DE60035049T2 - Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung - Google Patents

Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung Download PDF

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Publication number
DE60035049T2
DE60035049T2 DE60035049T DE60035049T DE60035049T2 DE 60035049 T2 DE60035049 T2 DE 60035049T2 DE 60035049 T DE60035049 T DE 60035049T DE 60035049 T DE60035049 T DE 60035049T DE 60035049 T2 DE60035049 T2 DE 60035049T2
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DE
Germany
Prior art keywords
cells
hse
adhesion
tnf
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60035049T
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German (de)
English (en)
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DE60035049D1 (de
Inventor
Charles Boulder DINARELLO
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Ares Trading SA
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Ares Trading SA
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Publication date
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Publication of DE60035049D1 publication Critical patent/DE60035049D1/de
Publication of DE60035049T2 publication Critical patent/DE60035049T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60035049T 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung Expired - Lifetime DE60035049T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL13104799 1999-07-22
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis

Publications (2)

Publication Number Publication Date
DE60035049D1 DE60035049D1 (de) 2007-07-12
DE60035049T2 true DE60035049T2 (de) 2007-09-27

Family

ID=11073044

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60035049T Expired - Lifetime DE60035049T2 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung
DE1206274T Pending DE1206274T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1206274T Pending DE1206274T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung

Country Status (31)

Country Link
US (1) US7741276B2 (https=)
EP (1) EP1206274B1 (https=)
JP (1) JP4827352B2 (https=)
KR (1) KR100682219B1 (https=)
CN (1) CN1173736C (https=)
AR (1) AR024907A1 (https=)
AT (1) ATE363288T1 (https=)
AU (1) AU782478B2 (https=)
BG (1) BG65800B1 (https=)
BR (1) BR0012675A (https=)
CA (1) CA2380216C (https=)
CY (1) CY1107932T1 (https=)
CZ (1) CZ302114B6 (https=)
DE (2) DE60035049T2 (https=)
DK (1) DK1206274T3 (https=)
EA (1) EA005419B1 (https=)
EE (1) EE04838B1 (https=)
ES (1) ES2186596T3 (https=)
HK (1) HK1048248B (https=)
HU (1) HU228780B1 (https=)
IL (2) IL131047A0 (https=)
MX (1) MXPA02000838A (https=)
NO (1) NO329827B1 (https=)
NZ (1) NZ516535A (https=)
PL (1) PL202477B1 (https=)
PT (1) PT1206274E (https=)
SK (1) SK287522B6 (https=)
TR (1) TR200200169T2 (https=)
UA (1) UA73745C2 (https=)
WO (1) WO2001007480A2 (https=)
ZA (1) ZA200200390B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2399148A1 (en) 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
JP2004528010A (ja) 2000-10-11 2004-09-16 バイロン・セラピューティックス・インコーポレーテッド 免疫モジュレーションのための核酸およびポリペプチド
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
EP1425028B1 (en) * 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Use of il-18 inhibitors for the treatement or prevention of sepsis
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
AU2003299919B2 (en) * 2002-10-08 2009-08-06 Ares Trading S.A. The use of cytokine able to bind IL-18BP and of inhibiting the activity of a second cytokine
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0178958B1 (ko) * 1992-09-02 1999-03-20 데이비드 제이.엑커 세포 흡착의 올리고누클레오티드 조절
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
SK122199A3 (en) * 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
PL202477B1 (pl) 2009-06-30
CY1107932T1 (el) 2013-09-04
HUP0202107A3 (en) 2005-01-28
ES2186596T1 (es) 2003-05-16
HK1048248B (zh) 2005-04-22
JP2003505472A (ja) 2003-02-12
EP1206274A2 (en) 2002-05-22
BG106311A (en) 2002-08-30
BG65800B1 (bg) 2009-12-31
NO20020153D0 (no) 2002-01-11
WO2001007480A2 (en) 2001-02-01
EA200200189A1 (ru) 2002-12-26
UA73745C2 (en) 2005-09-15
DE60035049D1 (de) 2007-07-12
US7741276B2 (en) 2010-06-22
IL147675A (en) 2009-05-04
DE1206274T1 (de) 2002-11-14
BRPI0012675B1 (pt) 2001-02-01
AR024907A1 (es) 2002-10-30
EE04838B1 (et) 2007-06-15
EA005419B1 (ru) 2005-02-24
NO329827B1 (no) 2011-01-03
AU5843200A (en) 2001-02-13
KR20020027493A (ko) 2002-04-13
CA2380216A1 (en) 2001-02-01
NZ516535A (en) 2004-04-30
JP4827352B2 (ja) 2011-11-30
CZ2002195A3 (cs) 2002-06-12
BRPI0012675B8 (https=) 2021-05-25
PT1206274E (pt) 2007-07-06
EE200200032A (et) 2003-02-17
NO20020153L (no) 2002-03-11
US20080003216A1 (en) 2008-01-03
ES2186596T3 (es) 2007-11-16
HK1048248A1 (en) 2003-03-28
WO2001007480A3 (en) 2001-05-10
PL353732A1 (en) 2003-12-01
MXPA02000838A (es) 2002-07-30
IL131047A0 (en) 2001-01-28
SK882002A3 (en) 2002-07-02
HUP0202107A2 (en) 2002-10-28
AU782478B2 (en) 2005-08-04
HU228780B1 (en) 2013-05-28
CN1364086A (zh) 2002-08-14
CZ302114B6 (cs) 2010-10-20
CN1173736C (zh) 2004-11-03
EP1206274B1 (en) 2007-05-30
BR0012675A (pt) 2002-04-09
SK287522B6 (sk) 2011-01-04
TR200200169T2 (tr) 2002-06-21
ATE363288T1 (de) 2007-06-15
KR100682219B1 (ko) 2007-02-12
ZA200200390B (en) 2003-04-30
DK1206274T3 (da) 2007-08-13
CA2380216C (en) 2012-01-31

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