GB1557420A - Preparation of isobutyramide derivatives - Google Patents

Preparation of isobutyramide derivatives

Info

Publication number
GB1557420A
GB1557420A GB10069/77A GB1006977A GB1557420A GB 1557420 A GB1557420 A GB 1557420A GB 10069/77 A GB10069/77 A GB 10069/77A GB 1006977 A GB1006977 A GB 1006977A GB 1557420 A GB1557420 A GB 1557420A
Authority
GB
United Kingdom
Prior art keywords
formula
isobutyramide
derivatives
preparation
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10069/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes de Produits Chimiques SA
Original Assignee
Societe dEtudes de Produits Chimiques SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes de Produits Chimiques SA filed Critical Societe dEtudes de Produits Chimiques SA
Priority to GB10069/77A priority Critical patent/GB1557420A/en
Priority to ZA00780618A priority patent/ZA78618B/en
Priority to IN94/DEL/78A priority patent/IN147801B/en
Priority to NZ186388A priority patent/NZ186388A/en
Priority to FI780472A priority patent/FI780472A/en
Priority to PT67667A priority patent/PT67667B/en
Priority to BE185268A priority patent/BE864075A/en
Priority to AU33459/78A priority patent/AU517807B2/en
Priority to NL7802024A priority patent/NL7802024A/en
Priority to CH200778A priority patent/CH628321A5/en
Priority to JP2168278A priority patent/JPS53112823A/en
Priority to AT148978A priority patent/AT352104B/en
Priority to ES467566A priority patent/ES467566A1/en
Priority to OA56427A priority patent/OA05902A/en
Priority to EG156/78A priority patent/EG13580A/en
Priority to AR271358A priority patent/AR214560A1/en
Priority to LU79195A priority patent/LU79195A1/en
Priority to SE7802694A priority patent/SE431202B/en
Priority to MX786923U priority patent/MX4826E/en
Priority to NO780834A priority patent/NO143969C/en
Priority to IE483/78A priority patent/IE46671B1/en
Priority to DK105078A priority patent/DK105078A/en
Priority to FR7806912A priority patent/FR2383167A1/en
Priority to DE2810505A priority patent/DE2810505C3/en
Publication of GB1557420A publication Critical patent/GB1557420A/en
Priority to HK288/80A priority patent/HK28880A/en
Priority to MY67/81A priority patent/MY8100067A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The derivatives of isobutyramide represented by the formula (I) <IMAGE> in which R1 is a halogen atom and n is an integer from 2 to 6, are prepared by reacting, in dioxane, the substituted phenoxyisobutyramide of formula: <IMAGE> with the N-cyanoalkylene of formula CH2=CH-(CH2)p-CN, in which p is an integer from 0 to 4, in the presence of a basic agent and at a temperature of between 50 and 65 DEG C. The compounds of formula (I) can be used as active substances, in combination with an excipient suited for the method of administration, in medicinal compositions, especially those having hypolipaemiating and hypotriglyceridaemiating and hypocholesterolaemiating actions.
GB10069/77A 1977-03-10 1977-03-10 Preparation of isobutyramide derivatives Expired GB1557420A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
GB10069/77A GB1557420A (en) 1977-03-10 1977-03-10 Preparation of isobutyramide derivatives
ZA00780618A ZA78618B (en) 1977-03-10 1978-02-01 New preparation of isobutyramide derivatives
IN94/DEL/78A IN147801B (en) 1977-03-10 1978-02-06
NZ186388A NZ186388A (en) 1977-03-10 1978-02-07 A process for the preparation of certain derivatives of isobtyramide: these derivatives when so prepared and therapeutic compositions cotanining them
FI780472A FI780472A (en) 1977-03-10 1978-02-14 FRAMSTAELLNING AV ISOBUTYRAMIDDERIVATER
PT67667A PT67667B (en) 1977-03-10 1978-02-16 New preparation of isobutyramide derivatives
BE185268A BE864075A (en) 1977-03-10 1978-02-17 NEW PROCESS FOR THE PREPARATION OF ISOBUTYRAMIDE DERIVATIVES
AU33459/78A AU517807B2 (en) 1977-03-10 1978-02-21 Preparation of isobutyramide derivatives
NL7802024A NL7802024A (en) 1977-03-10 1978-02-23 PROCESS FOR PREPARING ISOBUTYRAMIDE DERIVATIVES.
CH200778A CH628321A5 (en) 1977-03-10 1978-02-24 Process for the preparation of derivatives of isobutyramide and medical composition containing these derivatives
JP2168278A JPS53112823A (en) 1977-03-10 1978-02-28 Process for preparing isobutylamide derivative
AT148978A AT352104B (en) 1977-03-10 1978-03-02 METHOD FOR PRODUCING N-CYANOALKYL-P-HALOGENPHENOXY ISOBUTYRAMIDES
ES467566A ES467566A1 (en) 1977-03-10 1978-03-04 Preparation of isobutyramide derivatives
OA56427A OA05902A (en) 1977-03-10 1978-03-06 New process for the preparation of isobutyramide derivatives.
EG156/78A EG13580A (en) 1977-03-10 1978-03-07 Nouveau procede de preparation de derives de l'isobutyramide
AR271358A AR214560A1 (en) 1977-03-10 1978-03-08 PROCEDURE FOR THE PREPARATION OF N-CYANOALKYL (C2-6) -P-HALOPHENOXY-ISOBUTYRAMIDES
LU79195A LU79195A1 (en) 1977-03-10 1978-03-08 PREPARATION OF NEW ISOBUTYRAMIDE DERIVATIVES
IE483/78A IE46671B1 (en) 1977-03-10 1978-03-09 Preparation of isobutyramide derivatives
MX786923U MX4826E (en) 1977-03-10 1978-03-09 PROCEDURE FOR THE PREPARATION OF ISOBUTYRAMIDE DERIVATIVES
NO780834A NO143969C (en) 1977-03-10 1978-03-09 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE N-CYANOALKYL-P-HALOGENPHENOXY-ISOBUTYRAMIDES
SE7802694A SE431202B (en) 1977-03-10 1978-03-09 ANALOGY PROCEDURE FOR PREPARATION OF N-CYANOALKYL-P-HALOGENPHENOXY-ISOBUTYRAMIDES WITH BLOOD FAT CONTENTS
DK105078A DK105078A (en) 1977-03-10 1978-03-09 PROCEDURE FOR THE PREPARATION OF ISOBUTYRIDIUM DERIVATIVES
FR7806912A FR2383167A1 (en) 1977-03-10 1978-03-10 NEW PROCESS FOR THE PREPARATION OF ISOBUTYRAMIDE DERIVATIVES
DE2810505A DE2810505C3 (en) 1977-03-10 1978-03-10 Process for the preparation of isobutyramides
HK288/80A HK28880A (en) 1977-03-10 1980-05-22 Preparation of isobutyramide derivatives
MY67/81A MY8100067A (en) 1977-03-10 1981-12-30 Preparation of isobutyramide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB10069/77A GB1557420A (en) 1977-03-10 1977-03-10 Preparation of isobutyramide derivatives

