PT82460B - Processo para a preparacao de novos derivados de imidazoquinolina com actividade cardiotonica antitrombogenica e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados de imidazoquinolina com actividade cardiotonica antitrombogenica e de composicoes farmaceuticas que os contem

Info

Publication number
PT82460B
PT82460B PT82460A PT8246086A PT82460B PT 82460 B PT82460 B PT 82460B PT 82460 A PT82460 A PT 82460A PT 8246086 A PT8246086 A PT 8246086A PT 82460 B PT82460 B PT 82460B
Authority
PT
Portugal
Prior art keywords
antitrombogenic
imidazoquinolin
derivatives
contain
pharmaceutical compositions
Prior art date
Application number
PT82460A
Other languages
English (en)
Portuguese (pt)
Other versions
PT82460A (en
Inventor
John J Wright
Nicholas A Meanwell
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT82460A publication Critical patent/PT82460A/pt
Publication of PT82460B publication Critical patent/PT82460B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT82460A 1985-04-25 1986-04-24 Processo para a preparacao de novos derivados de imidazoquinolina com actividade cardiotonica antitrombogenica e de composicoes farmaceuticas que os contem PT82460B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (2)

Publication Number Publication Date
PT82460A PT82460A (en) 1986-05-01
PT82460B true PT82460B (pt) 1988-11-30

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82460A PT82460B (pt) 1985-04-25 1986-04-24 Processo para a preparacao de novos derivados de imidazoquinolina com actividade cardiotonica antitrombogenica e de composicoes farmaceuticas que os contem

Country Status (32)

Country Link
US (1) US4668686A (OSRAM)
KR (1) KR940000828B1 (OSRAM)
CN (1) CN1016175B (OSRAM)
AT (1) AT390257B (OSRAM)
AU (1) AU592983B2 (OSRAM)
BE (1) BE904671A (OSRAM)
CA (1) CA1298836C (OSRAM)
CH (1) CH675722A5 (OSRAM)
CY (1) CY1641A (OSRAM)
DE (1) DE3614132A1 (OSRAM)
DK (3) DK164868C (OSRAM)
EG (1) EG18104A (OSRAM)
ES (3) ES8708229A1 (OSRAM)
FI (1) FI83316C (OSRAM)
FR (1) FR2581065B1 (OSRAM)
GB (1) GB2174987B (OSRAM)
GR (1) GR861086B (OSRAM)
HK (1) HK64492A (OSRAM)
HU (1) HU195813B (OSRAM)
IL (1) IL78581A0 (OSRAM)
IT (1) IT1215651B (OSRAM)
LU (1) LU86406A1 (OSRAM)
MY (1) MY102086A (OSRAM)
NL (1) NL8601053A (OSRAM)
NO (1) NO163406C (OSRAM)
NZ (1) NZ215885A (OSRAM)
OA (1) OA08242A (OSRAM)
PT (1) PT82460B (OSRAM)
SE (1) SE461468B (OSRAM)
SG (1) SG29092G (OSRAM)
SU (3) SU1450746A3 (OSRAM)
YU (1) YU46054B (OSRAM)

Families Citing this family (45)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
WO2005018551A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Oxime substituted imidazo-containing compounds
CA2536136C (en) 2003-08-27 2012-10-30 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US8871782B2 (en) * 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
MY161812A (en) 2003-11-25 2017-05-15 3M Innovative Properties Co Substituted imidazo ring systems and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
JP2007517044A (ja) 2003-12-30 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
AU2005284835A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics Inc. Imidazoquinoline compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2592904C (en) 2004-12-30 2015-04-07 3M Innovative Properties Company Chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
WO2006086634A2 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1863814A1 (en) 2005-04-01 2007-12-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
EA017925B1 (ru) 2006-08-02 2013-04-30 Цитокинетикс, Инкорпорэйтед ПРОИЗВОДНЫЕ 1Н-ИМИДАЗО[4,5-b]ПИРАЗИНА
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
KR101951220B1 (ko) 2011-07-13 2019-02-22 싸이토키네틱스, 인코포레이티드 조합 als 치료법
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
DK190986D0 (da) 1986-04-24
DK165248B (da) 1992-10-26
YU116787A (en) 1988-04-30
DE3614132A1 (de) 1986-11-27
DK80291A (da) 1991-04-30
FI83316B (fi) 1991-03-15
PT82460A (en) 1986-05-01
ES8802521A1 (es) 1988-07-16
ES554336A0 (es) 1987-10-01
HUT42089A (en) 1987-06-29
ES557551A0 (es) 1988-02-16
CN1016175B (zh) 1992-04-08
CY1641A (en) 1992-11-06
MY102086A (en) 1992-03-31
YU46054B (sh) 1992-12-21
CN86102747A (zh) 1987-02-04
HU195813B (en) 1988-07-28
GB2174987A (en) 1986-11-19
IL78581A0 (en) 1986-08-31
DK81091D0 (da) 1991-05-01
GR861086B (en) 1986-09-01
FI83316C (fi) 1991-06-25
US4668686A (en) 1987-05-26
DK80291D0 (da) 1991-04-30
GB2174987B (en) 1989-08-02
HK64492A (en) 1992-09-04
DK164868B (da) 1992-08-31
IT8620206A0 (it) 1986-04-24
DK190986A (da) 1986-10-26
ES8708229A1 (es) 1987-10-01
EG18104A (en) 1992-09-30
ATA112186A (de) 1989-09-15
SE8601907D0 (sv) 1986-04-24
BE904671A (fr) 1986-10-24
SU1450746A3 (ru) 1989-01-07
NL8601053A (nl) 1986-11-17
LU86406A1 (fr) 1986-11-05
NO163406B (no) 1990-02-12
CA1298836C (en) 1992-04-14
AU5641386A (en) 1986-10-30
SE461468B (sv) 1990-02-19
FR2581065B1 (fr) 1990-02-02
KR860008177A (ko) 1986-11-12
DK165249B (da) 1992-10-26
NO163406C (no) 1990-05-23
FI861684A0 (fi) 1986-04-22
IT1215651B (it) 1990-02-22
GB8610037D0 (en) 1986-05-29
DK164868C (da) 1993-01-11
SU1560056A3 (ru) 1990-04-23
ES8801829A1 (es) 1988-02-16
FI861684L (fi) 1986-10-26
OA08242A (en) 1987-10-30
SE8601907L (sv) 1986-10-26
AT390257B (de) 1990-04-10
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
SG29092G (en) 1992-05-15
AU592983B2 (en) 1990-02-01
NO861617L (no) 1986-10-27
KR940000828B1 (ko) 1994-02-02
SU1470192A3 (ru) 1989-03-30
FR2581065A1 (fr) 1986-10-31
NZ215885A (en) 1989-04-26
DK165249C (da) 1993-03-22
CH675722A5 (OSRAM) 1990-10-31
ES557552A0 (es) 1988-07-16

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Effective date: 19941031