ES2186596T1 - Uso de inhibidores de il-18. - Google Patents

Uso de inhibidores de il-18.

Info

Publication number
ES2186596T1
ES2186596T1 ES00944201T ES00944201T ES2186596T1 ES 2186596 T1 ES2186596 T1 ES 2186596T1 ES 00944201 T ES00944201 T ES 00944201T ES 00944201 T ES00944201 T ES 00944201T ES 2186596 T1 ES2186596 T1 ES 2186596T1
Authority
ES
Spain
Prior art keywords
inhibitors
medicaments
preparation
action
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES00944201T
Other languages
English (en)
Other versions
ES2186596T3 (es
Inventor
Charles Dinarello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ares Trading SA
Original Assignee
Ares Trading SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading SA filed Critical Ares Trading SA
Publication of ES2186596T1 publication Critical patent/ES2186596T1/es
Application granted granted Critical
Publication of ES2186596T3 publication Critical patent/ES2186596T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Uso de inhibidores de la producción y/o acción de IL-18 en la preparación de medicamentos a fin de inhibir la metástasis de tumores.
ES00944201T 1999-07-22 2000-07-17 Uso de inhibidores de la interleucina-18 para inhibir metastasis tumorales. Expired - Lifetime ES2186596T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
IL131047 1999-07-22

Publications (2)

Publication Number Publication Date
ES2186596T1 true ES2186596T1 (es) 2003-05-16
ES2186596T3 ES2186596T3 (es) 2007-11-16

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00944201T Expired - Lifetime ES2186596T3 (es) 1999-07-22 2000-07-17 Uso de inhibidores de la interleucina-18 para inhibir metastasis tumorales.

Country Status (31)

Country Link
US (1) US7741276B2 (es)
EP (1) EP1206274B1 (es)
JP (1) JP4827352B2 (es)
KR (1) KR100682219B1 (es)
CN (1) CN1173736C (es)
AR (1) AR024907A1 (es)
AT (1) ATE363288T1 (es)
AU (1) AU782478B2 (es)
BG (1) BG65800B1 (es)
BR (1) BR0012675A (es)
CA (1) CA2380216C (es)
CY (1) CY1107932T1 (es)
CZ (1) CZ302114B6 (es)
DE (2) DE1206274T1 (es)
DK (1) DK1206274T3 (es)
EA (1) EA005419B1 (es)
EE (1) EE04838B1 (es)
ES (1) ES2186596T3 (es)
HK (1) HK1048248B (es)
HU (1) HU228780B1 (es)
IL (2) IL131047A0 (es)
MX (1) MXPA02000838A (es)
NO (1) NO329827B1 (es)
NZ (1) NZ516535A (es)
PL (1) PL202477B1 (es)
PT (1) PT1206274E (es)
SK (1) SK287522B6 (es)
TR (1) TR200200169T2 (es)
UA (1) UA73745C2 (es)
WO (1) WO2001007480A2 (es)
ZA (1) ZA200200390B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI373343B (en) 2000-02-10 2012-10-01 Abbott Gmbh & Co Kg Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
MXPA05003869A (es) * 2002-10-08 2005-06-22 Ares Trading Sa El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina.
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
WO2006128908A1 (en) 2005-06-03 2006-12-07 Ares Trading S.A. Production of recombinant il-18 binding protein
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT69922A (en) * 1992-09-02 1995-09-28 Isis Pharmaceuticals Inc Oligonucleotide modification of cell adhesion
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
BR9810409A (pt) * 1997-03-18 2000-08-22 Basf Ag Métodos e composições para a modulação de responsividade a corticosteróides
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
CZ302114B6 (cs) 2010-10-20
KR100682219B1 (ko) 2007-02-12
MXPA02000838A (es) 2002-07-30
EA005419B1 (ru) 2005-02-24
HK1048248A1 (en) 2003-03-28
CA2380216A1 (en) 2001-02-01
BRPI0012675B8 (es) 2021-05-25
DK1206274T3 (da) 2007-08-13
CZ2002195A3 (cs) 2002-06-12
CN1173736C (zh) 2004-11-03
BG106311A (en) 2002-08-30
SK882002A3 (en) 2002-07-02
HUP0202107A3 (en) 2005-01-28
HUP0202107A2 (en) 2002-10-28
WO2001007480A3 (en) 2001-05-10
PL202477B1 (pl) 2009-06-30
EP1206274A2 (en) 2002-05-22
EP1206274B1 (en) 2007-05-30
ATE363288T1 (de) 2007-06-15
HK1048248B (zh) 2005-04-22
EE04838B1 (et) 2007-06-15
US20080003216A1 (en) 2008-01-03
IL131047A0 (en) 2001-01-28
HU228780B1 (en) 2013-05-28
BRPI0012675B1 (pt) 2001-02-01
AU782478B2 (en) 2005-08-04
ES2186596T3 (es) 2007-11-16
PT1206274E (pt) 2007-07-06
NO20020153L (no) 2002-03-11
NO329827B1 (no) 2011-01-03
KR20020027493A (ko) 2002-04-13
DE60035049T2 (de) 2007-09-27
TR200200169T2 (tr) 2002-06-21
WO2001007480A2 (en) 2001-02-01
EE200200032A (et) 2003-02-17
NO20020153D0 (no) 2002-01-11
CN1364086A (zh) 2002-08-14
BR0012675A (pt) 2002-04-09
UA73745C2 (en) 2005-09-15
PL353732A1 (en) 2003-12-01
JP2003505472A (ja) 2003-02-12
CA2380216C (en) 2012-01-31
JP4827352B2 (ja) 2011-11-30
AR024907A1 (es) 2002-10-30
US7741276B2 (en) 2010-06-22
BG65800B1 (bg) 2009-12-31
CY1107932T1 (el) 2013-09-04
EA200200189A1 (ru) 2002-12-26
DE60035049D1 (de) 2007-07-12
SK287522B6 (sk) 2011-01-04
AU5843200A (en) 2001-02-13
IL147675A (en) 2009-05-04
ZA200200390B (en) 2003-04-30
DE1206274T1 (de) 2002-11-14
NZ516535A (en) 2004-04-30

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