HRP20171477T1 - Kristalični oblici od 5-kloro-n2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina - Google Patents
Kristalični oblici od 5-kloro-n2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina Download PDFInfo
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- HRP20171477T1 HRP20171477T1 HRP20171477TT HRP20171477T HRP20171477T1 HR P20171477 T1 HRP20171477 T1 HR P20171477T1 HR P20171477T T HRP20171477T T HR P20171477TT HR P20171477 T HRP20171477 T HR P20171477T HR P20171477 T1 HRP20171477 T1 HR P20171477T1
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- cancer
- phenyl
- piperidin
- crystalline form
- isopropoxy
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- VERWOWGGCGHDQE-UHFFFAOYSA-N ceritinib Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCNCC1 VERWOWGGCGHDQE-UHFFFAOYSA-N 0.000 title claims 10
- 238000000034 method Methods 0.000 claims 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- 239000012535 impurity Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000000354 decomposition reaction Methods 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 238000002411 thermogravimetry Methods 0.000 claims 2
- WNCJOPLFICTLPT-UHFFFAOYSA-N 5-chloro-2-n-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine;dihydrochloride Chemical compound Cl.Cl.CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCNCC1 WNCJOPLFICTLPT-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000012609 Cowden disease Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 201000003803 Inflammatory myofibroblastic tumor Diseases 0.000 claims 1
- 206010067917 Inflammatory myofibroblastic tumour Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010043515 Throat cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 201000002758 colorectal adenoma Diseases 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000020984 malignant renal pelvis neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000007444 renal pelvis carcinoma Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000010700 sporadic breast cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Claims (15)
1. Kristalični oblik, naznačen time, da je to kristalični oblik A od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji prikazuje jednu ili više vršnih vrijednosti difrakcije praha X-zraka, koje imaju maksimum s difrakcijskim kutom odabranim od sljedećih: 7,2°, 8,1°, 10,8°, 12,0°, 12,4°, 13,4°, 14,4°, 14,8°, 15,7°, 16,9°, 17,7°, 18,5°, 19,0°, 19,5°, 20,0°, 20,3°, 21,1°, 21,6°, 22,4°, 22,6°, 23,0°, 24,1°, 24,5°, 25,5°, 26,0°, 26,2°, 27,0°, 27,3°, 28,3°, 29,0°, 29,1°, 30,6°, 31,3°, 32,8°, 33,5°, 34,2° i 36,4° (2θ stupnjeva).
2. Kristalični oblik prema zahtjevu 1, naznačen time, da ima talište na 174°C, što je određeno kalorimetrijskim diferencijalnim skeniranjem, ili ima dekompozicijsku točku na više od 250°C i gubitak mase sušenjem od 0,1 % uz 200°C, što je određeno termogravimetrijskom analizom, ili ima karakteristične infracrvene apsorpcijske opsege na sljedećim vrijednostima: 3440,4, 3318,9, 2973,7, 2931,3, 2921,7, 1596,8, 1562,1, 1498,4, 1442,5, 1409,7, 1382,7, 1311,4, 1284,4, 1270,9, 1251,6, 1224,6, 1139,7, 1126,2, 1139,7, 1126,2, 1105,0, 1081,9, 1049,1, 1020,2, 1012,5, 952,7, 937,3, 894,8, 877,5, 860,1, 848,5, 817,7, 798,4, 781,0, 763,7, 756,0, 732,8, 686,6, 665,3, 644,1, 586,3 i 543,8
(u jedinicama valnih brojeva, cm-1), ili
ima ukupno nečistoća manje od 1,0 maseni %, ili
ima ukupno nečistoća manje od 0,5 masenih %, ili
ima ukupno nečistoća manje od 0,1 maseni %.
3. Kristalični oblik, naznačen time, da je to kristalični oblik B od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji prikazuje jednu ili više vršnih vrijednosti difrakcije praha X-zraka, koje imaju maksimum s difrakcijskim kutom odabranim od sljedećih: 5,1°, 5,5°, 5,6°, 9,5°, 9,6°, 10,1°, 11,0°, 11,8°, 12,1°, 12,6°, 13,7°, 14,5°, 14,9°, 15,2°, 16,1°, 16,6°, 16,7°, 17,0°, 17,1°, 17,5°, 17,7°, 18,0°, 18,8°, 19,0°, 19,3°, 19,5°, 20,5°, 20,9°, 21,5°, 21,9°, 22,1°, 22,4°, 22,8°, 23,2°, 23,7°, 23,9°, 24,3°, 24,5°, 24,8°, 25,1°, 25,4°, 25,9°, 26,4°, 26,8°, 27,8°, 28,1°, 28,6°, 29,1°, 29,6°, 29,8°, 30,6°, 31,6°, 32,7°, 33,5°, 34,2°, 35,4°, 35,6° i 36,8° (2θ stupnjeva).
4. Kristalični oblik prema zahtjevu 3, naznačen time, da ima talište na 162°C, što je određeno kalorimetrijskim diferencijalnim skeniranjem, ili ima dekompozicijsku točku na više od 250°C i gubitak mase sušenjem od 0,05 % uz 200°C, što je određeno termogravimetrijskom analizom, ili ima karakteristične infracrvene apsorpcijske opsege na sljedećim vrijednostima: 3418,7, 3309,5, 3202,3, 2976,2, 2936,3, 2806,9, 2731,8, 1683,9, 1652,8, 1598,4, 1568,9, 1507,0, 1483,5, 1447,1, 1411,0, 1314,9, 1288,1, 1261,1, 1220,8, 1195,7, 1170,8, 1140,1, 1124,6, 1083,2, 1053,3, 1010,1, 947,1, 874,5, 776,0, 758,7, 734,5, 706,5, 678,5, 652,1, 586,3, 544,7, 519,1, 472,6 i 456,8 (u jedinicama valnih brojeva, cm-1), ili
ima ukupno nečistoća manje od 1,0 maseni %, ili
ima ukupno nečistoća manje od 0,5 masenih %, ili
ima ukupno nečistoća manje od 0,1 maseni %.
5. Farmaceutski sastav, naznačen time, da obuhvaća kristalični oblik prema bilo kojem od zahtjeva 1 do 2, i jedan farmaceutski prihvatljiv nosač.
6. Farmaceutski sastav, naznačen time, da obuhvaća kristalični oblik prema bilo kojem od zahtjeva 3 do 4, i jedan farmaceutski prihvatljiv nosač.
7. Postupak proizvodnje kristaličnog oblika od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, naznačen time, da obuhvaća korak reakcije 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamin-dihidroklorida u otapalu s najmanje dva ekvivalenta vodenog natrijevog hidroksida.
8. Postupak prema zahtjevu 7, naznačen time, da se kod otapala radi o sadržaju acetona i vode u volumenskom omjeru od 3:1.
9. Postupak prema zahtjevu 8, naznačen time, da dodatno obuhvaća korak zagrijavanja reaktanata na temperaturu koja je u rasponu od 30 do 70°C.
10. Postupak pretvaranja kristaličnog oblika B od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji je definiran prema zahtjevu 3, u kristalični oblik A od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji je definiran prema zahtjevu 1, naznačen time, da se vrši pomoću dodavanja jedne male količine kristaličnog oblika A u suspenziju od oblika B od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina u otapalu.
11. Postupak prema zahtjevu 10, naznačen time, da količina oblika A koja je dodana, iznosi 1,0 maseni % ili manje.
12. Postupak prema zahtjevu 11, naznačen time, da se kod otapala radi o sadržaju acetona i vode u volumenskom omjeru od 1:1, na temperaturi koja je u rasponu od 20 do 40°C.
13. Postupak pretvaranja kristaličnog oblika B od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji je definiran prema zahtjevu 3, u kristalični oblik A od 5-kloro-N2-(2-izopropoksi- 5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, koji je definiran prema zahtjevu 1, naznačen time, da se vrši pomoću zagrijvanja suspenzije od oblika B od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina u otapalu.
