DE69514532T2 - Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung - Google Patents
Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendungInfo
- Publication number
- DE69514532T2 DE69514532T2 DE69514532T DE69514532T DE69514532T2 DE 69514532 T2 DE69514532 T2 DE 69514532T2 DE 69514532 T DE69514532 T DE 69514532T DE 69514532 T DE69514532 T DE 69514532T DE 69514532 T2 DE69514532 T2 DE 69514532T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date
- indol
- dione
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK105394 | 1994-09-14 | ||
PCT/EP1995/003593 WO1996008494A1 (en) | 1994-09-14 | 1995-09-12 | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69514532D1 DE69514532D1 (de) | 2000-02-17 |
DE69514532T2 true DE69514532T2 (de) | 2000-07-06 |
Family
ID=8100455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69514532T Expired - Lifetime DE69514532T2 (de) | 1994-09-14 | 1995-09-12 | Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung |
Country Status (12)
Country | Link |
---|---|
US (1) | US5917053A (de) |
EP (1) | EP0781284B1 (de) |
JP (1) | JP3164371B2 (de) |
AT (1) | ATE188700T1 (de) |
AU (1) | AU687255B2 (de) |
CA (1) | CA2199613C (de) |
DE (1) | DE69514532T2 (de) |
EE (1) | EE03355B1 (de) |
FI (1) | FI112482B (de) |
NO (1) | NO308852B1 (de) |
NZ (1) | NZ293265A (de) |
WO (1) | WO1996008494A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
DE69922936T2 (de) * | 1998-03-31 | 2005-12-08 | Neurosearch A/S | Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten |
DE60041399D1 (de) | 1999-05-19 | 2009-03-05 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
ES2266214T3 (es) * | 2000-01-24 | 2007-03-01 | Neurosearch A/S | Derivados de isatina con actividad neurotrofica. |
WO2002064139A1 (en) * | 2001-02-15 | 2002-08-22 | Neurosearch A/S | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
MXPA04000358A (es) | 2001-07-13 | 2004-05-04 | Pharmacia & Up John Company | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. |
EP1957486A4 (de) | 2005-11-23 | 2009-11-11 | Painceptor Pharma Corp | Zusammensetzungen und verfahren zur modulierung gesteuerter ionenkanäle |
US20100041691A1 (en) * | 2006-09-12 | 2010-02-18 | Neurosearch A/S | Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
CA2076948C (en) * | 1991-08-28 | 2002-04-16 | Frank Watjen | Isatineoxime derivatives, their preparation and use |
JPH08502483A (ja) * | 1992-10-13 | 1996-03-19 | ワーナー−ランバート・コンパニー | 新規なキノキサリンジオン誘導体、それらの製造および使用 |
-
1995
- 1995-09-12 AU AU35664/95A patent/AU687255B2/en not_active Ceased
- 1995-09-12 AT AT95932729T patent/ATE188700T1/de not_active IP Right Cessation
- 1995-09-12 US US08/809,082 patent/US5917053A/en not_active Expired - Lifetime
- 1995-09-12 EP EP95932729A patent/EP0781284B1/de not_active Expired - Lifetime
- 1995-09-12 EE EE9700052A patent/EE03355B1/xx not_active IP Right Cessation
- 1995-09-12 CA CA002199613A patent/CA2199613C/en not_active Expired - Fee Related
- 1995-09-12 JP JP50990796A patent/JP3164371B2/ja not_active Expired - Fee Related
- 1995-09-12 NZ NZ293265A patent/NZ293265A/en unknown
- 1995-09-12 WO PCT/EP1995/003593 patent/WO1996008494A1/en active IP Right Grant
- 1995-09-12 DE DE69514532T patent/DE69514532T2/de not_active Expired - Lifetime
-
1997
- 1997-02-21 FI FI970750A patent/FI112482B/fi active
- 1997-02-27 NO NO970904A patent/NO308852B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
US5917053A (en) | 1999-06-29 |
AU3566495A (en) | 1996-03-29 |
ATE188700T1 (de) | 2000-01-15 |
CA2199613C (en) | 2000-02-29 |
AU687255B2 (en) | 1998-02-19 |
CA2199613A1 (en) | 1996-03-21 |
NZ293265A (en) | 1998-01-26 |
FI112482B (fi) | 2003-12-15 |
JPH09511524A (ja) | 1997-11-18 |
EE03355B1 (et) | 2001-02-15 |
NO970904L (no) | 1997-04-24 |
NO308852B1 (no) | 2000-11-06 |
FI970750A0 (fi) | 1997-02-21 |
EP0781284A1 (de) | 1997-07-02 |
FI970750A (fi) | 1997-03-13 |
WO1996008494A1 (en) | 1996-03-21 |
NO970904D0 (no) | 1997-02-27 |
DE69514532D1 (de) | 2000-02-17 |
EP0781284B1 (de) | 2000-01-12 |
JP3164371B2 (ja) | 2001-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |