DK191186A - Indolderivater - Google Patents
Indolderivater Download PDFInfo
- Publication number
- DK191186A DK191186A DK191186A DK191186A DK191186A DK 191186 A DK191186 A DK 191186A DK 191186 A DK191186 A DK 191186A DK 191186 A DK191186 A DK 191186A DK 191186 A DK191186 A DK 191186A
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- indole derivatives
- alkoxy
- halogen
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
z er CH eller N, og Rfl har den for R3 ovenfor definerede betydning;
Rb er til stede, når X-Y-R2 er bundet til phenylringen, og er valgt blandt hydrogen, halogen, CF3, hydroxy, Cj^.g-alkoxy og alkyl;
Ri er hydrogen, halogen, CF3, C^.g-alkyl, C^.g-alkoxy, C^.g-alkyl-thio, Cj_.y-acyl, .7 -acylamino, Ci.g-alkylsulfonylamino, N-{Ci-g-alkylsulfonyl)-N-Ci.4-alkylamino, Ci.g -alkylsulfinyl, hydroxy, nitro eller araino, aminocarbonyl, aminosulfonyl, araino-sulfonylamino eller N-(aminosulfonyl)-Ci.^-alkylamino eventuelt N-substitueret med én eller to grupper valgt blandt Ci.g-alkyl, Cj.g-eyeloalkyl, Cj.g-cycloalkyl-Ci.^-alkyl, phenyl og phenyl-Ci_4*alkyl eller eventuelt N-disubstitueret med C^.g-polymeth-ylen; R2 er en gruppe med den almene formel (a), (b) eller (c)
U)
(b)
(c) hvor n er 2 eller 3; p og q uafhængigt af hinanden er 1-3; og i:· eller R5 er C^-alkyl, Cj.g-cycloalkyl, C3.g-cycloalkyl-C1.2-alkyl eller en gruppe (CH2)tRg, hvor t er 1 eller 2, og Rg er thienyl, pyrrolyl eller furyl eventuelt substitueret med én eller to substituenter valgt blandt Cj.g-alkyl, Ci_g-alkoxy, tri-fluormethyl og halogen, eller er phenyl eventuelt substitueret med én eller to substituenter valgt blandt Ci.^-alkoxy, tri- fluormethyl, halogen, nitro, carboxy, esterificeret carboxy og C^.^-alkyl, der eventuelt er substitueret med hydroxy, C^.^-alkoxy, carboxy, esterificeret carboxy eller in vivo hydrolyserbart acyloxy, fremstilles ved forskellige fremgangsmåder. Forbindelser I har 5-HT-antagonistvirkning og/eller gastrisk motilitetsforbedrende virkning og kan anvendes som farmaceutiske midler. t
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858510752A GB8510752D0 (en) | 1985-04-27 | 1985-04-27 | Compounds |
GB8510752 | 1985-04-27 | ||
GB858525913A GB8525913D0 (en) | 1985-10-21 | 1985-10-21 | Compounds |
GB8525913 | 1985-10-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK191186D0 DK191186D0 (da) | 1986-04-24 |
DK191186A true DK191186A (da) | 1986-10-28 |
DK170166B1 DK170166B1 (da) | 1995-06-06 |
Family
ID=26289173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK191186A DK170166B1 (da) | 1985-04-27 | 1986-04-24 | N-(endo-9-methyl-9-azabicyclo(3,3,1)non-3-yl)-1-m ethylindazol-3-carboxamid med 5-HT-antagonist-aktivitet, farmaceutiske præparater indeholdende forbindelsen, en fremgangsmåde til fremstilling af forbindelsen samt dens anvendelse som et farmaceutisk middel |
Country Status (17)
Country | Link |
---|---|
US (2) | US4886808A (da) |
EP (2) | EP0498466B1 (da) |
JP (1) | JP2696457B2 (da) |
AU (1) | AU594670B2 (da) |
BG (1) | BG61324B2 (da) |
CA (1) | CA1296004C (da) |
CY (1) | CY1721A (da) |
CZ (1) | CZ286325B6 (da) |
DE (2) | DE3687080T2 (da) |
DK (1) | DK170166B1 (da) |
ES (1) | ES8707948A1 (da) |
GR (1) | GR861103B (da) |
HK (1) | HK66993A (da) |
IE (1) | IE58313B1 (da) |
NZ (1) | NZ215945A (da) |
PT (1) | PT82463B (da) |
SG (1) | SG39393G (da) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
DE3687080T2 (de) * | 1985-04-27 | 1993-03-25 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung. |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
GB8515845D0 (en) * | 1985-06-22 | 1985-07-24 | Beecham Group Plc | Treatment |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
DE3687980T2 (de) * | 1986-01-07 | 1993-06-17 | Beecham Group Plc | Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen. |
EP0254584B1 (en) * | 1986-07-25 | 1992-10-07 | Beecham Group Plc | Azabicyclic compounds, process for their preparation, and their pharmaceutical use |
HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
AT396870B (de) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten |
ES2036587T5 (es) * | 1986-11-21 | 1995-10-16 | Glaxo Group Ltd | Medicamentos para el tratamiento o prevencion del sindrome de abstinencia. |
US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
US4973594A (en) * | 1986-12-17 | 1990-11-27 | Glaxo Group Limited | Medicaments |
US4985437A (en) * | 1986-12-17 | 1991-01-15 | Glaxo Group Limited | Medicaments |
US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
GB8806990D0 (en) * | 1988-03-23 | 1988-04-27 | Beecham Group Plc | Novel compounds |
GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
DE3852145T2 (de) * | 1987-02-18 | 1995-04-06 | Beecham Group Plc | Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten. |
US4918080A (en) * | 1987-04-14 | 1990-04-17 | Glaxo Group Limited | Imidazollyl containing ketone derivatives |
EP0289170B1 (en) * | 1987-04-25 | 1993-06-23 | Beecham Group Plc | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
DE3872872T2 (de) * | 1987-11-14 | 1993-02-04 | Beecham Group Plc | 5-ht3-rezeptor-antagonisten zur behandlung von husten und bronchokonstriktion. |
AU611976B2 (en) * | 1987-12-24 | 1991-06-27 | John Wyeth & Brother Limited | Aroyl urea and carbamic acid derivatives of azabicyclo compounds |
EP0350130A3 (en) * | 1988-07-07 | 1991-07-10 | Duphar International Research B.V | New substituted 1,7-annelated 1h-indazoles |
US5166341A (en) * | 1988-07-29 | 1992-11-24 | Dainippon Pharmaceutical Co., Ltd. | 6-amino-1,4-hexahydro-1H-diazepine derivatives |
US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
CA2004911A1 (en) * | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
DK0381422T3 (da) * | 1989-02-02 | 1997-03-10 | Yamanouchi Pharma Co Ltd | Tetrahydrobenzimidazolderivater |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
GB8916682D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Pharmaceutical compounds |
US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
US4992461A (en) * | 1989-09-11 | 1991-02-12 | G. D. Searle & Co. | N-azabicyclo(3.3.0)octane amides of aromatic acids, compositions, and methods of use thereof |
US5180728A (en) * | 1989-09-25 | 1993-01-19 | Fujisawa Pharmaceutical Company, Ltd. | Pyrimidoindole derivatives and processes for preparation thereof |
GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
GB8923209D0 (en) * | 1989-10-14 | 1989-11-29 | Wyeth John & Brother Ltd | Heterocyclic compounds |
US5225419A (en) * | 1989-10-14 | 1993-07-06 | John Wyeth & Brother, Limited | Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof |
GB8928837D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
GB9009389D0 (en) * | 1990-04-26 | 1990-06-20 | Smith Kline French Lab | Treatment |
GB9009542D0 (en) * | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Novel compounds |
AU7618991A (en) * | 1990-05-14 | 1991-11-14 | Syntex (U.S.A.) Inc. | Novel tricyclic compounds |
US5202318A (en) * | 1990-05-14 | 1993-04-13 | Syntex (U.S.A.) Inc. | Tricyclic compounds acting at serotonin receptor subtypes |
