PA8800701A1 - Sales de maleato de [e]-n-{4-[3-cloro-4-[2-piridinilmetoxi]anilino]-3-ciano-7-etoxi-6-quinolinil}-4-[dimetilamino]-2-butenamide, sus formas cristalinas, procesos para su preparacion, y metodos para su uso - Google Patents

Sales de maleato de [e]-n-{4-[3-cloro-4-[2-piridinilmetoxi]anilino]-3-ciano-7-etoxi-6-quinolinil}-4-[dimetilamino]-2-butenamide, sus formas cristalinas, procesos para su preparacion, y metodos para su uso

Info

Publication number
PA8800701A1
PA8800701A1 PA20088800701A PA8800701A PA8800701A1 PA 8800701 A1 PA8800701 A1 PA 8800701A1 PA 20088800701 A PA20088800701 A PA 20088800701A PA 8800701 A PA8800701 A PA 8800701A PA 8800701 A1 PA8800701 A1 PA 8800701A1
Authority
PA
Panama
Prior art keywords
piridinylmetoxi
quinolinil
etoxi
ciano
butenamide
Prior art date
Application number
PA20088800701A
Other languages
English (en)
Inventor
Lu Qinghong
Gloria K Cheal
Mahmoud Mirmehrabi
Anthony F Hadfield
Warren Chew
Mannching Sherry Ku
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8800701(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8800701A1 publication Critical patent/PA8800701A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

LAS FORMAS DE SAL DE MALEATO DE (E)-N-4-3-CLORO-4-(2-PIRIDINILMETOXI)ANILINO-3-CIANO-7-ETOXI-6-QUINOLINIL-4-(DIMETILAMINO)-2-BUTENAMIDA, MÉTODOS PARA PREPARAR FORMAS DE SAL DE MALEATO CRISTALINA, LOS COMPUESTOS ASOCIADOS, Y COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LAS SALES DE MALEATO. LAS SALES DE MALEATO SON ÚTILES EN EL TRATAMIENTO DE CÁNCER, PARTICULARMENTE AQUELLOS AFECTADOS POR LAS CINASAS DE LA FAMILIA DEL RECEPTOR DEL FACTOR DE CRECIMIENTO EPIDÉRMICO.
PA20088800701A 2007-10-17 2008-10-17 Sales de maleato de [e]-n-{4-[3-cloro-4-[2-piridinilmetoxi]anilino]-3-ciano-7-etoxi-6-quinolinil}-4-[dimetilamino]-2-butenamide, sus formas cristalinas, procesos para su preparacion, y metodos para su uso PA8800701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12479607P 2007-10-17 2007-10-17

Publications (1)

Publication Number Publication Date
PA8800701A1 true PA8800701A1 (es) 2009-05-15

Family

ID=40347915

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088800701A PA8800701A1 (es) 2007-10-17 2008-10-17 Sales de maleato de [e]-n-{4-[3-cloro-4-[2-piridinilmetoxi]anilino]-3-ciano-7-etoxi-6-quinolinil}-4-[dimetilamino]-2-butenamide, sus formas cristalinas, procesos para su preparacion, y metodos para su uso

Country Status (21)

Country Link
US (6) US8022216B2 (es)
EP (6) EP3088398A1 (es)
JP (10) JP2011500712A (es)
KR (5) KR20150039872A (es)
CN (7) CN103554086A (es)
AR (2) AR068932A1 (es)
AU (1) AU2008312474B2 (es)
BR (2) BRPI0818464B8 (es)
CA (2) CA2928071C (es)
CL (1) CL2008003088A1 (es)
ES (3) ES2602123T3 (es)
HK (2) HK1146405A1 (es)
IL (3) IL308687A (es)
IN (1) IN2015DN01135A (es)
MX (4) MX349332B (es)
NZ (3) NZ705641A (es)
PA (1) PA8800701A1 (es)
RU (2) RU2463300C2 (es)
SG (2) SG10201900175TA (es)
TW (1) TW200934761A (es)
WO (1) WO2009052264A2 (es)

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CN105949176B (zh) * 2016-06-24 2018-10-26 浙江海正药业股份有限公司 一种来那替尼的纯化方法
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