EE04838B1 - Interleukiin-18 inhibiitorite kasutamine kasvaja metastaaside pärssimiseks sobivate ravimite valmistamiseks ning selliseid inhibiitoreid sisaldav farmatseutiline kompositsioon - Google Patents

Interleukiin-18 inhibiitorite kasutamine kasvaja metastaaside pärssimiseks sobivate ravimite valmistamiseks ning selliseid inhibiitoreid sisaldav farmatseutiline kompositsioon

Info

Publication number
EE04838B1
EE04838B1 EEP200200032A EEP200200032A EE04838B1 EE 04838 B1 EE04838 B1 EE 04838B1 EE P200200032 A EEP200200032 A EE P200200032A EE P200200032 A EEP200200032 A EE P200200032A EE 04838 B1 EE04838 B1 EE 04838B1
Authority
EE
Estonia
Prior art keywords
inhibitors
interleukin
medicament
inhibition
preparation
Prior art date
Application number
EEP200200032A
Other languages
English (en)
Estonian (et)
Inventor
Dinarello Charles
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of EE200200032A publication Critical patent/EE200200032A/xx
Publication of EE04838B1 publication Critical patent/EE04838B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP200200032A 1999-07-22 2000-07-17 Interleukiin-18 inhibiitorite kasutamine kasvaja metastaaside pärssimiseks sobivate ravimite valmistamiseks ning selliseid inhibiitoreid sisaldav farmatseutiline kompositsioon EE04838B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis

Publications (2)

Publication Number Publication Date
EE200200032A EE200200032A (et) 2003-02-17
EE04838B1 true EE04838B1 (et) 2007-06-15

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200032A EE04838B1 (et) 1999-07-22 2000-07-17 Interleukiin-18 inhibiitorite kasutamine kasvaja metastaaside pärssimiseks sobivate ravimite valmistamiseks ning selliseid inhibiitoreid sisaldav farmatseutiline kompositsioon

Country Status (31)

Country Link
US (1) US7741276B2 (xx)
EP (1) EP1206274B1 (xx)
JP (1) JP4827352B2 (xx)
KR (1) KR100682219B1 (xx)
CN (1) CN1173736C (xx)
AR (1) AR024907A1 (xx)
AT (1) ATE363288T1 (xx)
AU (1) AU782478B2 (xx)
BG (1) BG65800B1 (xx)
BR (1) BR0012675A (xx)
CA (1) CA2380216C (xx)
CY (1) CY1107932T1 (xx)
CZ (1) CZ302114B6 (xx)
DE (2) DE1206274T1 (xx)
DK (1) DK1206274T3 (xx)
EA (1) EA005419B1 (xx)
EE (1) EE04838B1 (xx)
ES (1) ES2186596T3 (xx)
HK (1) HK1048248B (xx)
HU (1) HU228780B1 (xx)
IL (2) IL131047A0 (xx)
MX (1) MXPA02000838A (xx)
NO (1) NO329827B1 (xx)
NZ (1) NZ516535A (xx)
PL (1) PL202477B1 (xx)
PT (1) PT1206274E (xx)
SK (1) SK287522B6 (xx)
TR (1) TR200200169T2 (xx)
UA (1) UA73745C2 (xx)
WO (1) WO2001007480A2 (xx)
ZA (1) ZA200200390B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI373343B (en) 2000-02-10 2012-10-01 Abbott Gmbh & Co Kg Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
MXPA05003869A (es) * 2002-10-08 2005-06-22 Ares Trading Sa El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina.
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
WO2006128908A1 (en) 2005-06-03 2006-12-07 Ares Trading S.A. Production of recombinant il-18 binding protein
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT69922A (en) * 1992-09-02 1995-09-28 Isis Pharmaceuticals Inc Oligonucleotide modification of cell adhesion
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
BR9810409A (pt) * 1997-03-18 2000-08-22 Basf Ag Métodos e composições para a modulação de responsividade a corticosteróides
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
CZ302114B6 (cs) 2010-10-20
KR100682219B1 (ko) 2007-02-12
MXPA02000838A (es) 2002-07-30
EA005419B1 (ru) 2005-02-24
HK1048248A1 (en) 2003-03-28
CA2380216A1 (en) 2001-02-01
BRPI0012675B8 (xx) 2021-05-25
DK1206274T3 (da) 2007-08-13
CZ2002195A3 (cs) 2002-06-12
CN1173736C (zh) 2004-11-03
BG106311A (en) 2002-08-30
SK882002A3 (en) 2002-07-02
HUP0202107A3 (en) 2005-01-28
HUP0202107A2 (en) 2002-10-28
WO2001007480A3 (en) 2001-05-10
PL202477B1 (pl) 2009-06-30
EP1206274A2 (en) 2002-05-22
EP1206274B1 (en) 2007-05-30
ATE363288T1 (de) 2007-06-15
HK1048248B (zh) 2005-04-22
ES2186596T1 (es) 2003-05-16
US20080003216A1 (en) 2008-01-03
IL131047A0 (en) 2001-01-28
HU228780B1 (en) 2013-05-28
BRPI0012675B1 (pt) 2001-02-01
AU782478B2 (en) 2005-08-04
ES2186596T3 (es) 2007-11-16
PT1206274E (pt) 2007-07-06
NO20020153L (no) 2002-03-11
NO329827B1 (no) 2011-01-03
KR20020027493A (ko) 2002-04-13
DE60035049T2 (de) 2007-09-27
TR200200169T2 (tr) 2002-06-21
WO2001007480A2 (en) 2001-02-01
EE200200032A (et) 2003-02-17
NO20020153D0 (no) 2002-01-11
CN1364086A (zh) 2002-08-14
BR0012675A (pt) 2002-04-09
UA73745C2 (en) 2005-09-15
PL353732A1 (en) 2003-12-01
JP2003505472A (ja) 2003-02-12
CA2380216C (en) 2012-01-31
JP4827352B2 (ja) 2011-11-30
AR024907A1 (es) 2002-10-30
US7741276B2 (en) 2010-06-22
BG65800B1 (bg) 2009-12-31
CY1107932T1 (el) 2013-09-04
EA200200189A1 (ru) 2002-12-26
DE60035049D1 (de) 2007-07-12
SK287522B6 (sk) 2011-01-04
AU5843200A (en) 2001-02-13
IL147675A (en) 2009-05-04
ZA200200390B (en) 2003-04-30
DE1206274T1 (de) 2002-11-14
NZ516535A (en) 2004-04-30

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Legal Events

Date Code Title Description
HE1A Change of address
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231