JP3122671B2 (ja) * | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
GB9020927D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Pharmaceuticals |
US5200415A (en) * | 1990-11-01 | 1993-04-06 | Asahi Kasei Kogyo Kabushiki Kaisha | Pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives and their pharmaceutical use |
HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
GB9101221D0 (en) * | 1991-01-19 | 1991-02-27 | Smithkline Beecham Plc | Pharmaceuticals |
US5929059A (en) * | 1991-01-19 | 1999-07-27 | Smithkline Beecham P.L.C. | Pharmaceutical compositions containing granisetron and dexamethasone |
US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
US5225412A (en) * | 1991-04-29 | 1993-07-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
EP0517984A1 (en) * | 1991-06-11 | 1992-12-16 | Merrell Dow Pharmaceuticals Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
WO1993002677A1 (en) * | 1991-08-03 | 1993-02-18 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
CA2116024A1 (en) * | 1991-08-20 | 1993-03-04 | Francis David King | 5-ht4 receptor antagonists |
JPH0557982A (ja) * | 1991-09-02 | 1993-03-09 | Canon Inc | キヤリツジ駆動方法 |
DE69231395T3 (de) | 1991-09-20 | 2005-07-21 | Glaxo Group Ltd., Greenford | Neue medizinische Indikation für Tachykinin-Antagonisten |
AU3361693A (en) * | 1992-01-23 | 1993-09-01 | Smithkline Beecham Plc | Use of 5-HT4 receptor antagonists as medicaments for treating migraine |
US5344831A (en) * | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔3,2−b〕ピリジン誘導体 |
US5236931A (en) * | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
GR1001378B (el) * | 1992-10-08 | 1993-10-29 | Smithkline Beecham Plc | Ανταγωνιστές 5-ΗΤ4 πιπεριδυλαλκυλίου. |
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GB9305593D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Pharmaceuticals |
CN1039623C (zh) * | 1993-10-22 | 1998-09-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种防治运动病综合征的药物组合物及其制备方法 |
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GB9406857D0 (en) * | 1994-04-07 | 1994-06-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
GB9412995D0 (en) * | 1994-06-28 | 1994-10-26 | Prendergast Kenneth F | Safety enhancing pharmaceutical compositions of an active indazole |
WO1996010006A1 (fr) * | 1994-09-29 | 1996-04-04 | Idemitsu Petrochemical Co., Ltd. | Procede de production d'acides monocarboxyliques et/ou dicarboxyliques |
GB9502582D0 (en) * | 1995-02-10 | 1995-03-29 | Smithkline Beecham Plc | Novel process |
GB9502583D0 (en) * | 1995-02-10 | 1995-03-29 | Smithkline Beecham Plc | Novel process |
GB9504078D0 (en) * | 1995-03-01 | 1995-04-19 | Smithkline Beecham Plc | Novel process |
ES2124162B1 (es) * | 1995-03-01 | 1999-11-16 | Smithkline Beecham Plc | Un nuevo procedimiento para preparar compuestos farmaceuticamente activos. |
GB9506119D0 (en) * | 1995-03-25 | 1995-05-10 | Smithkline Beecham Plc | Chemical process |
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GB9602862D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
GB9602866D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
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JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
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ES2197001B1 (es) | 2002-03-26 | 2004-11-16 | Laboratorios Vita, S.A. | Procedimiento de obtencion de un compuesto farmaceuticamente activo. |
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FR2100909A1 (fr) * | 1970-07-15 | 1972-03-24 | Egyt Gyogyszervegyeszeti Gyar | Amides de l'acide indazole-3-carboxylique et procedes de preparation |