Publications (1)

Publication Number Publication Date
GB1557420A true GB1557420A (en) 1979-12-12

Family

ID=9960874

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10069/77A Expired GB1557420A (en) 1977-03-10 1977-03-10 Preparation of isobutyramide derivatives

Country Status (26)

Country Link
JP (1) JPS53112823A (en)
AR (1) AR214560A1 (en)
AT (1) AT352104B (en)
AU (1) AU517807B2 (en)
BE (1) BE864075A (en)
CH (1) CH628321A5 (en)
DE (1) DE2810505C3 (en)
DK (1) DK105078A (en)
EG (1) EG13580A (en)
ES (1) ES467566A1 (en)
FI (1) FI780472A (en)
FR (1) FR2383167A1 (en)
GB (1) GB1557420A (en)
HK (1) HK28880A (en)
IE (1) IE46671B1 (en)
IN (1) IN147801B (en)
LU (1) LU79195A1 (en)
MX (1) MX4826E (en)
MY (1) MY8100067A (en)
NL (1) NL7802024A (en)
NO (1) NO143969C (en)
NZ (1) NZ186388A (en)
OA (1) OA05902A (en)
PT (1) PT67667B (en)
SE (1) SE431202B (en)
ZA (1) ZA78618B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479483B2 (en) 1999-02-24 2002-11-12 Hoffmann-La Roche Inc. 4-phenyl-pyridine derivatives
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
US8852634B2 (en) 2005-09-23 2014-10-07 Hoffmann-La Roche Inc. Dosage formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE734725C (en) * 1940-04-17 1943-04-30 Ig Farbenindustrie Ag Process for the preparation of formylamino-ª ‰ -propionitriles
GB1064252A (en) * 1963-09-19 1967-04-05 Ici Ltd Amides and pharmaceutical compositions containing them
GB1041982A (en) * 1963-09-30 1966-09-07 Boots Pure Drug Co Ltd Herbicidal compounds and compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479483B2 (en) 1999-02-24 2002-11-12 Hoffmann-La Roche Inc. 4-phenyl-pyridine derivatives
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
US8852634B2 (en) 2005-09-23 2014-10-07 Hoffmann-La Roche Inc. Dosage formulation

Also Published As

Publication number Publication date
DE2810505B2 (en) 1979-08-30
EG13580A (en) 1981-12-31
IE46671B1 (en) 1983-08-24
PT67667B (en) 1979-07-20
NZ186388A (en) 1979-04-26
NO143969B (en) 1981-02-09
NO143969C (en) 1981-06-03
IE780483L (en) 1978-09-10
HK28880A (en) 1980-05-30
FR2383167B1 (en) 1980-04-25
ES467566A1 (en) 1978-10-16
FR2383167A1 (en) 1978-10-06
OA05902A (en) 1981-05-31
NO780834L (en) 1978-09-12
ATA148978A (en) 1979-02-15
FI780472A (en) 1978-09-11
AU3345978A (en) 1979-08-30
NL7802024A (en) 1978-09-12
AT352104B (en) 1979-09-10
SE431202B (en) 1984-01-23
SE7802694L (en) 1978-09-11
CH628321A5 (en) 1982-02-26
DE2810505A1 (en) 1978-09-14
DK105078A (en) 1978-09-11
BE864075A (en) 1978-06-16
IN147801B (en) 1980-06-28
JPS53112823A (en) 1978-10-02
AR214560A1 (en) 1979-06-29
DE2810505C3 (en) 1980-05-08
PT67667A (en) 1978-03-01
LU79195A1 (en) 1978-06-28
MY8100067A (en) 1981-12-31
AU517807B2 (en) 1981-08-27
ZA78618B (en) 1978-12-27
JPS5715831B2 (en) 1982-04-01
MX4826E (en) 1982-10-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee