PL135822B1 - Method of obtaining novel triple-substituted imidazole derivatives - Google Patents

Method of obtaining novel triple-substituted imidazole derivatives Download PDF

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Publication number
PL135822B1
PL135822B1 PL1981232352A PL23235281A PL135822B1 PL 135822 B1 PL135822 B1 PL 135822B1 PL 1981232352 A PL1981232352 A PL 1981232352A PL 23235281 A PL23235281 A PL 23235281A PL 135822 B1 PL135822 B1 PL 135822B1
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PL
Poland
Prior art keywords
acid
group
formula
phenyl
radical
Prior art date
Application number
PL1981232352A
Other languages
English (en)
Polish (pl)
Other versions
PL232352A1 (https=
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PL232352A1 publication Critical patent/PL232352A1/xx
Publication of PL135822B1 publication Critical patent/PL135822B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
PL1981232352A 1980-07-25 1981-07-25 Method of obtaining novel triple-substituted imidazole derivatives PL135822B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25

Publications (2)

Publication Number Publication Date
PL232352A1 PL232352A1 (https=) 1982-12-20
PL135822B1 true PL135822B1 (en) 1985-12-31

Family

ID=4298165

Family Applications (8)

Application Number Title Priority Date Filing Date
PL1981232352A PL135822B1 (en) 1980-07-25 1981-07-25 Method of obtaining novel triple-substituted imidazole derivatives
PL23700381A PL237003A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700481A PL237004A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700581A PL237005A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23699781A PL236997A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700181A PL237001A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700081A PL237000A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700281A PL237002A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole

Family Applications After (7)

Application Number Title Priority Date Filing Date
PL23700381A PL237003A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700481A PL237004A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700581A PL237005A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23699781A PL236997A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700181A PL237001A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700081A PL237000A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700281A PL237002A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole

Country Status (23)

Country Link
US (1) US4447431A (https=)
EP (1) EP0045081B1 (https=)
JP (1) JPS5756466A (https=)
KR (13) KR850000883B1 (https=)
AR (1) AR230269A1 (https=)
AT (1) ATE17349T1 (https=)
AU (2) AU7340481A (https=)
CA (1) CA1175431A (https=)
DD (2) DD201677A5 (https=)
DE (1) DE3173434D1 (https=)
DK (1) DK331881A (https=)
ES (8) ES504257A0 (https=)
FI (1) FI812326A7 (https=)
GB (1) GB2080805B (https=)
GR (1) GR75287B (https=)
IE (1) IE52071B1 (https=)
IL (1) IL63410A (https=)
NO (1) NO812542L (https=)
NZ (1) NZ197828A (https=)
PL (8) PL135822B1 (https=)
PT (1) PT73424B (https=)
SU (8) SU1235454A3 (https=)
ZA (1) ZA815078B (https=)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123831B (en) * 1981-07-20 1986-01-15 Ciba Geigy Ag Trisubstituted oxazo compounds
EP0084756A1 (de) * 1982-01-22 1983-08-03 Ciba-Geigy Ag Trisubstituierte Oxazaverbindungen
FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
US5916891A (en) * 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
EP0727998B1 (en) * 1993-11-08 2004-01-21 Smithkline Beecham Corporation Oxazoles for treating cytokine mediated diseases
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
IL118544A (en) * 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
PL187516B1 (pl) * 1996-01-11 2004-07-30 Smithkline Beecham Corp Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki
EP0889888A4 (en) * 1996-03-25 2003-01-08 Smithkline Beecham Corp NEW TREATMENT OF LESIONS IN THE CENTRAL NERVOUS SYSTEM
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US5965583A (en) * 1997-04-24 1999-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted imidazoles useful in the treatment of inflammatory disease
AU7966198A (en) 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
EP0994870A4 (en) 1997-06-19 2002-10-23 Smithkline Beecham NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
AR016294A1 (es) * 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
US6251914B1 (en) 1997-07-02 2001-06-26 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
CA2306077A1 (en) 1997-10-08 1999-04-15 Smithkline Beecham Corporation Novel cycloalkenyl substituted compounds
AU1924699A (en) 1997-12-19 1999-07-12 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
JP2002516322A (ja) 1998-05-22 2002-06-04 スミスクライン・ビーチャム・コーポレイション 新規２−アルキル置換イミダゾール化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
CA2341370A1 (en) * 1998-08-20 2000-03-02 Smithkline Beecham Corporation Novel substituted triazole compounds
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
AU1529901A (en) 1999-11-22 2001-06-04 Smithkline Beecham Plc Compounds
JP2003514900A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
EP1233950B1 (en) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ATE281439T1 (de) 1999-11-23 2004-11-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
ATE266022T1 (de) * 2000-03-06 2004-05-15 Smithkline Beecham Plc Imidazol derivate als raf kinase inhibitoren
CN100525768C (zh) * 2000-10-23 2009-08-12 史密丝克莱恩比彻姆公司 新化合物
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
US20040192689A1 (en) * 2001-09-05 2004-09-30 Dean David Kenneth Heterocycle-carboxamide derivatives as raf kinase inhibitors
ATE397925T1 (de) * 2001-12-18 2008-07-15 Hoffmann La Roche Cis-imidazoline als mdm2-hemmer
TW200505446A (en) * 2003-01-17 2005-02-16 Fuj Isawa Pharmaceutical Co Ltd Inhibitor of cox
MXPA05011855A (es) * 2003-05-08 2006-02-17 Astellas Pharma Inc 1,2-diarilimidazoles utiles como inhibidores de ciclooxigenasa.
US20080096905A1 (en) * 2005-03-25 2008-04-24 Glaxo Group Limited Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
MY145343A (en) * 2005-03-25 2012-01-31 Glaxo Group Ltd Novel compounds
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558645A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4-(4',5-diphenyl - 2 - imidazolyl)-phenoxy) lower aliphatic monocarboxylic acids
CH561717A5 (https=) * 1971-05-10 1975-05-15 Ciba Geigy Ag
GB1469532A (en) * 1973-06-28 1977-04-06 Dumex Ltd As Imimdazolyl-alkanoic acid derivatives
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
ES514582A0 (es) 1983-05-16
KR850002753A (ko) 1985-05-15
PL237000A1 (en) 1983-02-28
KR850002755A (ko) 1985-05-15
KR850001064B1 (ko) 1985-07-25
PL237005A1 (en) 1983-02-28
DD201677A5 (de) 1983-08-03
KR850002749A (ko) 1985-05-15
AU5655586A (en) 1986-09-11
PL237003A1 (en) 1983-02-28
GB2080805B (en) 1984-03-07
KR850000889B1 (ko) 1985-06-26
DD202554A5 (de) 1983-09-21
ES8301472A1 (es) 1982-12-01
ES8307245A1 (es) 1983-07-01
IE52071B1 (en) 1987-06-10
KR850002752A (ko) 1985-05-15
SU1152520A3 (en) 1985-04-23
ES8306124A1 (es) 1983-05-16
GB2080805A (en) 1982-02-10
SU1138023A3 (ru) 1985-01-30
AU7340481A (en) 1982-01-28
DK331881A (da) 1982-01-26
KR850000886B1 (ko) 1985-06-26
SU1205763A3 (ru) 1986-01-15
FI812326L (fi) 1982-01-26
KR850002754A (ko) 1985-05-15
ATE17349T1 (de) 1986-01-15
FI812326A7 (fi) 1982-01-26
AR230269A1 (es) 1984-03-01
KR850000891B1 (ko) 1985-06-26
NZ197828A (en) 1985-11-08
KR850000873B1 (ko) 1985-06-22
NO812542L (no) 1982-01-26
PL237002A1 (en) 1983-02-28
ES8306119A1 (es) 1983-05-16
ES504257A0 (es) 1982-12-01
IL63410A0 (en) 1981-10-30
KR850000888B1 (ko) 1985-06-26
EP0045081A2 (de) 1982-02-03
ES514584A0 (es) 1983-05-16
PT73424A (en) 1981-08-01
KR850000911B1 (ko) 1985-06-27
SU1205764A3 (ru) 1986-01-15
KR850000884B1 (ko) 1985-06-26
PT73424B (en) 1983-06-20
KR830006230A (ko) 1983-09-20
IL63410A (en) 1986-04-29
KR850000883B1 (ko) 1985-06-26
KR850002747A (ko) 1985-05-15
PL236997A1 (en) 1983-01-03
ES514579A0 (es) 1983-05-16
PL237004A1 (en) 1983-02-28
PL232352A1 (https=) 1982-12-20
EP0045081A3 (en) 1982-04-07
SU1169534A3 (ru) 1985-07-23
GR75287B (https=) 1984-07-13
KR850002745A (ko) 1985-05-15
JPS5756466A (en) 1982-04-05
KR850002756A (ko) 1985-05-15
ES514581A0 (es) 1983-05-16
IE811680L (en) 1982-01-25
KR850002750A (ko) 1985-05-15
SU1145928A3 (ru) 1985-03-15
KR850002744A (ko) 1985-05-15
EP0045081B1 (de) 1986-01-08
KR850002748A (ko) 1985-05-15
KR850002746A (ko) 1985-05-15
ES514583A0 (es) 1983-05-16
CA1175431A (en) 1984-10-02
ES8306123A1 (es) 1983-05-16
ES8306120A1 (es) 1983-05-16
KR850000887B1 (ko) 1985-06-26
ES8306121A1 (es) 1983-05-16
KR850000890B1 (ko) 1985-06-26
DE3173434D1 (en) 1986-02-20
ZA815078B (en) 1982-07-28
SU1227112A3 (ru) 1986-04-23
PL237001A1 (en) 1983-02-28
ES8306122A1 (es) 1983-05-16
SU1235454A3 (ru) 1986-05-30
KR850000892B1 (ko) 1985-06-26
US4447431A (en) 1984-05-08
ES514585A0 (es) 1983-07-01
ES514580A0 (es) 1983-05-16
KR850000885B1 (ko) 1985-06-26

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