PT1689846E - Conjugados de maitansinóide dm1 com anticorpo trastuzumab, ligado através de um ligante não clivável e sua utilização no tratamento de tumores - Google Patents

Conjugados de maitansinóide dm1 com anticorpo trastuzumab, ligado através de um ligante não clivável e sua utilização no tratamento de tumores Download PDF

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Publication number
PT1689846E
PT1689846E PT47938964T PT04793896T PT1689846E PT 1689846 E PT1689846 E PT 1689846E PT 47938964 T PT47938964 T PT 47938964T PT 04793896 T PT04793896 T PT 04793896T PT 1689846 E PT1689846 E PT 1689846E
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PT
Portugal
Prior art keywords
maytansinoid
conjugate
antibody
smcc
conjugates
Prior art date
Application number
PT47938964T
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English (en)
Portuguese (pt)
Inventor
Rita Steeves
Robert Lutz
Ravi Chari
Hongsheng Xie
Yelena Kovtun
Original Assignee
Immunogen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1689846(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of PT1689846E publication Critical patent/PT1689846E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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PT47938964T 2003-10-10 2004-10-12 Conjugados de maitansinóide dm1 com anticorpo trastuzumab, ligado através de um ligante não clivável e sua utilização no tratamento de tumores PT1689846E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Publications (1)

Publication Number Publication Date
PT1689846E true PT1689846E (pt) 2013-05-08

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