NO308852B1 - Indol-2,3-dion-3-oksim-derivater, farmasøytisk blanding og anvendelse av forbindelsen - Google Patents

Indol-2,3-dion-3-oksim-derivater, farmasøytisk blanding og anvendelse av forbindelsen

Info

Publication number
NO308852B1
NO308852B1 NO970904A NO970904A NO308852B1 NO 308852 B1 NO308852 B1 NO 308852B1 NO 970904 A NO970904 A NO 970904A NO 970904 A NO970904 A NO 970904A NO 308852 B1 NO308852 B1 NO 308852B1
Authority
NO
Norway
Prior art keywords
pct
dione
indole
compound
pharmaceutical composition
Prior art date
Application number
NO970904A
Other languages
English (en)
Norwegian (no)
Other versions
NO970904D0 (no
NO970904L (no
Inventor
Peter Moldt
Frank Wotjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO970904D0 publication Critical patent/NO970904D0/no
Publication of NO970904L publication Critical patent/NO970904L/no
Publication of NO308852B1 publication Critical patent/NO308852B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO970904A 1994-09-14 1997-02-27 Indol-2,3-dion-3-oksim-derivater, farmasøytisk blanding og anvendelse av forbindelsen NO308852B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK105394 1994-09-14
PCT/EP1995/003593 WO1996008494A1 (en) 1994-09-14 1995-09-12 Indole-2,3-dione-3-oxime derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
NO970904D0 NO970904D0 (no) 1997-02-27
NO970904L NO970904L (no) 1997-04-24
NO308852B1 true NO308852B1 (no) 2000-11-06

Family

ID=8100455

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970904A NO308852B1 (no) 1994-09-14 1997-02-27 Indol-2,3-dion-3-oksim-derivater, farmasøytisk blanding og anvendelse av forbindelsen

Country Status (12)

Country Link
US (1) US5917053A (de)
EP (1) EP0781284B1 (de)
JP (1) JP3164371B2 (de)
AT (1) ATE188700T1 (de)
AU (1) AU687255B2 (de)
CA (1) CA2199613C (de)
DE (1) DE69514532T2 (de)
EE (1) EE03355B1 (de)
FI (1) FI112482B (de)
NO (1) NO308852B1 (de)
NZ (1) NZ293265A (de)
WO (1) WO1996008494A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de) * 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
WO2000071102A2 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
ES2266214T3 (es) 2000-01-24 2007-03-01 Neurosearch A/S Derivados de isatina con actividad neurotrofica.
WO2002064139A1 (en) * 2001-02-15 2002-08-22 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
MXPA04000358A (es) 2001-07-13 2004-05-04 Pharmacia & Up John Company Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.
CA2630617C (en) 2005-11-23 2014-03-25 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2008031831A2 (en) * 2006-09-12 2008-03-20 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
AU680632B2 (en) * 1992-10-13 1997-08-07 Neurosearch A/S Quinoxalinedione derivatives as EAA antagonists

Also Published As

Publication number Publication date
JP3164371B2 (ja) 2001-05-08
DE69514532D1 (de) 2000-02-17
EP0781284B1 (de) 2000-01-12
US5917053A (en) 1999-06-29
CA2199613C (en) 2000-02-29
AU3566495A (en) 1996-03-29
FI970750A0 (fi) 1997-02-21
JPH09511524A (ja) 1997-11-18
DE69514532T2 (de) 2000-07-06
FI112482B (fi) 2003-12-15
EP0781284A1 (de) 1997-07-02
WO1996008494A1 (en) 1996-03-21
EE03355B1 (et) 2001-02-15
NZ293265A (en) 1998-01-26
CA2199613A1 (en) 1996-03-21
FI970750A (fi) 1997-03-13
NO970904D0 (no) 1997-02-27
NO970904L (no) 1997-04-24
ATE188700T1 (de) 2000-01-15
AU687255B2 (en) 1998-02-19

Similar Documents

Publication Publication Date Title
NO308772B1 (no) Sublingual eller buckal farmasoytisk blanding inneholdende trans-5-klor-2-metyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oksepino[4,5-c]pyrrol, samt anvendelse av forbindelsen for fremstilling av farmasoytisk blanding
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
ATE192149T1 (de) Neuroprotective indolone und verwandte derivate
EA199700098A1 (ru) Производные индола, пригодные для лечения остеопороза
NO306345B1 (no) Piperidin-derivater med PAF antagonist-aktivitet, anvendelse derav og farmasöytisk blanding
ATE201671T1 (de) Chinolon und acridinon derivate zur behandlung der harninkontinenz
NO308852B1 (no) Indol-2,3-dion-3-oksim-derivater, farmasøytisk blanding og anvendelse av forbindelsen
YU64400A (sh) Aril fuzirana azapoliciklična jedinjenja
FI92320C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
DK0628042T3 (da) Serotoninerge ergolinderivater
NO308851B1 (no) Fusjonerte indol- og kinoksalderivater, farmasøytisk blanding og anvendelse av forbindelsen
NO833528L (no) Fremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutan-derivater
FI955386A (fi) 4-p-fluoribentsoyyli-1-piperidinyyli-propoksi-kromen-4-onijohdannaiset, niiden valmistus ja käyttö psykoosin ja skitsofrenian hoidossa
ES8604843A1 (es) Un metodo para la preparacion de un derivado de acetileno
AU5608790A (en) New pyrrolidone derivatives, the process for their preparation and the pharmaceutical compositions containing them
PL311296A1 (en) Derivatives of benzo [f] quinoxalinodione, method of obtaining them and their application in therapeutic agents
SE8900725D0 (sv) Indolfoereningar och framstaellning daerav