NO974899D0 - Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analog - Google Patents
Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analogInfo
- Publication number
- NO974899D0 NO974899D0 NO974899A NO974899A NO974899D0 NO 974899 D0 NO974899 D0 NO 974899D0 NO 974899 A NO974899 A NO 974899A NO 974899 A NO974899 A NO 974899A NO 974899 D0 NO974899 D0 NO 974899D0
- Authority
- NO
- Norway
- Prior art keywords
- terminal end
- preparing
- polypeptide
- therapeutically active
- analogous process
- Prior art date
Links
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK105489A DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Polypeptid |
| DK494189A DK494189D0 (da) | 1989-10-06 | 1989-10-06 | Polypeptid |
| PCT/DK1990/000058 WO1990010075A1 (en) | 1989-03-03 | 1990-03-01 | Yeast processing system comprising a negatively charged amino acid adjacent to the processing site |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO974899L NO974899L (no) | 1997-10-23 |
| NO974899D0 true NO974899D0 (no) | 1997-10-23 |
Family
ID=26065137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO913427A NO304236B1 (no) | 1989-03-03 | 1991-09-02 | Polypeptid omfattende en sammensmelting av et signalpeptid, et lederpeptid og et heterologt protein eller polypeptid, DNA-konstruksjoner omfattende en DNA-sekvens som koder for polypeptidet samt gjµrstamme og vektor som kan uttrykke det |
| NO974899A NO974899D0 (no) | 1989-03-03 | 1997-10-23 | Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analog |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO913427A NO304236B1 (no) | 1989-03-03 | 1991-09-02 | Polypeptid omfattende en sammensmelting av et signalpeptid, et lederpeptid og et heterologt protein eller polypeptid, DNA-konstruksjoner omfattende en DNA-sekvens som koder for polypeptidet samt gjµrstamme og vektor som kan uttrykke det |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5395922A (no) |
| EP (1) | EP0461165B2 (no) |
| JP (1) | JP2609367B2 (no) |
| KR (1) | KR970005928B1 (no) |
| AT (1) | ATE110414T1 (no) |
| AU (1) | AU624694B2 (no) |
| CA (1) | CA2050336C (no) |
| CZ (1) | CZ285239B6 (no) |
| DD (1) | DD296965A5 (no) |
| DE (1) | DE69011853T3 (no) |
| DK (2) | DK105489D0 (no) |
| ES (1) | ES2062514T5 (no) |
| FI (1) | FI104985B (no) |
| HU (2) | HU215538B (no) |
| IE (1) | IE66469B1 (no) |
| IL (1) | IL93609A (no) |
| NO (2) | NO304236B1 (no) |
| NZ (1) | NZ232742A (no) |
| PL (1) | PL163532B1 (no) |
| RU (1) | RU2194758C2 (no) |
| UA (1) | UA27706C2 (no) |
| WO (1) | WO1990010075A1 (no) |
| ZA (1) | ZA901476B (no) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| EP0472658A4 (en) * | 1989-05-19 | 1992-08-26 | Biotechnology Res & Dev | Fusion proteins having an in vivo post-translational modification site and methods of manufacture and purification |
| GB9015825D0 (en) * | 1990-07-18 | 1990-09-05 | Ciba Geigy Ag | In vitro processing of fusion proteins |
| DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| GB9106185D0 (en) * | 1991-03-22 | 1991-05-08 | Wellcome Found | Biological control agents |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FI92601C (fi) * | 1992-03-11 | 1994-12-12 | Marja Makarow | Menetelmä hyötyproteiinien erittämiseksi hiivoista |
| US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
| DE4417353A1 (de) * | 1994-05-18 | 1996-01-25 | Bayer Ag | Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz |
| ZA954983B (en) * | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| US5861267A (en) * | 1995-05-01 | 1999-01-19 | Vertex Pharmaceuticals Incorporated | Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity |
| ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US5851800A (en) * | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
| DE19629982A1 (de) | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
| EP0948538B1 (en) | 1996-12-13 | 2008-06-11 | Novartis Vaccines and Diagnostics, Inc. | Analysis and separation of platelet-derived growth factor proteins |
| ES2258797T3 (es) * | 1996-12-20 | 2006-09-01 | Novo Nordisk A/S | Proteinas con extension n-terminal expresadas en la levadura. |
| JP2001527387A (ja) * | 1997-01-24 | 2001-12-25 | ノボ ノルディスク アクティーゼルスカブ | 合成リーダーペプチド配列 |
| US6046000A (en) * | 1997-11-07 | 2000-04-04 | Millennium Biotherapeutics, Inc. | Method for identifying genes encoding signal sequences |
| EP1049790A1 (en) | 1998-01-23 | 2000-11-08 | Novo Nordisk A/S | Process for making desired polypeptides in yeast |
| AU1995701A (en) | 1999-12-29 | 2001-07-16 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7507413B2 (en) * | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7595172B2 (en) | 2001-07-24 | 2009-09-29 | Novo Nordisk A/S | Method for making acylated polypeptides |
| WO2003060071A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2003059934A2 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7309505B2 (en) | 2002-09-13 | 2007-12-18 | Cornell Research Foundation, Inc. | Using mutations to improve Aspergillus phytases |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2007532096A (ja) | 2003-11-14 | 2007-11-15 | ノボ ノルディスク アクティーゼルスカブ | アシル化されたインスリンの製造方法 |
| AU2004295023A1 (en) | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
| US9056921B2 (en) | 2005-08-16 | 2015-06-16 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
| ATE482977T1 (de) | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
| US20080026376A1 (en) | 2006-07-11 | 2008-01-31 | Huaming Wang | KEX2 cleavage regions of recombinant fusion proteins |
| US8198046B2 (en) | 2006-07-11 | 2012-06-12 | Danisco Us Inc. | KEX2 cleavage regions of recombinant fusion proteins |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| WO2008037735A1 (en) | 2006-09-27 | 2008-04-03 | Novo Nordisk A/S | Method for making maturated insulin polypeptides |
| EP2084179B1 (en) | 2006-11-22 | 2013-05-22 | Novo Nordisk A/S | Method for making activated carboxypeptidases |
| CN101743252A (zh) | 2007-07-16 | 2010-06-16 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、peg化的胰岛素类似物 |
| EP2178909B1 (en) | 2007-08-13 | 2015-10-21 | Novo Nordisk A/S | Rapid acting insulin analogues |
| EP2708554A1 (en) | 2007-08-15 | 2014-03-19 | Novo Nordisk A/S | Insulin analogues with an acyl and alkylene glycol moiety |
| JP5721432B2 (ja) | 2007-08-15 | 2015-05-20 | ノボ・ノルデイスク・エー／エス | アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン |
| US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
| US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| ES2563553T3 (es) | 2008-04-01 | 2016-03-15 | Novo Nordisk A/S | Conjugados de insulina-albúmina |
| CA2755300A1 (en) * | 2009-03-12 | 2010-09-16 | Bigtec Private Limited | A polynucleotide and polypeptide sequence and methods thereof |
| RU2533217C3 (ru) | 2009-06-26 | 2020-12-21 | Ново Нордиск А/С | Препарат, содержащий инсулин, никотинамид и аминокислоту |
| CN102639559B (zh) | 2009-11-25 | 2015-04-29 | 诺沃—诺迪斯克有限公司 | 用于制备多肽的方法 |
| EP2526117B1 (en) | 2010-01-22 | 2015-05-06 | Novo Nordisk A/S | Process for preparing fgf-21 with low degree of o-glycosylation |
| EP2585484A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| RU2598273C2 (ru) | 2010-06-23 | 2016-09-20 | Ново Нордиск А/С | Производные инсулина, содержащие дополнительные дисульфидные связи |
| WO2011161083A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
| CN103249427A (zh) | 2010-12-14 | 2013-08-14 | 诺沃—诺迪斯克有限公司 | 速效胰岛素联合长效胰岛素 |
| JP2014501239A (ja) | 2010-12-14 | 2014-01-20 | ノヴォ ノルディスク アー／エス | インスリン、ニコチンアミドおよびアミノ酸を含む製剤 |
| JP6058646B2 (ja) | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 多置換インスリン |
| RU2460795C1 (ru) * | 2011-07-06 | 2012-09-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | Способ микробиологического синтеза секретируемого соматотропина человека и штамм дрожжей saccharomyces cerevisiae - продуцент секретируемого соматотропина человека |
| WO2013186138A1 (en) | 2012-06-14 | 2013-12-19 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and arginine |
| JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体 |
| CN103254277B (zh) * | 2013-05-03 | 2017-02-08 | 南京工业大学 | 强分泌性信号肽增强小肽模序及其应用 |
| CN105308067B (zh) | 2013-06-07 | 2020-07-24 | 诺和诺德股份有限公司 | 制备成熟胰岛素多肽的方法 |
| PL233560B1 (pl) | 2014-12-05 | 2019-10-31 | Mabion Spolka Akcyjna | Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka |
| WO2016144658A1 (en) | 2015-03-10 | 2016-09-15 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| CN107743494B (zh) | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | 具有极性重组延伸体的胰岛素 |
