PT1206274E - Utilização de inibidores de interleucina-18 para inibir a metástase de tumores. - Google Patents

Utilização de inibidores de interleucina-18 para inibir a metástase de tumores. Download PDF

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Publication number
PT1206274E
PT1206274E PT00944201T PT00944201T PT1206274E PT 1206274 E PT1206274 E PT 1206274E PT 00944201 T PT00944201 T PT 00944201T PT 00944201 T PT00944201 T PT 00944201T PT 1206274 E PT1206274 E PT 1206274E
Authority
PT
Portugal
Prior art keywords
cells
hse
adhesion
tnf
production
Prior art date
Application number
PT00944201T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of PT1206274E publication Critical patent/PT1206274E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT00944201T 1999-07-22 2000-07-17 Utilização de inibidores de interleucina-18 para inibir a metástase de tumores. PT1206274E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors

Publications (1)

Publication Number Publication Date
PT1206274E true PT1206274E (pt) 2007-07-06

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00944201T PT1206274E (pt) 1999-07-22 2000-07-17 Utilização de inibidores de interleucina-18 para inibir a metástase de tumores.

Country Status (31)

Country Link
US (1) US7741276B2 (https=)
EP (1) EP1206274B1 (https=)
JP (1) JP4827352B2 (https=)
KR (1) KR100682219B1 (https=)
CN (1) CN1173736C (https=)
AR (1) AR024907A1 (https=)
AT (1) ATE363288T1 (https=)
AU (1) AU782478B2 (https=)
BG (1) BG65800B1 (https=)
BR (1) BR0012675A (https=)
CA (1) CA2380216C (https=)
CY (1) CY1107932T1 (https=)
CZ (1) CZ302114B6 (https=)
DE (2) DE60035049T2 (https=)
DK (1) DK1206274T3 (https=)
EA (1) EA005419B1 (https=)
EE (1) EE04838B1 (https=)
ES (1) ES2186596T3 (https=)
HK (1) HK1048248B (https=)
HU (1) HU228780B1 (https=)
IL (2) IL131047A0 (https=)
MX (1) MXPA02000838A (https=)
NO (1) NO329827B1 (https=)
NZ (1) NZ516535A (https=)
PL (1) PL202477B1 (https=)
PT (1) PT1206274E (https=)
SK (1) SK287522B6 (https=)
TR (1) TR200200169T2 (https=)
UA (1) UA73745C2 (https=)
WO (1) WO2001007480A2 (https=)
ZA (1) ZA200200390B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2399148A1 (en) 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
JP2004528010A (ja) 2000-10-11 2004-09-16 バイロン・セラピューティックス・インコーポレーテッド 免疫モジュレーションのための核酸およびポリペプチド
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
EP1425028B1 (en) * 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Use of il-18 inhibitors for the treatement or prevention of sepsis
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
AU2003299919B2 (en) * 2002-10-08 2009-08-06 Ares Trading S.A. The use of cytokine able to bind IL-18BP and of inhibiting the activity of a second cytokine
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0178958B1 (ko) * 1992-09-02 1999-03-20 데이비드 제이.엑커 세포 흡착의 올리고누클레오티드 조절
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
SK122199A3 (en) * 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
PL202477B1 (pl) 2009-06-30
CY1107932T1 (el) 2013-09-04
HUP0202107A3 (en) 2005-01-28
ES2186596T1 (es) 2003-05-16
HK1048248B (zh) 2005-04-22
JP2003505472A (ja) 2003-02-12
EP1206274A2 (en) 2002-05-22
BG106311A (en) 2002-08-30
BG65800B1 (bg) 2009-12-31
NO20020153D0 (no) 2002-01-11
WO2001007480A2 (en) 2001-02-01
DE60035049T2 (de) 2007-09-27
EA200200189A1 (ru) 2002-12-26
UA73745C2 (en) 2005-09-15
DE60035049D1 (de) 2007-07-12
US7741276B2 (en) 2010-06-22
IL147675A (en) 2009-05-04
DE1206274T1 (de) 2002-11-14
BRPI0012675B1 (pt) 2001-02-01
AR024907A1 (es) 2002-10-30
EE04838B1 (et) 2007-06-15
EA005419B1 (ru) 2005-02-24
NO329827B1 (no) 2011-01-03
AU5843200A (en) 2001-02-13
KR20020027493A (ko) 2002-04-13
CA2380216A1 (en) 2001-02-01
NZ516535A (en) 2004-04-30
JP4827352B2 (ja) 2011-11-30
CZ2002195A3 (cs) 2002-06-12
BRPI0012675B8 (https=) 2021-05-25
EE200200032A (et) 2003-02-17
NO20020153L (no) 2002-03-11
US20080003216A1 (en) 2008-01-03
ES2186596T3 (es) 2007-11-16
HK1048248A1 (en) 2003-03-28
WO2001007480A3 (en) 2001-05-10
PL353732A1 (en) 2003-12-01
MXPA02000838A (es) 2002-07-30
IL131047A0 (en) 2001-01-28
SK882002A3 (en) 2002-07-02
HUP0202107A2 (en) 2002-10-28
AU782478B2 (en) 2005-08-04
HU228780B1 (en) 2013-05-28
CN1364086A (zh) 2002-08-14
CZ302114B6 (cs) 2010-10-20
CN1173736C (zh) 2004-11-03
EP1206274B1 (en) 2007-05-30
BR0012675A (pt) 2002-04-09
SK287522B6 (sk) 2011-01-04
TR200200169T2 (tr) 2002-06-21
ATE363288T1 (de) 2007-06-15
KR100682219B1 (ko) 2007-02-12
ZA200200390B (en) 2003-04-30
DK1206274T3 (da) 2007-08-13
CA2380216C (en) 2012-01-31

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