PT2651918T - Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidin-2,4-diamina - Google Patents
Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidin-2,4-diaminaInfo
- Publication number
- PT2651918T PT2651918T PT118060797T PT11806079T PT2651918T PT 2651918 T PT2651918 T PT 2651918T PT 118060797 T PT118060797 T PT 118060797T PT 11806079 T PT11806079 T PT 11806079T PT 2651918 T PT2651918 T PT 2651918T
- Authority
- PT
- Portugal
- Prior art keywords
- phenyl
- piperidin
- isopropoxy
- pyrimidine
- sulfonyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424194P | 2010-12-17 | 2010-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2651918T true PT2651918T (pt) | 2017-10-17 |
Family
ID=45464892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT16167355T PT3121171T (pt) | 2010-12-17 | 2011-12-15 | Formas cristalinas de 5-cloro-n2-(2-isopropóxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidina-2,4-diamina |
| PT118060797T PT2651918T (pt) | 2010-12-17 | 2011-12-15 | Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidin-2,4-diamina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT16167355T PT3121171T (pt) | 2010-12-17 | 2011-12-15 | Formas cristalinas de 5-cloro-n2-(2-isopropóxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidina-2,4-diamina |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US9309229B2 (pt) |
| EP (3) | EP2651918B1 (pt) |
| JP (1) | JP5916752B2 (pt) |
| KR (4) | KR102325775B1 (pt) |
| CN (7) | CN114989139A (pt) |
| AR (2) | AR084309A1 (pt) |
| AU (1) | AU2011343775B2 (pt) |
| BR (1) | BR112013015000A2 (pt) |
| CA (1) | CA2821102C (pt) |
| CL (1) | CL2013001723A1 (pt) |
| CO (1) | CO6801792A2 (pt) |
| CY (2) | CY1119474T1 (pt) |
| DK (2) | DK3121171T3 (pt) |
| EC (1) | ECSP13012770A (pt) |
| ES (3) | ES2696526T3 (pt) |
| GT (1) | GT201300153A (pt) |
| HR (2) | HRP20171477T1 (pt) |
| HU (1) | HUE041845T2 (pt) |
| IL (1) | IL226474A (pt) |
| LT (2) | LT2651918T (pt) |
| MA (1) | MA34771B1 (pt) |
| MX (1) | MX338210B (pt) |
| MY (2) | MY177742A (pt) |
| NZ (1) | NZ610713A (pt) |
| PE (1) | PE20140698A1 (pt) |
| PL (2) | PL2651918T3 (pt) |
| PT (2) | PT3121171T (pt) |
| RS (1) | RS57771B1 (pt) |
| RU (2) | RU2599785C3 (pt) |
| SG (2) | SG190856A1 (pt) |
| SI (2) | SI3121171T1 (pt) |
| TN (1) | TN2013000216A1 (pt) |
| TW (2) | TWI576344B (pt) |
| WO (1) | WO2012082972A1 (pt) |
| ZA (1) | ZA201303599B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102325775B1 (ko) * | 2010-12-17 | 2021-11-12 | 노파르티스 아게 | 5-클로로-ｎ2-(2-이소프로폭시-5-메틸-4-피페리딘-4-일-페닐)-ｎ4[2-(프로판-2-술포닐)-페닐]-피리미딘-2,4-디아민의 결정질 형태 |
| AU2013344049B2 (en) | 2012-11-06 | 2017-12-21 | Fochon Pharmaceuticals, Ltd. | ALK kinase inhibitors |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| CN105272921A (zh) * | 2014-06-09 | 2016-01-27 | 江苏奥赛康药业股份有限公司 | 一种制备Ceritinib的方法及其中间体化合物 |
| CN105294649B (zh) * | 2014-07-30 | 2019-05-14 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
| CN105294650A (zh) * | 2014-08-01 | 2016-02-03 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
| KR20210142781A (ko) | 2014-10-21 | 2021-11-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민 |
| WO2016081538A1 (en) | 2014-11-18 | 2016-05-26 | Teva Pharmaceuticals International Gmbh | Solid state forms of ceritinib and salts thereof |
| CN105601614A (zh) * | 2014-11-21 | 2016-05-25 | 奥浦顿（上海）医药科技有限公司 | 一种色瑞替尼晶型及其制备方法 |
| WO2016082795A1 (zh) * | 2014-11-28 | 2016-06-02 | 苏州晶云药物科技有限公司 | 色瑞替尼的晶型i及其制备方法 |
| CN105622577A (zh) * | 2014-11-29 | 2016-06-01 | 江苏先声药业有限公司 | 一种色瑞替尼的新晶型及其制备方法 |
| WO2016108123A2 (en) * | 2014-12-17 | 2016-07-07 | Dr. Reddy’S Laboratories Limited | Pure amorphous and amorphous solid dispersion of ceritinib |
| WO2016098042A1 (en) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Use of ceritinib (ldk-378) in the treatment of fes or fer mediated disorders, in particular proliferative disorders |
| WO2016098070A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Crystalline form of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2, 4-diamine |
| WO2017016529A1 (en) | 2015-07-28 | 2017-02-02 | Zentiva, K.S. | Solid forms of ceritinib free base |
| CN105061397B (zh) * | 2015-08-07 | 2018-01-02 | 武汉英普瑞医药科技有限公司 | 一种色瑞替尼的c型晶型及其制备方法与应用 |
| CN106699743B (zh) | 2015-11-05 | 2020-06-12 | 湖北生物医药产业技术研究院有限公司 | 嘧啶类衍生物及其用途 |
| WO2017152858A1 (zh) * | 2016-03-11 | 2017-09-14 | 苏州晶云药物科技有限公司 | 色瑞替尼的晶型及其制备方法 |
| US10604505B2 (en) | 2016-03-15 | 2020-03-31 | Natco Pharma Limited | Modified process for the preparation of Ceritinib and amorphous form of Ceritinib |
| JP2019196359A (ja) * | 2019-06-17 | 2019-11-14 | ノバルティス アーゲー | ピリミジン誘導体およびそれらの中間体を調製する化学的方法 |
| GB201915618D0 (en) | 2019-10-28 | 2019-12-11 | Univ Oslo | ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases |
| EP4092021A4 (en) * | 2020-01-17 | 2023-01-25 | Shandong Xuanzhu Pharma Co., Ltd. | CRYSTALLINE FORM OF A POLYCYCLIC ANAPLASIC LYMPHOMA KINASE INHIBITOR |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| DK1660458T3 (da) * | 2003-08-15 | 2012-05-07 | Irm Llc | 2, 4-pyrimidindiaminer egnede i behandling af neoplastiske sygdomme, in-flammatoriske lidelser og lidelser i immunsystemet. |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| MY148427A (en) * | 2006-12-08 | 2013-04-30 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2007333394C1 (en) | 2006-12-08 | 2011-08-18 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| JP2010538004A (ja) * | 2007-08-28 | 2010-12-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | キナーゼ阻害剤としての２−ビフェニルアミノ−４−アミノピリミジン誘導体 |
| WO2009032694A1 (en) * | 2007-08-28 | 2009-03-12 | Dana Farber Cancer Institute | Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis |
| CA2720946C (en) | 2008-04-07 | 2013-05-28 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| SI2300013T1 (en) * | 2008-05-21 | 2018-03-30 | Adriad Pharmacaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CA2763717A1 (en) * | 2009-06-10 | 2010-12-16 | Cellzome Limited | Pyrimidine derivatives as zap-70 inhibitors |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| KR102325775B1 (ko) * | 2010-12-17 | 2021-11-12 | 노파르티스 아게 | 5-클로로-ｎ2-(2-이소프로폭시-5-메틸-4-피페리딘-4-일-페닐)-ｎ4[2-(프로판-2-술포닐)-페닐]-피리미딘-2,4-디아민의 결정질 형태 |
| US8513436B2 (en) | 2010-12-17 | 2013-08-20 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| KR20140017520A (ko) | 2010-12-17 | 2014-02-11 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 살진균제 아조사이클릭 아미드 |
| CN105294650A (zh) | 2014-08-01 | 2016-02-03 | 江苏奥赛康药业股份有限公司 | 一种Ceritinib化合物及其药物组合物 |
| WO2016081538A1 (en) | 2014-11-18 | 2016-05-26 | Teva Pharmaceuticals International Gmbh | Solid state forms of ceritinib and salts thereof |
| US9566882B2 (en) | 2014-11-21 | 2017-02-14 | Tk Holdings Inc. | Airbag module |
| CN105622577A (zh) | 2014-11-29 | 2016-06-01 | 江苏先声药业有限公司 | 一种色瑞替尼的新晶型及其制备方法 |
| MX2017007097A (es) | 2014-12-04 | 2017-09-05 | Bristol Myers Squibb Co | Combinacion de anticuerpos anti-cs1 y anti-muerte programada 1 (pd1) para tratar cancer (mieloma). |
| WO2016098070A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Crystalline form of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2, 4-diamine |
| WO2017016529A1 (en) | 2015-07-28 | 2017-02-02 | Zentiva, K.S. | Solid forms of ceritinib free base |
| CN105061397B (zh) | 2015-08-07 | 2018-01-02 | 武汉英普瑞医药科技有限公司 | 一种色瑞替尼的c型晶型及其制备方法与应用 |
-
2011
- 2011-12-15 KR KR1020207009828A patent/KR102325775B1/ko active IP Right Grant
- 2011-12-15 ES ES16167355T patent/ES2696526T3/es active Active
- 2011-12-15 PL PL11806079T patent/PL2651918T3/pl unknown
- 2011-12-15 DK DK16167355.3T patent/DK3121171T3/en active
- 2011-12-15 AU AU2011343775A patent/AU2011343775B2/en active Active
- 2011-12-15 KR KR1020197005138A patent/KR20190022903A/ko active Search and Examination
- 2011-12-15 LT LTEP11806079.7T patent/LT2651918T/lt unknown
- 2011-12-15 CN CN202210792464.5A patent/CN114989139A/zh active Pending
- 2011-12-15 KR KR1020187007996A patent/KR20180032680A/ko not_active Application Discontinuation
- 2011-12-15 HU HUE16167355A patent/HUE041845T2/hu unknown
- 2011-12-15 EP EP11806079.7A patent/EP2651918B1/en not_active Revoked
- 2011-12-15 NZ NZ610713A patent/NZ610713A/en not_active IP Right Cessation
- 2011-12-15 BR BR112013015000A patent/BR112013015000A2/pt not_active Application Discontinuation
- 2011-12-15 SG SG2013039342A patent/SG190856A1/en unknown
- 2011-12-15 MY MYPI2016001551A patent/MY177742A/en unknown
- 2011-12-15 CN CN201710063793.5A patent/CN107056751A/zh active Pending
- 2011-12-15 SG SG10201510082XA patent/SG10201510082XA/en unknown
- 2011-12-15 MX MX2013006952A patent/MX338210B/es active IP Right Grant
- 2011-12-15 PL PL16167355T patent/PL3121171T3/pl unknown
- 2011-12-15 US US13/993,217 patent/US9309229B2/en active Active
- 2011-12-15 WO PCT/US2011/065030 patent/WO2012082972A1/en active Application Filing
- 2011-12-15 AR ARP110104703A patent/AR084309A1/es not_active Application Discontinuation
- 2011-12-15 DK DK11806079.7T patent/DK2651918T3/en active
- 2011-12-15 PT PT16167355T patent/PT3121171T/pt unknown
- 2011-12-15 RS RS20181240A patent/RS57771B1/sr unknown
- 2011-12-15 LT LTEP16167355.3T patent/LT3121171T/lt unknown
- 2011-12-15 CN CN202011050061.0A patent/CN112125884A/zh active Pending
- 2011-12-15 CA CA2821102A patent/CA2821102C/en active Active
- 2011-12-15 ES ES11806079.7T patent/ES2643016T3/es active Active
- 2011-12-15 JP JP2013544762A patent/JP5916752B2/ja active Active
- 2011-12-15 ES ES18186197T patent/ES2905973T3/es active Active
- 2011-12-15 CN CN201610217386.0A patent/CN106008462A/zh active Pending
- 2011-12-15 CN CN201410457562.9A patent/CN104262324A/zh active Pending
- 2011-12-15 CN CN201180060435XA patent/CN103282359A/zh active Pending
- 2011-12-15 PT PT118060797T patent/PT2651918T/pt unknown
- 2011-12-15 CN CN201710063792.0A patent/CN106831716A/zh active Pending
- 2011-12-15 RU RU2013132947A patent/RU2599785C3/ru active Protection Beyond IP Right Term
- 2011-12-15 SI SI201131583T patent/SI3121171T1/sl unknown
- 2011-12-15 MY MYPI2013001848A patent/MY164810A/en unknown
- 2011-12-15 PE PE2013001425A patent/PE20140698A1/es not_active Application Discontinuation
- 2011-12-15 KR KR1020137018605A patent/KR20130130022A/ko not_active Application Discontinuation
- 2011-12-15 EP EP18186197.2A patent/EP3453708B8/en active Active
- 2011-12-15 EP EP16167355.3A patent/EP3121171B1/en active Active
- 2011-12-15 RU RU2016136823A patent/RU2746159C2/ru active
- 2011-12-15 SI SI201131289T patent/SI2651918T1/sl unknown
- 2011-12-16 TW TW105112710A patent/TWI576344B/zh active
- 2011-12-16 TW TW100146987A patent/TWI576343B/zh active
-
2013
- 2013-05-17 ZA ZA2013/03599A patent/ZA201303599B/en unknown
- 2013-05-17 TN TNP2013000216A patent/TN2013000216A1/fr unknown
- 2013-05-20 IL IL226474A patent/IL226474A/en active IP Right Grant
- 2013-06-14 CL CL2013001723A patent/CL2013001723A1/es unknown
- 2013-06-17 GT GT201300153A patent/GT201300153A/es unknown
- 2013-06-28 MA MA36066A patent/MA34771B1/fr unknown
- 2013-07-04 CO CO13158446A patent/CO6801792A2/es not_active Application Discontinuation
- 2013-07-16 EC ECSP13012770 patent/ECSP13012770A/es unknown
-
2016
- 2016-03-02 US US15/058,489 patent/US20160175305A1/en not_active Abandoned
-
2017
- 2017-10-03 HR HRP20171477TT patent/HRP20171477T1/hr unknown
- 2017-10-11 CY CY20171101064T patent/CY1119474T1/el unknown
-
2018
- 2018-10-22 HR HRP20181737TT patent/HRP20181737T1/hr unknown
- 2018-11-09 CY CY181101192T patent/CY1121017T1/el unknown
-
2021
- 2021-03-19 AR ARP210100698A patent/AR122395A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL226474A0 (en) | Crystal forms of 5-chloro-n2-@@-isopropoxy-@-methyl-4-piperidine-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]pyrimidine-4,2-diamine | |
| IL242278A0 (en) | Compounds 4)-n-fluoro-2-methoxy-5-nitrophenyl)pyrimidine-2-converted amine and their salts | |
| GB201001075D0 (en) | Crystalline forms | |
| ZA201209029B (en) | Novel pyrimidine derivatives | |
| GB201012105D0 (en) | Novel pyrimidine compounds | |
| RS55269B1 (sr) | 2-(supstituisani-fenil)-ciklopentan-1,3-dion jedinjenja, i derivati od toga | |
| EP2445346A4 (en) | OXOHETEROCYCLIC FUSIONED PYRIMIDINE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE | |
| SI2175857T1 (sl) | Kristalna oblika (E) 4-((4-((4-(2-cianoetenil)-2,6-dimetilfenil)amino) 2-pirimidinil)amino)benzonitrila | |
| SI2545048T1 (sl) | Soli Raltegravirja in njegove kristalinične oblike | |
| HK1210403A1 (en) | Condensing implant | |
| EP2560655A4 (en) | SUBSTITUTED PYRIMIDINES | |
| PL2578595T3 (pl) | Krystaliczna lewoizowalerylospiramycyna I | |
| EP2758058A4 (en) | SUBSTITUTED PYRIMIDINES | |
| EP2735567A4 (en) | HETEROCYCLIC SUBSTITUTED PYRIMIDINE COMPOUND | |
| GB201019013D0 (en) | Bone formation | |
| ZA201106695B (en) | Substituted fused pyrimidine compounds | |
| AU2011904399A0 (en) | Intramedullary prosthesis |