| EP3341401A1 (en) | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| CN108368163A (zh) | 2015-08-25 | 2018-08-03 | 诺和诺德股份有限公司 | 新型胰岛素衍生物及其医学用途 |
| US11352406B2 (en) | 2015-08-25 | 2022-06-07 | Novo Nordisk A/S | Insulin derivatives and the medical uses hereof |
| KR102043067B1 (ko) * | 2017-08-08 | 2019-11-11 | 엘지전자 주식회사 | 차량용 사이드 미러 및 차량 |
| PE20211264A1 (es) | 2017-08-17 | 2021-07-15 | Novo Nordisk As | Analogos de insulina acilados novedosos y usos de estos |
| MX2022006251A (es) | 2019-12-11 | 2022-06-22 | Novo Nordisk As | Analogos de insulina novedosos y usos de estos. |
| WO2023144240A1 (en) | 2022-01-26 | 2023-08-03 | Novo Nordisk Research Centre Oxford Limited | Glucose sensitive insulin derivatives and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5712580A (en) * | 1979-04-05 | 1980-10-09 | James Joseph Connell | Engine charging and scavenging |
| US4546082A (en) * | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| JPS60501140A (ja) * | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
| US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| JPS61264000A (ja) * | 1985-03-21 | 1986-11-21 | イミユネツクス コ−ポレイシヨン | 標識ペプチドによるタンパク質の合成 |
| JPS6236183A (ja) * | 1985-06-20 | 1987-02-17 | ザ・サルク・インステイチユ−ト・バイオテクノロジ−／インダストリアル・アソシエイツ・インコ−ポレ−テツド | サツカロミセス・セレビシエからのポリペプチドの発現および分泌 |
| MC1834A1 (fr) * | 1986-07-10 | 1988-06-03 | Transgene Sa | Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation |
| DK175535B1 (da) * | 1987-03-04 | 2004-11-29 | Daiichi Suntory Pharma Co Ltd | Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid |
| JPH03503596A (ja) * | 1987-06-24 | 1991-08-15 | ノボ・ノルディスク エー／エス | 蛋白質若しくはポリペプチドの調製方法、該ポリペプチドをコードするｄｎａ配列、該ｄｎａ配列およびポリペプチドを有する微生物および該ポリペプチドの薬学的製剤としての利用 |
| DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
| DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| JPH01240191A (ja) * | 1988-02-16 | 1989-09-25 | Green Cross Corp:The | 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現 |
| DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
| AU633020B2 (en) * | 1988-07-23 | 1993-01-21 | Novozymes Delta Limited | New secretory leader sequences |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
-
1989
- 1989-03-03 DK DK105489A patent/DK105489D0/da not_active Application Discontinuation
-
1990
- 1990-02-27 ZA ZA901476A patent/ZA901476B/xx unknown
- 1990-03-01 CA CA002050336A patent/CA2050336C/en not_active Expired - Fee Related
- 1990-03-01 DE DE69011853T patent/DE69011853T3/de not_active Expired - Lifetime
- 1990-03-01 ES ES90904258T patent/ES2062514T5/es not_active Expired - Lifetime
- 1990-03-01 UA UA5010019A patent/UA27706C2/uk unknown
- 1990-03-01 AU AU52612/90A patent/AU624694B2/en not_active Ceased
- 1990-03-01 EP EP90904258A patent/EP0461165B2/en not_active Expired - Lifetime
- 1990-03-01 HU HU902376A patent/HU215538B/hu not_active IP Right Cessation
- 1990-03-01 KR KR1019910701029A patent/KR970005928B1/ko not_active IP Right Cessation
- 1990-03-01 WO PCT/DK1990/000058 patent/WO1990010075A1/en active IP Right Grant
- 1990-03-01 DK DK90904258.2T patent/DK0461165T3/da active
- 1990-03-01 JP JP2504527A patent/JP2609367B2/ja not_active Expired - Lifetime
- 1990-03-01 RU SU5010019/13A patent/RU2194758C2/ru not_active IP Right Cessation
- 1990-03-01 AT AT90904258T patent/ATE110414T1/de not_active IP Right Cessation
- 1990-03-01 NZ NZ232742A patent/NZ232742A/xx unknown
- 1990-03-02 DD DD90338353A patent/DD296965A5/de unknown
- 1990-03-02 IE IE74990A patent/IE66469B1/en not_active IP Right Cessation
- 1990-03-02 CZ CS901039A patent/CZ285239B6/cs not_active IP Right Cessation
- 1990-03-02 IL IL9360990A patent/IL93609A/en not_active IP Right Cessation
- 1990-03-02 PL PL90284146A patent/PL163532B1/pl not_active IP Right Cessation
-
1991
- 1991-09-02 NO NO913427A patent/NO304236B1/no unknown
- 1991-09-02 FI FI914125A patent/FI104985B/fi not_active IP Right Cessation
-
1994
- 1994-02-15 US US08/196,887 patent/US5395922A/en not_active Expired - Lifetime
-
1995
- 1995-03-02 US US08/397,597 patent/US5514585A/en not_active Expired - Lifetime
- 1995-03-02 US US08/397,595 patent/US5510249A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00592P patent/HU211600A9/hu unknown
-
1997
- 1997-10-23 NO NO974899A patent/NO974899D0/no unknown
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