GB2100259B (en) * | 1981-06-13 | 1984-10-31 | Merrell Toraude & Co | Treatment of migraine with tropyl benzoate derivatives |
FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
FR2548666A1 (fr) * | 1983-07-08 | 1985-01-11 | Delalande Sa | Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique |
CH664567A5 (de) * | 1983-08-26 | 1988-03-15 | Sandoz Ag | Aromatische carbonsaeure- und sulfonsaeureester oder -amide. |
GB8510752D0 (en) * | 1985-04-27 | 1985-06-05 | Beecham Group Plc | Compounds |
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
GB8525913D0 (en) * | 1985-10-21 | 1985-11-27 | Beecham Group Plc | Compounds |
DE3687080T2 (de) * | 1985-04-27 | 1993-03-25 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung. |
GB8520616D0 (en) * | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
-
1986
- 1986-04-21 DE DE8686302964T patent/DE3687080T2/de not_active Expired - Lifetime
- 1986-04-21 EP EP92104830A patent/EP0498466B1/en not_active Expired - Lifetime
- 1986-04-21 EP EP86302964A patent/EP0200444B1/en not_active Expired - Lifetime
- 1986-04-21 DE DE3650772T patent/DE3650772T2/de not_active Expired - Lifetime
- 1986-04-24 PT PT82463A patent/PT82463B/pt not_active IP Right Cessation
- 1986-04-24 AU AU56579/86A patent/AU594670B2/en not_active Expired
- 1986-04-24 NZ NZ215945A patent/NZ215945A/en unknown
- 1986-04-24 DK DK191186A patent/DK170166B1/da not_active IP Right Cessation
- 1986-04-25 IE IE109986A patent/IE58313B1/en not_active IP Right Cessation
- 1986-04-25 ES ES554405A patent/ES8707948A1/es not_active Expired
- 1986-04-25 CA CA000507639A patent/CA1296004C/en not_active Expired - Lifetime
- 1986-04-25 GR GR861103A patent/GR861103B/el unknown
-
1988
- 1988-03-16 US US07/171,141 patent/US4886808A/en not_active Expired - Lifetime
-
1989
- 1989-10-03 US US07/416,501 patent/US5034398A/en not_active Expired - Lifetime
-
1991
- 1991-11-01 CZ CS19913323A patent/CZ286325B6/cs not_active IP Right Cessation
-
1992
- 1992-06-03 JP JP4168503A patent/JP2696457B2/ja not_active Expired - Lifetime
-
1993
- 1993-04-07 SG SG393/93A patent/SG39393G/en unknown
- 1993-07-08 HK HK669/93A patent/HK66993A/xx not_active IP Right Cessation
- 1993-09-28 BG BG98127A patent/BG61324B2/bg unknown
-
1994
- 1994-05-06 CY CY172194A patent/CY1721A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU594670B2 (en) | 1990-03-15 |
JPH05194508A (ja) | 1993-08-03 |
NZ215945A (en) | 1990-04-26 |
EP0200444B1 (en) | 1992-11-11 |
EP0200444A2 (en) | 1986-11-05 |
DK170166B1 (da) | 1995-06-06 |
US4886808A (en) | 1989-12-12 |
ES554405A0 (es) | 1987-09-01 |
BG61324B2 (bg) | 1997-05-30 |
EP0498466A1 (en) | 1992-08-12 |
DE3687080T2 (de) | 1993-03-25 |
US5034398A (en) | 1991-07-23 |
ES8707948A1 (es) | 1987-09-01 |
PT82463A (en) | 1986-05-01 |
SG39393G (en) | 1993-06-11 |
DE3687080D1 (de) | 1992-12-17 |
IE58313B1 (en) | 1993-09-08 |
EP0498466B1 (en) | 2002-07-24 |
DE3650772D1 (de) | 2002-08-29 |
JP2696457B2 (ja) | 1998-01-14 |
DK191186D0 (da) | 1986-04-24 |
GR861103B (en) | 1986-08-11 |
PT82463B (pt) | 1988-10-14 |
AU5657986A (en) | 1986-11-06 |
EP0200444A3 (en) | 1988-12-14 |
HK66993A (en) | 1993-07-16 |
CA1296004C (en) | 1992-02-18 |
IE861099L (en) | 1986-10-27 |
CZ286325B6 (cs) | 2000-03-15 |
DE3650772T2 (de) | 2003-04-03 |
CS332391A3 (en) | 1992-06-17 |
CY1721A (en) | 1994-05-06 |
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B1 | Patent granted (law 1993) | ||
PUP | Patent expired |