DE69936572D1 - Benzisoxazolderivate mit d4-antagonistischer wirkung - Google Patents
Benzisoxazolderivate mit d4-antagonistischer wirkungInfo
- Publication number
- DE69936572D1 DE69936572D1 DE69936572T DE69936572T DE69936572D1 DE 69936572 D1 DE69936572 D1 DE 69936572D1 DE 69936572 T DE69936572 T DE 69936572T DE 69936572 T DE69936572 T DE 69936572T DE 69936572 D1 DE69936572 D1 DE 69936572D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- sulfonyl
- group
- dialkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98200400 | 1998-02-09 | ||
EP98200400 | 1998-02-09 | ||
PCT/EP1999/000852 WO1999040067A2 (en) | 1998-02-09 | 1999-02-05 | Benzisoxazole derivatives having d4-antagonistic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69936572D1 true DE69936572D1 (de) | 2007-08-30 |
DE69936572T2 DE69936572T2 (de) | 2008-06-19 |
Family
ID=8233376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69936572T Expired - Lifetime DE69936572T2 (de) | 1998-02-09 | 1999-02-05 | Benzisoxazolderivate mit d4-antagonistischer wirkung |
Country Status (11)
Country | Link |
---|---|
US (1) | US6335326B1 (de) |
EP (1) | EP1054885B1 (de) |
JP (1) | JP4627882B2 (de) |
AT (1) | ATE367389T1 (de) |
AU (1) | AU3327399A (de) |
CA (1) | CA2320120C (de) |
DE (1) | DE69936572T2 (de) |
DK (1) | DK1054885T3 (de) |
ES (1) | ES2291023T3 (de) |
PT (1) | PT1054885E (de) |
WO (1) | WO1999040067A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2291023T3 (es) * | 1998-02-09 | 2008-02-16 | Duphar International Research B.V | Derivados de benzisoxazol que tienen actividad antagonista de d4. |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
BR0014000A (pt) * | 1999-09-14 | 2002-05-14 | Aventis Pharma Inc | Derivados de benzisoxazolila-, piridoisoxazolila- e benztienila-fenóxi úteis como antagonistas de d4 |
US7253165B2 (en) | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
IL148522A0 (en) * | 1999-09-14 | 2002-09-12 | Aventis Pharm Prod Inc | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
IL148623A0 (en) * | 1999-09-14 | 2002-09-12 | Aventis Pharm Prod Inc | Thienoisoxazolyl-and thienylpyrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists |
WO2002072029A2 (en) | 2001-03-12 | 2002-09-19 | The Mclean Hospital Corporation | Dopamine d4 receptor antagonists as treatment for attention deficit-hyperactivity disorder |
DK1856114T3 (en) * | 2005-02-25 | 2014-11-17 | Raqualia Pharma Inc | Benzisoxazol-DERIVATIVES |
CA2694009A1 (en) * | 2007-07-26 | 2009-01-29 | F. Hoffmann-La Roche Ag | Dual modulators of 5-ht2a and d3 receptors |
US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
EP0602242A4 (en) | 1991-08-22 | 1994-06-29 | Yoshitomi Pharmaceutical | Benzisoxazole compound and use thereof. |
JPH0641125A (ja) * | 1992-03-26 | 1994-02-15 | Yoshitomi Pharmaceut Ind Ltd | ベンゾイソオキサゾール化合物およびその用途 |
DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
FR2749304B1 (fr) * | 1996-06-04 | 1998-06-26 | Adir | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
ES2291023T3 (es) | 1998-02-09 | 2008-02-16 | Duphar International Research B.V | Derivados de benzisoxazol que tienen actividad antagonista de d4. |
-
1999
- 1999-02-05 ES ES99914450T patent/ES2291023T3/es not_active Expired - Lifetime
- 1999-02-05 DK DK99914450T patent/DK1054885T3/da active
- 1999-02-05 AT AT99914450T patent/ATE367389T1/de active
- 1999-02-05 PT PT99914450T patent/PT1054885E/pt unknown
- 1999-02-05 AU AU33273/99A patent/AU3327399A/en not_active Abandoned
- 1999-02-05 CA CA002320120A patent/CA2320120C/en not_active Expired - Fee Related
- 1999-02-05 DE DE69936572T patent/DE69936572T2/de not_active Expired - Lifetime
- 1999-02-05 WO PCT/EP1999/000852 patent/WO1999040067A2/en active IP Right Grant
- 1999-02-05 JP JP2000530498A patent/JP4627882B2/ja not_active Expired - Fee Related
- 1999-02-05 EP EP99914450A patent/EP1054885B1/de not_active Expired - Lifetime
- 1999-02-05 US US09/601,795 patent/US6335326B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1054885A2 (de) | 2000-11-29 |
ES2291023T3 (es) | 2008-02-16 |
EP1054885B1 (de) | 2007-07-18 |
AU3327399A (en) | 1999-08-23 |
DE69936572T2 (de) | 2008-06-19 |
PT1054885E (pt) | 2007-10-03 |
ATE367389T1 (de) | 2007-08-15 |
WO1999040067A3 (en) | 1999-11-25 |
CA2320120A1 (en) | 1999-08-12 |
JP4627882B2 (ja) | 2011-02-09 |
DK1054885T3 (da) | 2007-10-15 |
CA2320120C (en) | 2009-08-11 |
JP2002502842A (ja) | 2002-01-29 |
WO1999040067A2 (en) | 1999-08-12 |
US6335326B1 (en) | 2002-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |