MX2013006952A - Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin -4-il-fenil)-n4-[2- (propan-2-sulfonil)-fenil]-pirimidin-2,4-diami na. - Google Patents

Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin -4-il-fenil)-n4-[2- (propan-2-sulfonil)-fenil]-pirimidin-2,4-diami na.

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Publication number
MX2013006952A
MX2013006952A MX2013006952A MX2013006952A MX2013006952A MX 2013006952 A MX2013006952 A MX 2013006952A MX 2013006952 A MX2013006952 A MX 2013006952A MX 2013006952 A MX2013006952 A MX 2013006952A MX 2013006952 A MX2013006952 A MX 2013006952A
Authority
MX
Mexico
Prior art keywords
phenyl
crystalline forms
isopropoxy
diamine
chloro
Prior art date
Application number
MX2013006952A
Other languages
English (en)
Other versions
MX338210B (es
Inventor
Lili Feng
Piotr H Karpinski
Liladhar Murlidhar Waykole
Baoqing Gong
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013006952(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013006952A publication Critical patent/MX2013006952A/es
Publication of MX338210B publication Critical patent/MX338210B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención describe formas cristalinas específicas de la 5-cloro-N-(2-isopropoxi-5-metil-4 (piperídin-4-il-fenil)-N-2-(i so-propil-sulfonil)-fenil)-2,4-diamina. (Ver Formula) La presente invención se refiere además a los métodos para la preparación de estas formas cristalinas, a composiciones farmacéuticas que comprenden dichas formas cristalinas, y a los métodos para utilizar las formas cristalinas y las composiciones farmacéuticas para tratar enfermedades.
MX2013006952A 2010-12-17 2011-12-15 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin -4-il-fenil)-n4-[2- (propan-2-sulfonil)-fenil]-pirimidin-2,4-diami na. MX338210B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17
PCT/US2011/065030 WO2012082972A1 (en) 2010-12-17 2011-12-15 Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Publications (2)

Publication Number Publication Date
MX2013006952A true MX2013006952A (es) 2013-07-15
MX338210B MX338210B (es) 2016-04-07

Family

ID=45464892

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006952A MX338210B (es) 2010-12-17 2011-12-15 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin -4-il-fenil)-n4-[2- (propan-2-sulfonil)-fenil]-pirimidin-2,4-diami na.

Country Status (35)

Country Link
US (2) US9309229B2 (es)
EP (3) EP2651918B1 (es)
JP (1) JP5916752B2 (es)
KR (4) KR20130130022A (es)
CN (7) CN104262324A (es)
AR (2) AR084309A1 (es)
AU (1) AU2011343775B2 (es)
BR (1) BR112013015000A2 (es)
CA (1) CA2821102C (es)
CL (1) CL2013001723A1 (es)
CO (1) CO6801792A2 (es)
CY (2) CY1119474T1 (es)
DK (2) DK2651918T3 (es)
EC (1) ECSP13012770A (es)
ES (3) ES2643016T3 (es)
GT (1) GT201300153A (es)
HR (2) HRP20171477T1 (es)
HU (1) HUE041845T2 (es)
IL (1) IL226474A (es)
LT (2) LT2651918T (es)
MA (1) MA34771B1 (es)
MX (1) MX338210B (es)
MY (2) MY164810A (es)
NZ (1) NZ610713A (es)
PE (1) PE20140698A1 (es)
PL (2) PL2651918T3 (es)
PT (2) PT2651918T (es)
RS (1) RS57771B1 (es)
RU (2) RU2599785C3 (es)
SG (2) SG10201510082XA (es)
SI (2) SI3121171T1 (es)
TN (1) TN2013000216A1 (es)
TW (2) TWI576343B (es)
WO (1) WO2012082972A1 (es)
ZA (1) ZA201303599B (es)

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CN105622577A (zh) * 2014-11-29 2016-06-01 江苏先声药业有限公司 一种色瑞替尼的新晶型及其制备方法
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CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

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SG10201510082XA (en) 2016-01-28
PE20140698A1 (es) 2014-06-11
SI2651918T1 (sl) 2017-10-30
BR112013015000A2 (pt) 2016-08-09
CL2013001723A1 (es) 2013-12-27
KR20190022903A (ko) 2019-03-06
RU2016136823A (ru) 2018-12-11
AR122395A2 (es) 2022-09-07
US9309229B2 (en) 2016-04-12
TWI576344B (zh) 2017-04-01
ECSP13012770A (es) 2013-10-31
TWI576343B (zh) 2017-04-01
MY177742A (en) 2020-09-23
MX338210B (es) 2016-04-07
AU2011343775A1 (en) 2013-07-18
MA34771B1 (fr) 2013-12-03
ZA201303599B (en) 2014-02-26
NZ610713A (en) 2014-10-31
KR20180032680A (ko) 2018-03-30
CO6801792A2 (es) 2013-11-29
TW201307299A (zh) 2013-02-16
US20130274279A1 (en) 2013-10-17
DK3121171T3 (en) 2018-12-10
TN2013000216A1 (en) 2014-11-10
KR20200039021A (ko) 2020-04-14
IL226474A (en) 2016-03-31
RU2599785C3 (ru) 2019-04-24
RU2599785C2 (ru) 2016-10-20
EP2651918A1 (en) 2013-10-23
MY164810A (en) 2018-01-30
CN112125884A (zh) 2020-12-25
CY1121017T1 (el) 2019-12-11
US20160175305A1 (en) 2016-06-23
PT3121171T (pt) 2018-11-27
EP3453708A1 (en) 2019-03-13
EP3453708B8 (en) 2022-03-16
KR20130130022A (ko) 2013-11-29
RU2746159C2 (ru) 2021-04-08
SI3121171T1 (sl) 2018-11-30
JP5916752B2 (ja) 2016-05-11
EP2651918B1 (en) 2017-07-12
CN114989139A (zh) 2022-09-02
RS57771B1 (sr) 2018-12-31
HRP20181737T1 (hr) 2018-12-28
CN106008462A (zh) 2016-10-12
EP3453708B1 (en) 2021-10-27
KR102325775B1 (ko) 2021-11-12
PT2651918T (pt) 2017-10-17
TW201629021A (zh) 2016-08-16
SG190856A1 (en) 2013-07-31
ES2643016T3 (es) 2017-11-21
IL226474A0 (en) 2013-07-31
CN103282359A (zh) 2013-09-04
PL3121171T3 (pl) 2019-01-31
AU2011343775B2 (en) 2015-12-03
AR084309A1 (es) 2013-05-08
ES2905973T3 (es) 2022-04-12
CN106831716A (zh) 2017-06-13
ES2696526T3 (es) 2019-01-16
RU2016136823A3 (es) 2020-02-06
CA2821102C (en) 2019-06-11
HRP20171477T1 (hr) 2017-11-17
GT201300153A (es) 2014-06-09
CA2821102A1 (en) 2012-06-21
WO2012082972A1 (en) 2012-06-21
CN104262324A (zh) 2015-01-07
EP3121171B1 (en) 2018-08-15
DK2651918T3 (en) 2017-10-23
HUE041845T2 (hu) 2019-05-28
CN107056751A (zh) 2017-08-18
CY1119474T1 (el) 2018-04-04
LT2651918T (lt) 2017-10-10
PL2651918T3 (pl) 2017-12-29
EP3121171A1 (en) 2017-01-25
RU2013132947A (ru) 2015-01-27
JP2013545812A (ja) 2013-12-26
LT3121171T (lt) 2018-11-12

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