MX9204914A - Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. - Google Patents

Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.

Info

Publication number
MX9204914A
MX9204914A MX9204914A MX9204914A MX9204914A MX 9204914 A MX9204914 A MX 9204914A MX 9204914 A MX9204914 A MX 9204914A MX 9204914 A MX9204914 A MX 9204914A MX 9204914 A MX9204914 A MX 9204914A
Authority
MX
Mexico
Prior art keywords
cyclic
branched
alkyl
hydrogen
isatinoxima
Prior art date
Application number
MX9204914A
Other languages
English (en)
Inventor
Frank Watjen
Bjarne H Dahl
Jorgen Drejer
Leif H Jensen
Original Assignee
Frank Watjen
Bjarne H Dahl
Jorgen Drejer
Leif H Jensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Watjen, Bjarne H Dahl, Jorgen Drejer, Leif H Jensen filed Critical Frank Watjen
Publication of MX9204914A publication Critical patent/MX9204914A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a derivados de indol-2,3-dion oxima, de anillo fusionado a un método de tratamiento que utiliza los mismos, a composiciones farmacéuticas que comprenden los compuestos y a un método para preparar los nuevos compuestos de la invención.
MX9204914A 1991-08-28 1992-08-26 Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. MX9204914A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05

Publications (1)

Publication Number Publication Date
MX9204914A true MX9204914A (es) 1993-07-01

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9204914A MX9204914A (es) 1991-08-28 1992-08-26 Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.

Country Status (18)

Country Link
EP (1) EP0529636B1 (es)
JP (1) JP3170584B2 (es)
KR (1) KR100277481B1 (es)
AT (1) ATE181552T1 (es)
AU (1) AU655672B2 (es)
CA (1) CA2076948C (es)
CZ (1) CZ282759B6 (es)
DE (1) DE69229461T2 (es)
DK (1) DK0529636T3 (es)
FI (1) FI107156B (es)
GE (1) GEP20002329B (es)
HU (2) HUT70753A (es)
MX (1) MX9204914A (es)
NO (1) NO301117B1 (es)
PL (1) PL170920B1 (es)
RU (1) RU2114827C1 (es)
SK (1) SK280578B6 (es)
WO (1) WO1993005043A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2109516T3 (es) 1992-10-13 1998-01-16 Warner Lambert Co Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
DE69407407T2 (de) * 1993-05-13 1998-04-09 Neurosearch As Ampa antagonisten und behandlungsmethode
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
NZ293266A (en) * 1994-09-14 1998-01-26 Neurosearch As Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions
JP3164371B2 (ja) * 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ インドール−２，３−ジオン−３−オキシム誘導体、その製造および使用
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) * 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
CA2369746A1 (en) 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
CN1298704C (zh) 2000-01-24 2007-02-07 神经研究公司 具有神经营养活性的靛红衍生物
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine
US7718641B2 (en) 2005-11-23 2010-05-18 Aros Pharma Aps Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels
MX2015007710A (es) * 2012-12-19 2015-09-23 Bayer Cropscience Ag Indanilcarboxamidas difluorometil-nicotinicas.
WO2015129592A1 (ja) * 2014-02-28 2015-09-03 住友化学株式会社 ２－（ハロゲノメチル）－３－メチルニトロベンゼンの製造方法
JP7021100B2 (ja) 2016-03-17 2022-02-16 エフ エム シー コーポレーション Ｓ－エナンチオマーのラセミ体への変換方法
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
CA2076948C (en) 2002-04-16
HU9400595D0 (en) 1994-05-30
CZ282759B6 (cs) 1997-09-17
NO940676D0 (no) 1994-02-25
SK23894A3 (en) 1994-12-07
FI107156B (fi) 2001-06-15
KR100277481B1 (ko) 2001-02-01
HUT70753A (en) 1995-10-30
FI940889A0 (fi) 1994-02-25
NO301117B1 (no) 1997-09-15
AU655672B2 (en) 1995-01-05
SK280578B6 (sk) 2000-04-10
CZ39594A3 (en) 1994-11-16
JPH06510056A (ja) 1994-11-10
RU2114827C1 (ru) 1998-07-10
CA2076948A1 (en) 1993-03-01
JP3170584B2 (ja) 2001-05-28
DE69229461D1 (de) 1999-07-29
FI940889A (fi) 1994-02-25
NO940676L (es) 1994-04-27
DK0529636T3 (da) 1999-12-13
GEP20002329B (en) 2000-12-25
DE69229461T2 (de) 1999-10-21
ATE181552T1 (de) 1999-07-15
AU2482092A (en) 1993-04-05
EP0529636B1 (en) 1999-06-23
WO1993005043A1 (en) 1993-03-18
PL170920B1 (pl) 1997-02-28
EP0529636A1 (en) 1993-03-03
HU211632A9 (en) 1995-12-28

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Legal Events

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MM Annulment or lapse due to non-payment of fees