DK0698025T3 - Ampa-antagonister samt fremgangsmåde til behandling dermed - Google Patents

Ampa-antagonister samt fremgangsmåde til behandling dermed

Info

Publication number
DK0698025T3
DK0698025T3 DK94917602T DK94917602T DK0698025T3 DK 0698025 T3 DK0698025 T3 DK 0698025T3 DK 94917602 T DK94917602 T DK 94917602T DK 94917602 T DK94917602 T DK 94917602T DK 0698025 T3 DK0698025 T3 DK 0698025T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
treatment
benzyl
phenyl
Prior art date
Application number
DK94917602T
Other languages
Danish (da)
English (en)
Inventor
Frank Waetjen
Jorgen Drejer
Joergen Drejer
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK55893A external-priority patent/DK55893D0/da
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK0698025T3 publication Critical patent/DK0698025T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94917602T 1993-05-13 1994-05-09 Ampa-antagonister samt fremgangsmåde til behandling dermed DK0698025T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK55893A DK55893D0 (da) 1993-05-13 1993-05-13 Nye receptoraktive forbindelser, deres fremstilling og anvendelse
DK13894 1994-02-02
PCT/EP1994/001492 WO1994026747A1 (en) 1993-05-13 1994-05-09 Ampa antagonists and a method of treatment therewith

Publications (1)

Publication Number Publication Date
DK0698025T3 true DK0698025T3 (da) 1998-08-24

Family

ID=26063386

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94917602T DK0698025T3 (da) 1993-05-13 1994-05-09 Ampa-antagonister samt fremgangsmåde til behandling dermed

Country Status (13)

Country Link
EP (1) EP0698025B1 (no)
JP (1) JP3439215B2 (no)
AT (1) ATE161259T1 (no)
AU (1) AU679075B2 (no)
CA (1) CA2161783C (no)
DE (1) DE69407407T2 (no)
DK (1) DK0698025T3 (no)
ES (1) ES2111930T3 (no)
FI (1) FI954965A (no)
GR (1) GR3026008T3 (no)
NO (1) NO305287B1 (no)
NZ (1) NZ267081A (no)
WO (1) WO1994026747A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
WO1996028445A1 (en) * 1995-03-14 1996-09-19 Warner-Lambert Company Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones
US6110911A (en) * 1995-06-07 2000-08-29 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5566694A (en) * 1995-06-07 1996-10-22 Allegheny Plastics, Inc. Continuous pickling tank with expandable seals
US5614508A (en) * 1995-06-07 1997-03-25 Warner-Lambert Company Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists
US5654303A (en) * 1995-06-07 1997-08-05 Warner-Lambert Company Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5874426A (en) * 1995-06-07 1999-02-23 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5773434A (en) * 1995-08-30 1998-06-30 Gary A. Rogers Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU5704898A (en) * 1996-12-16 1998-07-15 Warner-Lambert Company Tricyclic quinoxaline derivatives as neuroprotective agents
US6172065B1 (en) 1997-03-04 2001-01-09 Warner-Lambert Company Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
JP2002509885A (ja) 1998-03-31 2002-04-02 ニューロサーチ、アクティーゼルスカブ 治療に使用するためのインドール−２，３−ジオン−３−オキシム誘導体
US6096744A (en) * 1998-05-04 2000-08-01 Warner-Lambert Company Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
EP1183025B1 (en) 1999-05-19 2009-01-14 PainCeptor Pharma Corp. Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
CN1298704C (zh) * 2000-01-24 2007-02-07 神经研究公司 具有神经营养活性的靛红衍生物
DE10121215A1 (de) * 2001-04-30 2002-10-31 Merck Patent Gmbh Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
US7718641B2 (en) 2005-11-23 2010-05-18 Aros Pharma Aps Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels
WO2007115408A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
EP0664807B1 (en) * 1992-10-13 1997-09-10 Warner-Lambert Company Quinoxalinedione derivatives as eaa antagonists

Also Published As

Publication number Publication date
EP0698025A1 (en) 1996-02-28
NO954576L (no) 1996-01-15
EP0698025B1 (en) 1997-12-17
ES2111930T3 (es) 1998-03-16
CA2161783A1 (en) 1994-11-24
NO305287B1 (no) 1999-05-03
GR3026008T3 (en) 1998-04-30
NO954576D0 (no) 1995-11-13
NZ267081A (en) 1997-11-24
DE69407407T2 (de) 1998-04-09
JPH08510221A (ja) 1996-10-29
FI954965A (fi) 1995-11-10
AU6926494A (en) 1994-12-12
AU679075B2 (en) 1997-06-19
DE69407407D1 (de) 1998-01-29
ATE161259T1 (de) 1998-01-15
CA2161783C (en) 2006-08-15
WO1994026747A1 (en) 1994-11-24
JP3439215B2 (ja) 2003-08-25
FI954965A0 (fi) 1995-10-18

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