ATE367389T1 - Benzisoxazolderivate mit d4-antagonistischer wirkung - Google Patents

Benzisoxazolderivate mit d4-antagonistischer wirkung

Info

Publication number
ATE367389T1
ATE367389T1 AT99914450T AT99914450T ATE367389T1 AT E367389 T1 ATE367389 T1 AT E367389T1 AT 99914450 T AT99914450 T AT 99914450T AT 99914450 T AT99914450 T AT 99914450T AT E367389 T1 ATE367389 T1 AT E367389T1
Authority
AT
Austria
Prior art keywords
amino
sulfonyl
group
dialkyl
alkoxy
Prior art date
Application number
AT99914450T
Other languages
English (en)
Inventor
Hartog Jacobus A Den
Gerben Visser
Steen Bartholomeus Van
Martinus Tulp
Eric Ronken
Cornelis Kruse
Josephus H Lange
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Application granted granted Critical
Publication of ATE367389T1 publication Critical patent/ATE367389T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT99914450T 1998-02-09 1999-02-05 Benzisoxazolderivate mit d4-antagonistischer wirkung ATE367389T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98200400 1998-02-09

Publications (1)

Publication Number Publication Date
ATE367389T1 true ATE367389T1 (de) 2007-08-15

Family

ID=8233376

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914450T ATE367389T1 (de) 1998-02-09 1999-02-05 Benzisoxazolderivate mit d4-antagonistischer wirkung

Country Status (11)

Country Link
US (1) US6335326B1 (de)
EP (1) EP1054885B1 (de)
JP (1) JP4627882B2 (de)
AT (1) ATE367389T1 (de)
AU (1) AU3327399A (de)
CA (1) CA2320120C (de)
DE (1) DE69936572T2 (de)
DK (1) DK1054885T3 (de)
ES (1) ES2291023T3 (de)
PT (1) PT1054885E (de)
WO (1) WO1999040067A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2291023T3 (es) 1998-02-09 2008-02-16 Duphar International Research B.V Derivados de benzisoxazol que tienen actividad antagonista de d4.
CA2383340C (en) * 1999-09-14 2010-06-15 Aventis Pharmaceuticals Inc. Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
AR032135A1 (es) * 1999-09-14 2003-10-29 Aventis Pharma Inc Compuestos derivados de etilo y propilo tienoisoxazol fenoxi no sustituidos utiles como antagonistas d4, composiciones farmaceuticas, procedimientos de preparacion, compuestos intermediarios y usos en la fabricacion de medicamentos
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
EA200200356A1 (ru) * 1999-09-14 2002-10-31 Авентис Фармасьютикалз Инк. Бензизоксазолил-, пиридоизоксазолил- и бензтиенилфеноксипроизводные, используемые в качестве антагонистов рецептора d4
AU2002258506A1 (en) 2001-03-12 2002-09-24 The Mclean Hospital Corporation Dopamine d4 receptor antagonists as treatment for attention deficit-hyperactivity disorder
ES2523459T3 (es) * 2005-02-25 2014-11-26 Raqualia Pharma Inc Derivados de benzisoxazol
AU2008280187B2 (en) * 2007-07-26 2013-05-16 F. Hoffmann-La Roche Ag Dual modulators of 5-HT2A and D3 receptors
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
EP0602242A4 (en) 1991-08-22 1994-06-29 Yoshitomi Pharmaceutical Benzisoxazole compound and use thereof.
JPH0641125A (ja) * 1992-03-26 1994-02-15 Yoshitomi Pharmaceut Ind Ltd ベンゾイソオキサゾール化合物およびその用途
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
ES2291023T3 (es) * 1998-02-09 2008-02-16 Duphar International Research B.V Derivados de benzisoxazol que tienen actividad antagonista de d4.

Also Published As

Publication number Publication date
ES2291023T3 (es) 2008-02-16
WO1999040067A2 (en) 1999-08-12
EP1054885A2 (de) 2000-11-29
US6335326B1 (en) 2002-01-01
WO1999040067A3 (en) 1999-11-25
DK1054885T3 (da) 2007-10-15
JP4627882B2 (ja) 2011-02-09
DE69936572D1 (de) 2007-08-30
AU3327399A (en) 1999-08-23
CA2320120A1 (en) 1999-08-12
JP2002502842A (ja) 2002-01-29
PT1054885E (pt) 2007-10-03
EP1054885B1 (de) 2007-07-18
DE69936572T2 (de) 2008-06-19
CA2320120C (en) 2009-08-11

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