AR084309A1 - Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina - Google Patents

Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina

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Publication number
AR084309A1
AR084309A1 ARP110104703A ARP110104703A AR084309A1 AR 084309 A1 AR084309 A1 AR 084309A1 AR P110104703 A ARP110104703 A AR P110104703A AR P110104703 A ARP110104703 A AR P110104703A AR 084309 A1 AR084309 A1 AR 084309A1
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AR
Argentina
Prior art keywords
phenyl
piperidin
methyl
diamine
propan
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ARP110104703A
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English (en)
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Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR084309(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR084309A1 publication Critical patent/AR084309A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente describe formas cristalinas específicas de la 5-cloro-N-(2-isopropoxi-5-metil-4-(piperidin-4-il-fenil)-N-2-(iso-propil-sulfonil)-fenil)-2,4-diamina. La presente se refiere además a los métodos para la preparación de estas formas cristalinas, a composiciones farmacéuticas que comprenden dichas formas cristalinas, y a los métodos para utilizar las formas cristalinas y las composiciones farmacéuticas para tratar enfermedades.Reivindicación 1: Una forma cristalina de la 5-cloro-N2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-N4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina que exhibe uno o más picos de difracción en polvo de rayos-X que tienen la máxima en los ángulos de difracción seleccionados a partir de 7.2º, 8.1º, 10.8º, 12.0º, 12.4º, 13.4º, 14.4º, 14.8º, 15.7º, 16.9º, 17.7º, 18.5º, 19.0º, 19.5º, 20.0º, 20.3º, 21.1º, 21.6º, 22.4º, 22.6º, 23.0º, 24.1º, 24.5º, 25.5º, 26.0º, 26.2º, 27.0º, 27.3º, 28.3º, 29.0º, 29.1º, 30.6º, 31.3º, 32.8º, 33.5º, 34.2º y 36.4º (grados 2q).
ARP110104703A 2010-12-17 2011-12-15 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina AR084309A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17

Publications (1)

Publication Number Publication Date
AR084309A1 true AR084309A1 (es) 2013-05-08

Family

ID=45464892

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110104703A AR084309A1 (es) 2010-12-17 2011-12-15 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina
ARP210100698A AR122395A2 (es) 2010-12-17 2021-03-19 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP210100698A AR122395A2 (es) 2010-12-17 2021-03-19 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina

Country Status (35)

Country Link
US (2) US9309229B2 (es)
EP (3) EP2651918B1 (es)
JP (1) JP5916752B2 (es)
KR (4) KR20190022903A (es)
CN (7) CN106008462A (es)
AR (2) AR084309A1 (es)
AU (1) AU2011343775B2 (es)
BR (1) BR112013015000A2 (es)
CA (1) CA2821102C (es)
CL (1) CL2013001723A1 (es)
CO (1) CO6801792A2 (es)
CY (2) CY1119474T1 (es)
DK (2) DK2651918T3 (es)
EC (1) ECSP13012770A (es)
ES (3) ES2643016T3 (es)
GT (1) GT201300153A (es)
HR (2) HRP20171477T1 (es)
HU (1) HUE041845T2 (es)
IL (1) IL226474A (es)
LT (2) LT2651918T (es)
MA (1) MA34771B1 (es)
MX (1) MX338210B (es)
MY (2) MY164810A (es)
NZ (1) NZ610713A (es)
PE (1) PE20140698A1 (es)
PL (2) PL2651918T3 (es)
PT (2) PT3121171T (es)
RS (1) RS57771B1 (es)
RU (2) RU2746159C2 (es)
SG (2) SG190856A1 (es)
SI (2) SI2651918T1 (es)
TN (1) TN2013000216A1 (es)
TW (2) TWI576343B (es)
WO (1) WO2012082972A1 (es)
ZA (1) ZA201303599B (es)

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EP3328848A1 (en) 2015-07-28 2018-06-06 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

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RU2746159C2 (ru) 2021-04-08
MY177742A (en) 2020-09-23
CA2821102A1 (en) 2012-06-21
CN103282359A (zh) 2013-09-04
BR112013015000A2 (pt) 2016-08-09
AR122395A2 (es) 2022-09-07
PL3121171T3 (pl) 2019-01-31
US9309229B2 (en) 2016-04-12
TW201307299A (zh) 2013-02-16
HUE041845T2 (hu) 2019-05-28
EP3121171B1 (en) 2018-08-15
KR102325775B1 (ko) 2021-11-12
CN114989139A (zh) 2022-09-02
AU2011343775B2 (en) 2015-12-03
MX2013006952A (es) 2013-07-15
SG10201510082XA (en) 2016-01-28
CL2013001723A1 (es) 2013-12-27
EP3453708A1 (en) 2019-03-13
JP2013545812A (ja) 2013-12-26
RU2013132947A (ru) 2015-01-27
CN107056751A (zh) 2017-08-18
KR20190022903A (ko) 2019-03-06
DK3121171T3 (en) 2018-12-10
EP2651918B1 (en) 2017-07-12
CY1119474T1 (el) 2018-04-04
CN106008462A (zh) 2016-10-12
IL226474A0 (en) 2013-07-31
EP3453708B1 (en) 2021-10-27
TWI576344B (zh) 2017-04-01
KR20200039021A (ko) 2020-04-14
JP5916752B2 (ja) 2016-05-11
KR20180032680A (ko) 2018-03-30
HRP20171477T1 (hr) 2017-11-17
NZ610713A (en) 2014-10-31
US20130274279A1 (en) 2013-10-17
EP2651918A1 (en) 2013-10-23
HRP20181737T1 (hr) 2018-12-28
SG190856A1 (en) 2013-07-31
LT2651918T (lt) 2017-10-10
CO6801792A2 (es) 2013-11-29
EP3453708B8 (en) 2022-03-16
CN104262324A (zh) 2015-01-07
TN2013000216A1 (en) 2014-11-10
DK2651918T3 (en) 2017-10-23
IL226474A (en) 2016-03-31
ES2905973T3 (es) 2022-04-12
SI3121171T1 (sl) 2018-11-30
PL2651918T3 (pl) 2017-12-29
ZA201303599B (en) 2014-02-26
MY164810A (en) 2018-01-30
RU2599785C3 (ru) 2019-04-24
PE20140698A1 (es) 2014-06-11
TWI576343B (zh) 2017-04-01
MX338210B (es) 2016-04-07
RS57771B1 (sr) 2018-12-31
KR20130130022A (ko) 2013-11-29
ES2643016T3 (es) 2017-11-21
ECSP13012770A (es) 2013-10-31
RU2016136823A3 (es) 2020-02-06
CN112125884A (zh) 2020-12-25
PT3121171T (pt) 2018-11-27
SI2651918T1 (sl) 2017-10-30
US20160175305A1 (en) 2016-06-23
WO2012082972A1 (en) 2012-06-21
AU2011343775A1 (en) 2013-07-18
LT3121171T (lt) 2018-11-12
ES2696526T3 (es) 2019-01-16
GT201300153A (es) 2014-06-09
CN106831716A (zh) 2017-06-13
MA34771B1 (fr) 2013-12-03
CA2821102C (en) 2019-06-11
EP3121171A1 (en) 2017-01-25
CY1121017T1 (el) 2019-12-11
TW201629021A (zh) 2016-08-16
RU2016136823A (ru) 2018-12-11
PT2651918T (pt) 2017-10-17
RU2599785C2 (ru) 2016-10-20

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