CL2013001723A1 - Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina; metodos de preparacion; composicion farmaceutica; y el uso en el tratamiento de los trastornos mediados por la cinasa de linfoma anaplasico. - Google Patents

Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina; metodos de preparacion; composicion farmaceutica; y el uso en el tratamiento de los trastornos mediados por la cinasa de linfoma anaplasico.

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Publication number
CL2013001723A1
CL2013001723A1 CL2013001723A CL2013001723A CL2013001723A1 CL 2013001723 A1 CL2013001723 A1 CL 2013001723A1 CL 2013001723 A CL2013001723 A CL 2013001723A CL 2013001723 A CL2013001723 A CL 2013001723A CL 2013001723 A1 CL2013001723 A1 CL 2013001723A1
Authority
CL
Chile
Prior art keywords
phenyl
propan
pyrimidin
piperidin
isopropoxy
Prior art date
Application number
CL2013001723A
Other languages
English (en)
Inventor
Baoqing Gong
Piotr H Karpinski
Liladhar Murlidhar Waykole
Lili Feng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013001723(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2013001723A1 publication Critical patent/CL2013001723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CL2013001723A 2010-12-17 2013-06-14 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina; metodos de preparacion; composicion farmaceutica; y el uso en el tratamiento de los trastornos mediados por la cinasa de linfoma anaplasico. CL2013001723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17

Publications (1)

Publication Number Publication Date
CL2013001723A1 true CL2013001723A1 (es) 2013-12-27

Family

ID=45464892

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013001723A CL2013001723A1 (es) 2010-12-17 2013-06-14 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina; metodos de preparacion; composicion farmaceutica; y el uso en el tratamiento de los trastornos mediados por la cinasa de linfoma anaplasico.

Country Status (35)

Country Link
US (2) US9309229B2 (es)
EP (3) EP3121171B1 (es)
JP (1) JP5916752B2 (es)
KR (4) KR20190022903A (es)
CN (7) CN114989139A (es)
AR (2) AR084309A1 (es)
AU (1) AU2011343775B2 (es)
BR (1) BR112013015000A2 (es)
CA (1) CA2821102C (es)
CL (1) CL2013001723A1 (es)
CO (1) CO6801792A2 (es)
CY (2) CY1119474T1 (es)
DK (2) DK3121171T3 (es)
EC (1) ECSP13012770A (es)
ES (3) ES2696526T3 (es)
GT (1) GT201300153A (es)
HR (2) HRP20171477T1 (es)
HU (1) HUE041845T2 (es)
IL (1) IL226474A (es)
LT (2) LT2651918T (es)
MA (1) MA34771B1 (es)
MX (1) MX338210B (es)
MY (2) MY164810A (es)
NZ (1) NZ610713A (es)
PE (1) PE20140698A1 (es)
PL (2) PL2651918T3 (es)
PT (2) PT3121171T (es)
RS (1) RS57771B1 (es)
RU (2) RU2599785C3 (es)
SG (2) SG190856A1 (es)
SI (2) SI3121171T1 (es)
TN (1) TN2013000216A1 (es)
TW (2) TWI576343B (es)
WO (1) WO2012082972A1 (es)
ZA (1) ZA201303599B (es)

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BR112015010221B1 (pt) 2012-11-06 2022-09-13 Shanghai Fochon Pharmaceutical Co., Ltd. Inibidores de quinase alk, seus usos, composição farmacêutica, e método para fabricação de medicamento
KR101656382B1 (ko) * 2014-02-28 2016-09-09 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물
CN105272921A (zh) * 2014-06-09 2016-01-27 江苏奥赛康药业股份有限公司 一种制备Ceritinib的方法及其中间体化合物
CN105294649B (zh) * 2014-07-30 2019-05-14 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
CN105294650A (zh) * 2014-08-01 2016-02-03 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
WO2016081538A1 (en) 2014-11-18 2016-05-26 Teva Pharmaceuticals International Gmbh Solid state forms of ceritinib and salts thereof
CN105601614A (zh) * 2014-11-21 2016-05-25 奥浦顿（上海）医药科技有限公司 一种色瑞替尼晶型及其制备方法
WO2016082795A1 (zh) * 2014-11-28 2016-06-02 苏州晶云药物科技有限公司 色瑞替尼的晶型i及其制备方法
CN105622577A (zh) * 2014-11-29 2016-06-01 江苏先声药业有限公司 一种色瑞替尼的新晶型及其制备方法
WO2016108123A2 (en) * 2014-12-17 2016-07-07 Dr. Reddy’S Laboratories Limited Pure amorphous and amorphous solid dispersion of ceritinib
WO2016098042A1 (en) * 2014-12-19 2016-06-23 Novartis Ag Use of ceritinib (ldk-378) in the treatment of fes or fer mediated disorders, in particular proliferative disorders
WO2016098070A1 (en) 2014-12-19 2016-06-23 Novartis Ag Crystalline form of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2, 4-diamine
WO2017016529A1 (en) 2015-07-28 2017-02-02 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) * 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用
CN106699743B (zh) 2015-11-05 2020-06-12 湖北生物医药产业技术研究院有限公司 嘧啶类衍生物及其用途
WO2017152858A1 (zh) * 2016-03-11 2017-09-14 苏州晶云药物科技有限公司 色瑞替尼的晶型及其制备方法
WO2017158619A1 (en) 2016-03-15 2017-09-21 Natco Pharma Limited A modified process for the preparation of ceritinib and amorphous form of ceritinib
JP2019196359A (ja) * 2019-06-17 2019-11-14 ノバルティス アーゲー ピリミジン誘導体およびそれらの中間体を調製する化学的方法
GB201915618D0 (en) 2019-10-28 2019-12-11 Univ Oslo ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases
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CN105294650A (zh) 2014-08-01 2016-02-03 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
WO2016081538A1 (en) 2014-11-18 2016-05-26 Teva Pharmaceuticals International Gmbh Solid state forms of ceritinib and salts thereof
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CN105622577A (zh) 2014-11-29 2016-06-01 江苏先声药业有限公司 一种色瑞替尼的新晶型及其制备方法
JP2017537927A (ja) 2014-12-04 2017-12-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ がん（骨髄腫）を処置するための抗ｃｓ１および抗ｐｄ１抗体の併用
WO2016098070A1 (en) 2014-12-19 2016-06-23 Novartis Ag Crystalline form of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2, 4-diamine
WO2017016529A1 (en) 2015-07-28 2017-02-02 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

Also Published As

Publication number Publication date
CO6801792A2 (es) 2013-11-29
US20160175305A1 (en) 2016-06-23
MX2013006952A (es) 2013-07-15
TWI576343B (zh) 2017-04-01
ECSP13012770A (es) 2013-10-31
CN104262324A (zh) 2015-01-07
DK3121171T3 (en) 2018-12-10
CY1121017T1 (el) 2019-12-11
EP3453708A1 (en) 2019-03-13
IL226474A (en) 2016-03-31
PT2651918T (pt) 2017-10-17
DK2651918T3 (en) 2017-10-23
ES2643016T3 (es) 2017-11-21
PL2651918T3 (pl) 2017-12-29
PT3121171T (pt) 2018-11-27
CN107056751A (zh) 2017-08-18
LT3121171T (lt) 2018-11-12
KR20190022903A (ko) 2019-03-06
AU2011343775B2 (en) 2015-12-03
US20130274279A1 (en) 2013-10-17
MY177742A (en) 2020-09-23
RS57771B1 (sr) 2018-12-31
ES2905973T3 (es) 2022-04-12
JP5916752B2 (ja) 2016-05-11
ZA201303599B (en) 2014-02-26
EP3453708B8 (en) 2022-03-16
MA34771B1 (fr) 2013-12-03
SG190856A1 (en) 2013-07-31
WO2012082972A1 (en) 2012-06-21
MY164810A (en) 2018-01-30
HUE041845T2 (hu) 2019-05-28
CN106831716A (zh) 2017-06-13
KR20200039021A (ko) 2020-04-14
AR084309A1 (es) 2013-05-08
CA2821102C (en) 2019-06-11
EP2651918B1 (en) 2017-07-12
KR102325775B1 (ko) 2021-11-12
EP3453708B1 (en) 2021-10-27
TN2013000216A1 (en) 2014-11-10
RU2016136823A3 (es) 2020-02-06
CN106008462A (zh) 2016-10-12
HRP20171477T1 (hr) 2017-11-17
ES2696526T3 (es) 2019-01-16
RU2599785C2 (ru) 2016-10-20
RU2746159C2 (ru) 2021-04-08
JP2013545812A (ja) 2013-12-26
KR20180032680A (ko) 2018-03-30
TW201629021A (zh) 2016-08-16
EP2651918A1 (en) 2013-10-23
GT201300153A (es) 2014-06-09
SI2651918T1 (sl) 2017-10-30
CN114989139A (zh) 2022-09-02
EP3121171B1 (en) 2018-08-15
EP3121171A1 (en) 2017-01-25
PE20140698A1 (es) 2014-06-11
RU2016136823A (ru) 2018-12-11
TW201307299A (zh) 2013-02-16
CN112125884A (zh) 2020-12-25
AU2011343775A1 (en) 2013-07-18
CY1119474T1 (el) 2018-04-04
SI3121171T1 (sl) 2018-11-30
IL226474A0 (en) 2013-07-31
RU2013132947A (ru) 2015-01-27
RU2599785C3 (ru) 2019-04-24
CN103282359A (zh) 2013-09-04
AR122395A2 (es) 2022-09-07
BR112013015000A2 (pt) 2016-08-09
CA2821102A1 (en) 2012-06-21
NZ610713A (en) 2014-10-31
LT2651918T (lt) 2017-10-10
KR20130130022A (ko) 2013-11-29
SG10201510082XA (en) 2016-01-28
TWI576344B (zh) 2017-04-01
PL3121171T3 (pl) 2019-01-31
MX338210B (es) 2016-04-07
US9309229B2 (en) 2016-04-12
HRP20181737T1 (hr) 2018-12-28

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