MA34771B1 - Formes cristallines - Google Patents
Formes cristallinesInfo
- Publication number
- MA34771B1 MA34771B1 MA36066A MA36066A MA34771B1 MA 34771 B1 MA34771 B1 MA 34771B1 MA 36066 A MA36066 A MA 36066A MA 36066 A MA36066 A MA 36066A MA 34771 B1 MA34771 B1 MA 34771B1
- Authority
- MA
- Morocco
- Prior art keywords
- varieties
- modulation
- sensitive
- cells
- determining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention concerne des formes cristallines spécifiques de la 5 -chloro-n-(2-isopropoxy-5-méthyl-4-(pipéridin-4-ylphényl)-n-2-(isopropylsulfonyl)phényl)-2,4-diamine. La présente invention concerne en outre des procédés de préparation desdites formes cristallines, des compositions pharmaceutiques comprenant lesdites formes cristallines, et des procédés d'utilisation desdites formes cristallines et des compositions pharmaceutiques pour traiter une maladie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061424194P | 2010-12-17 | 2010-12-17 | |
PCT/US2011/065030 WO2012082972A1 (fr) | 2010-12-17 | 2011-12-15 | Formes cristallines de la 5-chloro-n2-(2-isopropoxy-5-méthyl-4-pipéridin-4-yl-phényl)-n4[2-(propane-2-sulfonyl)-phényl]-pyrimidine-2,4-diamine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34771B1 true MA34771B1 (fr) | 2013-12-03 |
Family
ID=45464892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36066A MA34771B1 (fr) | 2010-12-17 | 2013-06-28 | Formes cristallines |
Country Status (35)
Country | Link |
---|---|
US (2) | US9309229B2 (fr) |
EP (3) | EP2651918B1 (fr) |
JP (1) | JP5916752B2 (fr) |
KR (4) | KR20130130022A (fr) |
CN (7) | CN112125884A (fr) |
AR (2) | AR084309A1 (fr) |
AU (1) | AU2011343775B2 (fr) |
BR (1) | BR112013015000A2 (fr) |
CA (1) | CA2821102C (fr) |
CL (1) | CL2013001723A1 (fr) |
CO (1) | CO6801792A2 (fr) |
CY (2) | CY1119474T1 (fr) |
DK (2) | DK3121171T3 (fr) |
EC (1) | ECSP13012770A (fr) |
ES (3) | ES2643016T3 (fr) |
GT (1) | GT201300153A (fr) |
HR (2) | HRP20171477T1 (fr) |
HU (1) | HUE041845T2 (fr) |
IL (1) | IL226474A (fr) |
LT (2) | LT2651918T (fr) |
MA (1) | MA34771B1 (fr) |
MX (1) | MX338210B (fr) |
MY (2) | MY177742A (fr) |
NZ (1) | NZ610713A (fr) |
PE (1) | PE20140698A1 (fr) |
PL (2) | PL3121171T3 (fr) |
PT (2) | PT2651918T (fr) |
RS (1) | RS57771B1 (fr) |
RU (2) | RU2599785C3 (fr) |
SG (2) | SG10201510082XA (fr) |
SI (2) | SI2651918T1 (fr) |
TN (1) | TN2013000216A1 (fr) |
TW (2) | TWI576344B (fr) |
WO (1) | WO2012082972A1 (fr) |
ZA (1) | ZA201303599B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2651918B1 (fr) | 2010-12-17 | 2017-07-12 | Novartis AG | Formes cristallines de la 5-chloro-n2-(2-isopropoxy-5-méthyl-4-pipéridin-4-yl-phényl)-n4[2-(propane-2-sulfonyl)-phényl]-pyrimidine-2,4-diamine |
RU2675850C2 (ru) | 2012-11-06 | 2018-12-25 | Шанхай Фокон Фармасьютикал Ко Лтд | Ингибиторы alk-киназы |
KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
CN105272921A (zh) * | 2014-06-09 | 2016-01-27 | 江苏奥赛康药业股份有限公司 | 一种制备Ceritinib的方法及其中间体化合物 |
CN105294649B (zh) * | 2014-07-30 | 2019-05-14 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
CN105294650A (zh) * | 2014-08-01 | 2016-02-03 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
ES2813726T3 (es) | 2014-10-21 | 2021-03-24 | Ariad Pharma Inc | Formas cristalinas de 5-cloro-N4-[-2-(dimetilfosforilo)fenilo]-N2-{2-metoxi-4-[4-(4-metilpiperazina-1-ilo)piperidina-1- ilo]pirimidina-2,4-diamina |
WO2016081538A1 (fr) | 2014-11-18 | 2016-05-26 | Teva Pharmaceuticals International Gmbh | Formes solides de ceritinib et sels de ceux-ci |
CN105601614A (zh) * | 2014-11-21 | 2016-05-25 | 奥浦顿(上海)医药科技有限公司 | 一种色瑞替尼晶型及其制备方法 |
WO2016082795A1 (fr) * | 2014-11-28 | 2016-06-02 | 苏州晶云药物科技有限公司 | Forme cristalline i du ceritinib et son procédé de préparation |
CN105622577A (zh) * | 2014-11-29 | 2016-06-01 | 江苏先声药业有限公司 | 一种色瑞替尼的新晶型及其制备方法 |
WO2016108123A2 (fr) * | 2014-12-17 | 2016-07-07 | Dr. Reddy’S Laboratories Limited | Forme amorphe pure et dispersion solide amorphe de céritinib |
WO2016098070A1 (fr) | 2014-12-19 | 2016-06-23 | Novartis Ag | Forme cristalline de la 5-chloro-n2-(2-isopropoxy-5-méthyl-4-pipéridin-4-yl-phényl)-n4-[2-(propane-2-sulfonyl)-phényl]-pyrimidine-2,4-diamine |
WO2016098042A1 (fr) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Utilisation du céritinib (ldk -378) dans le traitement de troubles médiés par fes ou fer, en particulier des troubles prolifératifs |
WO2017016529A1 (fr) | 2015-07-28 | 2017-02-02 | Zentiva, K.S. | Formes solides de ceritinib base libre |
CN105061397B (zh) * | 2015-08-07 | 2018-01-02 | 武汉英普瑞医药科技有限公司 | 一种色瑞替尼的c型晶型及其制备方法与应用 |
CN106699743B (zh) | 2015-11-05 | 2020-06-12 | 湖北生物医药产业技术研究院有限公司 | 嘧啶类衍生物及其用途 |
WO2017152858A1 (fr) * | 2016-03-11 | 2017-09-14 | 苏州晶云药物科技有限公司 | Forme cristalline de céritinib et procédé pour sa préparation |
WO2017158619A1 (fr) | 2016-03-15 | 2017-09-21 | Natco Pharma Limited | Procédé modifié pour la préparation de céritinib et de forme amorphe de céritinib |
JP2019196359A (ja) * | 2019-06-17 | 2019-11-14 | ノバルティス アーゲー | ピリミジン誘導体およびそれらの中間体を調製する化学的方法 |
GB201915618D0 (en) | 2019-10-28 | 2019-12-11 | Univ Oslo | ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases |
US20230348443A1 (en) * | 2020-01-17 | 2023-11-02 | Shandong Xuanzhu Pharma Co., Ltd. | Crystal form of polycyclic anaplastic lymphoma kinase inhibitor |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
EP1660458B1 (fr) * | 2003-08-15 | 2012-01-25 | Novartis AG | 2, 4-pyrimidine diamines utiles dans le cadre du traitement de maladies neoplasiques, de troubles inflammatoires et de troubles du systeme immunitaire |
GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
UA100846C2 (uk) * | 2006-12-08 | 2013-02-11 | Айерем Елелсі | Сполуки та композиція як інгібітори протеїнкінази |
EP2091918B1 (fr) * | 2006-12-08 | 2014-08-27 | Irm Llc | Composés et compositions inhibant la protéine kinase |
WO2009032694A1 (fr) * | 2007-08-28 | 2009-03-12 | Dana Farber Cancer Institute | Pyrimidine substituée par amino, dérivés de pyrollopyridine et de pyrazolopyrimidine utilisés en tant qu'inhibiteurs de la kinase et dans le traitement de troubles prolifératifs et de maladies liées à l'angiogenèse |
EA017252B1 (ru) * | 2007-08-28 | 2012-11-30 | Айрм Ллк | Производные 2-бифениламино-4-аминопиримидина в качестве ингибиторов киназ |
EP2271630B1 (fr) * | 2008-04-07 | 2016-03-23 | Novartis AG | Composés et compositions comme inhibiteurs de la protéine kinase |
NO2300013T3 (fr) * | 2008-05-21 | 2018-02-03 | ||
US20120142667A1 (en) * | 2009-06-10 | 2012-06-07 | Nigel Ramsden | Pyrimidine derivatives as zap-70 inhibitors |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
ME02973B (fr) | 2010-12-17 | 2018-07-20 | Reata Pharmaceuticals Inc | Pyrazolyl- et pyrimidinyl-énones tricycliques en tant que modulateurs d'inflammation antioxydants |
EP2651918B1 (fr) * | 2010-12-17 | 2017-07-12 | Novartis AG | Formes cristallines de la 5-chloro-n2-(2-isopropoxy-5-méthyl-4-pipéridin-4-yl-phényl)-n4[2-(propane-2-sulfonyl)-phényl]-pyrimidine-2,4-diamine |
JP2014501246A (ja) | 2010-12-17 | 2014-01-20 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺菌・殺カビ性アゾ環式アミド |
CN105294650A (zh) | 2014-08-01 | 2016-02-03 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
WO2016081538A1 (fr) | 2014-11-18 | 2016-05-26 | Teva Pharmaceuticals International Gmbh | Formes solides de ceritinib et sels de ceux-ci |
DE112015005255B4 (de) | 2014-11-21 | 2023-10-26 | Joyson Safety Systems Acquisition Llc | Airbagmodul |
CN105622577A (zh) | 2014-11-29 | 2016-06-01 | 江苏先声药业有限公司 | 一种色瑞替尼的新晶型及其制备方法 |
US20170355768A1 (en) | 2014-12-04 | 2017-12-14 | Bristol-Myers Squibb Company | Combination of anti-cs1 and anti-pd1 antibodies to treat cancer (myeloma) |
WO2016098070A1 (fr) | 2014-12-19 | 2016-06-23 | Novartis Ag | Forme cristalline de la 5-chloro-n2-(2-isopropoxy-5-méthyl-4-pipéridin-4-yl-phényl)-n4-[2-(propane-2-sulfonyl)-phényl]-pyrimidine-2,4-diamine |
WO2017016529A1 (fr) | 2015-07-28 | 2017-02-02 | Zentiva, K.S. | Formes solides de ceritinib base libre |
CN105061397B (zh) | 2015-08-07 | 2018-01-02 | 武汉英普瑞医药科技有限公司 | 一种色瑞替尼的c型晶型及其制备方法与应用 |
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2011
- 2011-12-15 EP EP11806079.7A patent/EP2651918B1/fr not_active Revoked
- 2011-12-15 EP EP16167355.3A patent/EP3121171B1/fr active Active
- 2011-12-15 SI SI201131289T patent/SI2651918T1/sl unknown
- 2011-12-15 JP JP2013544762A patent/JP5916752B2/ja active Active
- 2011-12-15 PT PT118060797T patent/PT2651918T/pt unknown
- 2011-12-15 ES ES11806079.7T patent/ES2643016T3/es active Active
- 2011-12-15 RU RU2013132947A patent/RU2599785C3/ru active Protection Beyond IP Right Term
- 2011-12-15 AU AU2011343775A patent/AU2011343775B2/en active Active
- 2011-12-15 AR ARP110104703A patent/AR084309A1/es not_active Application Discontinuation
- 2011-12-15 LT LTEP11806079.7T patent/LT2651918T/lt unknown
- 2011-12-15 PT PT16167355T patent/PT3121171T/pt unknown
- 2011-12-15 KR KR1020137018605A patent/KR20130130022A/ko not_active Application Discontinuation
- 2011-12-15 CN CN202011050061.0A patent/CN112125884A/zh active Pending
- 2011-12-15 US US13/993,217 patent/US9309229B2/en active Active
- 2011-12-15 CN CN201610217386.0A patent/CN106008462A/zh active Pending
- 2011-12-15 KR KR1020197005138A patent/KR20190022903A/ko active Search and Examination
- 2011-12-15 CN CN202210792464.5A patent/CN114989139A/zh active Pending
- 2011-12-15 SG SG10201510082XA patent/SG10201510082XA/en unknown
- 2011-12-15 ES ES16167355T patent/ES2696526T3/es active Active
- 2011-12-15 PL PL16167355T patent/PL3121171T3/pl unknown
- 2011-12-15 SG SG2013039342A patent/SG190856A1/en unknown
- 2011-12-15 SI SI201131583T patent/SI3121171T1/sl unknown
- 2011-12-15 DK DK16167355.3T patent/DK3121171T3/en active
- 2011-12-15 EP EP18186197.2A patent/EP3453708B8/fr active Active
- 2011-12-15 DK DK11806079.7T patent/DK2651918T3/en active
- 2011-12-15 KR KR1020207009828A patent/KR102325775B1/ko active IP Right Grant
- 2011-12-15 PL PL11806079T patent/PL2651918T3/pl unknown
- 2011-12-15 CN CN201710063792.0A patent/CN106831716A/zh active Pending
- 2011-12-15 MY MYPI2016001551A patent/MY177742A/en unknown
- 2011-12-15 MY MYPI2013001848A patent/MY164810A/en unknown
- 2011-12-15 KR KR1020187007996A patent/KR20180032680A/ko not_active Application Discontinuation
- 2011-12-15 RS RS20181240A patent/RS57771B1/sr unknown
- 2011-12-15 LT LTEP16167355.3T patent/LT3121171T/lt unknown
- 2011-12-15 CN CN201710063793.5A patent/CN107056751A/zh active Pending
- 2011-12-15 HU HUE16167355A patent/HUE041845T2/hu unknown
- 2011-12-15 MX MX2013006952A patent/MX338210B/es active IP Right Grant
- 2011-12-15 CN CN201180060435XA patent/CN103282359A/zh active Pending
- 2011-12-15 BR BR112013015000A patent/BR112013015000A2/pt not_active Application Discontinuation
- 2011-12-15 WO PCT/US2011/065030 patent/WO2012082972A1/fr active Application Filing
- 2011-12-15 NZ NZ610713A patent/NZ610713A/en not_active IP Right Cessation
- 2011-12-15 ES ES18186197T patent/ES2905973T3/es active Active
- 2011-12-15 CA CA2821102A patent/CA2821102C/fr active Active
- 2011-12-15 RU RU2016136823A patent/RU2746159C2/ru active
- 2011-12-15 PE PE2013001425A patent/PE20140698A1/es not_active Application Discontinuation
- 2011-12-15 CN CN201410457562.9A patent/CN104262324A/zh active Pending
- 2011-12-16 TW TW105112710A patent/TWI576344B/zh active
- 2011-12-16 TW TW100146987A patent/TWI576343B/zh active
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2013
- 2013-05-17 TN TNP2013000216A patent/TN2013000216A1/fr unknown
- 2013-05-17 ZA ZA2013/03599A patent/ZA201303599B/en unknown
- 2013-05-20 IL IL226474A patent/IL226474A/en active IP Right Grant
- 2013-06-14 CL CL2013001723A patent/CL2013001723A1/es unknown
- 2013-06-17 GT GT201300153A patent/GT201300153A/es unknown
- 2013-06-28 MA MA36066A patent/MA34771B1/fr unknown
- 2013-07-04 CO CO13158446A patent/CO6801792A2/es not_active Application Discontinuation
- 2013-07-16 EC ECSP13012770 patent/ECSP13012770A/es unknown
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2016
- 2016-03-02 US US15/058,489 patent/US20160175305A1/en not_active Abandoned
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2017
- 2017-10-03 HR HRP20171477TT patent/HRP20171477T1/hr unknown
- 2017-10-11 CY CY20171101064T patent/CY1119474T1/el unknown
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2018
- 2018-10-22 HR HRP20181737TT patent/HRP20181737T1/hr unknown
- 2018-11-09 CY CY181101192T patent/CY1121017T1/el unknown
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2021
- 2021-03-19 AR ARP210100698A patent/AR122395A2/es unknown
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