14. Postupak prema zahtjevu 13, naznačen time, da se kod otapala radi o sadržaju acetona i vode u volumenskom omjeru od 1:1 do 5:1, na temperaturi koja je u rasponu od 30 do 70°C.
15. Kristalični oblik od 5-kloro-N2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina, prema bilo kojem od zahtjeva 1 do 14, naznačen time, da se upotrebljava u liječenju poremećaja posredovanih putem anaplastične kinaze limfoma, ili se upotrebljava u liječenju poremećaja, pri čemu se kod poremećaja radi o raku koji je odabran od sljedećih: anaplastični limfom velikih stanica; non-Hodgkin-limfom; upalni miofibrolastični tumor; neuroblastom; sarkom; rak pluća; rak bronhija; rak prostate; rak dojke (uključujući sporadične bolesti raka dojke i osobe koje pate od Cowdenove bolesti); rak gušterače; gastrointestinalni rak; rak debelog crijeva; rak rektuma; karcinom debelog crijeva; kolorektalni adenom; rak štitnjače; rak jetre; rak intrahepatskog žučnog trakta; rak jetrenih stanica; rak adrenalne žlijezde; rak želudca; gliom; glioblastom; endometrijski rak; melanom; rak bubrega; rak bubrežne karlice; rak mokraćnog mjehura; rak tijela maternice; rak grlića maternice; vaginalni rak; rak jajnika; višestruki mijelom; rak jednjaka; leukemija; akutna mijelogena leukemija; kronična mijelogena leukemija; limfocitna leukemija; mijeloidna leukemija; rak mozga; karcinom mozga; rak usne šupljine i ždrijela; rak grla; rak tankog crijeva; i melanom.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061424194P | 2010-12-17 | 2010-12-17 | |
EP11806079.7A EP2651918B1 (en) | 2010-12-17 | 2011-12-15 | Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine |
PCT/US2011/065030 WO2012082972A1 (en) | 2010-12-17 | 2011-12-15 | Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine |
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HRP20171477T1 true HRP20171477T1 (hr) | 2017-11-17 |
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HRP20171477TT HRP20171477T1 (hr) | 2010-12-17 | 2017-10-03 | Kristalični oblici od 5-kloro-n2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina |
HRP20181737TT HRP20181737T1 (hr) | 2010-12-17 | 2018-10-22 | Kristalni oblici od 5-kloro-n2-(2-izopropoksi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina |
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Country Status (35)
Country | Link |
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US (2) | US9309229B2 (hr) |
EP (3) | EP2651918B1 (hr) |
JP (1) | JP5916752B2 (hr) |
KR (4) | KR20130130022A (hr) |
CN (7) | CN104262324A (hr) |
AR (2) | AR084309A1 (hr) |
AU (1) | AU2011343775B2 (hr) |
BR (1) | BR112013015000A2 (hr) |
CA (1) | CA2821102C (hr) |
CL (1) | CL2013001723A1 (hr) |
CO (1) | CO6801792A2 (hr) |
CY (2) | CY1119474T1 (hr) |
DK (2) | DK2651918T3 (hr) |
EC (1) | ECSP13012770A (hr) |
ES (3) | ES2643016T3 (hr) |
GT (1) | GT201300153A (hr) |
HR (2) | HRP20171477T1 (hr) |
HU (1) | HUE041845T2 (hr) |
IL (1) | IL226474A (hr) |
LT (2) | LT2651918T (hr) |
MA (1) | MA34771B1 (hr) |
MX (1) | MX338210B (hr) |
MY (2) | MY164810A (hr) |
NZ (1) | NZ610713A (hr) |
PE (1) | PE20140698A1 (hr) |
PL (2) | PL2651918T3 (hr) |
PT (2) | PT2651918T (hr) |
RS (1) | RS57771B1 (hr) |
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KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
CN105272921A (zh) * | 2014-06-09 | 2016-01-27 | 江苏奥赛康药业股份有限公司 | 一种制备Ceritinib的方法及其中间体化合物 |
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CN105294650A (zh) * | 2014-08-01 | 2016-02-03 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
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