ATE181552T1 - Isatinoximderivate, ihre herstellung und anwendung - Google Patents

Isatinoximderivate, ihre herstellung und anwendung

Info

Publication number
ATE181552T1
ATE181552T1 AT92114654T AT92114654T ATE181552T1 AT E181552 T1 ATE181552 T1 AT E181552T1 AT 92114654 T AT92114654 T AT 92114654T AT 92114654 T AT92114654 T AT 92114654T AT E181552 T1 ATE181552 T1 AT E181552T1
Authority
AT
Austria
Prior art keywords
cyclic
branched
alkyl
hydrogen
straight
Prior art date
Application number
AT92114654T
Other languages
English (en)
Inventor
Frank Waetjen
Bjarne Hugo Dahl
Jorgen Drejer
Leif Helth Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE181552T1 publication Critical patent/ATE181552T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT92114654T 1991-08-28 1992-08-27 Isatinoximderivate, ihre herstellung und anwendung ATE181552T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05

Publications (1)

Publication Number Publication Date
ATE181552T1 true ATE181552T1 (de) 1999-07-15

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114654T ATE181552T1 (de) 1991-08-28 1992-08-27 Isatinoximderivate, ihre herstellung und anwendung

Country Status (18)

Country Link
EP (1) EP0529636B1 (de)
JP (1) JP3170584B2 (de)
KR (1) KR100277481B1 (de)
AT (1) ATE181552T1 (de)
AU (1) AU655672B2 (de)
CA (1) CA2076948C (de)
CZ (1) CZ282759B6 (de)
DE (1) DE69229461T2 (de)
DK (1) DK0529636T3 (de)
FI (1) FI107156B (de)
GE (1) GEP20002329B (de)
HU (2) HUT70753A (de)
MX (1) MX9204914A (de)
NO (1) NO301117B1 (de)
PL (1) PL170920B1 (de)
RU (1) RU2114827C1 (de)
SK (1) SK280578B6 (de)
WO (1) WO1993005043A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0664807B1 (de) 1992-10-13 1997-09-10 Warner-Lambert Company Chinoxalinderivate als eaa antagonisten
ES2111930T3 (es) * 1993-05-13 1998-03-16 Neurosearch As Antagonistas del acido amp y procedimientos de tratamiento con la ayuda de estos.
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
JP3164371B2 (ja) * 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ インドール−2,3−ジオン−3−オキシム誘導体、その製造および使用
CA2199614C (en) * 1994-09-14 2000-02-22 Peter Moldt Fused indole and quinoxaline derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) * 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
AU4910500A (en) 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US7282511B2 (en) 2000-01-24 2007-10-16 Neurosearch A/S Isatine derivatives with neurotrophic activity
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine
WO2007059608A1 (en) 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP2935213B1 (de) * 2012-12-19 2019-05-22 Bayer CropScience Aktiengesellschaft Difluormethyl-nicotin-indanylcarboxamide als fungizide
US9815768B2 (en) * 2014-02-28 2017-11-14 Sumitomo Chemical Company, Limited Method for producing 2-(halogenomethyl)-3-methylnitrobenzene
JP7021100B2 (ja) * 2016-03-17 2022-02-16 エフ エム シー コーポレーション S-エナンチオマーのラセミ体への変換方法
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
NO301117B1 (no) 1997-09-15
CZ39594A3 (en) 1994-11-16
MX9204914A (es) 1993-07-01
EP0529636B1 (de) 1999-06-23
SK280578B6 (sk) 2000-04-10
DK0529636T3 (da) 1999-12-13
AU655672B2 (en) 1995-01-05
KR100277481B1 (ko) 2001-02-01
DE69229461T2 (de) 1999-10-21
NO940676D0 (no) 1994-02-25
FI940889A (fi) 1994-02-25
CZ282759B6 (cs) 1997-09-17
AU2482092A (en) 1993-04-05
CA2076948A1 (en) 1993-03-01
HU211632A9 (en) 1995-12-28
DE69229461D1 (de) 1999-07-29
WO1993005043A1 (en) 1993-03-18
EP0529636A1 (de) 1993-03-03
CA2076948C (en) 2002-04-16
RU2114827C1 (ru) 1998-07-10
SK23894A3 (en) 1994-12-07
FI107156B (fi) 2001-06-15
JPH06510056A (ja) 1994-11-10
GEP20002329B (en) 2000-12-25
PL170920B1 (pl) 1997-02-28
JP3170584B2 (ja) 2001-05-28
NO940676L (de) 1994-04-27
FI940889A0 (fi) 1994-02-25
HU9400595D0 (en) 1994-05-30
HUT70753A (en) 1995-10-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee