PT82463B - Processo para a preparacao de novos derivados de aza-indole e de composicoes farmceuticas que os contem - Google Patents
Processo para a preparacao de novos derivados de aza-indole e de composicoes farmceuticas que os contemInfo
- Publication number
- PT82463B PT82463B PT82463A PT8246386A PT82463B PT 82463 B PT82463 B PT 82463B PT 82463 A PT82463 A PT 82463A PT 8246386 A PT8246386 A PT 8246386A PT 82463 B PT82463 B PT 82463B
- Authority
- PT
- Portugal
- Prior art keywords
- contain
- pharmaceutical compositions
- indole derivatives
- preparing new
- new aza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858510752A GB8510752D0 (en) | 1985-04-27 | 1985-04-27 | Compounds |
GB858525913A GB8525913D0 (en) | 1985-10-21 | 1985-10-21 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PT82463A PT82463A (en) | 1986-05-01 |
PT82463B true PT82463B (pt) | 1988-10-14 |
Family
ID=26289173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT82463A PT82463B (pt) | 1985-04-27 | 1986-04-24 | Processo para a preparacao de novos derivados de aza-indole e de composicoes farmceuticas que os contem |
Country Status (17)
Country | Link |
---|---|
US (2) | US4886808A (pt) |
EP (2) | EP0498466B1 (pt) |
JP (1) | JP2696457B2 (pt) |
AU (1) | AU594670B2 (pt) |
BG (1) | BG61324B2 (pt) |
CA (1) | CA1296004C (pt) |
CY (1) | CY1721A (pt) |
CZ (1) | CZ286325B6 (pt) |
DE (2) | DE3650772T2 (pt) |
DK (1) | DK170166B1 (pt) |
ES (1) | ES8707948A1 (pt) |
GR (1) | GR861103B (pt) |
HK (1) | HK66993A (pt) |
IE (1) | IE58313B1 (pt) |
NZ (1) | NZ215945A (pt) |
PT (1) | PT82463B (pt) |
SG (1) | SG39393G (pt) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | Hoffmann La Roche | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
GB8515845D0 (en) * | 1985-06-22 | 1985-07-24 | Beecham Group Plc | Treatment |
US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
ES2053451T3 (es) * | 1986-01-07 | 1994-08-01 | Beecham Group Plc | Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles. |
DE3782107T2 (de) * | 1986-07-25 | 1993-04-01 | Beecham Group Plc | Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
AT396870B (de) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten |
EP0279114B2 (en) * | 1986-11-21 | 1995-08-23 | Glaxo Group Limited | Medicaments for the treatment or prevention of the withdrawal syndrome |
US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
EP0278173B1 (en) * | 1986-12-17 | 1993-11-03 | Glaxo Group Limited | Use of heterocyclic derivatives in the treatment of depressions |
US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
ATE152623T1 (de) * | 1986-12-17 | 1997-05-15 | Glaxo Group Ltd | Verwendung von heterozyklischen derivaten zur herstellung von arzneimitteln |
GB8806990D0 (en) * | 1988-03-23 | 1988-04-27 | Beecham Group Plc | Novel compounds |
GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
DE3852145T2 (de) * | 1987-02-18 | 1995-04-06 | Beecham Group Plc | Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten. |
US4918080A (en) * | 1987-04-14 | 1990-04-17 | Glaxo Group Limited | Imidazollyl containing ketone derivatives |
EP0289170B1 (en) | 1987-04-25 | 1993-06-23 | Beecham Group Plc | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
EP0340270B1 (en) * | 1987-11-14 | 1992-07-15 | Beecham Group Plc | 5-ht 3? receptor antagonists for treatment of cough and bronchoconstriction |
AU611976B2 (en) * | 1987-12-24 | 1991-06-27 | John Wyeth & Brother Limited | Aroyl urea and carbamic acid derivatives of azabicyclo compounds |
US4950759A (en) * | 1988-07-07 | 1990-08-21 | Duphar International Research B.V. | Substituted 1,7-annelated 1H-indazoles |
US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
US5166341A (en) * | 1988-07-29 | 1992-11-24 | Dainippon Pharmaceutical Co., Ltd. | 6-amino-1,4-hexahydro-1H-diazepine derivatives |
CA2004911A1 (en) * | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
EP0381422B1 (en) * | 1989-02-02 | 1996-10-23 | Yamanouchi Pharmaceutical Co. Ltd. | Tetrahydrobenzimidazole derivatives |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
GB8916682D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Pharmaceutical compounds |
US4992461A (en) * | 1989-09-11 | 1991-02-12 | G. D. Searle & Co. | N-azabicyclo(3.3.0)octane amides of aromatic acids, compositions, and methods of use thereof |
US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
US5180728A (en) * | 1989-09-25 | 1993-01-19 | Fujisawa Pharmaceutical Company, Ltd. | Pyrimidoindole derivatives and processes for preparation thereof |
GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
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US5225419A (en) * | 1989-10-14 | 1993-07-06 | John Wyeth & Brother, Limited | Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof |
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GB9009389D0 (en) * | 1990-04-26 | 1990-06-20 | Smith Kline French Lab | Treatment |
GB9009542D0 (en) * | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Novel compounds |
US5202318A (en) * | 1990-05-14 | 1993-04-13 | Syntex (U.S.A.) Inc. | Tricyclic compounds acting at serotonin receptor subtypes |
