NO305287B1 - AMPA antagonister - Google Patents

AMPA antagonister

Info

Publication number
NO305287B1
NO305287B1 NO954576A NO954576A NO305287B1 NO 305287 B1 NO305287 B1 NO 305287B1 NO 954576 A NO954576 A NO 954576A NO 954576 A NO954576 A NO 954576A NO 305287 B1 NO305287 B1 NO 305287B1
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
benzyl
phenyl
compounds
Prior art date
Application number
NO954576A
Other languages
English (en)
Other versions
NO954576D0 (no
NO954576L (no
Inventor
Frank Wotjen
J Rgen Drejer
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK55893A external-priority patent/DK55893D0/da
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO954576D0 publication Critical patent/NO954576D0/no
Publication of NO954576L publication Critical patent/NO954576L/no
Publication of NO305287B1 publication Critical patent/NO305287B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
NO954576A 1993-05-13 1995-11-13 AMPA antagonister NO305287B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK55893A DK55893D0 (da) 1993-05-13 1993-05-13 Nye receptoraktive forbindelser, deres fremstilling og anvendelse
DK13894 1994-02-02
PCT/EP1994/001492 WO1994026747A1 (en) 1993-05-13 1994-05-09 Ampa antagonists and a method of treatment therewith

Publications (3)

Publication Number Publication Date
NO954576D0 NO954576D0 (no) 1995-11-13
NO954576L NO954576L (no) 1996-01-15
NO305287B1 true NO305287B1 (no) 1999-05-03

Family

ID=26063386

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954576A NO305287B1 (no) 1993-05-13 1995-11-13 AMPA antagonister

Country Status (13)

Country Link
EP (1) EP0698025B1 (no)
JP (1) JP3439215B2 (no)
AT (1) ATE161259T1 (no)
AU (1) AU679075B2 (no)
CA (1) CA2161783C (no)
DE (1) DE69407407T2 (no)
DK (1) DK0698025T3 (no)
ES (1) ES2111930T3 (no)
FI (1) FI954965A (no)
GR (1) GR3026008T3 (no)
NO (1) NO305287B1 (no)
NZ (1) NZ267081A (no)
WO (1) WO1994026747A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
AU4423496A (en) * 1995-03-14 1996-10-02 Warner-Lambert Company Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones
US5874426A (en) * 1995-06-07 1999-02-23 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US6110911A (en) * 1995-06-07 2000-08-29 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5614508A (en) * 1995-06-07 1997-03-25 Warner-Lambert Company Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists
US5566694A (en) * 1995-06-07 1996-10-22 Allegheny Plastics, Inc. Continuous pickling tank with expandable seals
US5654303A (en) * 1995-06-07 1997-08-05 Warner-Lambert Company Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5773434A (en) * 1995-08-30 1998-06-30 Gary A. Rogers Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU5704898A (en) * 1996-12-16 1998-07-15 Warner-Lambert Company Tricyclic quinoxaline derivatives as neuroprotective agents
US6172065B1 (en) 1997-03-04 2001-01-09 Warner-Lambert Company Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
DE69922936T2 (de) 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
US6096744A (en) * 1998-05-04 2000-08-01 Warner-Lambert Company Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
AU4910500A (en) * 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
WO2001055110A1 (en) * 2000-01-24 2001-08-02 Neurosearch A/S Isatine derivatives with neurotrophic activity
DE10121215A1 (de) * 2001-04-30 2002-10-31 Merck Patent Gmbh Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
CN101346375B (zh) * 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法
US20080004306A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
EP0664807B1 (en) * 1992-10-13 1997-09-10 Warner-Lambert Company Quinoxalinedione derivatives as eaa antagonists

Also Published As

Publication number Publication date
ES2111930T3 (es) 1998-03-16
DE69407407T2 (de) 1998-04-09
DK0698025T3 (da) 1998-08-24
CA2161783C (en) 2006-08-15
NO954576D0 (no) 1995-11-13
FI954965A0 (fi) 1995-10-18
AU6926494A (en) 1994-12-12
CA2161783A1 (en) 1994-11-24
JP3439215B2 (ja) 2003-08-25
GR3026008T3 (en) 1998-04-30
EP0698025B1 (en) 1997-12-17
AU679075B2 (en) 1997-06-19
ATE161259T1 (de) 1998-01-15
JPH08510221A (ja) 1996-10-29
WO1994026747A1 (en) 1994-11-24
NZ267081A (en) 1997-11-24
FI954965A (fi) 1995-11-10
DE69407407D1 (de) 1998-01-29
EP0698025A1 (en) 1996-02-28
NO954576L (no) 1996-01-15

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