04-21
YU9500A (sh) 2002-11-15
HUP0000748A3 (en) 2003-12-29
LU92745I2 (fr) 2015-08-17
IS5381A (is) 2000-08-25
SV2002000024A (es) 2002-01-23
DE60014216T2 (de) 2006-03-02
MY147451A (en) 2012-12-14
ES2171109B2 (es) 2003-09-16
SK2352000A3 (en) 2000-09-12
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GT200000017A (es) 2001-08-15
GB0003908D0 (en) 2000-04-05
CY2015041I2 (el) 2016-06-22
HRP20080306A2 (en) 2008-11-30
US6479483B2 (en) 2002-11-12
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IL134654A0 (en) 2001-04-30
UA71547C2 (uk) 2004-12-15

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