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JP3122671B2 (ja) * | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
GB9020927D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Pharmaceuticals |
US5200415A (en) * | 1990-11-01 | 1993-04-06 | Asahi Kasei Kogyo Kabushiki Kaisha | Pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives and their pharmaceutical use |
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US5929059A (en) * | 1991-01-19 | 1999-07-27 | Smithkline Beecham P.L.C. | Pharmaceutical compositions containing granisetron and dexamethasone |
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US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
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US5344831A (en) * | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔3,2−b〕ピリジン誘導体 |
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GB9305593D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Pharmaceuticals |
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CN103724343A (zh) | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
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EP2164848B1 (en) | 2007-06-13 | 2016-02-24 | Inke, S.A. | Polymorphic form of granisetron base, methods for obtaining it and formulation containing it |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2100909A1 (fr) * | 1970-07-15 | 1972-03-24 | Egyt Gyogyszervegyeszeti Gyar | Amides de l'acide indazole-3-carboxylique et procedes de preparation |
GB2100259B (en) * | 1981-06-13 | 1984-10-31 | Merrell Toraude & Co | Treatment of migraine with tropyl benzoate derivatives |
FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
FR2548666A1 (fr) * | 1983-07-08 | 1985-01-11 | Delalande Sa | Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique |
WO1985001048A1 (en) * | 1983-08-26 | 1985-03-14 | Sandoz Ag | Aromatic esters or amides of carboxylic acid and sulfonic acid |
GB8525913D0 (en) * | 1985-10-21 | 1985-11-27 | Beecham Group Plc | Compounds |
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
GB8510752D0 (en) * | 1985-04-27 | 1985-06-05 | Beecham Group Plc | Compounds |
DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | Hoffmann La Roche | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
GB8520616D0 (en) * | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
-
1986
- 1986-04-21 DE DE3650772T patent/DE3650772T2/de not_active Expired - Lifetime
- 1986-04-21 EP EP92104830A patent/EP0498466B1/en not_active Expired - Lifetime
- 1986-04-21 EP EP86302964A patent/EP0200444B1/en not_active Expired - Lifetime
- 1986-04-21 DE DE8686302964T patent/DE3687080T2/de not_active Expired - Lifetime
- 1986-04-24 AU AU56579/86A patent/AU594670B2/en not_active Expired
- 1986-04-24 PT PT82463A patent/PT82463B/pt not_active IP Right Cessation
- 1986-04-24 DK DK191186A patent/DK170166B1/da not_active IP Right Cessation
- 1986-04-24 NZ NZ215945A patent/NZ215945A/en unknown
- 1986-04-25 IE IE109986A patent/IE58313B1/en not_active IP Right Cessation
- 1986-04-25 ES ES554405A patent/ES8707948A1/es not_active Expired
- 1986-04-25 GR GR861103A patent/GR861103B/el unknown
- 1986-04-25 CA CA000507639A patent/CA1296004C/en not_active Expired - Lifetime
-
1988
- 1988-03-16 US US07/171,141 patent/US4886808A/en not_active Expired - Lifetime
-
1989
- 1989-10-03 US US07/416,501 patent/US5034398A/en not_active Expired - Lifetime
-
1991
- 1991-11-01 CZ CS19913323A patent/CZ286325B6/cs not_active IP Right Cessation
-
1992
- 1992-06-03 JP JP4168503A patent/JP2696457B2/ja not_active Expired - Lifetime
-
1993
- 1993-04-07 SG SG393/93A patent/SG39393G/en unknown
- 1993-07-08 HK HK669/93A patent/HK66993A/xx not_active IP Right Cessation
- 1993-09-28 BG BG98127A patent/BG61324B2/bg unknown
-
1994
- 1994-05-06 CY CY172194A patent/CY1721A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK191186A (da) | 1986-10-28 |
DE3650772D1 (de) | 2002-08-29 |
IE861099L (en) | 1986-10-27 |
NZ215945A (en) | 1990-04-26 |
AU5657986A (en) | 1986-11-06 |
DE3687080T2 (de) | 1993-03-25 |
DK191186D0 (da) | 1986-04-24 |
CY1721A (en) | 1994-05-06 |
EP0200444A2 (en) | 1986-11-05 |
JPH05194508A (ja) | 1993-08-03 |
PT82463A (en) | 1986-05-01 |
DE3687080D1 (de) | 1992-12-17 |
DK170166B1 (da) | 1995-06-06 |
EP0498466A1 (en) | 1992-08-12 |
HK66993A (en) | 1993-07-16 |
CZ286325B6 (cs) | 2000-03-15 |
US4886808A (en) | 1989-12-12 |
ES8707948A1 (es) | 1987-09-01 |
AU594670B2 (en) | 1990-03-15 |
IE58313B1 (en) | 1993-09-08 |
SG39393G (en) | 1993-06-11 |
US5034398A (en) | 1991-07-23 |
EP0200444A3 (en) | 1988-12-14 |
EP0200444B1 (en) | 1992-11-11 |
EP0498466B1 (en) | 2002-07-24 |
CS332391A3 (en) | 1992-06-17 |
CA1296004C (en) | 1992-02-18 |
DE3650772T2 (de) | 2003-04-03 |
BG61324B2 (bg) | 1997-05-30 |
ES554405A0 (es) | 1987-09-01 |
JP2696457B2 (ja) | 1998-01-14 |
GR861103B (en) | 1986-08-11 |
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Owner name: BEECHAM GROUP P.L.C. Effective date: 20010927 |
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